| MeSH term | MeSH ID | Detail |
|---|---|---|
| Persistent Fetal Circulation Syndrome | D010547 | 1 associated lipids |
| Zollinger-Ellison Syndrome | D015043 | 1 associated lipids |
| Mastocytosis, Systemic | D034721 | 1 associated lipids |
| Anal Gland Neoplasms | D000694 | 1 associated lipids |
| Trigeminal Neuralgia | D014277 | 1 associated lipids |
| Pulmonary Aspergillosis | D055732 | 1 associated lipids |
| Asthma, Aspirin-Induced | D055963 | 2 associated lipids |
| Choroid Diseases | D015862 | 2 associated lipids |
| Optic Neuropathy, Ischemic | D018917 | 2 associated lipids |
| Angioedemas, Hereditary | D054179 | 2 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Atkins PC et al. | In vivo antigen-induced cutaneous mediator release: simultaneous comparisons of histamine, tryptase, and prostaglandin D2 release and the effect of oral corticosteroid administration. | 1990 | J. Allergy Clin. Immunol. | pmid:1698845 |
| Pipkorn U | H1-antagonists as a tool in clarifying the pathophysiology of nasal allergy. | 1990 | Clin. Exp. Allergy | pmid:1699643 |
| Knapp HR | Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor. | 1990 | N. Engl. J. Med. | pmid:1701029 |
| Liu MC et al. | Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:2368958 |
| GarcÃa-Sáinz JA et al. | Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2. | 1990 | Biochem. J. | pmid:2375756 |
| Zavoico GB et al. | Enhancement of thrombin- and ionomycin-stimulated prostacyclin and platelet-activating factor production in cultured endothelial cells by a tumor-promoting phorbol ester. | 1990 | J. Cell. Physiol. | pmid:2113537 |
| Woodward DF et al. | Studies on the ocular pharmacology of prostaglandin D2. | 1990 | Invest. Ophthalmol. Vis. Sci. | pmid:2298534 |
| Goh Y and Nakajima M | Stimulatory effects of prostaglandin D2 analogues on adenylate cyclase in rabbit iris-ciliary body membrane fractions. | 1990 | Exp. Eye Res. | pmid:2249731 |
| Khan SH and Sorof S | Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2251282 |
| Nishimura G | [Antitumor activity and cell cycle effects of delta 12-PGJ2 in vivo]. | 1990 | Nihon Gan Chiryo Gakkai Shi | pmid:2351856 |
| Ford WD et al. | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. | 1990 | J. Pediatr. Surg. | pmid:2352080 |
| Okumura T and Saito K | Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver. | 1990 | Prostaglandins | pmid:2353117 |
| Perreault T et al. | Pulmonary vascular effects of prostaglandin D2 in newborn pig. | 1990 | Am. J. Physiol. | pmid:2337164 |
| Ingenito EP et al. | Bronchoalveolar lavage cell and mediator responses to hyperpnea-induced bronchoconstriction in the guinea pig. | 1990 | Am. Rev. Respir. Dis. | pmid:2339838 |
| Williams WR et al. | In vitro tests for the diagnosis of aspirin-sensitive asthma. | 1990 | J. Allergy Clin. Immunol. | pmid:2146311 |
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| Gadsby JE et al. | Prostaglandin F2 alpha receptors on enzyme-dissociated pig luteal cells throughout the estrous cycle. | 1990 | Endocrinology | pmid:2153525 |
| Friedmann PS et al. | Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di-acyl glycerol but not TPA. | 1990 | J. Cell. Physiol. | pmid:2303529 |
| Deffebach ME et al. | Prostaglandins alter methacholine-induced secretion in ferret in vitro trachea. | 1990 | Am. J. Physiol. | pmid:2407140 |
| Urade Y et al. | Mast cells contain spleen-type prostaglandin D synthetase. | 1990 | J. Biol. Chem. | pmid:2403560 |
| Mori H et al. | Augmentation of antiproliferative activity of recombinant human tumor necrosis factor by delta 12-prostaglandin J2. | 1990 | J Biol Response Mod | pmid:2341865 |
