PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Arai I et al. Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. 2007 Eur. J. Pharmacol. pmid:17141215
Chambers KT et al. PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17148750
Liu JJ et al. Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. 2007 Ann. Hematol. pmid:17089125
Jin YR et al. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. 2007 Atherosclerosis pmid:17092506
Nicoll-Griffith DA et al. In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites. 2007 Bioorg. Med. Chem. Lett. pmid:17095220
Hortobágyi L et al. Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of vasodilator prostanoids. 2007 Brain Res. pmid:17161389
Kang MA et al. Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. 2007 Life Sci. pmid:17161435
Tanaka Y et al. Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. 2007 Mol. Pharmacol. pmid:17151289
Rahman A et al. Interactive effect of histamine and prostaglandin D2 on nasal allergic symptoms in rats. 2007 Eur. J. Pharmacol. pmid:17112500
Jung SM et al. Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. 2007 Arthritis Res. Ther. pmid:17612394
Sugimoto M et al. The anti-pruritic efficacy of TS-022, a prostanoid DP1 receptor agonist, is dependent on the endogenous prostaglandin D2 level in the skin of NC/Nga mice. 2007 Eur. J. Pharmacol. pmid:17328887
Skogvall S et al. Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. 2007 Pulm Pharmacol Ther pmid:16731017
Ruano D et al. Family-based and case-control studies reveal no association of lipocalin-type prostaglandin D2 synthase with schizophrenia. 2007 Am. J. Med. Genet. B Neuropsychiatr. Genet. pmid:17230501
Rehan VK et al. In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17215434
Haack M et al. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. 2007 Sleep pmid:17910386
Mathew B et al. Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages. 2007 Am. J. Respir. Cell Mol. Biol. pmid:17204585
Gallant MA et al. Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2. 2007 Eur. J. Pharmacol. pmid:17207480
Xue L et al. Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2). 2007 Biochem. Pharmacol. pmid:17196174
Jin YR et al. Antiplatelet effect of NQ12: a possible mechanism through the arachidonic acid cascade. 2007 J. Pharmacol. Sci. pmid:17951980
Van Hecken A et al. The effect of MK-0524, a prostaglandin D(2) receptor antagonist, on prostaglandin D (2)-induced nasal airway obstruction in healthy volunteers. 2007 Eur. J. Clin. Pharmacol. pmid:17200838
Moreira V et al. Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E2 and D2, and expression of cyclooxygenases. 2007 Toxicon pmid:17241651
Liu M et al. Focal cerebral ischemia/reperfusion injury in mice induces hematopoietic prostaglandin D synthase in microglia and macrophages. 2007 Neuroscience pmid:17241746
Tinfo N and Komar C Potential role for peroxisome proliferator-activated receptor gamma in regulating luteal lifespan in the rat. 2007 Reproduction pmid:17244745
Lee JH et al. 15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes. 2007 J. Korean Med. Sci. pmid:17982241
Gayarre J et al. Modification of proteins by cyclopentenone prostaglandins is differentially modulated by GSH in vitro. 2007 Ann. N. Y. Acad. Sci. pmid:17405918
Hagens WI et al. Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated. 2007 Pharm. Res. pmid:17245650
Sugimoto M et al. Putative mechanism of the itch-scratch circle: repeated scratching decreases the cutaneous level of prostaglandin D2, a mediator that inhibits itching. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17250998
Li X et al. Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells. 2007 Nephrol. Dial. Transplant. pmid:17255125
Yang C et al. Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism. 2007 Am. J. Pathol. pmid:17255338
Schäffler A et al. Regulation and function of collagenous repeat containing sequence of 26-kDa protein gene product "cartonectin". 2007 Obesity (Silver Spring) pmid:17299102
Petrova LN et al. Effect of prostaglandins E2 and D2 on presynaptic NMDA receptors in rat cerebral cortex. 2007 Bull. Exp. Biol. Med. pmid:18457019
Li CF et al. [Effect of peroxisome proliferators-activated receptor-gamma in the mechanisms of sulindac against large intestine carcinoma]. 2007 Beijing Da Xue Xue Bao pmid:17304332
Hirano Y et al. Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells. 2007 Eur. J. Pharmacol. pmid:17307163
