| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
Prostaglandin E2
Prostaglandin E2 is a lipid of Fatty Acyls (FA) class. Prostaglandin e2 is associated with abnormalities such as Renal glomerular disease, Arthritis, Degenerative polyarthritis, Pancreatitis and Rheumatoid Arthritis. The involved functions are known as enzyme pathway, Atherogenesis, Anabolism, inhibitors and Oxidants. Prostaglandin e2 often locates in Tissue membrane, Blood, Extracellular, Membrane and Protoplasm. The associated genes with Prostaglandin E2 are PTGS2 gene, TP53 gene, TNFRSF5 gene, FASTK Gene and TNF gene. The related lipids are Lipopolysaccharides, Steroids, monooxyethylene trimethylolpropane tristearate, Fatty Acids, Unsaturated and Promega. The related experimental models are Arthritis, Adjuvant-Induced, Xenograft Model, Experimental Autoimmune Encephalomyelitis, Cancer Model and Knock-out.
Cross Reference
Introduction
To understand associated biological information of Prostaglandin E2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Prostaglandin E2?
Prostaglandin E2 is suspected in Asthma, Inflammatory disorder, Arthritis, Obesity, Renal tubular disorder, Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Prostaglandin E2
PubChem Associated disorders and diseases
What pathways are associated with Prostaglandin E2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Prostaglandin E2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Prostaglandin E2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Prostaglandin E2?
Related references are published most in these journals:
- Prostaglandins Other Lipid Mediat. (5)
- Eur. J. Pharmacol. (3)
- Am. J. Obstet. Gynecol. (3)
- Others (59)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Prostaglandin E2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Prostaglandin E2?
Arthritis, Collagen-Induced
Arthritis, Collagen-Induced are used in the study 'Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.' (Boniface K et al., 2009), Arthritis, Collagen-Induced are used in the study 'Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.' (Koeberle A and Werz O, 2015), Arthritis, Collagen-Induced are used in the study 'Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.' (Jiang J and Dingledine R, 2013), Arthritis, Collagen-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012) and Arthritis, Collagen-Induced are used in the study 'Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines.' (Pawlik M et al., 2011).
Arthritis, Adjuvant-Induced
Arthritis, Adjuvant-Induced are used in the study 'Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.' (Komatsu T and Sakurada T, 2012), Arthritis, Adjuvant-Induced are used in the study 'A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression.' (Wang Q et al., 2016) and Arthritis, Adjuvant-Induced are used in the study 'Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA.' (Kojima F et al., 2009).
Experimental Autoimmune Encephalomyelitis
Experimental Autoimmune Encephalomyelitis are used in the study 'Ginsenoside Rb1 prevents interleukin-1 beta induced inflammation and apoptosis in human articular chondrocytes.' (Cheng W et al., 2013), Experimental Autoimmune Encephalomyelitis are used in the study 'PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.' (Schiffmann S et al., 2014) and Experimental Autoimmune Encephalomyelitis are used in the study 'Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.' (Shin JH et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Prostaglandin E2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Keane TJ et al. | Restoring Mucosal Barrier Function and Modifying Macrophage Phenotype with an Extracellular Matrix Hydrogel: Potential Therapy for Ulcerative Colitis. | 2017 | J Crohns Colitis | pmid:27543807 |
| Lin MC et al. | PGE2 /EP4 Signaling Controls the Transfer of the Mammary Stem Cell State by Lipid Rafts in Extracellular Vesicles. | 2017 | Stem Cells | pmid:27506158 |
