| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
Prostaglandin E2
Prostaglandin E2 is a lipid of Fatty Acyls (FA) class. Prostaglandin e2 is associated with abnormalities such as Renal glomerular disease, Arthritis, Degenerative polyarthritis, Pancreatitis and Rheumatoid Arthritis. The involved functions are known as enzyme pathway, Atherogenesis, Anabolism, inhibitors and Oxidants. Prostaglandin e2 often locates in Tissue membrane, Blood, Extracellular, Membrane and Protoplasm. The associated genes with Prostaglandin E2 are PTGS2 gene, TP53 gene, TNFRSF5 gene, FASTK Gene and TNF gene. The related lipids are Lipopolysaccharides, Steroids, monooxyethylene trimethylolpropane tristearate, Fatty Acids, Unsaturated and Promega. The related experimental models are Arthritis, Adjuvant-Induced, Xenograft Model, Experimental Autoimmune Encephalomyelitis, Cancer Model and Knock-out.
Cross Reference
Introduction
To understand associated biological information of Prostaglandin E2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Prostaglandin E2?
Prostaglandin E2 is suspected in Asthma, Inflammatory disorder, Arthritis, Obesity, Renal tubular disorder, Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Prostaglandin E2
PubChem Associated disorders and diseases
What pathways are associated with Prostaglandin E2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Prostaglandin E2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Prostaglandin E2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Prostaglandin E2?
Related references are published most in these journals:
- Prostaglandins Other Lipid Mediat. (5)
- Eur. J. Pharmacol. (3)
- Am. J. Obstet. Gynecol. (3)
- Others (59)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Prostaglandin E2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Prostaglandin E2?
Arthritis, Collagen-Induced
Arthritis, Collagen-Induced are used in the study 'Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.' (Boniface K et al., 2009), Arthritis, Collagen-Induced are used in the study 'Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.' (Koeberle A and Werz O, 2015), Arthritis, Collagen-Induced are used in the study 'Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.' (Jiang J and Dingledine R, 2013), Arthritis, Collagen-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012) and Arthritis, Collagen-Induced are used in the study 'Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines.' (Pawlik M et al., 2011).
Arthritis, Adjuvant-Induced
Arthritis, Adjuvant-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012), Arthritis, Adjuvant-Induced are used in the study 'A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression.' (Wang Q et al., 2016) and Arthritis, Adjuvant-Induced are used in the study 'Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA.' (Kojima F et al., 2009).
Experimental Autoimmune Encephalomyelitis
Experimental Autoimmune Encephalomyelitis are used in the study 'Ginsenoside Rb1 prevents interleukin-1 beta induced inflammation and apoptosis in human articular chondrocytes.' (Cheng W et al., 2013), Experimental Autoimmune Encephalomyelitis are used in the study 'PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.' (Schiffmann S et al., 2014) and Experimental Autoimmune Encephalomyelitis are used in the study 'Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.' (Shin JH et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Prostaglandin E2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Koolpe M et al. | Expression of both P1 and P2 purine receptor genes by human articular chondrocytes and profile of ligand-mediated prostaglandin E2 release. | 1999 | Arthritis Rheum. | pmid:10025919 |
| Ingram JN et al. | Cortisol in fetal fluids and the fetal adrenal at parturition in the tammar wallaby (Macropus eugenii). | 1999 | Biol. Reprod. | pmid:10026112 |
