| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| LeJeune TM et al. | Mechanism of Action of Two Flavone Isomers Targeting Cancer Cells with Varying Cell Differentiation Status. | 2015 | PLoS ONE | pmid:26606169 |
| Jian J et al. | Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats. | 2015 | Drug Des Devel Ther | pmid:26604691 |
| Real Hernandez LM et al. | Berry Phenolic Compounds Increase Expression of Hepatocyte Nuclear Factor-1α (HNF-1α) in Caco-2 and Normal Colon Cells Due to High Affinities with Transcription and Dimerization Domains of HNF-1α. | 2015 | PLoS ONE | pmid:26413797 |
| Boesten DM et al. | Protective Pleiotropic Effect of Flavonoids on NAD⺠Levels in Endothelial Cells Exposed to High Glucose. | 2015 | Oxid Med Cell Longev | pmid:26180598 |
| Liu B et al. | A step toward simplified detection of serum albumin on SDS-PAGE using an environment-sensitive flavone sensor. | 2015 | Chem. Commun. (Camb.) | pmid:26068596 |
| Hu J et al. | Genome-wide analysis of DNA methylation in photoperiod- and thermo-sensitive male sterile rice Peiai 64S. | 2015 | BMC Genomics | pmid:25887533 |
| Lin CH et al. | Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. | 2015 | BMC Cancer | pmid:26675309 |
| Yao X et al. | Biochemical traits and proteomic changes in postharvest flowers of medicinal chrysanthemum exposed to enhanced UV-B radiation. | 2015 | J. Photochem. Photobiol. B, Biol. | pmid:26114222 |
| Untergehrer M et al. | Structure-Dependent Deconjugation of Flavonoid Glucuronides by Human β-Glucuronidase - In Vitro and In Silico Analyses. | 2015 | Planta Med. | pmid:26018917 |
| Ting Y et al. | Viscoelastic Emulsion Improved the Bioaccessibility and Oral Bioavailability of Crystalline Compound: A Mechanistic Study Using in Vitro and in Vivo Models. | 2015 | Mol. Pharm. | pmid:25984595 |
| Xu S et al. | A novel flavone-based fluorescent probe for relay recognition of HSO3(-) and Al(3+). | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25965168 |
| Kim K et al. | Ru(II)-Catalyzed Site-Selective Hydroxylation of Flavone and Chromone Derivatives: The Importance of the 5-Hydroxyl Motif for the Inhibition of Aurora Kinases. | 2015 | Org. Lett. | pmid:25946086 |
| Benabdallah H and Gharzouli K | Effects of flavone on the contractile activity of the circular smooth muscle of the rabbit middle colon in vitro. | 2015 | Eur. J. Pharmacol. | pmid:25895637 |
| Li Q et al. | A combined strategy of mass fragmentation, post-column cobalt complexation and shift in ultraviolet absorption spectra to determine the uridine 5'-diphospho-glucuronosyltransferase metabolism profiling of flavones after oral administration of a flavone mixture in rats. | 2015 | J Chromatogr A | pmid:25892633 |
| Songsong W et al. | Characterization and rapid identification of chemical constituents of NaoXinTong capsules by UHPLC-linear ion trap/Orbitrap mass spectrometry. | 2015 | J Pharm Biomed Anal | pmid:25880241 |
| Yao X et al. | The changes in quality ingredients of Qi chrysanthemum flowers treated with elevated UV-B radiation at different growth stages. | 2015 | J. Photochem. Photobiol. B, Biol. | pmid:25792150 |
| Wang RL et al. | A novel cytochrome P450 CYP6AB14 gene in Spodoptera litura (Lepidoptera: Noctuidae) and its potential role in plant allelochemical detoxification. | 2015 | J. Insect Physiol. | pmid:25783953 |
| Zhu W et al. | Flavone inhibits nitric oxide synthase (NOS) activity, nitric oxide production and protein S-nitrosylation in breast cancer cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25680459 |
| Zheng ZP et al. | Preparation, characterization, and preliminary antibrowning evaluations of norartocarpetin microemulsions. | 2015 | J. Agric. Food Chem. | pmid:25603116 |
| Hong H et al. | Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. | 2015 | Toxicol. Sci. | pmid:25349334 |