PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Trigeminal Neuralgia D014277 1 associated lipids
Pulmonary Aspergillosis D055732 1 associated lipids
Persistent Fetal Circulation Syndrome D010547 1 associated lipids
Zollinger-Ellison Syndrome D015043 1 associated lipids
Mastocytosis, Systemic D034721 1 associated lipids
Anal Gland Neoplasms D000694 1 associated lipids
Angioedemas, Hereditary D054179 2 associated lipids
Epilepsy, Tonic-Clonic D004830 2 associated lipids
Cryptorchidism D003456 2 associated lipids
Cystitis, Interstitial D018856 2 associated lipids
Decapitation D049248 2 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Choroid Diseases D015862 2 associated lipids
Optic Neuropathy, Ischemic D018917 2 associated lipids
Airway Remodeling D056151 3 associated lipids
Respiratory Sounds D012135 3 associated lipids
HTLV-I Infections D015490 3 associated lipids
Ascariasis D001196 3 associated lipids
Sleep Disorders, Circadian Rhythm D020178 3 associated lipids
Wounds, Stab D014951 3 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Cryptococcosis D003453 3 associated lipids
Cholangitis D002761 3 associated lipids
Dirofilariasis D004184 3 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Urticaria Pigmentosa D014582 4 associated lipids
Meningoencephalitis D008590 4 associated lipids
Coronavirus Infections D018352 4 associated lipids
Nasal Obstruction D015508 4 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Goiter D006042 4 associated lipids
Headache D006261 4 associated lipids
Actinobacillus Infections D000189 4 associated lipids
Hematoma D006406 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Muscular Dystrophy, Animal D009137 5 associated lipids
Vasculitis, Leukocytoclastic, Cutaneous D018366 5 associated lipids
Thrombophilia D019851 6 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Leukodystrophy, Globoid Cell D007965 6 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Sneezing D012912 6 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Tauopathies D024801 6 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Folliculitis D005499 7 associated lipids
Carotid Artery Thrombosis D002341 7 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Sleep Wake Disorders D012893 7 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Leukemia, Megakaryoblastic, Acute D007947 7 associated lipids
Thyroid Diseases D013959 8 associated lipids
Leiomyoma D007889 8 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Retinopathy of Prematurity D012178 9 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
Chondrosarcoma D002813 9 associated lipids
Coronary Restenosis D023903 10 associated lipids
Rhinitis D012220 10 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Dehydration D003681 11 associated lipids
Fetal Weight D020567 12 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Urticaria D014581 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Sarcoidosis D012507 13 associated lipids
Hypercalcemia D006934 13 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Astrocytoma D001254 15 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
HIV Seropositivity D006679 15 associated lipids
Thrombocytopenia D013921 15 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Encephalitis D004660 15 associated lipids
Blister D001768 16 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Down Syndrome D004314 18 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Bronchial Spasm D001986 18 associated lipids
Cough D003371 19 associated lipids
Hypothermia D007035 19 associated lipids
Peptic Ulcer D010437 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Johnston DE and Kroening C Stimulation of prostaglandin synthesis in cultured liver cells by CCl4. 1996 Hepatology pmid:8781342
Rozera C et al. Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block. 1996 J. Clin. Invest. pmid:8621762
Seghaye MC et al. Histamine liberation related to cardiopulmonary bypass in children: possible relation to transient postoperative arrhythmias. 1996 J. Thorac. Cardiovasc. Surg. pmid:8622322
Longphre M et al. PAF-induced airways hyperreactivity is modulated by mast cells in mice. 1996 Am. J. Respir. Cell Mol. Biol. pmid:8624251
Chilton FH et al. Antigen-induced generation of lyso-phospholipids in human airways. 1996 J. Exp. Med. pmid:8642333
Westcott JY et al. Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase. 1996 Biochim. Biophys. Acta pmid:8816855
Odani N et al. Induction of protein disulfide isomerase mRNA by delta 12-prostaglandin J2. 1996 Biochem. Biophys. Res. Commun. pmid:8645293
Genovese A et al. Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. 1996 Int. Arch. Allergy Immunol. pmid:8645973
Weidenbach H et al. Reduction of bile secretion by prostaglandins in the rat in vivo. 1996 Life Sci. pmid:8649182
Satoh S et al. Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8650205
Hayaishi O Tryptophan, oxygenase, and sleep. 1996 Adv. Exp. Med. Biol. pmid:8906236
