| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hookworm Infections | D006725 | 1 associated lipids |
Prostaglandin E2
Prostaglandin E2 is a lipid of Fatty Acyls (FA) class. Prostaglandin e2 is associated with abnormalities such as Renal glomerular disease, Arthritis, Degenerative polyarthritis, Pancreatitis and Rheumatoid Arthritis. The involved functions are known as enzyme pathway, Atherogenesis, Anabolism, inhibitors and Oxidants. Prostaglandin e2 often locates in Tissue membrane, Blood, Extracellular, Membrane and Protoplasm. The associated genes with Prostaglandin E2 are PTGS2 gene, TP53 gene, TNFRSF5 gene, FASTK Gene and TNF gene. The related lipids are Lipopolysaccharides, Steroids, monooxyethylene trimethylolpropane tristearate, Fatty Acids, Unsaturated and Promega. The related experimental models are Arthritis, Adjuvant-Induced, Xenograft Model, Experimental Autoimmune Encephalomyelitis, Cancer Model and Knock-out.
Cross Reference
Introduction
To understand associated biological information of Prostaglandin E2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Prostaglandin E2?
Prostaglandin E2 is suspected in Asthma, Inflammatory disorder, Arthritis, Obesity, Renal tubular disorder, Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Prostaglandin E2
PubChem Associated disorders and diseases
What pathways are associated with Prostaglandin E2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Prostaglandin E2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Prostaglandin E2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Prostaglandin E2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Prostaglandin E2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Prostaglandin E2?
Arthritis, Collagen-Induced
Arthritis, Collagen-Induced are used in the study 'Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.' (Boniface K et al., 2009), Arthritis, Collagen-Induced are used in the study 'Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.' (Koeberle A and Werz O, 2015), Arthritis, Collagen-Induced are used in the study 'Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.' (Jiang J and Dingledine R, 2013), Arthritis, Collagen-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012) and Arthritis, Collagen-Induced are used in the study 'Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines.' (Pawlik M et al., 2011).
Arthritis, Adjuvant-Induced
Arthritis, Adjuvant-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012), Arthritis, Adjuvant-Induced are used in the study 'A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression.' (Wang Q et al., 2016) and Arthritis, Adjuvant-Induced are used in the study 'Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA.' (Kojima F et al., 2009).
Experimental Autoimmune Encephalomyelitis
Experimental Autoimmune Encephalomyelitis are used in the study 'Ginsenoside Rb1 prevents interleukin-1 beta induced inflammation and apoptosis in human articular chondrocytes.' (Cheng W et al., 2013), Experimental Autoimmune Encephalomyelitis are used in the study 'PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.' (Schiffmann S et al., 2014) and Experimental Autoimmune Encephalomyelitis are used in the study 'Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.' (Shin JH et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Prostaglandin E2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Costa-Rodrigues J et al. | Complex osteoclastogenic inductive effects of nicotine over hydroxyapatite. | 2018 | J. Cell. Physiol. | pmid:28407244 |
| Anuforo OUU et al. | Natural killer cells play an essential role in resolution of antigen-induced inflammation in mice. | 2018 | Mol. Immunol. | pmid:29112834 |
| Peng TC et al. | Platonin mitigates vascular hyporeactivity of thoracic aorta in septic rats. | 2018 | J. Surg. Res. | pmid:29229127 |
| Ma W et al. | Pachydermoperiostosis of the complete type: A novel missense mutation c.101TÂ >Â C in the SLCO2A1 gene. | 2017 | Eur J Med Genet | pmid:28602931 |
| West HM et al. | Methods of term labour induction for women with a previous caesarean section. | 2017 | Cochrane Database Syst Rev | pmid:28599068 |
| Soares AS et al. | Naphthoquinones of Sinningia reitzii and Anti-inflammatory/Antinociceptive Activities of 8-Hydroxydehydrodunnione. | 2017 | J. Nat. Prod. | pmid:28598175 |
| Murakami K et al. | A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro. | 2017 | PLoS ONE | pmid:28708884 |
