FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

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Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Berthier A et al. Effect of 7-O-beta-D-glucopyranosylchrysin and its aglycone chrysin isolated from Podocytisus caramanicus on estrogen receptor alpha transcriptional activity. 2007 Planta Med. pmid:17948189
Stracke R et al. Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling. 2007 Plant J. pmid:17419845
Ebert B et al. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. 2007 Toxicol. Sci. pmid:17077187
Han X et al. Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography. 2007 J Chromatogr A pmid:17374377
Patel D et al. Apigenin and cancer chemoprevention: progress, potential and promise (review). 2007 Int. J. Oncol. pmid:17143534
Cai H et al. Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties. 2007 Cancer Chemother. Pharmacol. pmid:17089164
Lohner K et al. Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo. 2007 Mol Nutr Food Res pmid:17295420
Walle UK and Walle T Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. 2007 Drug Metab. Dispos. pmid:17709371
Mitchell AE et al. Isozyme- and gender-specific induction of glutathione S-transferases by flavonoids. 2007 Arch. Toxicol. pmid:17503020
Cabrera M et al. Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. 2007 Bioorg. Med. Chem. pmid:17383189
Patanasethanont D et al. Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function. 2007 J Pharm Sci pmid:17031860
Hämäläinen M et al. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. 2007 Mediators Inflamm. pmid:18274639
Tsuji PA and Walle T Benzo[a]pyrene-induced cytochrome P450 1A and DNA binding in cultured trout hepatocytes - inhibition by plant polyphenols. 2007 Chem. Biol. Interact. pmid:17583686
do Nascimento AM and de Oliveira DC A new 5-deoxyflavone glycoside from the aerial parts of Calea clausseniana. 2007 Carbohydr. Res. pmid:17420009
Ajay M et al. Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid. 2007 Pharmacol. Res. pmid:17317209
Geraets L et al. Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression. 2007 Eur. J. Pharmacol. pmid:17643414
Jung SM et al. Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. 2007 Arthritis Res. Ther. pmid:17612394
Bontempo P et al. Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities. 2007 Int. J. Biochem. Cell Biol. pmid:17604209
Walle T et al. Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. 2007 Biochem. Pharmacol. pmid:17250812
Ramajayam R et al. Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines. 2007 J Enzyme Inhib Med Chem pmid:18237024
Murakami S et al. Purification and characterization of three neutral extracellular isoperoxidases from rye leaves. 2007 Phytochemistry pmid:17266998
Yadava RN and Tiwari L New antifungal flavone glycoside from Butea monosperma O. Kuntze. 2007 J Enzyme Inhib Med Chem pmid:17847718
Bovicelli P et al. Efficient synthesis of polyoxygenated flavones from naturally occurring flavanones. 2007 J. Pharm. Pharmacol. pmid:18053332
Wan L et al. Quantitative determination of apigenin and its metabolism in rat plasma after intravenous bolus administration by HPLC coupled with tandem mass spectrometry. 2007 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:17561454
Jung J et al. Inhibition of estrogen action by 2-phenylchromone as AhR agonist in MCF-7 cells. 2007 Life Sci. pmid:17950758
Pham MH et al. Characterization of monohydroxylated derivatives of the anticancer agent flavone-8-acetic acid by liquid chromatography with on-line UV and mass spectrometry. 2007 Rapid Commun. Mass Spectrom. pmid:17891752
Wu Y et al. [Effects of the total flavone of radix puerariae on apoptotic cell and apoptotic related-gene in atherosclerotic plaques of apoE gene deficiency mice]. 2007 Zhonghua Xin Xue Guan Bing Za Zhi pmid:17711723
Liu S et al. Anticancer activity and quantitative analysis of flavone of Cirsium japonicum DC. 2007 Nat. Prod. Res. pmid:17680503
Yushchenko DA et al. Sensing of adenosine-5'-triphosphate anion in aqueous solutions and mitochondria by a fluorescent 3-hydroxyflavone dye. 2007 Anal. Biochem. pmid:17568555
Rodrigues J et al. An unusual C6-C6" linked flavonoid from Miconia cabucu (Melastomataceae). 2007 Phytochemistry pmid:17540417
Sarkar M and Samanta A Photophysical and density functional studies of the interaction of a flavone derivative with the halides. 2007 J Phys Chem B pmid:17523624
Ohtani H et al. Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells. 2007 Pharm. Res. pmid:17492365
