| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bourdillat B et al. | Mechanism of action of hispidulin, a natural flavone, on human platelets. | 1988 | Prog. Clin. Biol. Res. | pmid:2845433 |
| Urba WJ et al. | Enhancement of natural killer activity in human peripheral blood by flavone acetic acid. | 1988 | J. Natl. Cancer Inst. | pmid:2452890 |
| Hornung RL et al. | Augmentation of natural killer activity, induction of IFN and development tumor immunity during the successful treatment of established murine renal cancer using flavone acetic acid and IL-2. | 1988 | J. Immunol. | pmid:2460546 |
| Verweij J et al. | Rapid alkalinisation for flavone acetic acid administration: a potentially hazardous procedure. | 1988 | Lancet | pmid:2893206 |
| Davis HP et al. | Immune thrombocytopenia caused by flavone-8-acetic acid. | 1988 | Lancet | pmid:2893207 |
| Yamazoe Y et al. | Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450. | 1988 | Carcinogenesis | pmid:3121205 |
| Yamazoe Y et al. | Metabolic activation of pyrolysate arylamines by human liver microsomes; possible involvement of a P-488-H type cytochrome P-450. | 1988 | Jpn. J. Cancer Res. | pmid:3147272 |
| Armand J et al. | Flavonoids: a new class of anticancer agents? Preclinical and clinical data of flavone acetic acid. | 1988 | Prog. Clin. Biol. Res. | pmid:3051027 |
| Pratesi G et al. | Response of chemically induced primary colon tumours of the mouse to flavone acetic acid (NSC 347 512). | 1988 | Br. J. Cancer | pmid:3166904 |
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| Hill S et al. | Vascular collapse after flavone acetic acid: a possible mechanism of its anti-tumour action. | 1989 | Eur J Cancer Clin Oncol | pmid:2591434 |
| Ching LM and Baguley BC | Hyporesponsiveness of macrophages from C3H/HeJ (endotoxin-resistant) mice to the antitumour agent flavone acetic acid (NSC 347512). | 1989 | Eur J Cancer Clin Oncol | pmid:2591444 |
| Chabot GG et al. | Pharmacodynamics and causes of dose-dependent pharmacokinetics of flavone-8-acetic acid (LM-975; NSC-347512) in mice. | 1989 | Cancer Chemother. Pharmacol. | pmid:2597279 |
| Ching LM and Baguley BC | Reduction of cytotoxic effector cell activity in colon 38 tumours following treatment with flavone acetic acid. | 1989 | Eur J Cancer Clin Oncol | pmid:2597283 |
| Baguley BC et al. | Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice. | 1989 | Eur J Cancer Clin Oncol | pmid:2702981 |
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| Nagai T et al. | Inhibition of mouse liver sialidase by plant flavonoids. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2775264 |
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| Cassidy J et al. | Could interspecies differences in the protein binding of flavone acetic acid contribute to the failure to predict lack of efficacy in patients? | 1989 | Cancer Chemother. Pharmacol. | pmid:2713962 |
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