| Bakker R et al. | The role of prostaglandins E1 and E2, dinoprostone, and misoprostol in cervical ripening and the induction of labor: a mechanistic approach. | 2017 | Arch. Gynecol. Obstet. | pmid:28585102 |
| Lee S et al. | Penicillospirone from a marine isolate of Penicillium sp. (SF-5292) with anti-inflammatory activity. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28583797 |
| Wang XR et al. | Capsaicin-loaded nanolipoidal carriers for topical application: design, characterization, and in vitro/in vivo evaluation. | 2017 | Int J Nanomedicine | pmid:28579775 |
| Pedersen AL et al. | Central Administration of Indomethacin Mitigates the Injury-Induced Upregulation of Aromatase Expression and Estradiol Content in the Zebra Finch Brain. | 2017 | Endocrinology | pmid:28575175 |
| Middleton K et al. | Microfluidic co-culture platform for investigating osteocyte-osteoclast signalling during fluid shear stress mechanostimulation. | 2017 | J Biomech | pmid:28552413 |
| Tsai MH et al. | Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-κB. | 2017 | Int. J. Biochem. Cell Biol. | pmid:28495310 |
| Fan P et al. | Effect of 1,25-(OH)2D3 on Proliferation of Fibroblast-Like Synoviocytes and Expressions of Pro-Inflammatory Cytokines through Regulating MicroRNA-22 in a Rat Model of Rheumatoid Arthritis. | 2017 | Cell. Physiol. Biochem. | pmid:28528333 |
| Madariaga-Venegas F et al. | Characterization of a novel antibiofilm effect of nitric oxide-releasing aspirin (NCX-4040) on Candida albicans isolates from denture stomatitis patients. | 2017 | PLoS ONE | pmid:28493889 |
| Edelman MJ et al. | Phase III Randomized, Placebo-Controlled, Double-Blind Trial of Celecoxib in Addition to Standard Chemotherapy for Advanced Non-Small-Cell Lung Cancer With Cyclooxygenase-2 Overexpression: CALGB 30801 (Alliance). | 2017 | J. Clin. Oncol. | pmid:28489511 |
| Umei K et al. | Identification of novel 1,2,3,6-tetrahydropyridyl-substituted benzo[d]thiazoles: Lead generation and optimization toward potent and orally active EP1 receptor antagonists. | 2017 | Bioorg. Med. Chem. | pmid:28483455 |
| Wang Y et al. | Growth and adherence of Staphylococcus aureus were enhanced through the PGE2 produced by the activated COX-2/PGE2 pathway of infected oral epithelial cells. | 2017 | PLoS ONE | pmid:28472126 |
| Jia XJ et al. | Berbamine Exerts Anti-Inflammatory Effects via Inhibition of NF-κB and MAPK Signaling Pathways. | 2017 | Cell. Physiol. Biochem. | pmid:28456802 |
| Xie M et al. | Gastroprotective effect of gamma-aminobutyric acid against ethanol-induced gastric mucosal injury. | 2017 | Chem. Biol. Interact. | pmid:28456544 |
| López RM et al. | Effects of indomethacin on prostanoid synthesis and vasomotor responsiveness in endothelium-denuded abdominal and thoracic aortas of Wistar rats. | 2017 | Clin. Exp. Hypertens. | pmid:28448188 |
| Locatelli M et al. | Optimization of Aqueous Extraction and Biological Activity of Harpagophytum procumbens Root on Ex Vivo Rat Colon Inflammatory Model. | 2017 | Phytother Res | pmid:28447368 |
| Kim SJ et al. | Prostaglandin E2 produced following infection with Theiler's virus promotes the pathogenesis of demyelinating disease. | 2017 | PLoS ONE | pmid:28445497 |
| Kilborne AH et al. | Effects of hyaluronan alone or in combination with chondroitin sulfate and N-acetyl-d-glucosamine on lipopolysaccharide challenge-exposed equine fibroblast-like synovial cells. | 2017 | Am. J. Vet. Res. | pmid:28441052 |
| Eskilsson A et al. | Immune-Induced Fever Is Dependent on Local But Not Generalized Prostaglandin E2 Synthesis in the Brain. | 2017 | J. Neurosci. | pmid:28438967 |
| Yang Y et al. | The protection of meloxicam against chronic aluminium overload-induced liver injury in rats. | 2017 | Oncotarget | pmid:28423583 |
| Brencicova E et al. | Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma. | 2017 | PLoS ONE | pmid:28410380 |
| An JY et al. | Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28408221 |
| Choe J et al. | Positive feedback effect of PGE2 on cyclooxygenase-2 expression is mediated by inhibition of Akt phosphorylation in human follicular dendritic cell-like cells. | 2017 | Mol. Immunol. | pmid:28407559 |
| Muthukaman N et al. | Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28400234 |
| Li X et al. | Levels of hepatic Th17 cells and regulatory T cells upregulated by hepatic stellate cells in advanced HBV-related liver fibrosis. | 2017 | J Transl Med | pmid:28399886 |