Urade Y et al. Molecular mechanism of sleep regulation by prostaglandin D2. 1996 J Lipid Mediat Cell Signal pmid:8906548
Higashiyama K et al. Induction of c-fos protooncogene transcription and apoptosis by delta 12-prostaglandin J2 in human Pl-21 myeloid leukemia and RC-K8 pre-B lymphoma cells. 1996 Prostaglandins pmid:8908616
Naclerio RM et al. Origin of late phase histamine release. 1996 J. Allergy Clin. Immunol. pmid:8876545
Patella V et al. Oxatomide inhibits the release of proinflammatory mediators from human basophils and mast cells. 1996 Int. Arch. Allergy Immunol. pmid:8753840
de Graaf-in t Veld C et al. Relationship between nasal hyperreactivity, mediators and eosinophils in patients with perennial allergic rhinitis and controls. 1996 Clin. Exp. Allergy pmid:8877155
O'Sullivan S et al. Increased urinary excretion of the prostaglandin D2 metabolite 9 alpha, 11 beta-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. 1996 J. Allergy Clin. Immunol. pmid:8757220
Ashraf MM et al. Type II phospholipase A2 is linked to cyclooxygenase-2-mediated delayed prostaglandin D2 generation by cultured mouse mast cells following FcepsilonRI- and cytokine-dependent activation. 1996 Biochem. Biophys. Res. Commun. pmid:8954964
Patella V et al. Eosinophil granule proteins activate human heart mast cells. 1996 J. Immunol. pmid:8757629
Bingham CO et al. A heparin-sensitive phospholipase A2 and prostaglandin endoperoxide synthase-2 are functionally linked in the delayed phase of prostaglandin D2 generation in mouse bone marrow-derived mast cells. 1996 J. Biol. Chem. pmid:8824228
Sharif NA et al. Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases. 1996 J. Pharmacol. Exp. Ther. pmid:8819509
Chung HS et al. Heat contact urticaria--a case report. 1996 Yonsei Med. J. pmid:8826790
Conti C et al. Inhibition of poliovirus replication by prostaglandins A and J in human cells. 1996 Antimicrob. Agents Chemother. pmid:8834882
McClay EF et al. delta 12-Prostaglandin-J2 is cytotoxic in human malignancies and synergizes with both cisplatin and radiation. 1996 Cancer Res. pmid:8752147
Franzese O et al. Functional antagonism between IL-2 and PGA1 or PGJ2 in the control of proliferation of human cord blood-derived mononuclear cells. 1996 Int. J. Immunopharmacol. pmid:9089005
Norwitz ER et al. Prostaglandin production by human peripheral blood monocytes changes with in vitro differentiation. 1996 Prostaglandins pmid:8792444
Odani N et al. Regulation of BiP gene expression by cyclopentenone prostaglandins through unfolded protein response element. 1996 J. Biol. Chem. pmid:8663202
Shiroma T et al. [Production and metabolism of prostaglandin D2 by cultured chick retinal pigment epithelial cells]. 1996 Nippon Ganka Gakkai Zasshi pmid:8741332
Liao CH et al. Antiplatelet effect of demethyldiisoeugenol. 1996 Can. J. Physiol. Pharmacol. pmid:9022830
Sakai T [Molecular cancer epidemiology--the present status and future possibilities]. 1996 Nihon Eiseigaku Zasshi pmid:8720930
Shalev A and Meier CA Peroxisome proliferator-activated receptors: a nuclear hormone receptor involved in adipocyte differentiation and lipid homeostasis. 1996 Eur. J. Endocrinol. pmid:8664970
Vedin I et al. Stimulation of tumor necrosis factor-alpha release from lipopolysaccharide-activated human blood monocytes by prostaglandin J2 and metabolites of prostaglandin J2. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8931117
de Paulis A et al. Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization. 1996 Arthritis Rheum. pmid:8670335
Ashraf M et al. Cross-linking of the high-affinity IgE receptor induces the expression of cyclo-oxygenase 2 and attendant prostaglandin generation requiring interleukin 10 and interleukin 1 beta in mouse cultured mast cells. 1996 Biochem. J. pmid:9003387
Wagenmann M et al. Unilateral nasal allergen challenge leads to bilateral release of prostaglandin D2. 1996 Clin. Exp. Allergy pmid:8732233
Campbell A et al. Overview of allergic mechanisms. Ebastine has more than an antihistamine effect. 1996 Drugs pmid:8983912
Ishimoto T et al. Importance of the phospholipase D-initiated sequential pathway for arachidonic acid release and prostaglandin D2 generation by rat peritoneal mast cells. 1996 J. Biochem. pmid:8902628
Casimir DA et al. Preadipocyte differentiation blocked by prostaglandin stimulation of prostanoid FP2 receptor in murine 3T3-L1 cells. 1996 Differentiation pmid:8765050
Minami T et al. Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice. 1996 J. Pharmacol. Exp. Ther. pmid:8819497
Spannhake EW Down-regulation of canine airway mast cell function following exposure to ozone in vivo. 1996 Mar-Apr Exp. Lung Res. pmid:8706634
Jović N et al. Do prostaglandins E2, F2 alpha and D2 have a role in the development of idiopathic trigeminal neuralgia? 1996 May-Jun Vojnosanit Pregl pmid:9174396
Kiriyama M et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. 1997 Br. J. Pharmacol. pmid:9313928
Kanaoka Y et al. Cloning and crystal structure of hematopoietic prostaglandin D synthase. 1997 Cell pmid:9323136