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| Kawano S et al. | Protective effect of PGD2 against ethanol-induced gastric mucosal injury in rats. | 1990 | J. Clin. Gastroenterol. | pmid:2212542 |
| Woodward DF et al. | Thromboxane A2-mimetics are potent microvascular permeability factors in the conjunctiva. | 1990 | J. Pharmacol. Exp. Ther. | pmid:2213558 |
| Katsuura G et al. | Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1 beta-induced ACTH release. | 1990 | Am. J. Physiol. | pmid:1967907 |
| Vigano' T et al. | Binding sites for histamine and sulfidopeptide leukotrienes in normal and hypersensitized human lung fragments. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2144691 |
| Eggleston PA et al. | Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells. | 1990 | Am. Rev. Respir. Dis. | pmid:1691604 |
| Fukushima M | Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved. | 1990 | Eicosanoids | pmid:2073399 |
| Inoue M et al. | Interactions between the brain renin-angiotensin system and brain prostanoids in the control of vasopressin secretion. | 1990 | Exp Brain Res | pmid:2073934 |
| Bennegård B et al. | Luteotropic effects of prostaglandins I2 and D2 on isolated human corpora luteum. | 1990 | Fertil. Steril. | pmid:2168845 |
| Bettazzoli L et al. | Incorporation of arachidonic acid into glycerophospholipids of a murine bone marrow derived mast cell. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2169185 |
| Seiler S et al. | SQ-27986 inhibition of platelet aggregation is mediated through activation of platelet prostaglandin D2 receptors. | 1990 | Prostaglandins | pmid:2171039 |
| Eriksson LO et al. | Prostaglandin E2 binding sites in human renal tissue: characterization and localization by radioligand binding and autoradiography. | 1990 | Acta Physiol. Scand. | pmid:2173350 |
| Brass EP and Garrity MJ | Structural specificity for prostaglandin effects on hepatocyte glycogenolysis. | 1990 | Biochem. J. | pmid:2158311 |
| Lysz TW et al. | Kupffer cell-hepatocyte interactions and the changes in 1-14C-arachidonate incorporation in response to endotoxin in vitro. | 1990 | Prostaglandins | pmid:2112770 |
| Jongejan RC et al. | Effects of inflammatory mediators on the responsiveness of isolated human airways to methacholine. | 1990 | Am. Rev. Respir. Dis. | pmid:2240835 |
| Marui N et al. | N-myc suppression and cell cycle arrest at G1 phase by prostaglandins. | 1990 | FEBS Lett. | pmid:2226777 |
| Koyama Y et al. | Prostaglandin production by isolated Kupffer cells. | 1990 | Gastroenterol. Jpn. | pmid:2227259 |
| Hamid-Bloomfield S et al. | The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C. | 1990 | Br. J. Pharmacol. | pmid:2119842 |
| Ito S et al. | Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. | 1990 | Br. J. Pharmacol. | pmid:2158830 |
| Imura Y et al. | Antagonistic action of AA-2414 on thromboxane A2/prostaglandin endoperoxide receptor in platelets and blood vessels. | 1990 | Jpn. J. Pharmacol. | pmid:2137886 |
| Featherstone RL et al. | Evidence for thromboxane receptor mediated contraction of guinea-pig and human airways in vitro by prostaglandin (PG) D2, 9 alpha,11 beta-PGF2 and PGF2 alpha. | 1990 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2142256 |
| Virgolini I et al. | Effects of bopindolol on platelet function in hypertension at rest and during exercise. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2143586 |
| Nakahata N et al. | PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells. | 1990 | Prostaglandins | pmid:2177901 |
| Massey WA and Lichtenstein LM | The effects of antihistamines beyond H1 antagonism in allergic inflammation. | 1990 | J. Allergy Clin. Immunol. | pmid:1979797 |
