| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kubo I et al. | Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria. | 2000 | Bioorg. Med. Chem. | pmid:10976523 |
| Akao T et al. | Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. | 2000 | J. Pharm. Pharmacol. | pmid:11197087 |
| Tomazela DM et al. | Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities. | 2000 | Phytochemistry | pmid:11130676 |
| Rajendran NN et al. | Antinociceptive pattern of flavone and its mechanism as tested by formalin assay. | 2000 | Indian J. Exp. Biol. | pmid:11218837 |
| Collins-Burow BM et al. | Estrogenic and antiestrogenic activities of flavonoid phytochemicals through estrogen receptor binding-dependent and -independent mechanisms. | 2000 | Nutr Cancer | pmid:11525602 |
| Tunçbilek M et al. | Synthesis and antioxidant properties of some new flavone derivatives on lipid peroxidation in the rat liver. | 2000 | Pharmazie | pmid:11828615 |
| Kulevanova S et al. | HPLC identification and determination of flavone aglycones in Helichrysum plicatum DC. (Asteraceae). | 2000 | Pharmazie | pmid:11828624 |
| Huang HS et al. | [Advances in the research on pharmacological actions of flavone compounds]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516448 |
| Li Y et al. | Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. | 2000 | Clin. Cancer Res. | pmid:10656453 |
| Dertinger SD et al. | Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms. | 2000 | Biochem. Pharmacol. | pmid:10825463 |
| Motwani M et al. | Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. | 2000 | Clin. Cancer Res. | pmid:10741717 |
| Perez RM et al. | Isolation and hypoglycemic activity of 5, 7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia. | 2000 | Phytomedicine | pmid:10782487 |
| Liu IX et al. | Baicalin synergy with beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus and other beta-lactam-resistant strains of S. aureus. | 2000 | J. Pharm. Pharmacol. | pmid:10757427 |
| Schwinger RH et al. | Crataegus special extract WS 1442 increases force of contraction in human myocardium cAMP-independently. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10813370 |
| Sue M et al. | Purification and characterization of a hydroxamic acid glucoside beta-glucosidase from wheat (Triticum aestivum L.) seedlings. | 2000 | Planta | pmid:10750901 |
| BozdaÄŸ O et al. | Synthesis and hypoglycemic activity of some new flavone derivatives. 3rd communication: 3'-flavonyl-2,4-thiazolidinediones. | 2000 | Arzneimittelforschung | pmid:10965419 |
| Valenti P et al. | Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid. | 2000 | Bioorg. Med. Chem. | pmid:10968283 |
| Viola H et al. | 6,3'-dibromoflavone and 6-nitro-3'-bromoflavone: new additions to the 6,3'-disubstituted flavone family of high-affinity ligands of the brain benzodiazepine binding site with agonistic properties. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10873666 |
| BozdaÄŸ O et al. | Synthesis and hypoglycemic activity of some new flavone derivatives. 2nd communication: 4'-flavonyl-2,4-thiazolidinediones. | 2000 | Arzneimittelforschung | pmid:10918947 |
| Wenzel U et al. | Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. | 2000 | Cancer Res. | pmid:10919656 |
| Ramelet AA | Pharmacologic aspects of a phlebotropic drug in CVI-associated edema. | 2000 | Angiology | pmid:10667639 |
| Viola H et al. | 6-Chloro-3'-nitroflavone is a potent ligand for the benzodiazepine binding site of the GABA(A) receptor devoid of intrinsic activity. | 2000 | Pharmacol. Biochem. Behav. | pmid:10672984 |
| Ma YL et al. | Internal glucose residue loss in protonated O-diglycosyl flavonoids upon low-energy collision-induced dissociation. | 2000 | J. Am. Soc. Mass Spectrom. | pmid:10689666 |
| Arriaga AM et al. | Constituents of Bowdichia virgilioides. | 2000 | Fitoterapia | pmid:10727826 |
