PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Actinobacillus Infections D000189 4 associated lipids
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Anal Gland Neoplasms D000694 1 associated lipids
Anaphylaxis D000707 35 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Ascariasis D001196 3 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Simonin MA et al. PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts. 2002 Am. J. Physiol., Cell Physiol. pmid:11742805
Reilly TP et al. A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. 2001 Chem. Res. Toxicol. pmid:11743745
Noverr MC et al. Production of prostaglandins and leukotrienes by pathogenic fungi. 2002 Infect. Immun. pmid:11748207
Schoppee PD et al. Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells. 2002 Biol. Reprod. pmid:11751282
Fujitani Y et al. Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice. 2002 J. Immunol. pmid:11751991
Yagami T et al. Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosis. 2002 Mol. Pharmacol. pmid:11752212
Fu Y et al. Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages. 2002 Atherosclerosis pmid:11755918
Suzuki R and Freed AN Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. 2002 Am. J. Respir. Crit. Care Med. pmid:11779726
Keelan J et al. 15-deoxy-delta12,14-prostaglandin J2-induced apoptosis in amnion-like WISH cells. 2001 Prostaglandins Other Lipid Mediat. pmid:11785780
Shibata T et al. 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes. 2002 J. Biol. Chem. pmid:11786541
Hayaishi O Molecular genetic studies on sleep-wake regulation, with special emphasis on the prostaglandin D(2) system. 2002 J. Appl. Physiol. pmid:11796702
Hirai H et al. Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2. 2002 J. Immunol. pmid:11801628
Harris SG et al. 15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway. 2002 J. Immunol. pmid:11801678
Diaz BL et al. Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids. 2002 J. Immunol. pmid:11801681
Cheuk BL et al. Cyclooxygenase-2 regulates apoptosis in rat epididymis through prostaglandin D2. 2002 Biol. Reprod. pmid:11804951
Dieter P et al. Lipopolysaccharide-induced release of arachidonic acid and prostaglandins in liver macrophages: regulation by Group IV cytosolic phospholipase A2, but not by Group V and Group IIA secretory phospholipase A2. 2002 Cell. Signal. pmid:11812647
Michimata T et al. Accumulation of CRTH2-positive T-helper 2 and T-cytotoxic 2 cells at implantation sites of human decidua in a prostaglandin D(2)-mediated manner. 2002 Mol. Hum. Reprod. pmid:11818521
Pizzimenti S et al. Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation. 2002 Free Radic. Biol. Med. pmid:11827749
Hayaishi O and Urade Y Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives. 2002 Neuroscientist pmid:11843094
Harris SG and Phipps RP Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells. 2002 Immunology pmid:11849312