PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chou TC and Li CY | Inhibitory mechanisms of dantrolene on platelet aggregation. | 1999 | Thromb. Res. | pmid:10593433 |
| Heneka MT et al. | Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase. | 1999 | J. Neuroimmunol. | pmid:10695726 |
| Herschman HR | Function and regulation of prostaglandin synthase 2. | 1999 | Adv. Exp. Med. Biol. | pmid:10667302 |
| Murakami M et al. | Regulation of prostaglandin, leukotriene, and platelet-activating factor metabolism in mast cells. | 1999 | Adv. Exp. Med. Biol. | pmid:10667307 |
| Satoh H et al. | Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function. | 1999 | Biochem. Biophys. Res. Commun. | pmid:9920814 |
| Eguchi N et al. | Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9892701 |
| Rouaud C et al. | The cyclo-oxygenase-dependent regulation of rabbit vein contraction: evidence for a prostaglandin E2-mediated relaxation. | 1999 | Br. J. Pharmacol. | pmid:10051118 |
| Makker HK et al. | Airway endothelin levels in asthma: influence of endobronchial hypertonic saline challenge. | 1999 | Clin. Exp. Allergy | pmid:10051729 |
| Marx N et al. | PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073956 |
| Walch L et al. | Prostanoid receptors involved in the relaxation of human pulmonary vessels. | 1999 | Br. J. Pharmacol. | pmid:10193765 |
| Norel X et al. | Prostanoid receptors involved in the relaxation of human bronchial preparations. | 1999 | Br. J. Pharmacol. | pmid:10193766 |
| Miadonna A et al. | Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. | 1999 | Clin. Exp. Allergy | pmid:10383595 |
| Hayaishi O | Prostaglandin D2 and sleep--a molecular genetic approach. | 1999 | J Sleep Res | pmid:10389108 |
| Salińska E et al. | Role of Ca2+ release from ryanodine stores in generation of NMDA-induced Ca2+ signal in rabbit hippocampus. | 1999 | Ross Fiziol Zh Im I M Sechenova | pmid:10389178 |
| Pelton PD et al. | PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10425206 |
| Chinery R et al. | Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. | 1999 | Cancer Res. | pmid:10364000 |
| Crider JY et al. | Prostaglandin DP receptors positively coupled to adenylyl cyclase in embryonic bovine tracheal (EBTr) cells: pharmacological characterization using agonists and antagonists. | 1999 | Br. J. Pharmacol. | pmid:10369474 |
| Chan CL and Lau HY | Prostanoid DP receptor activation inhibits anti-IgE induced histamine release from rat peritoneal mast cells. | 1999 | Inflamm. Res. | pmid:10350148 |
| Urade Y and Hayaishi O | Prostaglandin D2 and sleep regulation. | 1999 | Biochim. Biophys. Acta | pmid:9989291 |
| Sakamoto H et al. | Effect of intracellular glutathione on the production of prostaglandin D2 in RBL-2H3 cells oxidized by tert-butyl hydroperoxide. | 1999 | J. Biochem. | pmid:9880802 |
| Furutani K et al. | Substance P- and antigen-induced release of leukotriene B4, prostaglandin D2 and histamine from guinea pig skin by different mechanisms in vitro. | 1999 Jul-Aug | Arch. Dermatol. Res. | pmid:10482019 |
| Marx N et al. | Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. | 2000 | J. Immunol. | pmid:10843708 |
| Pica F et al. | Delta(12)-prostaglandin J(2) is a potent inhibitor of influenza A virus replication. | 2000 | Antimicrob. Agents Chemother. | pmid:10602750 |
| Rossi A et al. | Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. | 2000 | Nature | pmid:10638762 |
| Clark RB et al. | The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses. | 2000 | J. Immunol. | pmid:10640751 |
| Reilly CM et al. | Inhibition of mesangial cell nitric oxide in MRL/lpr mice by prostaglandin J2 and proliferator activation receptor-gamma agonists. | 2000 | J. Immunol. | pmid:10640767 |
| Dumont I et al. | Regulation of endothelial nitric oxide synthase by PGD(2) in the developing choroid. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10644584 |
| Nojima H et al. | Arachidonic acid and prostaglandin D2 cooperatively accelerate desensitization of nicotinic acetylcholine receptor channel in mouse skeletal muscles. | 2000 | Brain Res. | pmid:10661520 |
| Galli A et al. | Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells. | 2000 | Hepatology | pmid:10613734 |
| Kuwamoto K et al. | Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice. | 2000 | J. Invest. Dermatol. | pmid:10651981 |
| Padilla J et al. | PPAR-gamma-mediated regulation of normal and malignant B lineage cells. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818446 |
| Padilla J et al. | Effects of 15-deoxy-delta 12,14-PGJ2 on B lineage cells. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818475 |
| Hwang SW et al. | Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10823958 |
