| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
Prostaglandin E2
Prostaglandin E2 is a lipid of Fatty Acyls (FA) class. Prostaglandin e2 is associated with abnormalities such as Renal glomerular disease, Arthritis, Degenerative polyarthritis, Pancreatitis and Rheumatoid Arthritis. The involved functions are known as enzyme pathway, Atherogenesis, Anabolism, inhibitors and Oxidants. Prostaglandin e2 often locates in Tissue membrane, Blood, Extracellular, Membrane and Protoplasm. The associated genes with Prostaglandin E2 are PTGS2 gene, TP53 gene, TNFRSF5 gene, FASTK Gene and TNF gene. The related lipids are Lipopolysaccharides, Steroids, monooxyethylene trimethylolpropane tristearate, Fatty Acids, Unsaturated and Promega. The related experimental models are Arthritis, Adjuvant-Induced, Xenograft Model, Experimental Autoimmune Encephalomyelitis, Cancer Model and Knock-out.
Cross Reference
Introduction
To understand associated biological information of Prostaglandin E2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Prostaglandin E2?
Prostaglandin E2 is suspected in Asthma, Inflammatory disorder, Arthritis, Obesity, Renal tubular disorder, Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Prostaglandin E2
PubChem Associated disorders and diseases
What pathways are associated with Prostaglandin E2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Prostaglandin E2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Prostaglandin E2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Prostaglandin E2?
Related references are published most in these journals:
- Prostaglandins Other Lipid Mediat. (5)
- Eur. J. Pharmacol. (3)
- Am. J. Obstet. Gynecol. (3)
- Others (59)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Prostaglandin E2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Prostaglandin E2?
Arthritis, Collagen-Induced
Arthritis, Collagen-Induced are used in the study 'Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.' (Boniface K et al., 2009), Arthritis, Collagen-Induced are used in the study 'Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.' (Koeberle A and Werz O, 2015), Arthritis, Collagen-Induced are used in the study 'Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.' (Jiang J and Dingledine R, 2013), Arthritis, Collagen-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012) and Arthritis, Collagen-Induced are used in the study 'Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines.' (Pawlik M et al., 2011).
Arthritis, Adjuvant-Induced
Arthritis, Adjuvant-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012), Arthritis, Adjuvant-Induced are used in the study 'A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression.' (Wang Q et al., 2016) and Arthritis, Adjuvant-Induced are used in the study 'Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA.' (Kojima F et al., 2009).
Experimental Autoimmune Encephalomyelitis
Experimental Autoimmune Encephalomyelitis are used in the study 'Ginsenoside Rb1 prevents interleukin-1 beta induced inflammation and apoptosis in human articular chondrocytes.' (Cheng W et al., 2013), Experimental Autoimmune Encephalomyelitis are used in the study 'PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.' (Schiffmann S et al., 2014) and Experimental Autoimmune Encephalomyelitis are used in the study 'Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.' (Shin JH et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Prostaglandin E2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Costa-Rodrigues J et al. | Complex osteoclastogenic inductive effects of nicotine over hydroxyapatite. | 2018 | J. Cell. Physiol. | pmid:28407244 |
| Anuforo OUU et al. | Natural killer cells play an essential role in resolution of antigen-induced inflammation in mice. | 2018 | Mol. Immunol. | pmid:29112834 |
