| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Kidney Neoplasms | D007680 | 29 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
chrysin
chrysin is a lipid of Polyketides (PK) class. Chrysin is associated with abnormalities such as Unconjugated hyperbilirubinemia, Metabolic Diseases, Hypogonadism, Renal tubular disorder and Colitis. The involved functions are known as Hypoxia, enzyme activity, Oxidation, inhibitors and Cell Survival. Chrysin often locates in Protoplasm, Plasma membrane, Back, Extracellular and Mitochondria. The associated genes with chrysin are CFB gene, P4HTM gene, UGT1A9 gene, CYP1A1 gene and UGT1A1 gene. The related lipids are Promega, estradiol-3-glucuronide, Steroids and Lipopolysaccharides. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of chrysin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with chrysin?
chrysin is suspected in Colitis, Toxic nephropathy, Unconjugated hyperbilirubinemia, Metabolic Diseases, Hypogonadism, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with chrysin
PubChem Associated disorders and diseases
What pathways are associated with chrysin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with chrysin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with chrysin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with chrysin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with chrysin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with chrysin?
Mouse Model
Mouse Model are used in the study 'Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway.' (Dou W et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with chrysin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yao J et al. | [Effects of chrysin on steroid-resistant asthma in a murine model]. | 2015 | Zhonghua Yi Xue Za Zhi | pmid:26710703 |
| Laishram S et al. | Chrysin rich Scutellaria discolor Colebr. induces cervical cancer cell death via the induction of cell cycle arrest and caspase-dependent apoptosis. | 2015 | Life Sci. | pmid:26541229 |
| Zhang K et al. | Chrysin suppresses human CD14(+) monocyte-derived dendritic cells and ameliorates experimental autoimmune encephalomyelitis. | 2015 | J. Neuroimmunol. | pmid:26531689 |
| Mistry BM et al. | Chrysin-benzothiazole conjugates as antioxidant and anticancer agents. | 2015 | Bioorg. Med. Chem. Lett. | pmid:26514745 |
| Yao J et al. | Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal-regulated kinase 1/2 signaling pathway. | 2015 | Mol Med Rep | pmid:26502995 |
| León IE et al. | Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model. | 2015 | J. Biol. Inorg. Chem. | pmid:26404080 |
| Naseer S et al. | LC-MS guided isolation, quantification and antioxidant evaluation of bioactive principles from Epimedium elatum. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25804994 |
| Zhang Z et al. | Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease. | 2015 | Free Radic. Biol. Med. | pmid:25769424 |
| Ge S et al. | Determination of pharmacokinetics of chrysin and its conjugates in wild-type FVB and Bcrp1 knockout mice using a validated LC-MS/MS method. | 2015 | J. Agric. Food Chem. | pmid:25715997 |
| Liang X et al. | High-speed counter-current chromatography coupled online to high performance liquid chromatography-diode array detector-mass spectrometry for purification, analysis and identification of target compounds from natural products. | 2015 | J Chromatogr A | pmid:25678319 |
| Pingili RB et al. | Systemic exposure of Paracetamol (acetaminophen) was enhanced by quercetin and chrysin co-administration in Wistar rats and in vitro model: risk of liver toxicity. | 2015 | Drug Dev Ind Pharm | pmid:25678313 |
| Xia Y et al. | Chrysin inhibits cell invasion by inhibition of Recepteur d'origine Nantais via suppressing early growth response-1 and NF-κB transcription factor activities in gastric cancer cells. | 2015 | Int. J. Oncol. | pmid:25625479 |
| Kasala ER et al. | Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives. | 2015 | Toxicol. Lett. | pmid:25596314 |
| Filho CB et al. | Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin. | 2015 | Neuroscience | pmid:25592430 |
| Rauf A et al. | Cytotoxic, antitumour-promoting and inhibition of protein denaturation effects of flavonoids, isolated from Potentilla evestita Th. Wolf. | 2015 | Nat. Prod. Res. | pmid:25588733 |
| Stepanic V et al. | Selected attributes of polyphenols in targeting oxidative stress in cancer. | 2015 | Curr Top Med Chem | pmid:25665579 |
| Xia Y et al. | Chrysin inhibits tumor promoter-induced MMP-9 expression by blocking AP-1 via suppression of ERK and JNK pathways in gastric cancer cells. | 2015 | PLoS ONE | pmid:25875631 |
| Manzolli ES et al. | Protective effects of the flavonoid chrysin against methylmercury-induced genotoxicity and alterations of antioxidant status, in vivo. | 2015 | Oxid Med Cell Longev | pmid:25810809 |
| Quan E et al. | Characterization of chrysin glucuronidation in UGT1A1-overexpressing HeLa cells: elucidating the transporters responsible for efflux of glucuronide. | 2015 | Drug Metab. Dispos. | pmid:25595598 |