| Inoue H et al. | Feedback control of cyclooxygenase-2 expression through PPARgamma. | 2000 | J. Biol. Chem. | pmid:10827178 |
| Straus DS et al. | 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781090 |
| Wächtershäuser A et al. | PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833422 |
| Koppal T et al. | Cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells. | 2000 | Brain Res. | pmid:10837804 |
| Asano T et al. | Peroxisome proliferator-activated receptor gamma1 (PPARgamma1) expresses in rat mesangial cells and PPARgamma agonists modulate its differentiation. | 2000 | Biochim. Biophys. Acta | pmid:10838168 |
| Viergutz T et al. | Relationship between different stages of the corpus luteum and the expression of the peroxisome proliferator-activated receptor gamma protein in bovine large lutein cells. | 2000 | J. Reprod. Fertil. | pmid:10793637 |
| Fennekohl A et al. | Induction by interleukin 6 of G(s)-coupled prostaglandin E(2) receptors in rat hepatocytes mediating a prostaglandin E(2)-dependent inhibition of the hepatocyte's acute phase response. | 2000 | Hepatology | pmid:10796889 |
| Rubin GL et al. | Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy. | 2000 | Cancer Res. | pmid:10749129 |
| Tsubouchi Y et al. | Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10753637 |
| Kawamoto Y et al. | Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes. 15-deoxy-delta(12,14)-prostaglandin j2-induced expression of glutathione S-transferases. | 2000 | J. Biol. Chem. | pmid:10753940 |
| Lee KH et al. | Stimulatory function of gp49A, a murine Ig-like receptor, in rat basophilic leukemia cells. | 2000 | J. Immunol. | pmid:11046024 |
| Kasai K et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11078701 |
| Dieter P et al. | Functional coupling of cyclooxygenase 1 and 2 to discrete prostanoid synthases in liver macrophages. | 2000 | Biochem. Biophys. Res. Commun. | pmid:11027502 |
| Enomoto A et al. | Redundant and segregated functions of granule-associated heparin-binding group II subfamily of secretory phospholipases A2 in the regulation of degranulation and prostaglandin D2 synthesis in mast cells. | 2000 | J. Immunol. | pmid:11034411 |
| Sugiyama H et al. | Peroxisome proliferator-activated receptors are expressed in human cultured mast cells: a possible role of these receptors in negative regulation of mast cell activation. | 2000 | Eur. J. Immunol. | pmid:11093153 |
| Faveeuw C et al. | Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-12 production in murine dendritic cells. | 2000 | FEBS Lett. | pmid:11119715 |
| Padilla J et al. | Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells. | 2000 | J. Immunol. | pmid:11120820 |
| Sharif NA et al. | Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand. | 2000 | Br. J. Pharmacol. | pmid:11082108 |
| Hortelano S et al. | Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages. | 2000 | J. Immunol. | pmid:11086094 |
| Fukushima S et al. | Preparation and evaluation of o/w type emulsions containing antitumor prostaglandin. | 2000 | Adv. Drug Deliv. Rev. | pmid:11104898 |
| Honma S et al. | Effects of naturally-occurring acid fog on inflammatory mediators in airway and pulmonary functions in asthmatic patients. | 2000 | Respir Med | pmid:11059945 |
| Schaiff WT et al. | Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner. | 2000 | J. Clin. Endocrinol. Metab. | pmid:11061552 |
| Saarinen JV et al. | Release of histamine and leukotriene C4 in immediate allergic wheal reaction as measured with the microdialysis technique. | 2000 | Arch. Dermatol. Res. | pmid:10966057 |
| Miyahara T et al. | Peroxisome proliferator-activated receptors and hepatic stellate cell activation. | 2000 | J. Biol. Chem. | pmid:10969082 |
| Vanaja DK et al. | Tumor prevention and antitumor immunity with heat shock protein 70 induced by 15-deoxy-delta12,14-prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells. | 2000 | Cancer Res. | pmid:10987274 |
| Soler M et al. | Human vascular smooth muscle cells but not endothelial cells express prostaglandin E synthase. | 2000 | Circ. Res. | pmid:10988243 |
| Sakamoto H et al. | Involvement of phospholipid hydroperoxide glutathione peroxidase in the modulation of prostaglandin D2 synthesis. | 2000 | J. Biol. Chem. | pmid:11010961 |
| Woodward DF et al. | Replacement of the carboxylic acid group of prostaglandin f(2alpha) with a hydroxyl or methoxy substituent provides biologically unique compounds. | 2000 | Br. J. Pharmacol. | pmid:10952685 |
| Nishio T et al. | Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10973807 |
| Heneka MT et al. | Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. | 2000 | J. Neurosci. | pmid:10995830 |