Meyer JD et al. Quantitative trait loci for maysin synthesis in maize (Zea mays L.) lines selected for high silk maysin content. 2007 Theor. Appl. Genet. pmid:17486311
Patanasethanont D et al. Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components. 2007 Eur. J. Pharmacol. pmid:17481606
Govindarajan R et al. Effect of Desmodium gangeticum extract on blood glucose in rats and on insulin secretion in vitro. 2007 Planta Med. pmid:17431824
Aboul-Enein HY et al. Scavenging effects of phenolic compounds on reactive oxygen species. 2007 Biopolymers pmid:17373654
Ono M [Molecular imaging of beta-amyloid plaques in the brain]. 2007 Brain Nerve pmid:17370649
Duarte-Almeida JM et al. Antiproliferative and antioxidant activities of a tricin acylated glycoside from sugarcane (Saccharum officinarum) juice. 2007 Phytochemistry pmid:17350657
Winkelmann I et al. The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes. 2007 Carcinogenesis pmid:17347140
Cacciola F et al. Comprehensive two-dimensional liquid chromatography with parallel gradients for separation of phenolic and flavone antioxidants. 2007 J Chromatogr A pmid:17331519
Boumendjel A et al. Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2. 2007 Bioorg. Med. Chem. pmid:17317193
Shukla S et al. Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. 2007 Cancer Res. pmid:17638904
Borges-Argáez R et al. Cytotoxic and antiprotozoal activity of flavonoids from Lonchocarpus spp. 2007 Phytomedicine pmid:17291734
Sarkar K et al. Antibody response against neem leaf preparation recognizes carcinoembryonic antigen. 2007 Int. Immunopharmacol. pmid:17276888
Iida N et al. A new flavone xyloside and two new flavan-3-ol glucosides from Juniperus communis var. depressa. 2007 Chem. Biodivers. pmid:17256732
Burns DC et al. A combined nuclear magnetic resonance and computational study of monohydroxyflavones applied to product ion mass spectra. 2007 Rapid Commun. Mass Spectrom. pmid:17216597
Fossen T et al. Covalent anthocyanin-flavone dimer from leaves of Oxalis triangularis. 2007 Phytochemistry pmid:17182069
Tremblay AM and Giguère V The NR3B subgroup: an ovERRview. 2007 Nucl Recept Signal pmid:18174917
Auffret G et al. Synthesis and antimalarial evaluation of a series of piperazinyl flavones. 2007 Bioorg. Med. Chem. Lett. pmid:17166718
Chen J et al. Phospholipase C/diacylglycerol kinase-mediated signalling is required for benzothiadiazole-induced oxidative burst and hypersensitive cell death in rice suspension-cultured cells. 2007 Protoplasma pmid:17111096
Ono M et al. Synthesis and characterization of styrylchromone derivatives as beta-amyloid imaging agents. 2007 Bioorg. Med. Chem. pmid:17035032
Jeon SB et al. Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit. 2007 Clin. Exp. Pharmacol. Physiol. pmid:17880363
Doronicheva N et al. Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method. 2007 Biol. Pharm. Bull. pmid:17268053
Kikuchi K et al. Flavonoids induce germination of basidiospores of the ectomycorrhizal fungus Suillus bovinus. 2007 Mycorrhiza pmid:17516095
Huang GC et al. Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages. 2007 Int. Immunopharmacol. pmid:17570322
Kunnumakkara AB et al. Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. 2007 Blood pmid:17332240
Lin J et al. Dietary intakes of flavonols and flavones and coronary heart disease in US women. 2007 Am. J. Epidemiol. pmid:17379619
Kim MJ et al. Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species. 2007 Ann. N. Y. Acad. Sci. pmid:17404061
Lee HS et al. In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes. 2007 Xenobiotica pmid:17701830
Gates MA et al. A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. 2007 Int. J. Cancer pmid:17471564
Galabov AS Virucidal agents in the eve of manorapid synergy. 2007 GMS Krankenhhyg Interdiszip pmid:20200679
Rossi A et al. Inhibition of inducible nitric oxide synthase expression by an acetonic extract from Feijoa sellowiana Berg. fruits. 2007 J. Agric. Food Chem. pmid:17550270
Akao T et al. Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2. 2007 J. Pharm. Pharmacol. pmid:17227625
Fukuda I et al. Interaction between the aryl hydrocarbon receptor and its antagonists, flavonoids. 2007 Biochem. Biophys. Res. Commun. pmid:17560542
Domínguez M et al. Pensteminoside, an unusual catalpol-type iridoid from Penstemon gentianoides HBK (Plantaginaceae). 2007 Phytochemistry pmid:17507063
Manna SK et al. Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis. 2007 Clin. Cancer Res. pmid:17404114
Snijman PW et al. The antimutagenic activity of the major flavonoids of rooibos (Aspalathus linearis): some dose-response effects on mutagen activation-flavonoid interactions. 2007 Mutat. Res. pmid:17537670
