| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Takada Y and Aggarwal BB | Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. | 2004 | J. Biol. Chem. | pmid:14630924 |
| Huen MS et al. | Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. | 2003 | Biochem. Pharmacol. | pmid:14637197 |
| Suetsugi M et al. | Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. | 2003 | Mol. Cancer Res. | pmid:14638870 |
| Martin HJ et al. | The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes. | 2003 | Chem. Biol. Interact. | pmid:14642735 |
| Wenzel U et al. | Nitric oxide levels in human preneoplastic colonocytes determine their susceptibility toward antineoplastic agents. | 2003 | Mol. Pharmacol. | pmid:14645680 |
| Jasso-Chávez R and Moreno-Sánchez R | Cytosol-mitochondria transfer of reducing equivalents by a lactate shuttle in heterotrophic Euglena. | 2003 | Eur. J. Biochem. | pmid:14653820 |
| Takano-Ishikawa Y et al. | Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha. | 2003 | Phytother Res | pmid:14669262 |
| Ouyang P et al. | [Effects of flavone from leaves of Diospyros kaki on adventitial fibroblast proliferation induced by advanced glycation end-products in vitro]. | 2003 | Di Yi Jun Yi Da Xue Xue Bao | pmid:14678884 |
| Jang SI et al. | Hepatoprotective effect of baicalin, a major flavone from Scutellaria radix, on acetaminophen-induced liver injury in mice. | 2003 | Immunopharmacol Immunotoxicol | pmid:14686800 |
| Dias C et al. | Structural elucidation of natural 2-hydroxy di- and tricarboxylic acids and esters, phenylpropanoid esters and a flavonoid from Autonoë madeirensis using gas chromatographic/electron ionization, electrospray ionization and tandem mass spectrometric techniques. | 2003 | J Mass Spectrom | pmid:14696202 |
| Alexandrakis M et al. | Flavones inhibit proliferation and increase mediator content in human leukemic mast cells (HMC-1). | 2003 | Eur. J. Haematol. | pmid:14703695 |
| Ueda H et al. | A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14745173 |
| Beyer G and Melzig MF | Effects of selected flavonoids and caffeic acid derivatives on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells. | 2003 | Planta Med. | pmid:14750029 |
| Herzog A et al. | Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. | 2004 | Int. J. Cancer | pmid:14750173 |
| Fernández S et al. | Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. | 2004 | Pharmacol. Biochem. Behav. | pmid:14751470 |
| Wenzel U et al. | Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. | 2004 | Carcinogenesis | pmid:14754875 |
| Niisato N et al. | Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells. | 2004 | Biochem. Pharmacol. | pmid:14757180 |
| Ching LM et al. | Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice. | 2004 | Br. J. Cancer | pmid:14970872 |
| Wenzel U and Daniel H | Early and late apoptosis events in human transformed and non-transformed colonocytes are independent on intracellular acidification. | 2004 | Cell. Physiol. Biochem. | pmid:14976408 |
| Gao H et al. | Structure-activity relationships for alpha-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: the effect of A-ring substitution. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14981300 |
| Geng XF et al. | [The progress of research on ginlcgobiobal flavone]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015321 |
| Zhang YJ et al. | [Identification and evaluation of TCM shayuanzi]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015323 |
| Betti L et al. | Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion. | 2004 | Bioorg. Med. Chem. | pmid:15018926 |
| Blonska M et al. | Effects of ethanol extract of propolis (EEP) and its flavones on inducible gene expression in J774A.1 macrophages. | 2004 | J Ethnopharmacol | pmid:15036463 |
| van Zanden JJ et al. | Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells. | 2004 | Biochem. Pharmacol. | pmid:15041478 |
| Yang L et al. | Purification and characterization of an isoflavone-conjugates-hydrolyzing beta-glucosidase from endophytic bacterium. | 2004 | J. Agric. Food Chem. | pmid:15053533 |
| Wang SP and Huang KJ | Determination of flavonoids by high-performance liquid chromatography and capillary electrophoresis. | 2004 | J Chromatogr A | pmid:15065805 |
| Onyilagha JC et al. | Effect of flavonoids on feeding preference and development of the crucifer pest Mamestra configurata Walker. | 2004 | J. Chem. Ecol. | pmid:15074660 |
| Choi JS et al. | Enhanced bioavailability of paclitaxel after oral coadministration with flavone in rats. | 2004 | Int J Pharm | pmid:15081147 |
| Wang HB et al. | Flavone glucosides with immunomodulatory activity from the leaves of Pleioblastus amarus. | 2004 | Phytochemistry | pmid:15081303 |
| Atkinson C et al. | Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]. | 2004 | Breast Cancer Res. | pmid:15084240 |
| Ohno S et al. | Flavonoid inhibition of overexpressed human 3beta-hydroxysteroid dehydrogenase type II. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15084349 |
| Hall BJ et al. | Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. | 2004 | Eur. J. Pharmacol. | pmid:15102527 |
| Kong C et al. | Two compounds from allelopathic rice accession and their inhibitory activity on weeds and fungal pathogens. | 2004 | Phytochemistry | pmid:15110693 |
| Tammela P et al. | Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles. | 2004 | Arch. Biochem. Biophys. | pmid:15111127 |
| Goppel M and Franz G | Stability control of senna leaves and senna extracts. | 2004 | Planta Med. | pmid:15124088 |
| Morimitsu Y et al. | Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations. | 2004 | Biol. Pharm. Bull. | pmid:15133252 |
| Souza J et al. | A study on the antipicornavirus activity of flavonoid compounds (flavones) by using quantum chemical and chemometric methods. | J Chem Inf Comput Sci | pmid:15154785 | |
| Scheidt HA et al. | Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy. | 2004 | Biochim. Biophys. Acta | pmid:15157612 |
| Gouédard C et al. | Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. | 2004 | Mol. Cell. Biol. | pmid:15169886 |
| Hirvonen T et al. | Flavonol and flavone intake and the risk of intermittent claudication in male smokers. | 2004 | Eur. J. Epidemiol. | pmid:15180100 |
| Leung LK et al. | Effect of dietary flavonols on oestrogen receptor transactivation and cell death induction. | 2004 | Br. J. Nutr. | pmid:15182386 |
| Son D et al. | Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation. | 2004 | Eur. J. Pharmacol. | pmid:15189769 |
| Quiney C et al. | Flavones and polyphenols inhibit the NO pathway during apoptosis of leukemia B-cells. | 2004 | Leuk. Res. | pmid:15203283 |
| McMullen MD et al. | Salmon silk genes contribute to the elucidation of the flavone pathway in maize (Zea mays L.). | 2004 May-Jun | J. Hered. | pmid:15220389 |
| O'Leary KA et al. | Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. | 2004 | Mutat. Res. | pmid:15225597 |
| Kavvadias D et al. | The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. | 2004 | Br. J. Pharmacol. | pmid:15231642 |
| Kong X et al. | Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken. | 2004 | Int. Immunopharmacol. | pmid:15233143 |
| Ambrozin AR et al. | Trypanocidal activity of Meliaceae and Rutaceae plant extracts. | 2004 | Mem. Inst. Oswaldo Cruz | pmid:15250481 |
| van Duursen MB et al. | Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage. | 2004 | Toxicol. Sci. | pmid:15254334 |