20-HEDE

20-hede is a lipid of Fatty Acyls (FA) class. 20-hede is associated with abnormalities such as Myocardial Infarction and Hypertensive disease. The involved functions are known as Infarction, Obstruction, Anabolism, inhibitors and caspase-3 activity. 20-hede often locates in Myocardium, Blood, Microsomes, cell body and Protoplasm. The associated genes with 20-HEDE are SLC33A1 gene and AGT gene.

Cross Reference

Introduction

To understand associated biological information of 20-HEDE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 20-HEDE?

20-HEDE is suspected in Myocardial Infarction, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 20-HEDE

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Hypertension D006973 115 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with 20-HEDE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 20-HEDE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 20-HEDE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 20-HEDE?

There are no associated biomedical information in the current reference collection.

What genes are associated with 20-HEDE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 20-HEDE?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 20-HEDE

Download all related citations
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Authors Title Published Journal PubMed Link
pmid:
Kaide J et al. Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries. 2003 Am. J. Physiol. Renal Physiol. pmid:12388396
Yu M et al. Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. 2004 Eur. J. Pharmacol. pmid:14985052
Parmentier JH et al. Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells. 2005 Life Sci. pmid:15964316
Wang H et al. Glomerular cytochrome P-450 and cyclooxygenase metabolites regulate efferent arteriole resistance. 2005 Hypertension pmid:16230518
Nithipatikom K et al. Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16214838
Medhora M et al. 20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells. 2008 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:18296498
Sodhi K et al. CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent. 2010 Hypertension pmid:20837888
Hoff U et al. Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury. 2011 Kidney Int. pmid:20962739
Roman RJ et al. 20-HETE in acute kidney injury. 2011 Kidney Int. pmid:21157458