PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Airway Remodeling D056151 3 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Pulmonary Aspergillosis D055732 1 associated lipids
Acute Lung Injury D055371 33 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Angioedemas, Hereditary D054179 2 associated lipids
Atherosclerosis D050197 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Kawata R et al. Prostaglandin synthase 1 and prostaglandin synthase 2 both participate in activation-induced prostaglandin D2 production in mast cells. 1995 J. Immunol. pmid:7608559
Diab A et al. Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis. 2002 J. Immunol. pmid:11859145
Patella V et al. Eosinophil granule proteins activate human heart mast cells. 1996 J. Immunol. pmid:8757629
Luna-Gomes T et al. Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation. 2011 J. Immunol. pmid:22102725
Katz HR et al. Secretory granule mediator release and generation of oxidative metabolites of arachidonic acid via Fc-IgG receptor bridging in mouse mast cells. 1992 J. Immunol. pmid:1309842
Raible DG et al. Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils. 1992 J. Immunol. pmid:1588043
Levi-Schaffer F et al. Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. 1987 J. Immunol. pmid:2445814
Nencioni A et al. Dendritic cell immunogenicity is regulated by peroxisome proliferator-activated receptor gamma. 2002 J. Immunol. pmid:12133943
Columbo M et al. The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils. 1992 J. Immunol. pmid:1378071
Kobayashi Y et al. Physiological levels of 15-deoxy-Delta12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation. 2005 J. Immunol. pmid:16237065
Robin JL et al. Regulation of mediator release from mouse bone marrow-derived mast cells by glucocorticoids. 1985 J. Immunol. pmid:3161947
Ogasawara T et al. Mouse bone marrow-derived mast cells undergo exocytosis, prostanoid generation, and cytokine expression in response to G protein-activating polybasic compounds after coculture with fibroblasts in the presence of c-kit ligand. 1997 J. Immunol. pmid:8977215
Chevalier E et al. Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. 2005 J. Immunol. pmid:16081770
Fox CC et al. Isolation and characterization of human intestinal mucosal mast cells. 1985 J. Immunol. pmid:2582045
Levi-Schaffer F et al. Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and IgE-mediated release of histamine, prostaglandin D2, and leukotrienes. 1987 J. Immunol. pmid:2439587
Patella V et al. Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. 1995 J. Immunol. pmid:7533185
Leal-Berumen I et al. Prostanoid enhancement of interleukin-6 production by rat peritoneal mast cells. 1995 J. Immunol. pmid:7536779
Cheron A et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process. 2004 J. Immunol. pmid:15187150
Murakami M et al. IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2. 1995 J. Immunol. pmid:7594606
Hammad H et al. Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1. 2003 J. Immunol. pmid:14530310
Schlezinger JJ et al. Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2. 2004 J. Immunol. pmid:15322177
Si Q et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications. 2004 J. Immunol. pmid:15322215
Massey WA et al. Human uterine mast cells. Isolation, purification, characterization, ultrastructure, and pharmacology. 1991 J. Immunol. pmid:1715365
Menè P Prostaglandin D2 : a Cinderella of vascular cell biology? 2002 J. Hypertens. pmid:12131515
Negoro H et al. Endogenous prostaglandin D2 synthesis reduces an increase in plasminogen activator inhibitor-1 following interleukin stimulation in bovine endothelial cells. 2002 J. Hypertens. pmid:12131531
Han XQ et al. Advanced glycation end products promote differentiation of CD4(+) T helper cells toward pro-inflammatory response. 2014 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:24496672
Zhang M et al. Peroxisome proliferator-activated receptor-gamma activated by ligands can inhibit human lung cancer cell growth through induction of apoptosis. 2003 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:12973930
López-Parra M et al. The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin. 2005 J. Hepatol. pmid:15629510
Tran-Thi TA et al. Net prostaglandin release by perfused rat liver after stimulation with phorbol 12-myristate 13-acetate. 1988 J. Hepatol. pmid:3166024
Hoffmann R et al. Regulation of interleukin-6 receptor expression in rat Kupffer cells: modulation by cytokines, dexamethasone and prostaglandin E2. 1994 J. Hepatol. pmid:7814800
Gressner OA et al. Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. 2008 J. Hepatol. pmid:18486259