| Chellappan DR et al. | Gastroprotective potential of hydro-alcoholic extract of Pattanga (Caesalpinia sappan Linn.). | 2017 | J Ethnopharmacol | pmid:27484929 |
| Jung YJ et al. | Tannerella forsythia GroEL induces inflammatory bone resorption and synergizes with interleukin-17. | 2017 | Mol Oral Microbiol | pmid:27484636 |
| Wang R et al. | c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression. | 2017 | Acta Physiol (Oxf) | pmid:27439062 |
| Kallens V et al. | Glucose Promotes a Pro-Oxidant and Pro-Inflammatory Stromal Microenvironment Which Favors Motile Properties in Breast Tumor Cells. | 2017 | J. Cell. Biochem. | pmid:27403856 |
| Lian S et al. | Prostaglandin E2 stimulates urokinase-type plasminogen activator receptor via EP2 receptor-dependent signaling pathways in human AGS gastric cancer cells. | 2017 | Mol. Carcinog. | pmid:27377703 |
| Garbuzenko OB et al. | Combinatorial treatment of idiopathic pulmonary fibrosis using nanoparticles with prostaglandin E and siRNA(s). | 2017 | Nanomedicine | pmid:28434932 |
| Caron MMJ et al. | Indomethacin induces differential effects on in vitro endochondral ossification depending on the chondrocyte's differentiation stage. | 2017 | J. Orthop. Res. | pmid:27273119 |
| Platas J et al. | Anti-senescence and Anti-inflammatory Effects of the C-terminal Moiety of PTHrP Peptides in OA Osteoblasts. | 2017 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:27271252 |
| Thorbiörnson A et al. | Oral versus vaginal prostaglandin for labor induction. | 2017 | J. Matern. Fetal. Neonatal. Med. | pmid:27186795 |
| Miyagishi H et al. | Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis. | 2017 | Cell. Mol. Neurobiol. | pmid:27140190 |
| Gerarduzzi C et al. | Prostaglandin E2-Dependent Phosphorylation of RAS Inhibition 1 (RIN1) at Ser 291 and 292 Inhibits Transforming Growth Factor-β-Induced RAS Activation Pathway in Human Synovial Fibroblasts: Role in Cell Migration. | 2017 | J. Cell. Physiol. | pmid:27137893 |
| Burgos J et al. | Induction of labor in breech presentation at term: a retrospective cohort study. | 2017 | J Perinat Med | pmid:27105484 |
| Roy HK et al. | Spectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin. | 2017 | Gut | pmid:26503631 |
| Akhtar N et al. | Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis. | 2017 | Nutrition | pmid:27908544 |
| Alfajaro MM et al. | Activation of COX-2/PGE2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production. | 2017 | J. Virol. | pmid:27881647 |
| Wang-Sheng C et al. | Piperine attenuates lipopolysaccharide (LPS)-induced inflammatory responses in BV2 microglia. | 2017 | Int. Immunopharmacol. | pmid:27875748 |
| McCarthy MM and Wright CL | Convergence of Sex Differences and the Neuroimmune System in Autism Spectrum Disorder. | 2017 | Biol. Psychiatry | pmid:27871670 |
| Tachibana T et al. | Lipopolysaccharide reduces food passage rate from the crop by a prostaglandin-independent mechanism in chickens. | 2017 | Br. Poult. Sci. | pmid:27871194 |
| de Matos RF et al. | Nimesulide inhibits pathogenic fungi: PGE2-dependent mechanisms. | 2017 | Folia Microbiol. (Praha) | pmid:27866353 |
| Kim HB et al. | Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice. | 2017 | Gastroenterology | pmid:27864128 |
| Graubner FR et al. | Decidualization of the canine uterus: From early until late gestational in vivo morphological observations, and functional characterization of immortalized canine uterine stromal cell lines. | 2017 | Reprod. Domest. Anim. | pmid:27862405 |
| Tigistu-Sahle F et al. | Metabolism and phospholipid assembly of polyunsaturated fatty acids in human bone marrow mesenchymal stromal cells. | 2017 | J. Lipid Res. | pmid:27856675 |
| Shui S et al. | The investigation of anti-inflammatory activity of Yi Guanjian decoction by serum metabonomics approach. | 2017 | J Pharm Biomed Anal | pmid:27856104 |