| Peng TC et al. | Platonin mitigates vascular hyporeactivity of thoracic aorta in septic rats. | 2018 | J. Surg. Res. | pmid:29229127 |
| Murakami K et al. | A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro. | 2017 | PLoS ONE | pmid:28708884 |
| Kim HG et al. | Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells. | 2017 | Food Chem. Toxicol. | pmid:28571770 |
| Aoyagi T et al. | Interleukin-36γ and IL-36 receptor signaling mediate impaired host immunity and lung injury in cytotoxic Pseudomonas aeruginosa pulmonary infection: Role of prostaglandin E2. | 2017 | PLoS Pathog. | pmid:29166668 |
| Motwani MP et al. | Prolonged immune alteration following resolution of acute inflammation in humans. | 2017 | PLoS ONE | pmid:29073216 |
| Sabirov RZ et al. | The organic anion transporter SLCO2A1 constitutes the core component of the Maxi-Cl channel. | 2017 | EMBO J. | pmid:29046334 |
| Xiao L et al. | Angtensin II elicits a cAMP-dependent intestinal anion secretion by stimulating PGE2 release through AT1 subtype receptors in rat ileum. | 2017 | Biochem. Biophys. Res. Commun. | pmid:29032204 |
| Kassab SE et al. | Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities. | 2017 | Eur J Med Chem | pmid:29031075 |
| Raak C et al. | Use of the Bovine Udder Skin model to evaluate the tolerability of Mesem cosmetic cream. | 2017 | Altern Lab Anim | pmid:28994299 |
| Araki Y et al. | PGE1 and E3 show lower efficacies than E2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors. | 2017 | FEBS Lett. | pmid:28986997 |
| Liu W et al. | Gastroprotective effects of chebulagic acid against ethanol-induced gastric injury in rats. | 2017 | Chem. Biol. Interact. | pmid:28963034 |
| Jang HJ et al. | Anti-inflammatory Activity of Eudesmane-Type Sesquiterpenoids from Salvia plebeia. | 2017 | J. Nat. Prod. | pmid:28960981 |
| Wang C et al. | Endoplasmic Reticulum Stress and NF-[Formula: see text]B Pathway in Salidroside Mediated Neuroprotection: Potential of Salidroside in Neurodegenerative Diseases. | 2017 | Am. J. Chin. Med. | pmid:28946765 |
| Carvalho de Freitas R et al. | Trypanosoma cruzi: Inhibition of infection of human monocytes by aspirin. | 2017 | Exp. Parasitol. | pmid:28939444 |
| Salinas-Parra N et al. | Prostaglandin E2 Induces Prorenin-Dependent Activation of (Pro)renin Receptor and Upregulation of Cyclooxygenase-2 in Collecting Duct Cells. | 2017 | Am. J. Med. Sci. | pmid:28918839 |
| Bai L et al. | Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway. | 2017 | Endocrinology | pmid:28911173 |
| Vogel JP et al. | Pharmacological and mechanical interventions for labour induction in outpatient settings. | 2017 | Cochrane Database Syst Rev | pmid:28901007 |
| Ikari J et al. | Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease. | 2017 | PLoS ONE | pmid:28880936 |
| Taylor EJA et al. | Prostaglandin E2 Inhibits Histamine-Evoked Ca2+ Release in Human Aortic Smooth Muscle Cells through Hyperactive cAMP Signaling Junctions and Protein Kinase A. | 2017 | Mol. Pharmacol. | pmid:28877931 |
| Schippers M et al. | Upregulation of Epac-1 in Hepatic Stellate Cells by Prostaglandin E2 in Liver Fibrosis Is Associated with Reduced Fibrogenesis. | 2017 | J. Pharmacol. Exp. Ther. | pmid:28864467 |
| Ding X et al. | Leptin siRNA promotes ovarian granulosa cell apoptosis and affects steroidogenesis by increasing NPY2 receptor expression. | 2017 | Gene | pmid:28864114 |
| Li S et al. | mPGES-1-Derived PGE2 Contributes to Indoxyl Sulfate-Induced Mesangial Cell Proliferation. | 2017 | Cell. Physiol. Biochem. | pmid:28854439 |
| Jantaruk P et al. | Potential role of an antimicrobial peptide, KLK in inhibiting lipopolysaccharide-induced macrophage inflammation. | 2017 | PLoS ONE | pmid:28850608 |
| Che D et al. | Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE2/β-catenin signalling pathway. | 2017 | Mol. Immunol. | pmid:28837884 |
