| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim YW et al. | Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones. | 2004 | J. Med. Chem. | pmid:15267241 |
| Ouyang P et al. | [Effects of flavone from leaves of Diospyros kaki on adventitial fibroblasts proliferation by advanced oxidation protein products in vitro]. | 2004 | Zhong Yao Cai | pmid:15272781 |
| Herzog A et al. | Pleiotropic molecular effects of the pro-apoptotic dietary constituent flavone in human colon cancer cells identified by protein and mRNA expression profiling. | 2004 | Proteomics | pmid:15274140 |
| Verbeek R et al. | The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells. | 2004 | Biochem. Pharmacol. | pmid:15276069 |
| Chen YC et al. | Flavone inhibition of tumor growth via apoptosis in vitro and in vivo. | 2004 | Int. J. Oncol. | pmid:15289867 |
| del Baño MJ et al. | Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway. | 2004 | J. Agric. Food Chem. | pmid:15291464 |
| Jones DJ et al. | Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity. | 2004 | Br. J. Cancer | pmid:15292928 |
| Wu W et al. | Structural analysis of selected characteristic flavones by electrospray tandem mass spectrometry. | 2004 | Anal Sci | pmid:15293412 |
| Maheswara M et al. | Two new 5-deoxyflavonoids from Calliandra inermis. | 2004 | Chem. Pharm. Bull. | pmid:15304993 |
| Kim DH et al. | Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells. | 2004 | Biochem. Pharmacol. | pmid:15313404 |
| Burns SA et al. | Direct liquid chromatography-mass spectrometry method for the detection of glutathione S-transferase isozymes and investigation of their expression in response to dietary flavone. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15315784 |
| Cai H et al. | Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo. | 2004 | Br. J. Cancer | pmid:15316567 |
| Sanderson JT et al. | Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. | 2004 | Toxicol. Sci. | pmid:15319488 |
| Chen CC et al. | Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. | 2004 | Mol. Pharmacol. | pmid:15322261 |
| Sato Y et al. | Variation in synergistic activity by flavone and its related compounds on the increased susceptibility of various strains of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics. | 2004 | Int. J. Antimicrob. Agents | pmid:15325425 |
| Mizoyama Y et al. | Inhibitory effect of flavonoids on N-acetylation of 5-aminosalicylic acid in cultured rat hepatocytes. | 2004 | Biol. Pharm. Bull. | pmid:15340238 |
| Saracoglu I et al. | Acylated flavonoids and phenol glycosides from Veronica thymoides subsp. pseudocinerea. | 2004 | Phytochemistry | pmid:15381011 |
| Badria FA and Zidan OA | Natural products for dental caries prevention. | 2004 | J Med Food | pmid:15383236 |
| Kanaze FI et al. | A validated HPLC determination of the flavone aglycone diosmetin in human plasma. | 2004 | Biomed. Chromatogr. | pmid:15386576 |
| BOHR DF et al. | The effects of various flavone glucosides on the rate of passage of Evans blue through the damaged capillary wall. | 1949 | J. Pharmacol. Exp. Ther. | pmid:15391936 |
| Wenzel U et al. | Activation of mitochondrial lactate uptake by flavone induces apoptosis in human colon cancer cells. | 2005 | J. Cell. Physiol. | pmid:15452831 |
| Wang QE et al. | Isolation and purification of inflacoumarin A and licochalcone A from licorice by high-speed counter-current chromatography. | 2004 | J Chromatogr A | pmid:15453418 |
| Wu W et al. | Studies on the flavones using liquid chromatography-electrospray ionization tandem mass spectrometry. | 2004 | J Chromatogr A | pmid:15460251 |
| Kim DO and Lee CY | Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. | 2004 | Crit Rev Food Sci Nutr | pmid:15462129 |
| Silvério CA and Okano LT | Laser flash photolysis and time-resolved fluorescence measurements of the aggregation number of SDS-biopolymer complexes. | 2004 | Colloids Surf B Biointerfaces | pmid:15465303 |
| Kim SJ et al. | Inhibition of nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells by synthetic flavones: structure-activity relationship and action mechanism. | 2004 | Arch. Pharm. Res. | pmid:15473664 |
| Most MM | Estimated phytochemical content of the dietary approaches to stop hypertension (DASH) diet is higher than in the Control Study Diet. | 2004 | J Am Diet Assoc | pmid:15499362 |
| Arakaki N et al. | Induction of G1 cell cycle arrest in human umbilical vein endothelial cells by flavone's inhibition of the extracellular signal regulated kinase cascade. | 2004 | Biochem. Cell Biol. | pmid:15499387 |
| Ruberto G and Tringali C | Secondary metabolites from the leaves of Feijoa sellowiana Berg. | 2004 | Phytochemistry | pmid:15501265 |
| Kanho H et al. | Glucosylation of phenolic compounds by Pharbitis nil hairy roots: I. Glucosylation of coumarin and flavone derivatives. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15502347 |
| Kim HP et al. | Anti-inflammatory plant flavonoids and cellular action mechanisms. | 2004 | J. Pharmacol. Sci. | pmid:15539763 |
| Park HJ et al. | Baicalin induces NAD(P)H:quinone reductase through the transactivation of AP-1 and NF-kappaB in Hepa 1c1c7 cells. | 2004 | Eur. J. Cancer Prev. | pmid:15548947 |
| Tsai PL and Tsai TH | Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study. | 2004 | Planta Med. | pmid:15549664 |
| Marrero-Ponce Y | Linear indices of the "molecular pseudograph's atom adjacency matrix": definition, significance-interpretation, and application to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors. | J Chem Inf Comput Sci | pmid:15554670 | |
| David JP et al. | A new sesquiterpene from the fruits of Allophylus laevigatus. | 2004 | Fitoterapia | pmid:15567269 |
| Sato S et al. | Flavopiridol as a radio-sensitizer for esophageal cancer cell lines. | 2004 | Dis. Esophagus | pmid:15569374 |
| Ohba S et al. | Swertisin dihydrate. | 2004 | Acta Crystallogr C | pmid:15579976 |
| Akao T et al. | Enteric excretion of baicalein, a flavone of Scutellariae Radix, via glucuronidation in rat: involvement of multidrug resistance-associated protein 2. | 2004 | Pharm. Res. | pmid:15587936 |
| Chi YS and Kim HP | Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15589400 |
| Schütz K et al. | Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography/electrospray ionization mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:15593267 |
| Tao SH and Wu FE | A new flavone from Hypericum wightianum. | 2004 | J Asian Nat Prod Res | pmid:15621592 |
| Cong Y et al. | A new flavonoside from Leonurus heterophyllus. | 2005 | J Asian Nat Prod Res | pmid:15621638 |
| Singh RP et al. | Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. | 2005 | Carcinogenesis | pmid:15637089 |
| Boyer J et al. | In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. | 2005 | Nutr J | pmid:15644141 |
| Xiao R et al. | Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis. | 2005 | Mol. Cancer | pmid:15644144 |
| Furuya H et al. | Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant. | 2005 | Biochem. Pharmacol. | pmid:15652241 |
| Griffin RJ et al. | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. | 2005 | J. Med. Chem. | pmid:15658870 |
| Madan V et al. | Requirement of the vesicular system for membrane permeabilization by Sindbis virus. | 2005 | Virology | pmid:15661162 |
| Watanabe J et al. | Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells. | 2005 | Biosci. Biotechnol. Biochem. | pmid:15665459 |
| Horvath CR et al. | Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection. | 2005 | J Chromatogr A | pmid:15679157 |