| White RP et al. | Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus. | 1990 | Am. J. Med. Sci. | pmid:2321665 |
| Broide DH et al. | Airway levels of mast cell-derived mediators in exercise-induced asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:1689974 |
| Undem BJ et al. | Inhibition by adenosine 3':5'-monophosphate of eicosanoid and platelet-activating factor biosynthesis in the mouse PT-18 mast cell. | 1990 | J. Biol. Chem. | pmid:1691175 |
| Proud D et al. | Inflammatory mediator release on conjunctival provocation of allergic subjects with allergen. | 1990 | J. Allergy Clin. Immunol. | pmid:1692049 |
| Miadonna A et al. | Mediator release after endobronchial antigen challenge in patients with respiratory allergy. | 1990 | J. Allergy Clin. Immunol. | pmid:1692050 |
| D'Onofrio C et al. | The antiproliferative effect of prostaglandin A and J on HTLV-I transformed cells is associated with induction of a heat-shock protein. | 1990 Sep-Oct | Pharmacol. Res. | pmid:2284244 |
| Yamaguchi K and Hama H | Separation of periventricular dopaminergic and alpha-adrenergic systems from the vasopressin-secreting mechanisms activated by prostaglandin D2. | 1991 | Brain Res. | pmid:1665382 |
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| Georgitis JW et al. | Nasal inflammatory mediator release in ragweed allergic rhinitis: correlation with cellular influx into nasal secretions. | 1991 | Int. Arch. Allergy Appl. Immunol. | pmid:1666629 |
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| Goerg KJ et al. | Antisecretory effect of prostaglandin D2 in rat colon in vitro: action sites. | 1991 | Am. J. Physiol. | pmid:1676243 |
| Fox CC et al. | Modulation of mediator release from human intestinal mast cells by sulfasalazine and 5-aminosalicylic acid. | 1991 | Dig. Dis. Sci. | pmid:1703070 |
| Keenan CM and Rangachari PK | Contrasting effects of PGE2 and PGD2: ion transport in the canine proximal colon. | 1991 | Am. J. Physiol. | pmid:2003610 |
| Roberts LJ and Oates JA | Biochemical diagnosis of systemic mast cell disorders. | 1991 | J. Invest. Dermatol. | pmid:16799604 |
| Massey WA et al. | Profile of prostanoid release following antigen challenge in vivo in the skin of man. | 1991 | Br. J. Dermatol. | pmid:1760357 |
| Sinzinger H et al. | Platelet lipoxygenase defect (Wien-Penzing defect) in two patients with myocardial infarction. | 1991 | Am. J. Hematol. | pmid:1899965 |
| Brodsky L et al. | Arachidonic acid metabolites in middle ear effusions of children. | 1991 | Ann. Otol. Rhinol. Laryngol. | pmid:1648326 |
| Tasaki Y et al. | Prostaglandin D2 metabolite stimulates collagen synthesis by human osteoblasts during calcification. | 1991 | Prostaglandins | pmid:1871375 |
| Vesin MF et al. | Preferential synthesis of prostaglandin D2 by neurons and prostaglandin E2 by fibroblasts and nonneuronal cells in chick dorsal root ganglia. | 1991 | J. Neurochem. | pmid:2051162 |
| Hori T et al. | Prostaglandins antagonize fibroblast proliferation stimulated by tumor necrosis factor. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1993070 |
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| Sasaki H et al. | Human ovarian cancer cell lines resistant to cisplatin, doxorubicin, and L-phenylalanine mustard are sensitive to delta 7-prostaglandin A1 and delta 12-prostaglandin J2. | 1991 | Gynecol. Oncol. | pmid:2026357 |
| Marui N et al. | Delta 12-prostaglandin J2 mimics heat shock in inducing cell cycle arrest at G1 phase. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1930204 |
| Nakajima M et al. | Effects of prostaglandin D2 and its analogue, BW245C, on intraocular pressure in humans. | 1991 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:1937072 |