| Grösch S et al. | Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain. | 2017 | Expert Opin Investig Drugs | pmid:27841017 |
| Maingret V et al. | PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease. | 2017 | Neurobiol. Aging | pmid:27837675 |
| Kawano Y et al. | G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2. | 2017 | Blood | pmid:27827823 |
| Feng X et al. | Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. | 2017 | Cancer Lett. | pmid:27826040 |
| Chen HT et al. | Novel augmentation by bufalin of protein kinase C-induced cyclooxygenase-2 and IL-8 production in human breast cancer cells. | 2017 | Innate Immun | pmid:27821648 |
| Ebener S et al. | Toll-like receptor 4 activation attenuates profibrotic response in control lung fibroblasts but not in fibroblasts from patients with IPF. | 2017 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27815256 |
| Laan LC et al. | The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells. | 2017 | FASEB J. | pmid:27806992 |
| Giménez-Bastida JA et al. | Buckwheat bioactive compounds, their derived phenolic metabolites and their health benefits. | 2017 | Mol Nutr Food Res | pmid:27709826 |
| Dadi PK et al. | Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx. | 2017 | ACS Chem Neurosci | pmid:27805811 |
| Miyoshi H et al. | Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. | 2017 | EMBO J. | pmid:27797821 |
| Padmore T et al. | Quantitative analysis of the role of fiber length on phagocytosis and inflammatory response by alveolar macrophages. | 2017 | Biochim. Biophys. Acta | pmid:27784615 |
| Luo R et al. | Deficiency of mPGES-1 exacerbates renal fibrosis and inflammation in mice with unilateral ureteral obstruction. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:27784694 |
| Moltu K et al. | Proximal signaling responses in peripheral T cells from colorectal cancer patients are affected by high concentrations of circulating prostaglandin E2. | 2017 | Hum. Immunol. | pmid:27769746 |
| Svensson A et al. | Identification of two distinct mesenchymal stromal cell populations in human malignant glioma. | 2017 | J. Neurooncol. | pmid:27757723 |
| Xu H et al. | Biological responses of osteocytic connexin 43 hemichannels to simulated microgravity. | 2017 | J. Orthop. Res. | pmid:26945892 |
| Kansu-Celik H et al. | Prostaglandin E2 induction of labor and cervical ripening for term isolated oligohydramnios in pregnant women with Bishop score ≤ 5. | 2017 | J Chin Med Assoc | pmid:27745800 |
| Muñoz-Carrillo JL et al. | Resiniferatoxin lowers TNF-α, NO and PGE2 in the intestinal phase and the parasite burden in the muscular phase of Trichinella spiralis infection. | 2017 | Parasite Immunol. | pmid:27743486 |
| Tomazoni SS et al. | Effects of photobiomodulation therapy, pharmacological therapy, and physical exercise as single and/or combined treatment on the inflammatory response induced by experimental osteoarthritis. | 2017 | Lasers Med Sci | pmid:27726040 |
| Tilwani RK et al. | Oxygen tension modulates the effects of TNFα in compressed chondrocytes. | 2017 | Inflamm. Res. | pmid:27658702 |
| Chang J et al. | Prostaglandin synthesis by the porcine corpus luteum: effect of tumor necrosis factor-α. | 2017 | Domest. Anim. Endocrinol. | pmid:27658124 |
| Hansen M and Andersen MH | The role of dendritic cells in cancer. | 2017 | Semin Immunopathol | pmid:27638181 |
| Singh A et al. | Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. | 2017 | J. Leukoc. Biol. | pmid:27630217 |
| Matsuura T et al. | Involvement of CX3CL1 in the Migration of Osteoclast Precursors Across Osteoblast Layer Stimulated by Interleukin-1ß. | 2017 | J. Cell. Physiol. | pmid:27579490 |
| Guan NN et al. | Prostaglandin D2 effects and DP1 /DP2 receptor distribution in guinea pig urinary bladder out-flow region. | 2017 | J. Cell. Mol. Med. | pmid:27664012 |
| Ferrari D et al. | Cyanidin-3-O-glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation. | 2016 | Toxicol. Lett. | pmid:27793764 |