Li Y et al. Differential effects of various eicosanoids on the production or prevention of arrhythmias in cultured neonatal rat cardiac myocytes. 1997 Prostaglandins pmid:9380795
Fournier T et al. Tumor necrosis factor-alpha inversely regulates prostaglandin D2 and prostaglandin E2 production in murine macrophages. Synergistic action of cyclic AMP on cyclooxygenase-2 expression and prostaglandin E2 synthesis. 1997 J. Biol. Chem. pmid:9388257
Genovese A et al. Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells. 1997 Clin. Exp. Allergy pmid:9179431
Murakami M et al. Detection of secretory phospholipase A2s related but not identical to type IIA isozyme in cultured mast cells. 1997 FEBS Lett. pmid:9280291
Harbige LS et al. Cytokine secretion by human T cell clones is differentially regulated by eicosanoids. 1997 Biochem. Soc. Trans. pmid:9191392
Murakami M et al. Cyclooxygenase-2-dependent delayed prostaglandin D2 generation is initiated by nerve growth factor in rat peritoneal mast cells: its augmentation by extracellular type II secretory phospholipase A2. 1997 J. Immunol. pmid:9200484
ElAttar TM and Virji AS Inhibition of growth in oral squamous carcinoma cells by cyclopentenone prostaglandins: comparison with chemotherapeutic agents. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9223658
Sampson SE et al. Effect of inhaled prostaglandin D2 in normal and atopic subjects, and of pretreatment with leukotriene D4. 1997 Thorax pmid:9227716
Abran D et al. Regulation of prostanoid vasomotor effects and receptors in choroidal vessels of newborn pigs. 1997 Am. J. Physiol. pmid:9087666
Kanamori Y et al. Migration of neutrophils from blood to tissue: alteration of modulatory effects of prostanoid on superoxide generation in rabbits and humans. 1997 Life Sci. pmid:9096262
Ram A et al. CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats. 1997 Brain Res. pmid:9098570
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Mahmud I et al. Prostaglandin D synthase in human megakaryoblastic cells. 1997 J. Biol. Chem. pmid:9353279
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Tsuri T et al. Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: orally active, potent, and selective prostaglandin D2 receptor antagonists. 1997 J. Med. Chem. pmid:9357516
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Ogasawara T et al. Mouse bone marrow-derived mast cells undergo exocytosis, prostanoid generation, and cytokine expression in response to G protein-activating polybasic compounds after coculture with fibroblasts in the presence of c-kit ligand. 1997 J. Immunol. pmid:8977215
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Mezei Z et al. Platelet eicosanoids and the effect of captopril in blood pressure regulation. 1997 Eur. J. Pharmacol. pmid:9527508
el Attar TM and Virji AS Effects of indomethacin, cisplatin and delta 12-prostaglandin J2 on growth of oral squamous carcinoma cells. 1997 Nov-Dec Anticancer Res. pmid:9494540
Yang VW et al. Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis. 1998 Cancer Res. pmid:9563494
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Fiebich BL et al. Potential link between interleukin-6 and arachidonic acid metabolism in Alzheimer's disease. 1998 J. Neural Transm. Suppl. pmid:9850935
Christman BW Lipid mediator dysregulation in primary pulmonary hypertension. 1998 Chest pmid:9741570
Takahashi S et al. Localization of a cyclopentenone prostaglandin to the endoplasmic reticulum and induction of BiP mRNA. 1998 Biochem. J. pmid:9742210
Csala M et al. Prostaglandin-independent stimulation of interleukin-6 production by fibrinogen degradation product D in perfused murine liver. 1998 Scand. J. Immunol. pmid:9743211
Kilunga Kubata B et al. Plasmodium falciparum produces prostaglandins that are pyrogenic, somnogenic, and immunosuppressive substances in humans. 1998 J. Exp. Med. pmid:9743538
Torii SI et al. Thiazolidinedione induces the adipose differentiation of fibroblast-like cells resident within bovine skeletal muscle. 1998 Cell Biol. Int. pmid:10328850
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O'Sullivan S et al. Exposure of healthy volunteers to swine house dust increases formation of leukotrienes, prostaglandin D2, and bronchial responsiveness to methacholine. 1998 Thorax pmid:10195076
Longo WE et al. Contribution of cyclooxygenase-1 and cyclooxygenase-2 to prostanoid formation by human enterocytes stimulated by calcium ionophore and inflammatory agents. 1998 Prostaglandins Other Lipid Mediat. pmid:9990676
Löhrke B et al. Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells. 1998 J. Endocrinol. pmid:9834460
Haberl C et al. Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity. 1998 Mediators Inflamm. pmid:9836493
Longo WE et al. The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation. 1998 Mediators Inflamm. pmid:9836494
Takafuji S et al. Release of granule proteins from human eosinophils stimulated with mast-cell mediators. 1998 Allergy pmid:9821474