FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Cabrera M et al. Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. 2007 Bioorg. Med. Chem. pmid:17383189
Golub AG et al. Discovery and characterization of synthetic 4'-hydroxyflavones-New CK2 inhibitors from flavone family. 2013 Bioorg. Med. Chem. pmid:24011954
Kuemmerle J et al. Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid. 2008 Bioorg. Med. Chem. pmid:18337106
Springsteel MF et al. Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. 2003 Bioorg. Med. Chem. pmid:12927873
Wang TC et al. Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives. 2005 Bioorg. Med. Chem. pmid:15990314
Boumendjel A et al. Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2. 2007 Bioorg. Med. Chem. pmid:17317193
Dei S et al. Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR). 2018 Bioorg. Med. Chem. pmid:29162309
Ullah Mughal E et al. Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones. 2006 Bioorg. Med. Chem. pmid:16603364
Xiang H et al. Synthesis and biological evaluation of isoflavone fatty acid esters with potential weight loss and hypolipidemic activities. 2010 Bioorg. Med. Chem. pmid:20392645
Dong X et al. Identification of SVM-based classification model, synthesis and evaluation of prenylated flavonoids as vasorelaxant agents. 2008 Bioorg. Med. Chem. pmid:18678502
Göker H et al. Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles. 2005 Bioorg. Med. Chem. pmid:15698788
Mavel S et al. Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1). 2006 Bioorg. Med. Chem. pmid:16263302
Marder M et al. Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABA(A) receptor complex. 2001 Bioorg. Med. Chem. pmid:11249125
Lewin G et al. Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk. 2011 Bioorg. Med. Chem. pmid:21146994
Li HQ et al. Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics. 2009 Bioorg. Med. Chem. pmid:19664929
Lewin G et al. Influence of the skeleton on the cytotoxicity of flavonoids. 2012 Bioorg. Med. Chem. pmid:22257529
Mays JR et al. The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone. 2010 Bioorg. Med. Chem. pmid:19932969
Liu H et al. New synthetic flavone derivatives induce apoptosis of hepatocarcinoma cells. 2010 Bioorg. Med. Chem. pmid:20674374
Lebeau J et al. Beneficial effects of different flavonoids, on functional recovery after ischemia and reperfusion in isolated rat heart. 2001 Bioorg. Med. Chem. Lett. pmid:11140725
Hatnapure GD et al. Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. 2012 Bioorg. Med. Chem. Lett. pmid:22981334