Takaoka A et al. Role of scratch-induced cutaneous prostaglandin D production on atopic-like scratching behaviour in mice. 2007 Exp. Dermatol. pmid:17359340
Ito W et al. Hepatocyte growth factor attenuates eotaxin and PGD2-induced chemotaxis of human eosinophils. 2007 Allergy pmid:17362253
Yang WZ et al. [The effect of ligand of peroxisome proliferators-activated receptor gamma 15d-PGJ2 on the proliferation and activation of hepatic stellate cells]. 2007 Zhonghua Gan Zang Bing Za Zhi pmid:17362636
Wilhelm D et al. SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. 2007 J. Biol. Chem. pmid:17277314
Park JM et al. Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. 2007 Cancer Res. pmid:17283118
Hammad H et al. Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. 2007 J. Exp. Med. pmid:17283205
Kim HJ et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain. 2007 Cancer Res. pmid:17363578
Yamada K et al. Nose-to-brain delivery of TS-002, prostaglandin D2 analogue. 2007 J Drug Target pmid:17365274
Fionda C et al. 15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors. 2007 J. Immunol. pmid:17371958
Saleem S et al. PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury. 2007 Eur. J. Neurosci. pmid:17573924
Wu L et al. Divergent effects of prostaglandin receptor signaling on neuronal survival. 2007 Neurosci. Lett. pmid:17574754
Hasegawa H et al. A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production. 2007 Blood pmid:17551094
Ueki S et al. Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions. 2007 Int. Arch. Allergy Immunol. pmid:17541271
Chiba T et al. Possible novel receptor for PGD2 on human bronchial epithelial cells. 2007 Int. Arch. Allergy Immunol. pmid:17541272
Engdahl R et al. 15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) mediates repression of TNF-alpha by decreasing levels of acetylated histone H3 and H4 at its promoter. 2007 Biochem. Biophys. Res. Commun. pmid:17532302
Lin MS et al. Activation of peroxisome proliferator-activated receptor gamma inhibits cell growth via apoptosis and arrest of the cell cycle in human colorectal cancer. 2007 J Dig Dis pmid:17532820
Futaki N et al. Role of prostaglandins on mechanical scratching-induced cutaneous barrier disruption in mice. 2007 Exp. Dermatol. pmid:17518991
Taniguchi H et al. Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury. 2007 J. Neurosci. pmid:17442814
Zhang XC et al. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. 2007 J. Pharmacol. Exp. Ther. pmid:17483291
Ponferrada A et al. The role of PPARgamma on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction. 2007 Gastroenterology pmid:17484875
Renedo M et al. Modification and activation of Ras proteins by electrophilic prostanoids with different structure are site-selective. 2007 Biochemistry pmid:17489560
Cerbone A et al. 4-Hydroxynonenal and PPARgamma ligands affect proliferation, differentiation, and apoptosis in colon cancer cells. 2007 Free Radic. Biol. Med. pmid:17462534
Yano M et al. Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages. 2007 Circ. Res. pmid:17463321
Hwang J et al. 15-deoxy-Delta12,14-prostaglandin J2-induced down-regulation of endothelial nitric oxide synthase in association with HSP70 induction. 2007 Biochem. Biophys. Res. Commun. pmid:17418102
Arnold R et al. Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. 2007 Immunology pmid:17425601
Li SJ et al. [Effects of peroxisome proliferator-activated receptor gamma and its ligands on cytotrophoblast invasion in first trimester of pregnancy and mechanism thereof]. 2007 Zhonghua Yi Xue Za Zhi pmid:17425848
Schuligoi R et al. PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors. 2007 Biochem. Pharmacol. pmid:17452035
Richman JG et al. Nicotinic acid receptor agonists differentially activate downstream effectors. 2007 J. Biol. Chem. pmid:17452318
Schütz TC et al. Effects of COX-2 inhibitor in temporomandibular joint acute inflammation. 2007 J. Dent. Res. pmid:17452571
Zhao X et al. Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. 2007 Ann. Neurol. pmid:17457822
Berry A et al. IL-13 induces expression of CD36 in human monocytes through PPARgamma activation. 2007 Eur. J. Immunol. pmid:17458857
Takeda K et al. Neuroendocrine functions of melanocytes: beyond the skin-deep melanin maker. 2007 Tohoku J. Exp. Med. pmid:17347546
Mazid MA et al. Development of enzyme-linked immunosorbent assay for prostaglandin D2 using the stable isosteric analogue as a hapten mimic and its application. 2007 Prostaglandins Other Lipid Mediat. pmid:17481559
