| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
Prostaglandin E2
Prostaglandin E2 is a lipid of Fatty Acyls (FA) class. Prostaglandin e2 is associated with abnormalities such as Renal glomerular disease, Arthritis, Degenerative polyarthritis, Pancreatitis and Rheumatoid Arthritis. The involved functions are known as enzyme pathway, Atherogenesis, Anabolism, inhibitors and Oxidants. Prostaglandin e2 often locates in Tissue membrane, Blood, Extracellular, Membrane and Protoplasm. The associated genes with Prostaglandin E2 are PTGS2 gene, TP53 gene, TNFRSF5 gene, FASTK Gene and TNF gene. The related lipids are Lipopolysaccharides, Steroids, monooxyethylene trimethylolpropane tristearate, Fatty Acids, Unsaturated and Promega. The related experimental models are Arthritis, Adjuvant-Induced, Xenograft Model, Experimental Autoimmune Encephalomyelitis, Cancer Model and Knock-out.
Cross Reference
Introduction
To understand associated biological information of Prostaglandin E2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Prostaglandin E2?
Prostaglandin E2 is suspected in Asthma, Inflammatory disorder, Arthritis, Obesity, Renal tubular disorder, Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Prostaglandin E2
PubChem Associated disorders and diseases
What pathways are associated with Prostaglandin E2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Prostaglandin E2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Prostaglandin E2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Prostaglandin E2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Prostaglandin E2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Prostaglandin E2?
Arthritis, Collagen-Induced
Arthritis, Collagen-Induced are used in the study 'Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.' (Boniface K et al., 2009), Arthritis, Collagen-Induced are used in the study 'Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.' (Koeberle A and Werz O, 2015), Arthritis, Collagen-Induced are used in the study 'Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.' (Jiang J and Dingledine R, 2013), Arthritis, Collagen-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012) and Arthritis, Collagen-Induced are used in the study 'Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines.' (Pawlik M et al., 2011).
Arthritis, Adjuvant-Induced
Arthritis, Adjuvant-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012), Arthritis, Adjuvant-Induced are used in the study 'A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression.' (Wang Q et al., 2016) and Arthritis, Adjuvant-Induced are used in the study 'Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA.' (Kojima F et al., 2009).
Experimental Autoimmune Encephalomyelitis
Experimental Autoimmune Encephalomyelitis are used in the study 'Ginsenoside Rb1 prevents interleukin-1 beta induced inflammation and apoptosis in human articular chondrocytes.' (Cheng W et al., 2013), Experimental Autoimmune Encephalomyelitis are used in the study 'PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.' (Schiffmann S et al., 2014) and Experimental Autoimmune Encephalomyelitis are used in the study 'Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.' (Shin JH et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Prostaglandin E2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Maddur MS et al. | Regulatory T cell frequency, but not plasma IL-33 levels, represents potential immunological biomarker to predict clinical response to intravenous immunoglobulin therapy. | 2017 | J Neuroinflammation | pmid:28320438 |
| Passeron T | Medical and Maintenance Treatments for Vitiligo. | 2017 | Dermatol Clin | pmid:28317526 |
| Wang YW et al. | Protective effects of Garcinol against neuropathic pain - Evidence from in vivo and in vitro studies. | 2017 | Neurosci. Lett. | pmid:28302538 |
| Li X et al. | Aconitine: A potential novel treatment for systemic lupus erythematosus. | 2017 | J. Pharmacol. Sci. | pmid:28302448 |
