| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Plowman J et al. | Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. | 1986 | Cancer Treat Rep | pmid:3708611 |
| Weiss GR et al. | New anticancer agents. | 1987 | Cancer Chemother Biol Response Modif | pmid:2484330 |
| Rubin J et al. | Flavone-8-acetic acid inhibits ristocetin-induced platelet agglutination and prolongs bleeding time. | 1987 | Lancet | pmid:2889983 |
| Ohchi H et al. | Effects of dietary xenobiotics on the metabolism of copper, alpha-tocopherol and cholesterol in rats. | 1987 | J. Nutr. Sci. Vitaminol. | pmid:3125311 |
| Bibby MC et al. | Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid). | 1987 | Br. J. Cancer | pmid:3814485 |
| Dodion P et al. | Sensitivity of normal human bone marrow myeloid progenitor cells to anthracycline, cisplatin, anthracene and flavone acetic acid derivatives, and its relevance for the prediction of human plasma concentrations of anticancer drugs. | 1987 | Eur J Cancer Clin Oncol | pmid:3436354 |
| Ching LM and Baguley BC | Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347 512). | 1987 | Eur J Cancer Clin Oncol | pmid:3665989 |
| Abdalla SS and Abu Zarga MH | Effects of cirsimaritin, a flavone isolated from Artemisia judaica, on isolated guinea-pig ileum. | 1987 | Planta Med. | pmid:3671552 |
| Kerr DJ et al. | Phase I and pharmacokinetic study of flavone acetic acid. | 1987 | Cancer Res. | pmid:3677106 |
| Capolongo LS et al. | Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent. | 1987 | Eur J Cancer Clin Oncol | pmid:3678316 |
| O'Dwyer PJ et al. | Flavone acetic acid (LM 975, NSC 347512). A novel antitumor agent. | 1987 | Cancer Chemother. Pharmacol. | pmid:3545524 |
| Ruffmann R and Sartani A | Flavoxate, a drug with smooth muscle relaxing activity. | 1987 | Drugs Exp Clin Res | pmid:3595445 |
| Dodion PF et al. | Clinical and pharmacokinetic phase I trial with the diethylaminoester of flavone acetic acid (LM985, NSC 293015). | 1987 | Eur J Cancer Clin Oncol | pmid:3653200 |
| Schroyens WA et al. | In vitro chemosensitivity testing of flavone acetic acid (LM975; NSC 347512) and its diethylaminoethyl ester derivative (LM985; NSC 293015). | 1987 | Eur J Cancer Clin Oncol | pmid:3653209 |
| Smith GP et al. | Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours. | 1987 | Eur J Cancer Clin Oncol | pmid:3653213 |
| Fisher RF et al. | Extended Region of Nodulation Genes in Rhizobium meliloti 1021. II. Nucleotide Sequence, Transcription Start Sites and Protein Products. | 1987 | Genetics | pmid:17246400 |
| Kapulnik Y et al. | Flavone limitations to root nodulation and symbiotic nitrogen fixation in alfalfa. | 1987 | Plant Physiol. | pmid:16665583 |
| Gao F et al. | Sesquiterpene lactones and flavonoids from Helianthus species. | 1987 Jan-Feb | J. Nat. Prod. | pmid:3598595 |
| Evelhoch JL et al. | Flavone acetic acid (NSC 347512)-induced modulation of murine tumor physiology monitored by in vivo nuclear magnetic resonance spectroscopy. | 1988 | Cancer Res. | pmid:3409216 |
| Gouyette A et al. | Flavone acetic acid: a nonlinear pharmacokinetic model. | 1988 | Cancer Chemother. Pharmacol. | pmid:3409441 |