Lim HJ et al. 15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells. 2007 Toxicol. Appl. Pharmacol. pmid:17631927
Olmos G et al. Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism. 2007 Cell. Signal. pmid:17658243
Xiang Z et al. 15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells. 2007 J Neuroinflammation pmid:17634127
Ye Y et al. Activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2. 2007 Prostaglandins Other Lipid Mediat. pmid:17643887
Desmarais JA et al. The peroxisome proliferator-activated receptor gamma regulates trophoblast cell differentiation in mink (Mustela vison). 2007 Biol. Reprod. pmid:17615406
Nagai H [The role of lipid mediators in allergic diseases]. 2007 Arerugi pmid:17615500
Kaplan J et al. Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells. 2007 Shock pmid:17621259
Pierzchalska M et al. Deficiency of cyclooxygenases transcripts in cultured primary bronchial epithelial cells of aspirin-sensitive asthmatics. 2007 J. Physiol. Pharmacol. pmid:17622692
Lin TH et al. PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats. 2007 Bone pmid:17669705
Fionda C et al. Inhibition of trail gene expression by cyclopentenonic prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in T lymphocytes. 2007 Mol. Pharmacol. pmid:17673570
Moulin D et al. Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells. 2007 Cytokine pmid:18023358
Mizutani N et al. Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. 2007 J. Immunol. pmid:18025192
Tanaka H et al. [Synthesis of chemical probes based on combinatorial chemistry and lab automation]. 2007 Tanpakushitsu Kakusan Koso pmid:18051395
Kim WJ et al. Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A. 2007 EMBO J. pmid:18034160
Haworth O and Buckley CD Resolving the problem of persistence in the switch from acute to chronic inflammation. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:18093938
Wang LH et al. Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP. 2007 Blood pmid:17785586
Han H et al. 15-Deoxy-delta 12,14-prostaglandin J2 (15d-PGJ 2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation. 2007 Apoptosis pmid:17786557
Yoon EK et al. ERK-1/-2 and p38 kinase oppositely regulate 15-deoxy-delta(12,14)-prostaglandinJ(2)-Induced PPAR-gamma activation that mediates dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. 2007 J. Korean Med. Sci. pmid:18162716
Kushikata T et al. [Sleep and anesthesia--Part 1, Recent findings in research]. 2007 Masui pmid:17877045
Kershaw EE et al. PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17848638
Brunoldi EM et al. Cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione. 2007 Chem. Res. Toxicol. pmid:17854155
Siddhivarn C et al. Mechanical loading and delta12prostaglandin J2 induce bone morphogenetic protein-2, peroxisome proliferator-activated receptor gamma-1, and bone nodule formation in an osteoblastic cell line. 2007 J. Periodont. Res. pmid:17760815
Wu P et al. Inflammation pro-resolving potential of 3,4-dihydroxyacetophenone through 15-deoxy-delta12,14-prostaglandin J2 in murine macrophages. 2007 Int. Immunopharmacol. pmid:17761349
Saito Y et al. Protective effects of 15-deoxy-Delta12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione. 2007 J. Neurochem. pmid:17697048
Iikura M et al. IL-33 can promote survival, adhesion and cytokine production in human mast cells. 2007 Lab. Invest. pmid:17700564
Kondoh K et al. Inhibition of estrogen receptor beta-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Delta(12,14)-prostaglandin J(2)-induced apoptosis in cancer cells. 2007 Exp. Cell Res. pmid:17706193
Richard CL et al. 15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways. 2007 Exp. Cell Res. pmid:17707368
Chen Y et al. Prostaglandin D2 suppresses human NK cell function via signaling through D prostanoid receptor. 2007 J. Immunol. pmid:17709490
Li Y et al. Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonist. 2007 J. Am. Chem. Soc. pmid:17691773
Parameswaran K et al. Modulation of human airway smooth muscle migration by lipid mediators and Th-2 cytokines. 2007 Am. J. Respir. Cell Mol. Biol. pmid:17431098
Rehan VK et al. A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17435078
Vinall SL et al. A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes. 2007 Immunology pmid:17437532
Meyers CD et al. Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush. 2007 Atherosclerosis pmid:16945375
García-Bueno B et al. Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats. 2007 Neuropsychopharmacology pmid:17119541