| Zang S et al. | PGE2 synthesis and signaling in malignant transformation and progression of human hepatocellular carcinoma. | 2017 | Hum. Pathol. | pmid:28300577 |
| Zasłona Z et al. | The Induction of Pro-IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production. | 2017 | J. Immunol. | pmid:28298525 |
| Eymard F et al. | Knee and hip intra-articular adipose tissues (IAATs) compared with autologous subcutaneous adipose tissue: a specific phenotype for a central player in osteoarthritis. | 2017 | Ann. Rheum. Dis. | pmid:28298375 |
| Gui T et al. | Enhanced SOCS3 in osteoarthiritis may limit both proliferation and inflammation. | 2017 | Biotech Histochem | pmid:28296552 |
| Beckmann M et al. | Predictors of mode of birth and duration of labour following induction using prostaglandin vaginal gel. | 2017 | Aust N Z J Obstet Gynaecol | pmid:28295174 |
| Wang Y et al. | N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2. | 2017 | ACS Chem Neurosci | pmid:28292183 |
| Yang CM et al. | Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-κB in human rheumatoid arthritis synovial fibroblasts. | 2017 | Biochem. Pharmacol. | pmid:28288820 |
| Cheng W et al. | Chondroprotective Effects of Ginsenoside Rg1 in Human Osteoarthritis Chondrocytes and a Rat Model of Anterior Cruciate Ligament Transection. | 2017 | Nutrients | pmid:28287423 |
| Singh AK et al. | Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain. | 2017 | J. Clin. Invest. | pmid:28287401 |
| Chen L et al. | The therapeutic effects of Periploca forrestii Schltr. Stem extracts on collagen-induced arthritis by inhibiting the activation of Src/NF-κB signaling pathway in rats. | 2017 | J Ethnopharmacol | pmid:28286042 |
| Yoshitake R et al. | Molecular investigation of the direct anti-tumour effects of nonsteroidal anti-inflammatory drugs in a panel of canine cancer cell lines. | 2017 | Vet. J. | pmid:28283079 |
| Hu YP et al. | Reactive Oxygen Species Mediated Prostaglandin E2 Contributes to Acute Response of Epithelial Injury. | 2017 | Oxid Med Cell Longev | pmid:28280524 |
| Hsu HH et al. | Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. | 2017 | World J. Gastroenterol. | pmid:28275297 |
| Yang WS et al. | AKT-targeted anti-inflammatory activity of the methanol extract of Chrysanthemum indicum var. albescens. | 2017 | J Ethnopharmacol | pmid:28274893 |
| Danielczok J et al. | Does Erythropoietin Regulate TRPC Channels in Red Blood Cells? | 2017 | Cell. Physiol. Biochem. | pmid:28268218 |
| Penteado LA et al. | Distinctive role of efferocytosis in dendritic cell maturation and migration in sterile or infectious conditions. | 2017 | Immunology | pmid:28267881 |
| Jin J et al. | Prostaglandin E2 regulates renal function in C57/BL6 mouse with 5/6 nephrectomy. | 2017 | Life Sci. | pmid:28263803 |
| Yu L et al. | D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways. | 2017 | Mol Med Rep | pmid:28260017 |
| Turcotte C et al. | The Endocannabinoid Metabolite Prostaglandin E2 (PGE2)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors. | 2017 | J. Immunol. | pmid:28258202 |
| Chen D et al. | E-Prostanoid 3 Receptor Mediates Sprouting Angiogenesis Through Suppression of the Protein Kinase A/β-Catenin/Notch Pathway. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:28254818 |
| Brown J and Beckmann M | Induction of labour using balloon catheter and prostaglandin gel. | 2017 | Aust N Z J Obstet Gynaecol | pmid:28251639 |
| Lu LY et al. | Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway. | 2017 | J. Orthop. Res. | pmid:28248001 |
| Park HJ et al. | TNFα Increases RANKL Expression via PGE₂-Induced Activation of NFATc1. | 2017 | Int J Mol Sci | pmid:28245593 |
| de Oliveira RG et al. | Dilodendron bipinnatum Radlk. inhibits pro-inflammatory mediators through the induction of MKP-1 and the down-regulation of MAPKp38/JNK/NF-κB pathways and COX-2 in LPS-activated RAW 264.7 cells. | 2017 | J Ethnopharmacol | pmid:28238828 |
