FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Rudolf JL et al. The influence of diet composition on phase I and II biotransformation enzyme induction. 2008 Arch. Toxicol. pmid:18488195
Jung SM et al. Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. 2007 Arthritis Res. Ther. pmid:17612394
Kang HK et al. Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. 2009 Arthritis Res. Ther. pmid:19405952
Bozdağ-Dündar O et al. Synthesis and antimicrobial activity of flavone-3'-carboxaldehyde oxime ether derivatives. 2003 Arzneimittelforschung pmid:12918219
BozdaÄŸ O et al. Synthesis and hypoglycemic activity of some new flavone derivatives. 3rd communication: 3'-flavonyl-2,4-thiazolidinediones. 2000 Arzneimittelforschung pmid:10965419
BozdaÄŸ O et al. Synthesis and hypoglycemic activity of some new flavone derivatives. 2nd communication: 4'-flavonyl-2,4-thiazolidinediones. 2000 Arzneimittelforschung pmid:10918947
Lonchampt M et al. Protective effect of a purified flavonoid fraction against reactive oxygen radicals. In vivo and in vitro study. 1989 Arzneimittelforschung pmid:2818676
Kosmider B et al. Structure-activity relationship and apoptosis induction in A549 cells by the potential anticancer compound cis-bis(3-aminoflavone)dichloroplatinum(II). 2010 Arzneimittelforschung pmid:20422947
Wang H et al. Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor. 2010 Asian J. Androl. pmid:20436506
Zhong LR et al. Radix tetrastigma hemsleyani flavone induces apoptosis in human lung carcinoma a549 cells by modulating the MAPK pathway. 2013 Asian Pac. J. Cancer Prev. pmid:24289612
Belinky PA et al. The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. 1998 Atherosclerosis pmid:9568736
Zhao Z et al. Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. 2008 Behav. Brain Res. pmid:18655806
Derdemezis CS et al. Effect of Plant Polyphenols on Adipokine Secretion from Human SGBS Adipocytes. 2011 Biochem Res Int pmid:21949907
Morita K et al. Stimulatory actions of bioflavonoids on tyrosine uptake into cultured bovine adrenal chromaffin cells. 1990 Biochem. Biophys. Res. Commun. pmid:1977385
Ghosh DK et al. Microsomal benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: assay and characterization of the enzyme system. 1983 Biochem. Biophys. Res. Commun. pmid:6409103
Dutta D et al. Induction of benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: evidences of multiple forms of cytochrome P-450. 1983 Biochem. Biophys. Res. Commun. pmid:6626210
Liu LZ et al. Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway. 2011 Biochem. Biophys. Res. Commun. pmid:21893035
Sawada Y and Ayabe S Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue. 2005 Biochem. Biophys. Res. Commun. pmid:15809082
Nagai T et al. Inhibition of mouse liver sialidase by plant flavonoids. 1989 Biochem. Biophys. Res. Commun. pmid:2775264
Viola H et al. 6,3'-dibromoflavone and 6-nitro-3'-bromoflavone: new additions to the 6,3'-disubstituted flavone family of high-affinity ligands of the brain benzodiazepine binding site with agonistic properties. 2000 Biochem. Biophys. Res. Commun. pmid:10873666
Fukuda I et al. Interaction between the aryl hydrocarbon receptor and its antagonists, flavonoids. 2007 Biochem. Biophys. Res. Commun. pmid:17560542
Shin EK et al. Chrysin, a natural flavone, improves murine inflammatory bowel diseases. 2009 Biochem. Biophys. Res. Commun. pmid:19233127
Zhu W et al. Flavone inhibits nitric oxide synthase (NOS) activity, nitric oxide production and protein S-nitrosylation in breast cancer cells. 2015 Biochem. Biophys. Res. Commun. pmid:25680459
Geraets L et al. Inhibition of LPS-induced pulmonary inflammation by specific flavonoids. 2009 Biochem. Biophys. Res. Commun. pmid:19292976
Yashiroda Y et al. A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. 2010 Biochem. Biophys. Res. Commun. pmid:20214890
Arakaki N et al. Induction of G1 cell cycle arrest in human umbilical vein endothelial cells by flavone's inhibition of the extracellular signal regulated kinase cascade. 2004 Biochem. Cell Biol. pmid:15499387
KOEPPEN BH et al. The flavone C-glycosides and flavonol O-glycosides of Aspalathus acuminatus (rooibos tea). 1962 Biochem. J. pmid:14457727
MARSH CA Glucuronide metabolism in plants. II. The isolation of flavone glucosiduronic acids from plants. 1955 Biochem. J. pmid:14351142
Wiejak J et al. Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. 2013 Biochem. J. pmid:23782265
Cutroneo KR et al. Induction of benzpyrene hydroxylase by flavone and its derivatives in fetal rat liver explants. 1972 Biochem. Pharmacol. pmid:5064734
Walle T et al. Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. 2007 Biochem. Pharmacol. pmid:17250812
Ansó E et al. Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism. 2010 Biochem. Pharmacol. pmid:20153296
Okuda J et al. Inhibition of aldose reductases from rat and bovine lenses by flavonoids. 1982 Biochem. Pharmacol. pmid:6818971
Bandyopadhyay S et al. Attenuation of osteoclastogenesis and osteoclast function by apigenin. 2006 Biochem. Pharmacol. pmid:16750176
Quintieri L et al. Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes. 2008 Biochem. Pharmacol. pmid:18191104
Lin HY et al. Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1. 2003 Biochem. Pharmacol. pmid:14563492
Chi YS et al. Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. 2001 Biochem. Pharmacol. pmid:11322923
Verbeek R et al. The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells. 2004 Biochem. Pharmacol. pmid:15276069
Huen MS et al. Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. 2003 Biochem. Pharmacol. pmid:14637197
Kim MJ et al. TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cells. 2010 Biochem. Pharmacol. pmid:20804741
Dertinger SD et al. Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms. 2000 Biochem. Pharmacol. pmid:10825463
Niisato N et al. Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells. 2004 Biochem. Pharmacol. pmid:14757180
Chi YS et al. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. 2003 Biochem. Pharmacol. pmid:14505806
Nose K Inhibition by flavonoids of RNA synthesis in permeable WI-38 cells and of transcription by RNA polymerase II. 1984 Biochem. Pharmacol. pmid:6508836
Furuya H et al. Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant. 2005 Biochem. Pharmacol. pmid:15652241
Kim DH et al. Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells. 2004 Biochem. Pharmacol. pmid:15313404
Kundu R et al. Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. 2011 Biochem. Pharmacol. pmid:21801714
van Zanden JJ et al. Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells. 2004 Biochem. Pharmacol. pmid:15041478
Vargo MA et al. Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. 2006 Biochem. Pharmacol. pmid:16844095
Fang J and Beattie DS Novel FMN-containing rotenone-insensitive NADH dehydrogenase from Trypanosoma brucei mitochondria: isolation and characterization. 2002 Biochemistry pmid:11863445