| Froes TQ et al. | Virtual screening and biological evaluation of novel antipyretic compounds. | 2017 | Chem Biol Drug Des | pmid:28390086 |
| Chen CL et al. | Silibinin treatment prevents endotoxin-induced uveitis in rats in vivo and in vitro. | 2017 | PLoS ONE | pmid:28376126 |
| Seo JY et al. | Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response. | 2017 | Mediators Inflamm. | pmid:28373747 |
| Coste Mazeau P et al. | [Cervical ripening after previous cesarean section with dinoprostone vaginal insert]. | 2017 | Gynecol Obstet Fertil Senol | pmid:28368799 |
| Ko CJ et al. | Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis. | 2017 | Oncogene | pmid:28368394 |
| Wu P et al. | A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities. | 2017 | Int J Mol Sci | pmid:28368343 |
| Cabezas-Cruz A et al. | Salivary Prostaglandin E2: Role in Tick-Induced Allergy to Red Meat. | 2017 | Trends Parasitol. | pmid:28365087 |
| Salina AC et al. | Efferocytosis-induced prostaglandin E2 production impairs alveolar macrophage effector functions during Streptococcus pneumoniae infection. | 2017 | Innate Immun | pmid:28359217 |
| Jin R et al. | Adipose-Derived Stem Cells Suppress Inflammation Induced by IL-1β through Down-Regulation of P2X7R Mediated by miR-373 in Chondrocytes of Osteoarthritis. | 2017 | Mol. Cells | pmid:28343378 |
| Xu HB et al. | Guggulsterone sensitized drug-resistant human hepatocarcinoma cells to doxorubicin through a Cox-2/P-gp dependent pathway. | 2017 | Eur. J. Pharmacol. | pmid:28342979 |
| Samuchiwal SK et al. | Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway. | 2017 | J. Biol. Chem. | pmid:28341741 |
| Fong D et al. | Lysosomal rupture induced by structurally distinct chitosans either promotes a type 1 IFN response or activates the inflammasome in macrophages. | 2017 | Biomaterials | pmid:28340358 |
| Nuttinck F et al. | Prosurvival effect of cumulus prostaglandin G/H synthase 2/prostaglandin2 signaling on bovine blastocyst: impact on in vivo posthatching development. | 2017 | Biol. Reprod. | pmid:28339853 |
| Heikkilä HM et al. | The effect of intra-articular botulinum toxin A on substance P, prostaglandin E2, and tumor necrosis factor alpha in the canine osteoarthritic joint. | 2017 | BMC Vet. Res. | pmid:28327134 |
| Jeoung JW et al. | Microarray-based analysis of gene expression profiles in peripheral blood of patients with acute primary angle closure. | 2017 | Ophthalmic Genet. | pmid:28323501 |
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| Kan KKW et al. | Role of prostanoid EP3/1 receptors in mechanisms of emesis and defaecation in ferrets. | 2017 | Eur. J. Pharmacol. | pmid:28322837 |
| Vandooren J et al. | Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. | 2017 | PLoS ONE | pmid:28369077 |
| Yao L et al. | 15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury. | 2017 | PLoS ONE | pmid:28423012 |
| Al-Roujayee AS | Naringenin improves the healing process of thermally-induced skin damage in rats. | 2017 | J. Int. Med. Res. | pmid:28415935 |
| Kim HG et al. | Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells. | 2017 | Food Chem. Toxicol. | pmid:28571770 |
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| Bai L et al. | Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway. | 2017 | Endocrinology | pmid:28911173 |
| Vogel JP et al. | Pharmacological and mechanical interventions for labour induction in outpatient settings. | 2017 | Cochrane Database Syst Rev | pmid:28901007 |
| Ikari J et al. | Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease. | 2017 | PLoS ONE | pmid:28880936 |
| Taylor EJA et al. | Prostaglandin E2 Inhibits Histamine-Evoked Ca2+ Release in Human Aortic Smooth Muscle Cells through Hyperactive cAMP Signaling Junctions and Protein Kinase A. | 2017 | Mol. Pharmacol. | pmid:28877931 |
| Schippers M et al. | Upregulation of Epac-1 in Hepatic Stellate Cells by Prostaglandin E2 in Liver Fibrosis Is Associated with Reduced Fibrogenesis. | 2017 | J. Pharmacol. Exp. Ther. | pmid:28864467 |
| Ding X et al. | Leptin siRNA promotes ovarian granulosa cell apoptosis and affects steroidogenesis by increasing NPY2 receptor expression. | 2017 | Gene | pmid:28864114 |
| Li S et al. | mPGES-1-Derived PGE2 Contributes to Indoxyl Sulfate-Induced Mesangial Cell Proliferation. | 2017 | Cell. Physiol. Biochem. | pmid:28854439 |
| Jantaruk P et al. | Potential role of an antimicrobial peptide, KLK in inhibiting lipopolysaccharide-induced macrophage inflammation. | 2017 | PLoS ONE | pmid:28850608 |
