Prostaglandin E2 is a lipid of Fatty Acyls (FA) class. Prostaglandin e2 is associated with abnormalities such as Renal glomerular disease, Arthritis, Degenerative polyarthritis, Pancreatitis and Rheumatoid Arthritis. The involved functions are known as enzyme pathway, Atherogenesis, Anabolism, inhibitors and Oxidants. Prostaglandin e2 often locates in Tissue membrane, Blood, Extracellular, Membrane and Protoplasm. The associated genes with Prostaglandin E2 are PTGS2 gene, TP53 gene, TNFRSF5 gene, FASTK Gene and TNF gene. The related lipids are Lipopolysaccharides, Steroids, monooxyethylene trimethylolpropane tristearate, Fatty Acids, Unsaturated and Promega. The related experimental models are Arthritis, Adjuvant-Induced, Xenograft Model, Experimental Autoimmune Encephalomyelitis, Cancer Model and Knock-out.
To understand associated biological information of Prostaglandin E2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Prostaglandin E2 is suspected in Asthma, Inflammatory disorder, Arthritis, Obesity, Renal tubular disorder, Ischemia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Prostaglandin E2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Arthritis, Collagen-Induced are used in the study 'Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.' (Boniface K et al., 2009), Arthritis, Collagen-Induced are used in the study 'Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.' (Koeberle A and Werz O, 2015), Arthritis, Collagen-Induced are used in the study 'Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.' (Jiang J and Dingledine R, 2013), Arthritis, Collagen-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012) and Arthritis, Collagen-Induced are used in the study 'Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines.' (Pawlik M et al., 2011).
Arthritis, Adjuvant-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012), Arthritis, Adjuvant-Induced are used in the study 'A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression.' (Wang Q et al., 2016) and Arthritis, Adjuvant-Induced are used in the study 'Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA.' (Kojima F et al., 2009).
Experimental Autoimmune Encephalomyelitis are used in the study 'Ginsenoside Rb1 prevents interleukin-1 beta induced inflammation and apoptosis in human articular chondrocytes.' (Cheng W et al., 2013), Experimental Autoimmune Encephalomyelitis are used in the study 'PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.' (Schiffmann S et al., 2014) and Experimental Autoimmune Encephalomyelitis are used in the study 'Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.' (Shin JH et al., 2012).
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Koolpe M et al. | Expression of both P1 and P2 purine receptor genes by human articular chondrocytes and profile of ligand-mediated prostaglandin E2 release. | 1999 | Arthritis Rheum. | pmid:10025919 |
Ingram JN et al. | Cortisol in fetal fluids and the fetal adrenal at parturition in the tammar wallaby (Macropus eugenii). | 1999 | Biol. Reprod. | pmid:10026112 |
Xiao CW et al. | Down-regulation of oxytocin-induced cyclooxygenase-2 and prostaglandin F synthase expression by interferon-tau in bovine endometrial cells. | 1999 | Biol. Reprod. | pmid:10026113 |
Baguma-Nibasheka M et al. | Delay of preterm delivery in sheep by omega-3 long-chain polyunsaturates. | 1999 | Biol. Reprod. | pmid:10026118 |
Saunders MA et al. | Mechanisms of prostaglandin E2 release by intact cells expressing cyclooxygenase-2: evidence for a 'two-component' model. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10027847 |
Van de Weerdt ML et al. | Ketoprofen and phenylbutazone attenuation of PAF-induced lung inflammation in calves. | 1999 | Vet. J. | pmid:10030127 |
Boyle JE et al. | Prostaglandin-E2 counteracts interleukin-1beta-stimulated upregulation of platelet-derived growth factor alpha-receptor on rat pulmonary myofibroblasts. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10030841 |
Hirst WD et al. | Expression of COX-2 by normal and reactive astrocytes in the adult rat central nervous system. | 1999 | Mol. Cell. Neurosci. | pmid:10049531 |
Gan L et al. | A new computerized biomechanical perfusion model for ex vivo study of fluid mechanical forces in intact conduit vessels. | J. Vasc. Res. | pmid:10050075 | |
Rouaud C et al. | The cyclo-oxygenase-dependent regulation of rabbit vein contraction: evidence for a prostaglandin E2-mediated relaxation. | 1999 | Br. J. Pharmacol. | pmid:10051118 |
Cunha FQ et al. | Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4. | 1999 | Br. J. Pharmacol. | pmid:10051119 |
Hamilton SG et al. | The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. | 1999 | Br. J. Pharmacol. | pmid:10051152 |
Bastepe M and Ashby B | Identification of a region of the C-terminal domain involved in short-term desensitization of the prostaglandin EP4 receptor. | 1999 | Br. J. Pharmacol. | pmid:10051157 |
pmid:10051237 | ||||
Roland CR et al. | Gadolinium blocks rat Kupffer cell calcium channels: relevance to calcium-dependent prostaglandin E2 synthesis and septic mortality. | 1999 | Hepatology | pmid:10051477 |
Fitzgerald J and Hughes-Fulford M | Mechanically induced c-fos expression is mediated by cAMP in MC3T3-E1 osteoblasts. | 1999 | FASEB J. | pmid:10064622 |
Yucel-Lindberg T et al. | Signal transduction pathways involved in the synergistic stimulation of prostaglandin production by interleukin-1beta and tumor necrosis factor alpha in human gingival fibroblasts. | 1999 | J. Dent. Res. | pmid:10065947 |
Watson CS et al. | Prostaglandin E2 inhibition of fetal breathing movements is not sustained during prolonged reduced uterine blood flow in sheep. | 1998 | Can. J. Physiol. Pharmacol. | pmid:10066135 |
Goddard PJ et al. | HCO3-secretion by bullfrog duodenum: dependence on nutrient Na+ during secretory stimulation. | 1998 | Can. J. Physiol. Pharmacol. | pmid:10066138 |