| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Böcker D and Verspohl EJ | Role of protein kinase C, PI3-kinase and tyrosine kinase in activation of MAP kinase by glucose and agonists of G-protein coupled receptors in INS-1 cells. | 2001 | Int. J. Exp. Diabetes Res. | pmid:12369712 |
| Lebeau J et al. | Beneficial effects of different flavonoids, on functional recovery after ischemia and reperfusion in isolated rat heart. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11140725 |
| Saarinen N et al. | No evidence for the in vivo activity of aromatase-inhibiting flavonoids. | 2001 | J. Steroid Biochem. Mol. Biol. | pmid:11595503 |
| Park BK et al. | Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. | 2001 | Eur. J. Pharmacol. | pmid:11502282 |
| Rajendran NN et al. | Modulation by insulin rather than blood glucose of the pain threshold in acute physiological and flavone induced antinociception in mice. | 2001 | Indian J. Exp. Biol. | pmid:11883508 |
| Kim SJ | Effect of biflavones of Ginkgo biloba against UVB-induced cytotoxicity in vitro. | 2001 | J. Dermatol. | pmid:11449670 |
| Andrade-Cetto A and Wiedenfeld H | Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. | 2001 | J Ethnopharmacol | pmid:11694359 |
| Chung MI et al. | Synthesis, antiplatelet and vasorelaxing effects of monooxygenated flavones and flavonoxypropanolamines. | 2001 | J. Pharm. Pharmacol. | pmid:11804390 |
| Kestell P et al. | Measurement of plasma 5-hydroxyindoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents. | 2001 | Clin. Chim. Acta | pmid:11718691 |
| Hirvonen T et al. | Flavonol and flavone intake and the risk of cancer in male smokers (Finland). | 2001 | Cancer Causes Control | pmid:11714106 |
| Hirvonen T et al. | Intake of flavonols and flavones and risk of coronary heart disease in male smokers. | 2001 | Epidemiology | pmid:11138821 |
| Lee SE et al. | Inhibitory effects of naturally occurring compounds on aflatoxin B(1) biotransformation. | 2001 | J. Agric. Food Chem. | pmid:11714299 |
| Harris SR et al. | Oxidative stress contributes to the anti-proliferative effects of flavone acetic acid on endothelial cells. | 2000 Jul-Aug | Anticancer Res. | pmid:10953282 |
| Shao ZM et al. | Genistein's "ER-dependent and independent" actions are mediated through ER pathways in ER-positive breast carcinoma cell lines. | 2000 Jul-Aug | Anticancer Res. | pmid:10953303 |
| Wollenweber E et al. | Epicuticular flavonoids of some Scrophulariaceae. | 2000 Jan-Feb | Z. Naturforsch., C, J. Biosci. | pmid:10739092 |
| Kubo I et al. | Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria. | 2000 | Bioorg. Med. Chem. | pmid:10976523 |
| Akao T et al. | Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. | 2000 | J. Pharm. Pharmacol. | pmid:11197087 |
| Tomazela DM et al. | Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities. | 2000 | Phytochemistry | pmid:11130676 |
| Rajendran NN et al. | Antinociceptive pattern of flavone and its mechanism as tested by formalin assay. | 2000 | Indian J. Exp. Biol. | pmid:11218837 |
| Collins-Burow BM et al. | Estrogenic and antiestrogenic activities of flavonoid phytochemicals through estrogen receptor binding-dependent and -independent mechanisms. | 2000 | Nutr Cancer | pmid:11525602 |
| Tunçbilek M et al. | Synthesis and antioxidant properties of some new flavone derivatives on lipid peroxidation in the rat liver. | 2000 | Pharmazie | pmid:11828615 |
| Kulevanova S et al. | HPLC identification and determination of flavone aglycones in Helichrysum plicatum DC. (Asteraceae). | 2000 | Pharmazie | pmid:11828624 |
| Huang HS et al. | [Advances in the research on pharmacological actions of flavone compounds]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516448 |
| Li Y et al. | Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. | 2000 | Clin. Cancer Res. | pmid:10656453 |
| Dertinger SD et al. | Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms. | 2000 | Biochem. Pharmacol. | pmid:10825463 |