| Perreault T and De Marte J | Endothelin-1 has a dilator effect on neonatal pig pulmonary vasculature. | 1991 | J. Cardiovasc. Pharmacol. | pmid:1719291 |
| van der Donk EM et al. | Leukotriene C4 formation by enriched human basophil preparations from normal and asthmatic subjects. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1719566 |
| Murakami M et al. | Group II phospholipase A2 inhibitors suppressed lysophosphatidylserine-dependent degranulation of rat peritoneal mast cells. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1721808 |
| Myers AC et al. | Influence of antigen on membrane properties of guinea pig bronchial ganglion neurons. | 1991 | J. Appl. Physiol. | pmid:1721906 |
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| Inoue M et al. | Interactions between brain acetylcholine and prostaglandins in control of vasopressin release. | 1991 | Am. J. Physiol. | pmid:1877699 |
| Francis HP et al. | BAY u3405 an antagonist of thromboxane A2- and prostaglandin D2-induced bronchoconstriction in the guinea-pig. | 1991 | Br. J. Pharmacol. | pmid:1797323 |
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| Massey WA et al. | Human uterine mast cells. Isolation, purification, characterization, ultrastructure, and pharmacology. | 1991 | J. Immunol. | pmid:1715365 |
| Butchers PR et al. | Salmeterol: a potent and long-acting inhibitor of inflammatory mediator release from human lung. | 1991 | Br. J. Pharmacol. | pmid:1724629 |
| Misawa M and Kanai Y | Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs. | 1991 | Arzneimittelforschung | pmid:1725697 |
| Abman SH and Accurso FJ | Sustained fetal pulmonary vasodilation with prolonged atrial natriuretic factor and GMP infusions. | 1991 | Am. J. Physiol. | pmid:1847014 |
| Sladek K et al. | Formation of PGD2 after allergen inhalation in atopic asthmatics. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1847781 |
| King LS et al. | Pulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation. | 1991 | Circ. Res. | pmid:1825033 |
| Arzubiaga C et al. | Neuropeptide Y, a putative cotransmitter in noradrenergic neurons, induces mast cell degranulation but not prostaglandin D2 release. | 1991 | J. Allergy Clin. Immunol. | pmid:1825102 |
| Koshihara Y et al. | Prostaglandin D2 stimulates calcification by human osteoblastic cells. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825424 |
| Atsmon J et al. | Modulation of the antiproliferative activity of 9-deoxy-delta 9,delta 12(E)-PGD2 by conjugation with intracellular glutathione. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825432 |
| Akerboom T et al. | Cholestasis and changes of portal pressure caused by chlorpromazine in the perfused rat liver. | 1991 | Hepatology | pmid:1899850 |
| Koizumi K et al. | Induction of 31,000 protein by PGD2-treated vascular endothelial cells. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825433 |
| Woodward DF et al. | Studies on leukotriene D4 as an eosinophil chemoattractant. | 1991 | Drugs Exp Clin Res | pmid:1841046 |
| Walls AF et al. | Inflammatory mediators and cellular infiltration of the lungs in a guinea pig model of the late asthmatic reaction. | 1991 | Lung | pmid:1921474 |
| Crivellari MT et al. | Eicosanoid release and mepyramine, LTC4 and LTD4 binding in passively sensitized human lung parenchyma in vitro. | 1991 | Biochem. Pharmacol. | pmid:1859453 |
| Marriott DR et al. | Substance P-induced release of prostaglandins from astrocytes: regional specialisation and correlation with phosphoinositol metabolism. | 1991 | J. Neurochem. | pmid:1702831 |
| Smith GS et al. | Adaptive cytoprotection against alcohol injury in the rat stomach is not due to increased prostanoid synthesis. | 1991 | Prostaglandins | pmid:1906621 |