Prostaglandin E2

Prostaglandin E2 is a lipid of Fatty Acyls (FA) class. Prostaglandin e2 is associated with abnormalities such as Renal glomerular disease, Arthritis, Degenerative polyarthritis, Pancreatitis and Rheumatoid Arthritis. The involved functions are known as enzyme pathway, Atherogenesis, Anabolism, inhibitors and Oxidants. Prostaglandin e2 often locates in Tissue membrane, Blood, Extracellular, Membrane and Protoplasm. The associated genes with Prostaglandin E2 are PTGS2 gene, TP53 gene, TNFRSF5 gene, FASTK Gene and TNF gene. The related lipids are Lipopolysaccharides, Steroids, monooxyethylene trimethylolpropane tristearate, Fatty Acids, Unsaturated and Promega. The related experimental models are Arthritis, Adjuvant-Induced, Xenograft Model, Experimental Autoimmune Encephalomyelitis, Cancer Model and Knock-out.

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Introduction

To understand associated biological information of Prostaglandin E2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Prostaglandin E2?

Prostaglandin E2 is suspected in Asthma, Inflammatory disorder, Arthritis, Obesity, Renal tubular disorder, Ischemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Prostaglandin E2

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diarrhea D003967 32 associated lipids
Hypoxia D000860 23 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Prostaglandin E2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Prostaglandin E2?

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What functions are associated with Prostaglandin E2?


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What lipids are associated with Prostaglandin E2?

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What genes are associated with Prostaglandin E2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Prostaglandin E2?

Arthritis, Collagen-Induced

Arthritis, Collagen-Induced are used in the study 'Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.' (Boniface K et al., 2009), Arthritis, Collagen-Induced are used in the study 'Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.' (Koeberle A and Werz O, 2015), Arthritis, Collagen-Induced are used in the study 'Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.' (Jiang J and Dingledine R, 2013), Arthritis, Collagen-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012) and Arthritis, Collagen-Induced are used in the study 'Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines.' (Pawlik M et al., 2011).

Arthritis, Adjuvant-Induced

Arthritis, Adjuvant-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012), Arthritis, Adjuvant-Induced are used in the study 'A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression.' (Wang Q et al., 2016) and Arthritis, Adjuvant-Induced are used in the study 'Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA.' (Kojima F et al., 2009).

Experimental Autoimmune Encephalomyelitis

Experimental Autoimmune Encephalomyelitis are used in the study 'Ginsenoside Rb1 prevents interleukin-1 beta induced inflammation and apoptosis in human articular chondrocytes.' (Cheng W et al., 2013), Experimental Autoimmune Encephalomyelitis are used in the study 'PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.' (Schiffmann S et al., 2014) and Experimental Autoimmune Encephalomyelitis are used in the study 'Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.' (Shin JH et al., 2012).

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NCBI Entrez Crosslinks

All references with Prostaglandin E2

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Authors Title Published Journal PubMed Link
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Duggan AE et al. Protection against aspirin-induced human gastric mucosal injury by bosentan, a new endothelin-1 receptor antagonist. 1999 Aliment. Pharmacol. Ther. pmid:10233186
Barzanti V et al. Effect of dietary oils containing different amounts of precursor and derivative fatty acids on prostaglandin E2 synthesis in liver, kidney and lung of rats. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10319917
Takahashi M et al. Effect of prostaglandin and bisphosphonate on cancellous bone volume and structure in the ovariectomized rat studied by quantitative three-dimensional nuclear magnetic resonance microscopy. 1999 J. Bone Miner. Res. pmid:10320516
Inoue H et al. SC-19220, a prostaglandin E2 antagonist, inhibits osteoclast formation by 1,25-dihydroxyvitamin D3 in cell cultures. 1999 J. Endocrinol. pmid:10320820
Cangiano JL et al. Renal hemodynamic effects of nabumetone, sulindac, and placebo in patients with osteoarthritis. 1999 Clin Ther pmid:10321419
Stojadinovic A et al. Anti-inflammatory effects of U74389F in a rat model of intestinal ischemia/reperfusion injury. 1999 Crit. Care Med. pmid:10321667
Schwartz Z et al. Prostaglandins mediate the effects of 1,25-(OH)2D3 and 24,25-(OH)2D3 on growth plate chondrocytes in a metabolite-specific and cell maturation-dependent manner. 1999 Bone pmid:10321907
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Agnoli GC et al. Renal function and urinary prostanoid excretions in salt-depleted women: comparative effects of enalapril and indomethacin treatments. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10328327
Peredo HA and Filinger EJ Effect of dipyridamole on prostanoid production in rat isolated atria. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10328333
Amin AR et al. Nitric oxide synthase and cyclooxygenases: distribution, regulation, and intervention in arthritis. 1999 Curr Opin Rheumatol pmid:10328580
Shin HC et al. Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. 1999 Cytokine pmid:10328864
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Pelletier JP and Reginster JY The influence of tissular cross-talking on osteoarthritis progression: role of nonsteroidal antiinflammatory drugs. 1999 Osteoarthr. Cartil. pmid:10329307
Henroitin Y and Reginster JY In-vitro differences among nonsteroidal antiinflammatory drugs in their activities related to osteoarthritis pathophysiology. 1999 Osteoarthr. Cartil. pmid:10329331
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Poore KR et al. Efficacy of the selective prostaglandin synthase type 2 inhibitor nimesulide in blocking basal prostaglandin production and delaying glucocorticoid-induced premature labor in sheep. 1999 Am. J. Obstet. Gynecol. pmid:10329885
Skarzynski DJ and Okuda K Sensitivity of bovine corpora lutea to prostaglandin F2alpha is dependent on progesterone, oxytocin, and prostaglandins. 1999 Biol. Reprod. pmid:10330083
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Farquhar WB and Kenney WL Age and renal prostaglandin inhibition during exercise and heat stress. 1999 J. Appl. Physiol. pmid:10368359
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Hewett SJ Interferon-gamma reduces cyclooxygenase-2-mediated prostaglandin E2 production from primary mouse astrocytes independent of nitric oxide formation. 1999 J. Neuroimmunol. pmid:10376946
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Perkins DJ and Kniss DA Blockade of nitric oxide formation down-regulates cyclooxygenase-2 and decreases PGE2 biosynthesis in macrophages. 1999 J. Leukoc. Biol. pmid:10380901
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Kato S et al. Changes in gastric mucosal ulcerogenic responses in rats with adjuvant arthritis: role of nitric oxide. 1999 Aliment. Pharmacol. Ther. pmid:10383515
Borger P et al. Allergen challenge primes for IL-5 mRNA production and abrogates beta-adrenergic function in peripheral blood T lymphocytes from asthmatics. 1999 Clin. Exp. Allergy pmid:10383594
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