| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Kidney Neoplasms | D007680 | 29 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
chrysin
chrysin is a lipid of Polyketides (PK) class. Chrysin is associated with abnormalities such as Unconjugated hyperbilirubinemia, Metabolic Diseases, Hypogonadism, Renal tubular disorder and Colitis. The involved functions are known as Hypoxia, enzyme activity, Oxidation, inhibitors and Cell Survival. Chrysin often locates in Protoplasm, Plasma membrane, Back, Extracellular and Mitochondria. The associated genes with chrysin are CFB gene, P4HTM gene, UGT1A9 gene, CYP1A1 gene and UGT1A1 gene. The related lipids are Promega, estradiol-3-glucuronide, Steroids and Lipopolysaccharides. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of chrysin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with chrysin?
chrysin is suspected in Colitis, Toxic nephropathy, Unconjugated hyperbilirubinemia, Metabolic Diseases, Hypogonadism, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with chrysin
PubChem Associated disorders and diseases
What pathways are associated with chrysin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with chrysin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with chrysin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with chrysin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with chrysin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with chrysin?
Mouse Model
Mouse Model are used in the study 'Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway.' (Dou W et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with chrysin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu TC et al. | Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. | 2018 | Chem. Biol. Interact. | pmid:30016632 |
| Zhao Q et al. | Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensis. | 2018 | Mol Plant | pmid:28842248 |
| Goes ATR et al. | Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins. | 2018 | Chem. Biol. Interact. | pmid:29054324 |
| Šarić Mustapić D et al. | The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. | 2018 | Molecules | pmid:30301254 |
| Heriniaina RM et al. | Effects of six compounds with different chemical structures on melanogenesis. | 2018 | Chin J Nat Med | pmid:30322610 |
| Sun L et al. | Potential Antinociceptive Effects of Chinese Propolis and Identification on Its Active Compounds. | 2018 | J Immunol Res | pmid:30356413 |
| Aksu EH et al. | Improvement in colistin-induced reproductive damage, apoptosis, and autophagy in testes via reducing oxidative stress by chrysin. | 2018 | J. Biochem. Mol. Toxicol. | pmid:30273961 |
| Yang M et al. | Chrysin attenuates interstitial fibrosis and improves cardiac function in a rat model of acute myocardial infarction. | 2018 | J. Mol. Histol. | pmid:30225683 |
| Park W et al. | Chrysin disrupts intracellular homeostasis through mitochondria-mediated cell death in human choriocarcinoma cells. | 2018 | Biochem. Biophys. Res. Commun. | pmid:30139515 |
| Yang Z et al. | Chrysin attenuates carrageenan-induced pleurisy and lung injury via activation of SIRT1/NRF2 pathway in rats. | 2018 | Eur. J. Pharmacol. | pmid:30118661 |
| Kang MK et al. | Chrysin Ameliorates Malfunction of Retinoid Visual Cycle through Blocking Activation of AGE-RAGE-ER Stress in Glucose-Stimulated Retinal Pigment Epithelial Cells and Diabetic Eyes. | 2018 | Nutrients | pmid:30096827 |
| Hwang SH et al. | Anti-glycation, Carbonyl Trapping and Anti-inflammatory Activities of Chrysin Derivatives. | 2018 | Molecules | pmid:30018253 |
| Zhao X et al. | Simultaneous Determination of Chrysin and Tectochrysin from Fruits by UPLC-MS/MS and Its Application to a Comparative Pharmacokinetic Study in Normal and Dementia Rats. | 2018 | Molecules | pmid:30002311 |
| Lee EJ et al. | Chrysin Inhibits Advanced Glycation End Products-Induced Kidney Fibrosis in Renal Mesangial Cells and Diabetic Kidneys. | 2018 | Nutrients | pmid:29987200 |
| Firouzi-Amandi A et al. | Chrysin-nanoencapsulated PLGA-PEG for macrophage repolarization: Possible application in tissue regeneration. | 2018 | Biomed. Pharmacother. | pmid:29909345 |
| Nagasaka M et al. | Anti-Tumorigenic Activity of Chrysin from via Non-Genotoxic p53 Activation through the ATM-Chk2 Pathway. | 2018 | Molecules | pmid:29890668 |
| Kalhotra P et al. | Structureâ»Activity Relationship and Molecular Docking of Natural Product Library Reveal Chrysin as a Novel Dipeptidyl Peptidase-4 (DPP-4) Inhibitor: An Integrated In Silico and In Vitro Study. | 2018 | Molecules | pmid:29882783 |
| Mehnath S et al. | Co-encapsulation of dual drug loaded in MLNPs: Implication on sustained drug release and effectively inducing apoptosis in oral carcinoma cells. | 2018 | Biomed. Pharmacother. | pmid:29803180 |
| Babangida S et al. | The role of molecular modelling strategies in validating the effects of chrysin on sodium arsenite-induced chromosomal and DNA damage. | 2018 | Hum Exp Toxicol | pmid:29308674 |
| Bagheri R et al. | Synergistic Effect of Free and Nano-encapsulated Chrysin-Curcumin on Inhibition of hTERT Gene Expression in SW480 Colorectal Cancer Cell Line. | 2018 | Drug Res (Stuttg) | pmid:29294495 |