| Santos BL et al. | Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression. | 2015 | Chem. Biol. Interact. | pmid:26408079 |
| Balta C et al. | Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway. | 2015 | Chem. Biol. Interact. | pmid:26297989 |
| Li X et al. | Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53. | 2015 | Chem. Biol. Interact. | pmid:25770930 |
| Hsu CW et al. | Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. | 2014 | Sci Rep | pmid:25257666 |
| Lee PJ et al. | Upregulation of both heme oxygenase-1 and ATPase inhibitory factor 1 renders tumoricidal activity by synthetic flavonoids via depleting cellular ATP. | 2014 | Bioorg. Med. Chem. Lett. | pmid:25223958 |
| Kilic T et al. | Preventive effect of chrysin on bleomycin-induced lung fibrosis in rats. | 2014 | Inflammation | pmid:24973983 |
| Deng X et al. | Anti-tumor effects of flavonoids from the ethnic medicine Docynia delavayi (Franch.) Schneid. and its possible mechanism. | 2014 | J Med Food | pmid:24940817 |
| Badjah Hadj Ahmed AY et al. | High-performance liquid chromatography analysis of phenolic acid, flavonoid, and phenol contents in various natural Yemeni honeys using multi-walled carbon nanotubes as a solid-phase extraction adsorbent. | 2014 | J. Agric. Food Chem. | pmid:24871957 |
| Li R et al. | Chrysin ameliorates diabetes-associated cognitive deficits in Wistar rats. | 2014 | Neurol. Sci. | pmid:24737349 |
| Zheng H et al. | Nanoparticles generated by PEG-Chrysin conjugates for efficient anticancer drug delivery. | 2014 | Eur J Pharm Biopharm | pmid:24691159 |
| Abdolahzadeh S et al. | The role of carboxylato ligand dissociation in the oxidation of chrysin with H₂O₂ catalysed by [Mn₂(III,IV)(μ-CH₃COO)(μ-O)₂(Me₄dtne)](PF₆)₂. | 2014 | Dalton Trans | pmid:24647519 |
| Gómez-Florit M et al. | Identification of quercitrin as a potential therapeutic agent for periodontal applications. | 2014 | J. Periodontol. | pmid:24548116 |
| Samarghandian S et al. | Role of caspases, Bax and Bcl-2 in chrysin-induced apoptosis in the A549 human lung adenocarcinoma epithelial cells. | 2014 | Anticancer Agents Med Chem | pmid:24521149 |
| Mantawy EM et al. | Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis. | 2014 | Eur. J. Pharmacol. | pmid:24509133 |
| Rashid S et al. | Mitigation of 5-Fluorouracil induced renal toxicity by chrysin via targeting oxidative stress and apoptosis in wistar rats. | 2014 | Food Chem. Toxicol. | pmid:24486618 |
| Yao Y et al. | Chrysin protects against focal cerebral ischemia/reperfusion injury in mice through attenuation of oxidative stress and inflammation. | 2014 | Int J Mol Sci | pmid:25402649 |
| Xiao J et al. | Chrysin attenuates experimental autoimmune neuritis by suppressing immuno-inflammatory responses. | 2014 | Neuroscience | pmid:24412705 |
| Oršolić N et al. | Role of flavonoids on oxidative stress and mineral contents in the retinoic acid-induced bone loss model of rat. | 2014 | Eur J Nutr | pmid:24271527 |
| El-Bassossy HM et al. | Chrysin and luteolin alleviate vascular complications associated with insulin resistance mainly through PPAR-γ activation. | 2014 | Am. J. Chin. Med. | pmid:25169908 |
| Wang QQ et al. | Synthesis, nitric oxide release, and α-glucosidase inhibition of nitric oxide donating apigenin and chrysin derivatives. | 2014 | Bioorg. Med. Chem. | pmid:24508143 |
| Darwish HA et al. | Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: comparison with celecoxib. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24932515 |
| Liu H et al. | A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1. | 2014 | Cancer Prev Res (Phila) | pmid:24169959 |
| Jiang B et al. | Molecular docking and reaction kinetic studies of chrysin binding to serum albumin. | 2014 | Nat Prod Commun | pmid:24689288 |
| Feng X et al. | Chrysin attenuates inflammation by regulating M1/M2 status via activating PPARγ. | 2014 | Biochem. Pharmacol. | pmid:24704474 |
| Zhao H and Chen Z | Screening of neuraminidase inhibitors from traditional Chinese medicines by integrating capillary electrophoresis with immobilized enzyme microreactor. | 2014 | J Chromatogr A | pmid:24679826 |
| Singh P et al. | Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities. | 2014 | Bioorg. Med. Chem. Lett. | pmid:24332492 |
| Mehri S et al. | Chrysin reduced acrylamide-induced neurotoxicity in both in vitro and in vivo assessments. | 2014 | Iran. Biomed. J. | pmid:24518551 |
| Zhu ZY et al. | Synthesis and antitumor activity evaluation of chrysin derivatives. | 2014 | Eur J Med Chem | pmid:24556144 |
| Yang B et al. | Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway. | 2014 | J Appl Toxicol | pmid:24122885 |
| Jin H et al. | Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II. | 2014 | Fitoterapia | pmid:24468190 |
| Adem S et al. | Investigation of the effects of some phenolic compounds on the activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase from human erythrocytes. | 2014 | J. Biochem. Mol. Toxicol. | pmid:25130191 |