Li L et al. Molecular mechanisms regulating the antifibrogenic protein heme-oxygenase-1 in human hepatic myofibroblasts. 2004 J. Hepatol. pmid:15336443
Tran-Thi TA et al. Effects of hypoxia on the oxygen-dependent metabolism of prostaglandins and adenosine in liver cells. 1994 J. Hepatol. pmid:8071531
Tran-Thi TA et al. Studies on synthesis and degradation of eicosanoids by rat hepatocytes in primary culture. 1987 J. Hepatol. pmid:2828463
Santoro MG et al. PGJ2, a new antiviral prostaglandin: inhibition of Sendai virus replication and alteration of virus protein synthesis. 1987 J. Gen. Virol. pmid:3033130
Rollins MD et al. Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis. 2006 Sep-Oct J. Gastrointest. Surg. pmid:16966031
Yamamoto Y et al. Role of peroxisome proliferator-activated receptor-gamma (PPARgamma) during liver regeneration in rats. 2008 J. Gastroenterol. Hepatol. pmid:18565023
Berruyer C et al. Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. 2006 J. Exp. Med. pmid:17145956
Mellor EA et al. Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. 2002 J. Exp. Med. pmid:11877481
Honda K et al. Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. 2003 J. Exp. Med. pmid:12925672
Murakami M et al. The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. 1995 J. Exp. Med. pmid:7540649
Chilton FH et al. Antigen-induced generation of lyso-phospholipids in human airways. 1996 J. Exp. Med. pmid:8642333
Angeli V et al. Role of the parasite-derived prostaglandin D2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection. 2001 J. Exp. Med. pmid:11369785
Hirai H et al. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. 2001 J. Exp. Med. pmid:11208866
Hammad H et al. Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. 2007 J. Exp. Med. pmid:17283205
Kilunga Kubata B et al. Plasmodium falciparum produces prostaglandins that are pyrogenic, somnogenic, and immunosuppressive substances in humans. 1998 J. Exp. Med. pmid:9743538
Kubata BK et al. Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. 2000 J. Exp. Med. pmid:11067881
Kubata BK et al. A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi. 2002 J. Exp. Med. pmid:12417633
Hsieh FH et al. T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C(4) synthase expression by interleukin 4. 2001 J. Exp. Med. pmid:11136826
Kong D et al. PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation. 2016 J. Exp. Med. pmid:27621415
Tasaka K et al. Prostaglandin D2 induces release of luteinizing hormone from the rat pituitary gland without the modulation of hypothalamic luteinizing hormone releasing hormone. 1983 J. Endocrinol. pmid:6361197
Kurtz M et al. Peroxisome proliferator-activated receptor ligands regulate lipid content, metabolism, and composition in fetal lungs of diabetic rats. 2014 J. Endocrinol. pmid:24389592
Knepel W et al. Inhibition by prostaglandin E2 of the release of vasopressin and beta-endorphin from rat pituitary neurointermediate lobe or medial basal hypothalamus in vitro. 1985 J. Endocrinol. pmid:3160802
Löhrke B et al. Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells. 1998 J. Endocrinol. pmid:9834460
Takano H and Komuro I Roles of peroxisome proliferator-activated receptor gamma in cardiovascular disease. 2002 Jan-Feb J. Diabetes Complicat. pmid:11872377
Goya K et al. The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells. 2006 Sep-Oct J. Diabetes Complicat. pmid:16949522
Soifer SJ et al. The developmental effects of prostaglandin D2 on the pulmonary and systemic circulations in the newborn lamb. 1983 J. Dev. Physiol. pmid:6579103
Hau CS et al. Suppressive effects of antimycotics on thymic stromal lymphopoietin production in human keratinocytes. 2013 J. Dermatol. Sci. pmid:23688403
Pierron A et al. PGJ2 restores RA sensitivity in melanoma cells by decreasing PRAME and EZH2. 2014 J. Dermatol. Sci. pmid:24289988
Amon U et al. Investigations on plasma levels of mast cell mediators in acute atopic dermatitis. 1994 J. Dermatol. Sci. pmid:8193085
Schütz TC et al. Effects of COX-2 inhibitor in temporomandibular joint acute inflammation. 2007 J. Dent. Res. pmid:17452571
Fukuchi K et al. Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone. 2003 J. Dent. Res. pmid:14514760
Lutzow YS et al. 15-Deoxy-Delta12,14-prostaglandin J2 induces chemokine expression, oxidative stress and microfilament reorganization in bovine mammary epithelial cells. 2008 J. Dairy Res. pmid:18226310
Kunkel SL et al. Suppression of immune complex vasculitis in rats by prostaglandin. 1979 J. Clin. Invest. pmid:159314
Rozera C et al. Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block. 1996 J. Clin. Invest. pmid:8621762
Benyó Z et al. GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. 2005 J. Clin. Invest. pmid:16322797