| Che D et al. | Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE2/β-catenin signalling pathway. | 2017 | Mol. Immunol. | pmid:28837884 |
| McGonigle TA et al. | PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo. | 2017 | Exp. Hematol. | pmid:28822771 |
| Zhang H et al. | Ceramide enhances COX-2 expression and VSMC contractile hyperreactivity via ER stress signal activation. | 2017 | Vascul. Pharmacol. | pmid:28797762 |
| Garth JM et al. | IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection. | 2017 | J. Immunol. | pmid:28784844 |
| Ware JS et al. | Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia. | 2017 | J. Clin. Invest. | pmid:28783044 |
| Liu Y et al. | Activated hepatic stellate cells directly induce pathogenic Th17 cells in chronic hepatitis B virus infection. | 2017 | Exp. Cell Res. | pmid:28780305 |
| Hokanson JA et al. | OAB without an overactive bladder in the acute prostaglandin E2 rat model. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28768666 |
| Maier A et al. | Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice. | 2017 | FASEB J. | pmid:28760743 |
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| Maia J et al. | The endocannabinoid system expression in the female reproductive tract is modulated by estrogen. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:28743542 |
| Yip-Schneider MT et al. | Prostaglandin E2: A Pancreatic Fluid Biomarker of Intraductal Papillary Mucinous Neoplasm Dysplasia. | 2017 | J. Am. Coll. Surg. | pmid:28739154 |
| Wettlaufer SH et al. | Distinct PKA regulatory subunits mediate PGE2 inhibition of TGFβ-1-stimulated collagen I translation and myofibroblast differentiation. | 2017 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:28729346 |
| Cantaut-Belarif Y et al. | Microglia control the glycinergic but not the GABAergic synapses via prostaglandin E2 in the spinal cord. | 2017 | J. Cell Biol. | pmid:28716844 |
| McGonigle TA et al. | UV Irradiation of Skin Enhances Glycolytic Flux and Reduces Migration Capabilities in Bone Marrow-Differentiated Dendritic Cells. | 2017 | Am. J. Pathol. | pmid:28708972 |
| Gonzalez AA et al. | PGE2 upregulates renin through E-prostanoid receptor 1 via PKC/cAMP/CREB pathway in M-1 cells. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28701311 |
| Peng X et al. | Increased urinary prostaglandin E2 metabolite: A potential therapeutic target of Gitelman syndrome. | 2017 | PLoS ONE | pmid:28700713 |
| Kang SH et al. | Aronia Berry Extract Ameliorates the Severity of Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice. | 2017 | J Med Food | pmid:28677983 |
| Shah F et al. | Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. | 2017 | Cell Chem Biol | pmid:28669525 |
| Kim DS et al. | Eclipta prostrata Improves DSS-Induced Colitis through Regulation of Inflammatory Response in Intestinal Epithelial Cells. | 2017 | Am. J. Chin. Med. | pmid:28659027 |
| Li YP et al. | ARISTOLOCHIA BRACTEOLATE RETZ. ATTENUATES HYPERURICEMIA IN A METABOLIC ARTHRITIS RAT MODEL. | 2017 | Afr J Tradit Complement Altern Med | pmid:28638881 |
| Prince LR et al. | NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival. | 2017 | Blood | pmid:28637666 |
| Flórez-Grau G et al. | Up-regulation of EP2 and EP3 receptors in human tolerogenic dendritic cells boosts the immunosuppressive activity of PGE2. | 2017 | J. Leukoc. Biol. | pmid:28630103 |
| Zhuang Y et al. | Activation of COX-2/mPGES-1/PGE2 Cascade via NLRP3 Inflammasome Contributes to Albumin-Induced Proximal Tubule Cell Injury. | 2017 | Cell. Physiol. Biochem. | pmid:28628921 |
| Psarra A et al. | Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review. | 2017 | Expert Opin Ther Pat | pmid:28627961 |
| Liang Y et al. | Folic acid attenuates cobalt chloride-induced PGE2 production in HUVECs via the NO/HIF-1alpha/COX-2 pathway. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28624453 |
| Langdale CL et al. | Stimulation of the pelvic nerve increases bladder capacity in the prostaglandin E2 rat model of overactive bladder. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28615244 |
| Cordaro M et al. | Effects of a co-micronized composite containing palmitoylethanolamide and polydatin in an experimental model of benign prostatic hyperplasia. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28610993 |
| Hooper KM et al. | Prostaglandin E2 inhibits Tr1 cell differentiation through suppression of c-Maf. | 2017 | PLoS ONE | pmid:28604806 |