| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim JH et al. | Characterization of flavonoid 7-O-glucosyltransferase from Arabidopsis thaliana. | 2006 | Biosci. Biotechnol. Biochem. | pmid:16794327 |
| Ferrer-Sueta G et al. | Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite. | 2006 | Free Radic. Biol. Med. | pmid:16843831 |
| Vargo MA et al. | Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16844095 |
| Hayeshi R et al. | The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux. | 2006 | Eur J Pharm Sci | pmid:16846720 |
| Liu S et al. | Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. | 2006 | Int. Immunopharmacol. | pmid:16846832 |
| Lévy V et al. | A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia. | 2006 | Br. J. Cancer | pmid:16847470 |
| da Fonseca R et al. | Molecular interactions between human cytochrome P450 1A2 and flavone derivatives. | 2006 | Med Chem | pmid:16848753 |
| Nagai S et al. | Kinetic study of the quenching reaction of singlet oxygen by flavonoids in ethanol solution. | 2005 | J Phys Chem B | pmid:16851486 |
| Gobbi S et al. | Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. | 2006 | J. Med. Chem. | pmid:16854084 |
| Innocenti G et al. | In vitro estrogenic activity of Achillea millefolium L. | 2007 | Phytomedicine | pmid:16860978 |
| Wang D et al. | Immunologic synergism with IL-2 and effects of cCHMIs on mRNA expression of IL-2 and IFN-gamma in chicken peripheral T lymphocyte. | 2006 | Vaccine | pmid:16887240 |
| Lameira J et al. | Structure-activity relationship study of flavone compounds with anti-HIV-1 integrase activity: a density functional theory study. | 2006 | Bioorg. Med. Chem. | pmid:16890444 |
| González B et al. | Respiratory system of Gluconacetobacter diazotrophicus PAL5. Evidence for a cyanide-sensitive cytochrome bb and cyanide-resistant cytochrome ba quinol oxidases. | 2006 | Biochim. Biophys. Acta | pmid:16934215 |
| Iwashina T et al. | Analysis of flavonoids in pubescence of soybean near-isogenic lines for pubescence color loci. | J. Hered. | pmid:16985083 | |
| Lotito SB and Frei B | Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism. | 2006 | J. Biol. Chem. | pmid:16987811 |
| Schutte ME et al. | An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16997339 |
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| Moorthy NS et al. | Synthesis, biological evaluation and in silico metabolic and toxicity prediction of some flavanone derivatives. | 2006 | Chem. Pharm. Bull. | pmid:17015974 |
| Zhang J et al. | Transposition of reversed Ac element ends generates novel chimeric genes in maize. | 2006 | PLoS Genet. | pmid:17029561 |
| Patanasethanont D et al. | Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function. | 2007 | J Pharm Sci | pmid:17031860 |
| Ono M et al. | Synthesis and characterization of styrylchromone derivatives as beta-amyloid imaging agents. | 2007 | Bioorg. Med. Chem. | pmid:17035032 |
| Casadesus G et al. | Targeting gonadotropins: an alternative option for Alzheimer disease treatment. | 2006 | J. Biomed. Biotechnol. | pmid:17047306 |
| Ebert B et al. | Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. | 2007 | Toxicol. Sci. | pmid:17077187 |
| Zabala G et al. | Transcriptome changes in the phenylpropanoid pathway of Glycine max in response to Pseudomonas syringae infection. | 2006 | BMC Plant Biol. | pmid:17083738 |
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| Hamada M et al. | TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers. | 2006 | J. Agric. Food Chem. | pmid:17090139 |
| He YM et al. | [Effects of Pollen Typhae total flavone on glucose and lipid metabolism in 3T3-L1 adipocytes]. | 2006 | Zhong Xi Yi Jie He Xue Bao | pmid:17090374 |
| Gidda SK and Varin L | Biochemical and molecular characterization of flavonoid 7-sulfotransferase from Arabidopsis thaliana. | Plant Physiol. Biochem. | pmid:17095238 | |
| Chen J et al. | Phospholipase C/diacylglycerol kinase-mediated signalling is required for benzothiadiazole-induced oxidative burst and hypersensitive cell death in rice suspension-cultured cells. | 2007 | Protoplasma | pmid:17111096 |
| Hui RH et al. | [Simultaneous determination of total flavone and total saponin in Gynostemma pentaphyllum by signal multiplier spectrophotometry]. | 2006 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:17112063 |
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| Fossen T et al. | Covalent anthocyanin-flavone dimer from leaves of Oxalis triangularis. | 2007 | Phytochemistry | pmid:17182069 |
| Wang TC et al. | Synthesis, and cytotoxic and antiplatelet activities of oxime- and methyloxime-containing flavone, isoflavone, and xanthone derivatives. | 2005 | Chem. Biodivers. | pmid:17191978 |
| Feng Y et al. | Iridoid glucosides and flavones from the aerial parts of Avicennia marina. | 2006 | Chem. Biodivers. | pmid:17193312 |
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| Akao T et al. | Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2. | 2007 | J. Pharm. Pharmacol. | pmid:17227625 |
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| Murakami S et al. | Purification and characterization of three neutral extracellular isoperoxidases from rye leaves. | 2007 | Phytochemistry | pmid:17266998 |
| Doronicheva N et al. | Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method. | 2007 | Biol. Pharm. Bull. | pmid:17268053 |
| Sarkar K et al. | Antibody response against neem leaf preparation recognizes carcinoembryonic antigen. | 2007 | Int. Immunopharmacol. | pmid:17276888 |
| Borges-Argáez R et al. | Cytotoxic and antiprotozoal activity of flavonoids from Lonchocarpus spp. | 2007 | Phytomedicine | pmid:17291734 |
| Lohner K et al. | Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo. | 2007 | Mol Nutr Food Res | pmid:17295420 |