| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Smith GP et al. | Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours. | 1987 | Eur J Cancer Clin Oncol | pmid:3653213 |
| Ching LM and Baguley BC | Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347 512). | 1987 | Eur J Cancer Clin Oncol | pmid:3665989 |
| Abdalla SS and Abu Zarga MH | Effects of cirsimaritin, a flavone isolated from Artemisia judaica, on isolated guinea-pig ileum. | 1987 | Planta Med. | pmid:3671552 |
| Kerr DJ et al. | Phase I and pharmacokinetic study of flavone acetic acid. | 1987 | Cancer Res. | pmid:3677106 |
| Capolongo LS et al. | Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent. | 1987 | Eur J Cancer Clin Oncol | pmid:3678316 |
| Kerr DJ et al. | Phase I and pharmacokinetic study of LM985 (flavone acetic acid ester). | 1986 | Cancer Res. | pmid:3698028 |
| Plowman J et al. | Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. | 1986 | Cancer Treat Rep | pmid:3708611 |
| Double JA et al. | Pharmacokinetics and anti-tumour activity of LM985 in mice bearing transplantable adenocarcinomas of the colon. | 1986 | Br. J. Cancer | pmid:3778803 |
| Zaharko DS et al. | Therapeutic and pharmacokinetic relationships of flavone acetic acid: an agent with activity against solid tumors. | 1986 | Cancer Treat Rep | pmid:3791254 |
| Bibby MC et al. | Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid). | 1987 | Br. J. Cancer | pmid:3814485 |
| Hii CS and Howell SL | Effects of flavonoids on insulin secretion and 45Ca2+ handling in rat islets of Langerhans. | 1985 | J. Endocrinol. | pmid:3900267 |
| Alworth WL and Slaga TJ | Effects of ellipticine, flavone, and 7,8-benzoflavone upon 7,12-dimethylbenz[a]anthracene, 7,14-dimethyldibenzo[a,h]anthracene and dibenzo[a,h]anthracene initiated skin tumors in mice. | 1985 | Carcinogenesis | pmid:3921269 |
| Sziklai I and Ribári O | The effect of flavone treatment on human otosclerotic ossicle organ cultures. | 1985 | Arch Otorhinolaryngol | pmid:4038152 |
| Friedman FK et al. | Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase. | 1985 | Pharmacology | pmid:4059325 |
| Cavé A et al. | [Pachypodol (5,4'-dihydroxy 3,7,3'-trimethoxy flavone or 3,7,3'-quercetol trimethylether), a new flavonoid isolated from Pachypodanthium confine Engler and Diels (annonaceae)]. | 1973 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4201538 |
| Dorneanu V et al. | [Determination of flavone derivatives. I. Quantitative determination of condensation products of rutin with epsiolon-aminocaproic acid]. | 1974 Oct-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:4453725 |
| Matsuura S and Kunii T | [Synthetic studies of the flavone derivatives. II. Synthesis of cirsimaritin (author's transl)]. | 1974 | Yakugaku Zasshi | pmid:4473114 |
| Buset H and Scheline RR | Identification of urinary metabolites of flavanone in the rat. | 1979 | Biomed. Mass Spectrom. | pmid:476285 |
| Takido M et al. | [On the revised structure of skullcapflavone I, a flavone compound in the roots of Scutellaria baicalensis Georgi (Wogon) (author's transl)]. | 1979 | Yakugaku Zasshi | pmid:480145 |
| Imre S | [Additional anthraquinone and flavone compounds from the leaves of Digitalis viridiflora. 3. Flavone and anthraquinone dyes of digitalis species]. | 1972 | Planta Med. | pmid:5047478 |