Ahmed N et al. Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates. 2007 Bioorg. Med. Chem. Lett. pmid:17379515
Jeong MA et al. Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. 2007 Ann. N. Y. Acad. Sci. pmid:17404058
Enomoto R et al. Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid. 2007 Ann. N. Y. Acad. Sci. pmid:17404053
Lee E et al. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. 2007 Ann. N. Y. Acad. Sci. pmid:17404065
Zhao JH et al. Chemical chaperone and inhibitor discovery: potential treatments for protein conformational diseases. 2007 Perspect Medicin Chem pmid:19812735
Young J et al. Antimicrobial effects of flavone analogues and their structure-activity relationships. 2007 J. Microbiol. Biotechnol. pmid:18050960
Gao D et al. Hypoglycemic effects and mechanisms of action of Cortex Lycii Radicis on alloxan-induced diabetic mice. 2007 Yakugaku Zasshi pmid:17917429
Jung SH et al. Aldose reductase and advanced glycation endproducts inhibitory effect of Phyllostachys nigra. 2007 Biol. Pharm. Bull. pmid:17666823
Trusheva B et al. Different extraction methods of biologically active components from propolis: a preliminary study. 2007 Chem Cent J pmid:17880743
Enomoto R et al. Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action. 2007 J. Pharmacol. Sci. pmid:17690528
Pham MH et al. Identification of new flavone-8-acetic acid metabolites using mouse microsomes and comparison with human microsomes. 2007 Drug Metab. Dispos. pmid:17664249
Zeng Y et al. Baicalin reduces the severity of experimental autoimmune encephalomyelitis. 2007 Braz. J. Med. Biol. Res. pmid:17653455
Zamora Rodríguez ZB et al. Antioxidant mechanism is involved in the gastroprotective effects of ozonized sunflower oil in ethanol-induced ulcers in rats. 2007 Mediators Inflamm. pmid:17497036
Zhang J et al. Flavone synthases from Medicago truncatula are flavanone-2-hydroxylases and are important for nodulation. 2007 Plant Physiol. pmid:17434990
Burns DC et al. A predictive tool for assessing (13)C NMR chemical shifts of flavonoids. 2007 Magn Reson Chem pmid:17729229
Ullmannova V and Popescu NC Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines. 2007 Cancer Detect. Prev. pmid:17418982
Chen S and Li X Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes. 2007 BMC Evol. Biol. pmid:17381843
Hinnen P and Eskens FA Vascular disrupting agents in clinical development. 2007 Br. J. Cancer pmid:17375046
Joshi KS et al. P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. 2007 Mol. Cancer Ther. pmid:17363487
Perry JD et al. Evaluation of novel chromogenic substrates for the detection of bacterial beta-glucosidase. 2007 J. Appl. Microbiol. pmid:17241346
Pikulski M et al. Tunable transition metal-ligand complexation for enhanced elucidation of flavonoid diglycosides by electrospray ionization mass spectrometry. 2007 J. Am. Soc. Mass Spectrom. pmid:17112735
Mbouangouere RN et al. Piptaderol from Piptadenia africana. 2007 Afr J Tradit Complement Altern Med pmid:20161892
Kim JH et al. Characterization of flavonoid 7-O-glucosyltransferase from Arabidopsis thaliana. 2006 Biosci. Biotechnol. Biochem. pmid:16794327
Gobbi S et al. Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. 2006 J. Med. Chem. pmid:16854084
da Fonseca R et al. Molecular interactions between human cytochrome P450 1A2 and flavone derivatives. 2006 Med Chem pmid:16848753
Liu S et al. Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. 2006 Int. Immunopharmacol. pmid:16846832
González B et al. Respiratory system of Gluconacetobacter diazotrophicus PAL5. Evidence for a cyanide-sensitive cytochrome bb and cyanide-resistant cytochrome ba quinol oxidases. 2006 Biochim. Biophys. Acta pmid:16934215
Kite GC et al. Data-directed scan sequence for the general assignment of C-glycosylflavone O-glycosides in plant extracts by liquid chromatography-ion trap mass spectrometry. 2006 J Chromatogr A pmid:16360661
Chemler JA et al. Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. 2006 Microb. Cell Fact. pmid:16719921
Park H et al. Anti-inflammatory activity of the synthetic C-C biflavonoids. 2006 J. Pharm. Pharmacol. pmid:17331331
Zhang J et al. Transposition of reversed Ac element ends generates novel chimeric genes in maize. 2006 PLoS Genet. pmid:17029561
Moorthy NS et al. Synthesis, biological evaluation and in silico metabolic and toxicity prediction of some flavanone derivatives. 2006 Chem. Pharm. Bull. pmid:17015974
Lévy V et al. A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia. 2006 Br. J. Cancer pmid:16847470