| Zou W et al. | Rhizoma Smilacis Glabrae inhibits pathogen-induced upper genital tract inflammation in rats through suppression of NF-κB pathway. | 2017 | J Ethnopharmacol | pmid:28238827 |
| Bitto A et al. | Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice. | 2017 | Inflamm. Res. | pmid:28238167 |
| Fourie R et al. | Pseudomonas aeruginosa produces aspirin insensitive eicosanoids and contributes to the eicosanoid profile of polymicrobial biofilms with Candida albicans. | 2017 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:28237086 |
| Luan YH et al. | Action of β-endorphin and nonsteroidal anti-inflammatory drugs, and the possible effects of nonsteroidal anti-inflammatory drugs on β-endorphin. | 2017 | J Clin Anesth | pmid:28235500 |
| Lin JT et al. | Molecular mechanisms of the effects of the ethanolic extract of Muntingia calabura Linn. fruit on lipopolysaccharide-induced pro-inflammatory mediators in macrophages. | 2017 | Food Funct | pmid:28232982 |
| Schmidt A et al. | Direct growth-inhibitory effects of prostaglandin E2 in pancreatic cancer cells in vitro through an EP4/PKA-mediated mechanism. | 2017 | Surgery | pmid:28222855 |
| Tan S et al. | PGE2 /EP4 receptor attenuated mucosal injury via β-arrestin1/Src/EGFR-mediated proliferation in portal hypertensive gastropathy. | 2017 | Br. J. Pharmacol. | pmid:28213942 |
| Loo TM et al. | Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity. | 2017 | Cancer Discov | pmid:28202625 |
| Lee J et al. | Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria. | 2017 | BMC Complement Altern Med | pmid:28202081 |
| Bosmans JW et al. | Functional mucous layer and healing of proximal colonic anastomoses in an experimental model. | 2017 | Br J Surg | pmid:28195642 |
| Horvatinovich JM et al. | Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14+ Monocytes. | 2017 | J. Immunol. | pmid:28193829 |
| Neuman JC et al. | Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E2 Signaling and Enhances Diabetic β-Cell Function. | 2017 | Diabetes | pmid:28193789 |
| Zhou J et al. | MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and PGE2 production in mouse ovarian granulosa cells. | 2017 | Cell Death Dis | pmid:28182010 |
| Walusimbi SS et al. | Isolation of luteal endothelial cells and functional interactions with T lymphocytes. | 2017 | Reproduction | pmid:28174320 |
| Aoki T et al. | Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. | 2017 | Sci Signal | pmid:28174280 |
| Cruz FF et al. | Effects of caffeine on behavioral and inflammatory changes elicited by copper in zebrafish larvae: Role of adenosine receptors. | 2017 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:28163255 |
| Kuroyanagi G et al. | (-)-Epigallocatechin gallate synergistically potentiates prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts. | 2017 | Prostaglandins Other Lipid Mediat. | pmid:28163121 |
| Brencicova E and Diebold SS | Antibody-mediated depletion of immunosuppressive factors from ovarian carcinoma-associated ascites for investigation of paracrine versus autocrine effects. | 2017 | J. Immunol. Methods | pmid:28159551 |
| Jose GM and Kurup GM | The efficacy of sulfated polysaccharides from Padina tetrastromatica in modulating the immune functions of RAW 264.7 cells. | 2017 | Biomed. Pharmacother. | pmid:28152476 |
| Howarth C et al. | A Critical Role for Astrocytes in Hypercapnic Vasodilation in Brain. | 2017 | J. Neurosci. | pmid:28137973 |
| Kutyrev IA et al. | Prostaglandins E2 and D2-regulators of host immunity in the model parasite Diphyllobothrium dendriticum: An immunocytochemical and biochemical study. | 2017 | Mol. Biochem. Parasitol. | pmid:28137629 |
| Subedi L et al. | Equol, a Dietary Daidzein Gut Metabolite Attenuates Microglial Activation and Potentiates Neuroprotection In Vitro. | 2017 | Nutrients | pmid:28264445 |