| Motwani M et al. | Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. | 2000 | Clin. Cancer Res. | pmid:10741717 |
| Perez RM et al. | Isolation and hypoglycemic activity of 5, 7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia. | 2000 | Phytomedicine | pmid:10782487 |
| Liu IX et al. | Baicalin synergy with beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus and other beta-lactam-resistant strains of S. aureus. | 2000 | J. Pharm. Pharmacol. | pmid:10757427 |
| Schwinger RH et al. | Crataegus special extract WS 1442 increases force of contraction in human myocardium cAMP-independently. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10813370 |
| Sue M et al. | Purification and characterization of a hydroxamic acid glucoside beta-glucosidase from wheat (Triticum aestivum L.) seedlings. | 2000 | Planta | pmid:10750901 |
| BozdaÄŸ O et al. | Synthesis and hypoglycemic activity of some new flavone derivatives. 3rd communication: 3'-flavonyl-2,4-thiazolidinediones. | 2000 | Arzneimittelforschung | pmid:10965419 |
| Valenti P et al. | Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid. | 2000 | Bioorg. Med. Chem. | pmid:10968283 |
| El-Subbagh HI et al. | Synthesis and biological evaluation of certain alpha,beta-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents. | 2000 | J. Med. Chem. | pmid:10956199 |
| La Casa C et al. | Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. | 2000 | J Ethnopharmacol | pmid:10904145 |
| Aitken RA et al. | Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 4: Variation of the basic structure. | 2000 | Arch. Pharm. (Weinheim) | pmid:10909190 |
| Nielsen SE et al. | Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. | 2000 | Food Chem. Toxicol. | pmid:10930694 |
| Viola H et al. | 6,3'-dibromoflavone and 6-nitro-3'-bromoflavone: new additions to the 6,3'-disubstituted flavone family of high-affinity ligands of the brain benzodiazepine binding site with agonistic properties. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10873666 |
| BozdaÄŸ O et al. | Synthesis and hypoglycemic activity of some new flavone derivatives. 2nd communication: 4'-flavonyl-2,4-thiazolidinediones. | 2000 | Arzneimittelforschung | pmid:10918947 |
| Wenzel U et al. | Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. | 2000 | Cancer Res. | pmid:10919656 |
| Ramelet AA | Pharmacologic aspects of a phlebotropic drug in CVI-associated edema. | 2000 | Angiology | pmid:10667639 |
| Viola H et al. | 6-Chloro-3'-nitroflavone is a potent ligand for the benzodiazepine binding site of the GABA(A) receptor devoid of intrinsic activity. | 2000 | Pharmacol. Biochem. Behav. | pmid:10672984 |
| Ma YL et al. | Internal glucose residue loss in protonated O-diglycosyl flavonoids upon low-energy collision-induced dissociation. | 2000 | J. Am. Soc. Mass Spectrom. | pmid:10689666 |
| Arriaga AM et al. | Constituents of Bowdichia virgilioides. | 2000 | Fitoterapia | pmid:10727826 |
| Mruk JS et al. | Flavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury In vivo. | 2000 | Circulation | pmid:10645930 |
| Siess MH et al. | Mechanisms involved in the chemoprevention of flavonoids. | 2000 | Biofactors | pmid:11216486 |
| da Silva EL et al. | Inhibitory effect of flavonoids on low-density lipoprotein peroxidation catalyzed by mammalian 15-lipoxygenase. | 2000 | IUBMB Life | pmid:10995031 |
| Carvalho JC et al. | Anti-inflammatory activity of flavone and some of its derivates from Virola michelli Heckel. | 1999 | J Ethnopharmacol | pmid:10197753 |
| Houghten RA et al. | Mixture-based synthetic combinatorial libraries. | 1999 | J. Med. Chem. | pmid:10508425 |
| Reiners JJ et al. | Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor. | 1999 | Carcinogenesis | pmid:10426807 |
| Maulik SK et al. | Effect of flavone in a canine model of myocardial stunning. | 1999 | Indian J. Exp. Biol. | pmid:10783754 |