Zhao J et al. Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. 2011 J. Clin. Invest. pmid:22105170
Braciale TJ and Kim TS Slowing down with age: lung DCs do it too. 2011 J. Clin. Invest. pmid:22105176
Weinreich D and Undem BJ Immunological regulation of synaptic transmission in isolated guinea pig autonomic ganglia. 1987 J. Clin. Invest. pmid:2437156
Adler DH et al. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. 2008 J. Clin. Invest. pmid:18451993
Kawahito Y et al. 15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. 2000 J. Clin. Invest. pmid:10903334
Togias AG et al. Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement. 1985 J. Clin. Invest. pmid:2414318
Creticos PS et al. Nasal challenge with ragweed pollen in hay fever patients. Effect of immunotherapy. 1985 J. Clin. Invest. pmid:2416777
Adams M et al. Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation. 1997 J. Clin. Invest. pmid:9399962
Passeron T et al. Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid. 2009 J. Clin. Invest. pmid:19273910
Charlesworth EN et al. Cutaneous late-phase response to allergen. Mediator release and inflammatory cell infiltration. 1989 J. Clin. Invest. pmid:2468688
Schulman ES et al. Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release. 1988 J. Clin. Invest. pmid:2449462
Pipkorn U et al. Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge. 1987 J. Clin. Invest. pmid:2443539
Schleimer RP et al. Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells. 1983 J. Clin. Invest. pmid:6134755
Powell WS 15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product? 2003 J. Clin. Invest. pmid:12975467
Bell-Parikh LC et al. Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. 2003 J. Clin. Invest. pmid:12975479
Tokudome S et al. Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. 2009 J. Clin. Invest. pmid:19451694
Su CG et al. A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. 1999 J. Clin. Invest. pmid:10449430
Beasley CR et al. 9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways. 1987 J. Clin. Invest. pmid:3469218
Song WL et al. Niacin and biosynthesis of PGDâ‚‚by platelet COX-1 in mice and humans. 2012 J. Clin. Invest. pmid:22406532
Chearwae W and Bright JJ 15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte. 2008 J. Clin. Immunol. pmid:18463970
Kawano S et al. Protective effect of PGD2 against ethanol-induced gastric mucosal injury in rats. 1990 J. Clin. Gastroenterol. pmid:2212542
Kasim-Karakas SE et al. Metabolic and endocrine effects of a polyunsaturated fatty acid-rich diet in polycystic ovary syndrome. 2004 J. Clin. Endocrinol. Metab. pmid:14764771
Mitchell MD et al. Identification of 9alpha,11beta-prostaglandin F2 in human amniotic fluid and characterization of its production by human gestational tissues. 2005 J. Clin. Endocrinol. Metab. pmid:15840748
Schaiff WT et al. Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner. 2000 J. Clin. Endocrinol. Metab. pmid:11061552
Helliwell RJ et al. Gestational age-dependent up-regulation of prostaglandin D synthase (PGDS) and production of PGDS-derived antiinflammatory prostaglandins in human placenta. 2006 J. Clin. Endocrinol. Metab. pmid:16291703
Lappas M et al. Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone. 2002 J. Clin. Endocrinol. Metab. pmid:12364456
Carr BR et al. Prostaglandin secretion by the neocortex and fetal zones of the human fetal adrenal gland. 1983 J. Clin. Endocrinol. Metab. pmid:6313732
Lindström TM and Bennett PR 15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications. 2005 J. Clin. Endocrinol. Metab. pmid:15755849
Schwartz MS et al. Determination of a prostaglandin D2 antagonist and its acyl glucuronide metabolite in human plasma by high performance liquid chromatography with tandem mass spectrometric detection--a lack of MS/MS selectivity between a glucuronide conjugate and a phase I metabolite. 2006 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16716772
Schmidt R et al. LC-MS/MS-analysis of prostaglandin E2 and D2 in microdialysis samples of rats. 2005 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16172029
Morrow JD and Minton TA Improved assay for the quantification of 11-dehydrothromboxane B2 by gas chromatography-mass spectrometry. 1993 J. Chromatogr. pmid:8468374
Chiabrando C et al. Quantitative profiling of prostaglandins and thromboxane by high-resolution gas chromatography-selected--ion monitoring. 1983 J. Chromatogr. pmid:6584432
Zhao X et al. 15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. 2006 J. Cereb. Blood Flow Metab. pmid:16208315
Pereira MP et al. Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. 2006 J. Cereb. Blood Flow Metab. pmid:16034372