| Xiao CW et al. | Down-regulation of oxytocin-induced cyclooxygenase-2 and prostaglandin F synthase expression by interferon-tau in bovine endometrial cells. | 1999 | Biol. Reprod. | pmid:10026113 |
| Baguma-Nibasheka M et al. | Delay of preterm delivery in sheep by omega-3 long-chain polyunsaturates. | 1999 | Biol. Reprod. | pmid:10026118 |
| Saunders MA et al. | Mechanisms of prostaglandin E2 release by intact cells expressing cyclooxygenase-2: evidence for a 'two-component' model. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10027847 |
| Van de Weerdt ML et al. | Ketoprofen and phenylbutazone attenuation of PAF-induced lung inflammation in calves. | 1999 | Vet. J. | pmid:10030127 |
| Boyle JE et al. | Prostaglandin-E2 counteracts interleukin-1beta-stimulated upregulation of platelet-derived growth factor alpha-receptor on rat pulmonary myofibroblasts. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10030841 |
| Hirst WD et al. | Expression of COX-2 by normal and reactive astrocytes in the adult rat central nervous system. | 1999 | Mol. Cell. Neurosci. | pmid:10049531 |
| Gan L et al. | A new computerized biomechanical perfusion model for ex vivo study of fluid mechanical forces in intact conduit vessels. | J. Vasc. Res. | pmid:10050075 | |
| Rouaud C et al. | The cyclo-oxygenase-dependent regulation of rabbit vein contraction: evidence for a prostaglandin E2-mediated relaxation. | 1999 | Br. J. Pharmacol. | pmid:10051118 |
| Cunha FQ et al. | Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4. | 1999 | Br. J. Pharmacol. | pmid:10051119 |
| Hamilton SG et al. | The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. | 1999 | Br. J. Pharmacol. | pmid:10051152 |
| Bastepe M and Ashby B | Identification of a region of the C-terminal domain involved in short-term desensitization of the prostaglandin EP4 receptor. | 1999 | Br. J. Pharmacol. | pmid:10051157 |
| pmid:10051237 | ||||
| Roland CR et al. | Gadolinium blocks rat Kupffer cell calcium channels: relevance to calcium-dependent prostaglandin E2 synthesis and septic mortality. | 1999 | Hepatology | pmid:10051477 |
| Fitzgerald J and Hughes-Fulford M | Mechanically induced c-fos expression is mediated by cAMP in MC3T3-E1 osteoblasts. | 1999 | FASEB J. | pmid:10064622 |
| Yucel-Lindberg T et al. | Signal transduction pathways involved in the synergistic stimulation of prostaglandin production by interleukin-1beta and tumor necrosis factor alpha in human gingival fibroblasts. | 1999 | J. Dent. Res. | pmid:10065947 |
| Watson CS et al. | Prostaglandin E2 inhibition of fetal breathing movements is not sustained during prolonged reduced uterine blood flow in sheep. | 1998 | Can. J. Physiol. Pharmacol. | pmid:10066135 |
| Goddard PJ et al. | HCO3-secretion by bullfrog duodenum: dependence on nutrient Na+ during secretory stimulation. | 1998 | Can. J. Physiol. Pharmacol. | pmid:10066138 |
| Aley KO and Levine JD | Role of protein kinase A in the maintenance of inflammatory pain. | 1999 | J. Neurosci. | pmid:10066271 |
| Langberg H et al. | Metabolism and inflammatory mediators in the peritendinous space measured by microdialysis during intermittent isometric exercise in humans. | 1999 | J. Physiol. (Lond.) | pmid:10066916 |
| Evans AR et al. | The cAMP transduction cascade mediates the PGE2-induced inhibition of potassium currents in rat sensory neurones. | 1999 | J. Physiol. (Lond.) | pmid:10066931 |
| Amano K et al. | Elective induction of labor at 39 weeks of gestation: a prospective randomized trial. | 1999 | J. Obstet. Gynaecol. Res. | pmid:10067011 |
| Miner TJ et al. | Ischemia-reperfusion protects the rat small intestine against subsequent injury. | 1999 | J. Surg. Res. | pmid:10068518 |
| Hisakawa N et al. | Down regulation by iron of prostaglandin E2 production by human synovial fibroblasts. | 1998 | Ann. Rheum. Dis. | pmid:10070275 |
