| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Berim A et al. | Unexpected roles for ancient proteins: flavone 8-hydroxylase in sweet basil trichomes is a Rieske-type, PAO-family oxygenase. | 2014 | Plant J. | pmid:25139498 |
| Goyal N et al. | Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1. | 2014 | Chem. Res. Toxicol. | pmid:25033111 |
| Prasad VG et al. | Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer. | 2014 | Biomed Res Int | pmid:24995310 |
| Li LZ et al. | Flavonoids and other constituents from Aletris spicata and their chemotaxonomic significance. | 2014 | Nat. Prod. Res. | pmid:24896299 |
| Feng XT et al. | Pollen Typhae total flavone improves insulin resistance in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats. | 2014 | Biosci. Biotechnol. Biochem. | pmid:25273139 |
| Wang MH et al. | A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi. | 2014 | Nat. Prod. Res. | pmid:24995563 |
| Ahmed N et al. | Design, synthesis and antiproliferative activity of functionalized flavone-triazole-tetrahydropyran conjugates against human cancer cell lines. | 2014 | Eur J Med Chem | pmid:24941129 |
| Raghav N and Garg S | SAR studies of o-hydroxychalcones and their cyclized analogs and study them as novel inhibitors of cathepsin B and cathepsin H. | 2014 | Eur J Pharm Sci | pmid:24780403 |
| Berczyński P et al. | Studies on the antioxidant activity of some thiazolidinedione, imidazolidinedione and rhodanine derivatives having a flavone core. | 2014 | Luminescence | pmid:24733694 |
| Venditti A et al. | A C-methylated resacetophenone from Cistus monspeliensis L. | 2014 | Fitoterapia | pmid:24685506 |
| Lin SH and Shih YW | Antitumor effects of the flavone chalcone: inhibition of invasion and migration through the FAK/JNK signaling pathway in human gastric adenocarcinoma AGS cells. | 2014 | Mol. Cell. Biochem. | pmid:24510324 |
| Fan Y et al. | The design of propolis flavone microemulsion and its effect on enhancing the immunity and antioxidant activity in mice. | 2014 | Int. J. Biol. Macromol. | pmid:24463267 |
| Modelli A and Pshenichnyuk SA | Gas-phase dissociative electron attachment to flavonoids and possible similarities to their metabolic pathways. | 2013 | Phys Chem Chem Phys | pmid:23243660 |
| Golub AG et al. | Discovery and characterization of synthetic 4'-hydroxyflavones-New CK2 inhibitors from flavone family. | 2013 | Bioorg. Med. Chem. | pmid:24011954 |
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| D'Abrosca B et al. | A new acylated flavone glycoside with antioxidant and radical scavenging activities from Teucrium polium leaves. | 2013 | Nat. Prod. Res. | pmid:22708583 |
| Choe H et al. | Structure-based design of flavone-based inhibitors of wild-type and T315I mutant of ABL. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23790540 |
| Richter D et al. | Effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells. | 2013 | Nutr Cancer | pmid:23859042 |
| Hapuarachchi SD et al. | Andrographidine G, a new flavone glucoside from Andrographis paniculata. | 2013 | Nat Prod Commun | pmid:23678804 |
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| Rane RA et al. | Synthesis and evaluation of novel marine bromopyrrole alkaloid-based hybrids as anticancer agents. | 2013 | Eur J Med Chem | pmid:23584542 |
| Sun Y et al. | Enrichment and antioxidant properties of flavone C-glycosides from trollflowers using macroporous resin. | 2013 | Food Chem | pmid:23768390 |
| Zhong LR et al. | Radix tetrastigma hemsleyani flavone induces apoptosis in human lung carcinoma a549 cells by modulating the MAPK pathway. | 2013 | Asian Pac. J. Cancer Prev. | pmid:24289612 |
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| Cai X et al. | Digitoflavone inhibits IκBα kinase and enhances apoptosis induced by TNFα through downregulation of expression of nuclear factor κB-regulated gene products in human pancreatic cancer cells. | 2013 | PLoS ONE | pmid:24146961 |
| Wang KW et al. | A new lignan with anti-tumour activity from Polygonum perfoliatum L. | 2013 | Nat. Prod. Res. | pmid:22533633 |
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| Ni F et al. | Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice. | 2012 | PLoS ONE | pmid:22693649 |
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| Chen WC et al. | Baicalin induces apoptosis in SW620 human colorectal carcinoma cells in vitro and suppresses tumor growth in vivo. | 2012 | Molecules | pmid:22456615 |
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