| McGonigle TA et al. | PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo. | 2017 | Exp. Hematol. | pmid:28822771 |
| Zhang H et al. | Ceramide enhances COX-2 expression and VSMC contractile hyperreactivity via ER stress signal activation. | 2017 | Vascul. Pharmacol. | pmid:28797762 |
| Garth JM et al. | IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection. | 2017 | J. Immunol. | pmid:28784844 |
| Ware JS et al. | Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia. | 2017 | J. Clin. Invest. | pmid:28783044 |
| Liu Y et al. | Activated hepatic stellate cells directly induce pathogenic Th17 cells in chronic hepatitis B virus infection. | 2017 | Exp. Cell Res. | pmid:28780305 |
| Hokanson JA et al. | OAB without an overactive bladder in the acute prostaglandin E2 rat model. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28768666 |
| Maier A et al. | Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice. | 2017 | FASEB J. | pmid:28760743 |
| Zhou S et al. | Design, synthesis and bioactivities of Celecoxib analogues or derivatives. | 2017 | Bioorg. Med. Chem. | pmid:28757100 |
| Maia J et al. | The endocannabinoid system expression in the female reproductive tract is modulated by estrogen. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:28743542 |
| Yip-Schneider MT et al. | Prostaglandin E2: A Pancreatic Fluid Biomarker of Intraductal Papillary Mucinous Neoplasm Dysplasia. | 2017 | J. Am. Coll. Surg. | pmid:28739154 |
| Wettlaufer SH et al. | Distinct PKA regulatory subunits mediate PGE2 inhibition of TGFβ-1-stimulated collagen I translation and myofibroblast differentiation. | 2017 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:28729346 |
| Cantaut-Belarif Y et al. | Microglia control the glycinergic but not the GABAergic synapses via prostaglandin E2 in the spinal cord. | 2017 | J. Cell Biol. | pmid:28716844 |
| McGonigle TA et al. | UV Irradiation of Skin Enhances Glycolytic Flux and Reduces Migration Capabilities in Bone Marrow-Differentiated Dendritic Cells. | 2017 | Am. J. Pathol. | pmid:28708972 |
| Gonzalez AA et al. | PGE2 upregulates renin through E-prostanoid receptor 1 via PKC/cAMP/CREB pathway in M-1 cells. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28701311 |
| Peng X et al. | Increased urinary prostaglandin E2 metabolite: A potential therapeutic target of Gitelman syndrome. | 2017 | PLoS ONE | pmid:28700713 |
| Kang SH et al. | Aronia Berry Extract Ameliorates the Severity of Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice. | 2017 | J Med Food | pmid:28677983 |
| Shah F et al. | Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. | 2017 | Cell Chem Biol | pmid:28669525 |
| Kim DS et al. | Eclipta prostrata Improves DSS-Induced Colitis through Regulation of Inflammatory Response in Intestinal Epithelial Cells. | 2017 | Am. J. Chin. Med. | pmid:28659027 |
| Li YP et al. | ARISTOLOCHIA BRACTEOLATE RETZ. ATTENUATES HYPERURICEMIA IN A METABOLIC ARTHRITIS RAT MODEL. | 2017 | Afr J Tradit Complement Altern Med | pmid:28638881 |
| Prince LR et al. | NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival. | 2017 | Blood | pmid:28637666 |
| Flórez-Grau G et al. | Up-regulation of EP2 and EP3 receptors in human tolerogenic dendritic cells boosts the immunosuppressive activity of PGE2. | 2017 | J. Leukoc. Biol. | pmid:28630103 |
| Zhuang Y et al. | Activation of COX-2/mPGES-1/PGE2 Cascade via NLRP3 Inflammasome Contributes to Albumin-Induced Proximal Tubule Cell Injury. | 2017 | Cell. Physiol. Biochem. | pmid:28628921 |
| Psarra A et al. | Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review. | 2017 | Expert Opin Ther Pat | pmid:28627961 |
| Liang Y et al. | Folic acid attenuates cobalt chloride-induced PGE2 production in HUVECs via the NO/HIF-1alpha/COX-2 pathway. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28624453 |