| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
Prostaglandin E2
Prostaglandin E2 is a lipid of Fatty Acyls (FA) class. Prostaglandin e2 is associated with abnormalities such as Renal glomerular disease, Arthritis, Degenerative polyarthritis, Pancreatitis and Rheumatoid Arthritis. The involved functions are known as enzyme pathway, Atherogenesis, Anabolism, inhibitors and Oxidants. Prostaglandin e2 often locates in Tissue membrane, Blood, Extracellular, Membrane and Protoplasm. The associated genes with Prostaglandin E2 are PTGS2 gene, TP53 gene, TNFRSF5 gene, FASTK Gene and TNF gene. The related lipids are Lipopolysaccharides, Steroids, monooxyethylene trimethylolpropane tristearate, Fatty Acids, Unsaturated and Promega. The related experimental models are Arthritis, Adjuvant-Induced, Xenograft Model, Experimental Autoimmune Encephalomyelitis, Cancer Model and Knock-out.
Cross Reference
Introduction
To understand associated biological information of Prostaglandin E2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Prostaglandin E2?
Prostaglandin E2 is suspected in Asthma, Inflammatory disorder, Arthritis, Obesity, Renal tubular disorder, Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Prostaglandin E2
PubChem Associated disorders and diseases
What pathways are associated with Prostaglandin E2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Prostaglandin E2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Prostaglandin E2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Prostaglandin E2?
Related references are published most in these journals:
- Prostaglandins Other Lipid Mediat. (5)
- Eur. J. Pharmacol. (3)
- Am. J. Obstet. Gynecol. (3)
- Others (59)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Prostaglandin E2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Prostaglandin E2?
Arthritis, Collagen-Induced
Arthritis, Collagen-Induced are used in the study 'Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.' (Boniface K et al., 2009), Arthritis, Collagen-Induced are used in the study 'Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.' (Koeberle A and Werz O, 2015), Arthritis, Collagen-Induced are used in the study 'Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.' (Jiang J and Dingledine R, 2013), Arthritis, Collagen-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012) and Arthritis, Collagen-Induced are used in the study 'Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines.' (Pawlik M et al., 2011).
Arthritis, Adjuvant-Induced
Arthritis, Adjuvant-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012), Arthritis, Adjuvant-Induced are used in the study 'A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression.' (Wang Q et al., 2016) and Arthritis, Adjuvant-Induced are used in the study 'Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA.' (Kojima F et al., 2009).
Experimental Autoimmune Encephalomyelitis
Experimental Autoimmune Encephalomyelitis are used in the study 'Ginsenoside Rb1 prevents interleukin-1 beta induced inflammation and apoptosis in human articular chondrocytes.' (Cheng W et al., 2013), Experimental Autoimmune Encephalomyelitis are used in the study 'PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.' (Schiffmann S et al., 2014) and Experimental Autoimmune Encephalomyelitis are used in the study 'Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.' (Shin JH et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Prostaglandin E2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Muthukaman N et al. | Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28400234 |
| Li X et al. | Levels of hepatic Th17 cells and regulatory T cells upregulated by hepatic stellate cells in advanced HBV-related liver fibrosis. | 2017 | J Transl Med | pmid:28399886 |
| Froes TQ et al. | Virtual screening and biological evaluation of novel antipyretic compounds. | 2017 | Chem Biol Drug Des | pmid:28390086 |
| Chen CL et al. | Silibinin treatment prevents endotoxin-induced uveitis in rats in vivo and in vitro. | 2017 | PLoS ONE | pmid:28376126 |
| Seo JY et al. | Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response. | 2017 | Mediators Inflamm. | pmid:28373747 |
| Coste Mazeau P et al. | [Cervical ripening after previous cesarean section with dinoprostone vaginal insert]. | 2017 | Gynecol Obstet Fertil Senol | pmid:28368799 |
| Ko CJ et al. | Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis. | 2017 | Oncogene | pmid:28368394 |
| Wu P et al. | A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities. | 2017 | Int J Mol Sci | pmid:28368343 |
| Cabezas-Cruz A et al. | Salivary Prostaglandin E2: Role in Tick-Induced Allergy to Red Meat. | 2017 | Trends Parasitol. | pmid:28365087 |
| Salina AC et al. | Efferocytosis-induced prostaglandin E2 production impairs alveolar macrophage effector functions during Streptococcus pneumoniae infection. | 2017 | Innate Immun | pmid:28359217 |
| Jin R et al. | Adipose-Derived Stem Cells Suppress Inflammation Induced by IL-1β through Down-Regulation of P2X7R Mediated by miR-373 in Chondrocytes of Osteoarthritis. | 2017 | Mol. Cells | pmid:28343378 |
| Xu HB et al. | Guggulsterone sensitized drug-resistant human hepatocarcinoma cells to doxorubicin through a Cox-2/P-gp dependent pathway. | 2017 | Eur. J. Pharmacol. | pmid:28342979 |
| Samuchiwal SK et al. | Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway. | 2017 | J. Biol. Chem. | pmid:28341741 |
| Fong D et al. | Lysosomal rupture induced by structurally distinct chitosans either promotes a type 1 IFN response or activates the inflammasome in macrophages. | 2017 | Biomaterials | pmid:28340358 |
| Nuttinck F et al. | Prosurvival effect of cumulus prostaglandin G/H synthase 2/prostaglandin2 signaling on bovine blastocyst: impact on in vivo posthatching development. | 2017 | Biol. Reprod. | pmid:28339853 |
| Heikkilä HM et al. | The effect of intra-articular botulinum toxin A on substance P, prostaglandin E2, and tumor necrosis factor alpha in the canine osteoarthritic joint. | 2017 | BMC Vet. Res. | pmid:28327134 |
| Jeoung JW et al. | Microarray-based analysis of gene expression profiles in peripheral blood of patients with acute primary angle closure. | 2017 | Ophthalmic Genet. | pmid:28323501 |
| Spindola HM et al. | Derivatives of furanditerpenes from Pterodon genus: Pharmacological studies disclose their potential as chronic pain relief in mice. | 2017 | Eur. J. Pharmacol. | pmid:28322839 |
| Kan KKW et al. | Role of prostanoid EP3/1 receptors in mechanisms of emesis and defaecation in ferrets. | 2017 | Eur. J. Pharmacol. | pmid:28322837 |
| Vandooren J et al. | Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. | 2017 | PLoS ONE | pmid:28369077 |