| Shoieb SM et al. | Chrysin attenuates testosterone-induced benign prostate hyperplasia in rats. | 2018 | Food Chem. Toxicol. | pmid:29247772 |
| Zeinali M et al. | Protective effects of chrysin on sub-acute diazinon-induced biochemical, hematological, histopathological alterations, and genotoxicity indices in male BALB/c mice. | 2018 | Drug Chem Toxicol | pmid:29092670 |
| Lim W et al. | Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction. | 2018 | J. Cell. Physiol. | pmid:28816359 |
| Sassi A et al. | Chrysin, a natural and biologically active flavonoid suppresses tumor growth of mouse B16F10 melanoma cells: In vitro and In vivo study. | 2018 | Chem. Biol. Interact. | pmid:29352974 |
| Mani R and Natesan V | Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action. | 2018 | Phytochemistry | pmid:29161583 |
| Ribeiro NCS et al. | Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils. | 2018 | Fitoterapia | pmid:29132837 |
| Das S et al. | Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29102848 |
| Lin YM et al. | Chrysin Attenuates Cell Viability of Human Colorectal Cancer Cells through Autophagy Induction Unlike 5-Fluorouracil/Oxaliplatin. | 2018 | Int J Mol Sci | pmid:29899208 |
| Menon AH et al. | Sustained release of chrysin from chitosan-based scaffolds promotes mesenchymal stem cell proliferation and osteoblast differentiation. | 2018 | Carbohydr Polym | pmid:29804987 |
| Rasouli S and Zarghami N | Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression | 2018 | Asian Pac. J. Cancer Prev. | pmid:29693804 |
| Wang J et al. | Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway. | 2018 | Drug Des Devel Ther | pmid:29662304 |
| KuÅ› P et al. | Extraction of bioactive phenolics from black poplar (Populus nigra L.) buds by supercritical CO and its optimization by response surface methodology. | 2018 | J Pharm Biomed Anal | pmid:29414004 |
| Bortolotto VC et al. | Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. | 2018 | Eur. J. Pharmacol. | pmid:29355556 |
| George MY et al. | In vivo cellular and molecular gastroprotective mechanisms of chrysin; Emphasis on oxidative stress, inflammation and angiogenesis. | 2018 | Eur. J. Pharmacol. | pmid:29126792 |
| Deng X et al. | Synthesis and evaluation of antitumour activity in vitro and in vivo of chrysin salicylate derivatives. | 2018 | Nat. Prod. Res. | pmid:28871827 |
| Deldar Y et al. | An in vitro examination of the antioxidant, cytoprotective and anti-inflammatory properties of chrysin-loaded nanofibrous mats for potential wound healing applications. | 2018 | Artif Cells Nanomed Biotechnol | pmid:28595461 |
| Larit F et al. | Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants. | 2018 | Phytomedicine | pmid:29496172 |
| Chassagne F et al. | A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases. | 2018 | Fitoterapia | pmid:29477305 |
| van Vugt-Lussenburg BMA et al. | Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity. | 2018 | Reprod. Toxicol. | pmid:29162470 |
| Khaligh F et al. | Effects of in ovo injection of chrysin, quercetin and ascorbic acid on hatchability, somatic attributes, hepatic oxidative status and early post-hatch performance of broiler chicks. | 2018 | J Anim Physiol Anim Nutr (Berl) | pmid:28636279 |
| Mansour SZ et al. | Protective effect of 5, 7-dihydroxyflavone on brain of rats exposed to acrylamide or γ-radiation. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:28888167 |
| Choi JK et al. | Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes. | 2017 | Food Chem. Toxicol. | pmid:29050978 |
| Lee BK et al. | Chrysin Attenuates VCAM-1 Expression and Monocyte Adhesion in Lipopolysaccharide-Stimulated Brain Endothelial Cells by Preventing NF-κB Signaling. | 2017 | Int J Mol Sci | pmid:28671640 |
| Zeinali M et al. | An overview on immunoregulatory and anti-inflammatory properties of chrysin and flavonoids substances. | 2017 | Biomed. Pharmacother. | pmid:28609844 |
| Kang MK et al. | Chrysin ameliorates podocyte injury and slit diaphragm protein loss via inhibition of the PERK-eIF2α-ATF-CHOP pathway in diabetic mice. | 2017 | Acta Pharmacol. Sin. | pmid:28502979 |
| Zheng W et al. | Chrysin Attenuates IL-1β-Induced Expression of Inflammatory Mediators by Suppressing NF-κB in Human Osteoarthritis Chondrocytes. | 2017 | Inflammation | pmid:28364187 |
| Lin S et al. | Synthesis, characterization and xanthine oxidase inhibition of Cu(II)-chrysin complex. | 2017 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:28167361 |
| Xie Z et al. | Sensitive, simultaneous determination of chrysin and baicalein based on TaO-chitosan composite modified carbon paste electrode. | 2017 | Talanta | pmid:28153298 |
| Dong D et al. | Sodium Oleate-Based Nanoemulsion Enhances Oral Absorption of Chrysin through Inhibition of UGT-Mediated Metabolism. | 2017 | Mol. Pharm. | pmid:27983856 |
| Lim HK et al. | Chrysin Increases the Therapeutic Efficacy of Docetaxel and Mitigates Docetaxel-Induced Edema. | 2017 | Integr Cancer Ther | pmid:27151585 |