MeSH term | MeSH ID | Detail |
---|---|---|
Neovascularization, Pathologic | D009389 | 39 associated lipids |
Reperfusion Injury | D015427 | 65 associated lipids |
Hypertension | D006973 | 115 associated lipids |
20-hede is a lipid of Fatty Acyls (FA) class. 20-hede is associated with abnormalities such as Myocardial Infarction and Hypertensive disease. The involved functions are known as Infarction, Obstruction, Anabolism, inhibitors and caspase-3 activity. 20-hede often locates in Myocardium, Blood, Microsomes, cell body and Protoplasm. The associated genes with 20-HEDE are SLC33A1 gene and AGT gene.
To understand associated biological information of 20-HEDE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
20-HEDE is suspected in Myocardial Infarction, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 20-HEDE
MeSH term | MeSH ID | Detail |
---|---|---|
Neovascularization, Pathologic | D009389 | 39 associated lipids |
Reperfusion Injury | D015427 | 65 associated lipids |
Hypertension | D006973 | 115 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Nithipatikom K et al. | Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16214838 |
Renic M et al. | Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22245774 |
Medhora M et al. | 20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18296498 |
Kaide J et al. | Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries. | 2003 | Am. J. Physiol. Renal Physiol. | pmid:12388396 |
Ding Y et al. | 20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension. | 2013 | Am. J. Physiol. Renal Physiol. | pmid:23825080 |
Ren Y et al. | Mechanism of impaired afferent arteriole myogenic response in Dahl salt-sensitive rats: role of 20-HETE. | 2014 | Am. J. Physiol. Renal Physiol. | pmid:24990891 |
Yu M et al. | Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. | 2004 | Eur. J. Pharmacol. | pmid:14985052 |
Sodhi K et al. | CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent. | 2010 | Hypertension | pmid:20837888 |
Wang H et al. | Glomerular cytochrome P-450 and cyclooxygenase metabolites regulate efferent arteriole resistance. | 2005 | Hypertension | pmid:16230518 |