FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

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Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Kassem ME et al. A sulphated flavone glycoside from Livistona australis and its antioxidant and cytotoxic activity. 2012 Nat. Prod. Res. pmid:21793764
Fong YK et al. In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of baicalein. 2012 J Ethnopharmacol pmid:21906668
Tsai IT et al. Flavone is efficient to protect zebrafish fins from UV-induced damage. 2012 Drug Chem Toxicol pmid:22289409
Wei Z et al. Cardamonin protects septic mice from acute lung injury by preventing endothelial barrier dysfunction. 2012 J. Biochem. Mol. Toxicol. pmid:22696397
Shih HC and Yang LL Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle. 2012 Pharm Biol pmid:22471999
Duraipandiyan V et al. Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm. 2012 BMC Complement Altern Med pmid:22397713
Adejumo OE et al. Moringa oleifera Lam. (Moringaceae) grown in Nigeria: In vitro antisickling activity on deoxygenated erythrocyte cells. 2012 J Pharm Bioallied Sci pmid:22557922
Guo AJ et al. Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. 2012 Chin Med pmid:22546174
Asadi S and Theoharides TC Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin. 2012 J Neuroinflammation pmid:22559745
Chen HJ et al. Determination of phenolic acids and flavonoids in Taraxacum formosanum Kitam by liquid chromatography-tandem mass spectrometry coupled with a post-column derivatization technique. 2012 Int J Mol Sci pmid:22312251
Wink M et al. Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents. 2012 Front Microbiol pmid:22536197
Peterson JJ et al. Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations. 2012 Nutr. Rev. pmid:22946850
Yuqing Z et al. Flavone ingredients can synergistically inhibit NDV infecting cell and improve ND vaccine's protective rate. 2012 Int. J. Biol. Macromol. pmid:22575392
Fan Y et al. Liposome and epimedium polysaccharide-propolis flavone can synergistically enhance immune effect of vaccine. 2012 Int. J. Biol. Macromol. pmid:22020157
Zhou G and Lv G [Comparative studies on scavenging DPPH free radicals activity of flavone C-glycosides from different parts of Dendrobium officinale]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22993976
Resende FA et al. Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test. 2012 Molecules pmid:22565478
Lies B et al. Flavone potently stimulates an apical transporter for flavonoids in human intestinal Caco-2 cells. 2012 Mol Nutr Food Res pmid:22965487
Lee JH et al. Flavone reduces the production of virulence factors, staphyloxanthin and α-hemolysin, in Staphylococcus aureus. 2012 Curr. Microbiol. pmid:22965624
Hostetler GL et al. Endogenous enzymes, heat, and pH affect flavone profiles in parsley (Petroselinum crispum var. neapolitanum) and celery (Apium graveolens) during juice processing. 2012 J. Agric. Food Chem. pmid:22224550
Greeff J et al. Antioxidant properties of 4-quinolones and structurally related flavones. 2012 Bioorg. Med. Chem. pmid:22197671
Welch A et al. Habitual flavonoid intakes are positively associated with bone mineral density in women. 2012 J. Bone Miner. Res. pmid:22549983
Yarmolinsky L et al. Potent antiviral flavone glycosides from Ficus benjamina leaves. 2012 Fitoterapia pmid:22155188
Clark BR et al. Flavone C-glycosides from Anthurium andraeanum. 2012 Nat Prod Commun pmid:22816298
Niraula NP et al. Biotransformation of flavone by CYP105P2 from Streptomyces peucetius. 2012 J. Microbiol. Biotechnol. pmid:22713981
Chen LY et al. Structural elucidation and bioactivity of biflavonoids from the stems of Wikstroemia taiwanensis. 2012 Int J Mol Sci pmid:22312302
Li Y et al. [Simultaneous determination of five active components in resina draconis and its extract by HPLC]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22792791
Li H et al. De novo transcriptome of safflower and the identification of putative genes for oleosin and the biosynthesis of flavonoids. 2012 PLoS ONE pmid:22363528
Hostetler G et al. Flavone deglycosylation increases their anti-inflammatory activity and absorption. 2012 Mol Nutr Food Res pmid:22351119
Zhang H and Zhang C Vasoprotection by dietary supplements and exercise: role of TNFα signaling. 2012 Exp Diabetes Res pmid:22110483
Shi L et al. Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. 2012 Cell. Mol. Neurobiol. pmid:21984341
Yang WS et al. Nanostructured, self-assembling peptide K5 blocks TNF-α and PGE₂ production by suppression of the AP-1/p38 pathway. 2012 Mediators Inflamm. pmid:22315508
Toton E et al. The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. 2012 Eur. J. Pharmacol. pmid:22381066
Skizim NJ et al. Metabolic pathways for photobiological hydrogen production by nitrogenase- and hydrogenase-containing unicellular cyanobacteria Cyanothece. 2012 J. Biol. Chem. pmid:22128188
Fasinu PS et al. An overview of the evidence and mechanisms of herb-drug interactions. 2012 Front Pharmacol pmid:22557968
Engelbertz J et al. Bioassay-guided fractionation of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect. 2012 J Ethnopharmacol pmid:22465593
Chan LP et al. Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin. 2012 Biochim. Biophys. Acta pmid:22554915
Cai M et al. The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice. 2012 Eur. J. Pharmacol. pmid:22683875
Wang Y et al. Flavone C-glycosides from the leaves of Lophatherum gracile and their in vitro antiviral activity. 2012 Planta Med. pmid:21870321
Berim A et al. A set of regioselective O-methyltransferases gives rise to the complex pattern of methoxylated flavones in sweet basil. 2012 Plant Physiol. pmid:22923679
Ulrich-Merzenich G et al. Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine. 2012 Phytomedicine pmid:22743246
Wilczańska-Barska A et al. Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. 2012 Biotechnol. Lett. pmid:22639092
Surichan S et al. Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells. 2012 Food Chem. Toxicol. pmid:22743247
Guo F et al. Effect of the citrus lycopene β-cyclase transgene on carotenoid metabolism in transgenic tomato fruits. 2012 PLoS ONE pmid:22384184
Fatima T et al. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. 2012 PLoS ONE pmid:22558083
Zhang T et al. Inhibitory effects and underlying mechanism of 7-hydroxyflavone phosphate ester in HeLa cells. 2012 PLoS ONE pmid:22574207
Lin TY et al. Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. 2012 Toxicol. Appl. Pharmacol. pmid:22759588
Pohanka M Antioxidants countermeasures against sulfur mustard. 2012 Mini Rev Med Chem pmid:22512566
Xiao L et al. Transcriptome of protoplasts reprogrammed into stem cells in Physcomitrella patens. 2012 PLoS ONE pmid:22545152
Begum N et al. Apigenin ameliorates gamma radiation-induced cytogenetic alterations in cultured human blood lymphocytes. 2012 Mutat. Res. pmid:22516036
Duchnowicz P et al. Hypolipidemic and antioxidant effects of hydroxycinnamic acids, quercetin, and cyanidin 3-glucoside in hypercholesterolemic erythrocytes (in vitro study). 2012 Eur J Nutr pmid:21755326