| Mruk JS et al. | Flavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury In vivo. | 2000 | Circulation | pmid:10645930 |
| Siess MH et al. | Mechanisms involved in the chemoprevention of flavonoids. | 2000 | Biofactors | pmid:11216486 |
| da Silva EL et al. | Inhibitory effect of flavonoids on low-density lipoprotein peroxidation catalyzed by mammalian 15-lipoxygenase. | 2000 | IUBMB Life | pmid:10995031 |
| Wollenweber E et al. | Epicuticular flavonoids of some Scrophulariaceae. | 2000 Jan-Feb | Z. Naturforsch., C, J. Biosci. | pmid:10739092 |
| Harris SR et al. | Oxidative stress contributes to the anti-proliferative effects of flavone acetic acid on endothelial cells. | 2000 Jul-Aug | Anticancer Res. | pmid:10953282 |
| Shao ZM et al. | Genistein's "ER-dependent and independent" actions are mediated through ER pathways in ER-positive breast carcinoma cell lines. | 2000 Jul-Aug | Anticancer Res. | pmid:10953303 |
| Baranowska I and Raróg D | Application of derivative spectrophotometry to determination of flavonoid mixtures. | 2001 | Talanta | pmid:18968363 |
| Duportail G et al. | Neutral fluorescence probe with strong ratiometric response to surface charge of phospholipid membranes. | 2001 | FEBS Lett. | pmid:11718715 |
| Krakauer T et al. | The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. | 2001 | FEBS Lett. | pmid:11434925 |
| Fabre N et al. | Determination of flavone, flavonol, and flavanone aglycones by negative ion liquid chromatography electrospray ion trap mass spectrometry. | 2001 | J. Am. Soc. Mass Spectrom. | pmid:11401161 |
| Kanwar JR et al. | Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci. | 2001 | Cancer Res. | pmid:11280751 |
| Tanaka S et al. | Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1. | 2001 | Planta Med. | pmid:11301853 |
| Chi YS et al. | Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. | 2001 | Biochem. Pharmacol. | pmid:11322923 |
| Seo HJ and Surh YJ | Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells. | 2001 | Mutat. Res. | pmid:11551495 |
| Philpott M et al. | The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator with other inducers of tumour necrosis factor. | 2001 | Eur. J. Cancer | pmid:11576850 |
| Mcmullen MD et al. | The biological basis of epistasis between quantitative trait loci for flavone and 3-deoxyanthocyanin synthesis in maize (Zea mays L.). | 2001 | Genome | pmid:11550903 |
| Kumazawa T et al. | Synthesis of 8-C-glucosylflavones. | 2001 | Carbohydr. Res. | pmid:11513825 |
| Pepper C et al. | Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia. | 2001 | Br. J. Haematol. | pmid:11472347 |
| MarÃn FR and Del RÃo JA | Selection of hybrids and edible citrus species with a high content in the diosmin functional compound. Modulating effect of plant growth regulators on contents. | 2001 | J. Agric. Food Chem. | pmid:11453775 |
| D'arc Felicio J et al. | Biflavonoids from Ouratea multiflora. | 2001 | Fitoterapia | pmid:11395278 |
| Lim SS et al. | Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. | 2001 | J. Pharm. Pharmacol. | pmid:11370705 |
| Stochmal A et al. | Acylated apigenin glycosides from alfalfa (Medicago sativa L.) var. Artal. | 2001 | Phytochemistry | pmid:11454348 |
| Schrag ML and Wienkers LC | Covalent alteration of the CYP3A4 active site: evidence for multiple substrate binding domains. | 2001 | Arch. Biochem. Biophys. | pmid:11414684 |
| Huang X et al. | 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors. | 2001 | J. Med. Chem. | pmid:11384234 |
| Velázquez I and Pardo JP | Kinetic characterization of the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. | 2001 | Arch. Biochem. Biophys. | pmid:11370674 |
| Tabak C et al. | Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN Study. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11435239 |