| Takahashi H et al. | Ureteral obstruction reverses glomerular proliferation in immune complex glomerulonephritis. | 1999 | J. Lab. Clin. Med. | pmid:10072261 |
| Bao JF et al. | Effect of sodium glycyrrhetinate on chemical peritonitis in rats. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072951 |
| Dean DD et al. | Ultrahigh molecular weight polyethylene particles have direct effects on proliferation, differentiation, and local factor production of MG63 osteoblast-like cells. | 1999 | J. Orthop. Res. | pmid:10073642 |
| Dinarello CA et al. | Fever: links with an ancient receptor. | 1999 | Curr. Biol. | pmid:10074418 |
| Kwiatkowski P et al. | High-level porcine endothelial cell expression of alpha(1,2)-fucosyltransferase reduces human monocyte adhesion and activation. | 1999 | Transplantation | pmid:10075584 |
| Scholtka B et al. | Acute increase, stimulated by prostaglandin E2, in glucose absorption via the sodium dependent glucose transporter-1 in rat intestine. | 1999 | Gut | pmid:10075955 |
| Denison FC et al. | The action of prostaglandin E2 on the human cervix: stimulation of interleukin 8 and inhibition of secretory leukocyte protease inhibitor. | 1999 | Am. J. Obstet. Gynecol. | pmid:10076137 |
| Derman SG et al. | Transforming growth factor-beta1 is a potent inhibitor of interleukin-1beta action in whole ovarian dispersates. | 1999 | J. Endocrinol. | pmid:10076187 |
| Hua XY et al. | Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids. | 1999 | Neuroscience | pmid:10077333 |
| Denis D and Riendeau D | Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes. | 1999 | Eur. J. Pharmacol. | pmid:10079010 |
| Kokubu T et al. | Low intensity pulsed ultrasound exposure increases prostaglandin E2 production via the induction of cyclooxygenase-2 mRNA in mouse osteoblasts. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10079177 |
| Nakamoto H et al. | Effects of cicletanine on the progression of renal failure in 5/6 nephrectomized hypertensive rats. | 1999 | Clin. Exp. Pharmacol. Physiol. | pmid:10081620 |
| Ota S et al. | Nonsteroidal anti-inflammatory drugs may prevent colon cancer through suppression of hepatocyte growth factor expression. | 1999 | Eur. J. Pharmacol. | pmid:10082276 |
| Yasuda T et al. | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. | 1999 | Jpn. J. Pharmacol. | pmid:10082319 |
| McCracken BA et al. | Weaning anorexia may contribute to local inflammation in the piglet small intestine. | 1999 | J. Nutr. | pmid:10082764 |
| Pestana M et al. | Kidney graft-infiltrating cells synthesize significantly higher amounts of prostaglandin E2 pre and during acute rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083119 |
| van den Dorpel MA et al. | Beneficial effects of conversion from cyclosporine to azathioprine on fibrinolysis in renal transplant recipients. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083130 |
| Blaheta RA et al. | Mycophenolate mofetil impairs transendothelial migration of allogeneic CD4 and CD8 T-cells. | Transplant. Proc. | pmid:10083559 | |
| pmid:10084948 | ||||
| Chen X and Levine JD | NOS inhibitor antagonism of PGE2-induced mechanical sensitization of cutaneous C-fiber nociceptors in the rat. | 1999 | J. Neurophysiol. | pmid:10085324 |
| Cocks TM et al. | A protective role for protease-activated receptors in the airways. | 1999 | Nature | pmid:10086357 |
| Garcia-Pastor P et al. | Effects of petrosaspongiolide M, a novel phospholipase A2 inhibitor, on acute and chronic inflammation. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10087000 |
| Avella M et al. | Regulation of Cl- secretion in seawater fish (Dicentrarchus labrax) gill respiratory cells in primary culture. | 1999 | J. Physiol. (Lond.) | pmid:10087336 |
| Kolenko V et al. | Downregulation of JAK3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic adenosine monophosphate-elevating agents: impact on interleukin-2 receptor signaling pathway. | 1999 | Blood | pmid:10090941 |