| Uchida K | Induction of glutathione S-transferase by prostaglandins. | 2000 | Mech. Ageing Dev. | pmid:10996013 |
| Miwa Y et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) induces G(1) arrest and differentiation marker expression in vascular smooth muscle cells. | 2000 | Mol. Pharmacol. | pmid:10999955 |
| Jozkowicz A et al. | Ligands of peroxisome proliferator-activated receptor-gamma increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages. | 2000 | Acta Biochim. Pol. | pmid:11996104 |
| Steinbrink K et al. | Induction of dendritic cell maturation and modulation of dendritic cell-induced immune responses by prostaglandins. | 2000 | Arch. Dermatol. Res. | pmid:11000287 |
| Sugimoto Y et al. | Influences of everninomicin, vancomycin and teicoplanin on chemical mediator release from rat peritoneal mast cells. | 2000 | Jpn. J. Pharmacol. | pmid:11001175 |
| Kawahito Y et al. | 15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. | 2000 | J. Clin. Invest. | pmid:10903334 |
| Kershenovich A et al. | Angiotensin II does not mediate the pressor response to PGD2 (icv). | 2000 | J Renin Angiotensin Aldosterone Syst | pmid:11967813 |
| Gaspar Elsas MI et al. | Murine myeloid progenitor responses to GM-CSF and eosinophil precursor responses to IL-5 represent distinct targets for downmodulation by prostaglandin E(2). | 2000 | Br. J. Pharmacol. | pmid:10903977 |
| Karimi K et al. | Stem cell factor and interleukin-4 increase responsiveness of mast cells to substance P. | 2000 | Exp. Hematol. | pmid:10880748 |
| Chattopadhyay N et al. | Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPARgamma agonists as inducers of apoptosis. | 2000 | J. Neurosci. Res. | pmid:10861801 |
| Paik JH et al. | Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. | 2000 | J. Biol. Chem. | pmid:10866999 |
| Maggi LB et al. | Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression. | 2000 | Diabetes | pmid:10868955 |
| Abdelaziz MM et al. | The potential of active metabolites of antihistamines in the management of allergic disease. | 2000 | Allergy | pmid:10843422 |
| Norwitz ER and Wilson T | Secretory component: a potential regulator of endometrial-decidual prostaglandin production in early human pregnancy. | 2000 | Am. J. Obstet. Gynecol. | pmid:10920317 |
| Yoshida Y et al. | Prostaglandin E (EP) receptor subtypes and sleep: promotion by EP4 and inhibition by EP1/EP2. | 2000 | Neuroreport | pmid:10923657 |
| Marra F et al. | Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. | 2000 | Gastroenterology | pmid:10930382 |
| Ikeda Y et al. | Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2. | 2000 | J. Biol. Chem. | pmid:10930400 |
| Bamba H et al. | Prostaglandins up-regulate vascular endothelial growth factor production through distinct pathways in differentiated U937 cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10873632 |
| Ikeda U et al. | Peroxisome proliferator-activated receptor-gamma ligands inhibit nitric oxide synthesis in vascular smooth muscle cells. | 2000 | Hypertension | pmid:10856269 |
| Ajuebor MN et al. | Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10898767 |
| Sugiyama H et al. | Peroxisome proliferator-activated receptors are expressed in mouse bone marrow-derived mast cells. | 2000 | FEBS Lett. | pmid:10675550 |
| Matsuoka T et al. | Prostaglandin D2 as a mediator of allergic asthma. | 2000 | Science | pmid:10720327 |
| Hayaishi O | Molecular mechanisms of sleep-wake regulation: a role of prostaglandin D2. | 2000 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:10724461 |
| Castrillo A et al. | Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophages. | 2000 | Mol. Cell. Biol. | pmid:10669746 |
| Butler R et al. | Nonapoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferator-activated receptor gamma ligand, 15-deoxy-delta12,14-prostaglandin J2. | 2000 | Cell Growth Differ. | pmid:10672903 |
| Liu JH | Circadian variations of prostaglandins in the rabbit aqueous humor. | 2000 | J Ocul Pharmacol Ther | pmid:10673131 |
| Kowalski ML et al. | Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10673176 |
| Yamashita M et al. | Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells. | 2000 | Br. J. Pharmacol. | pmid:10694244 |
| Kubata BK et al. | Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. | 2000 | J. Exp. Med. | pmid:11067881 |
| Takeda K et al. | Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells. | 2000 | Circulation | pmid:11023940 |
| Reich EE et al. | Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. | 2000 | Biochemistry | pmid:10694406 |
| Åazarewicz JW et al. | NMDA receptors and nitric oxide regulate prostaglandin D2 synthesis in the rabbit hippocampus in vivo. | 2000 | Acta Neurobiol Exp (Wars) | pmid:11200170 |
| Zuckerman SH et al. | The effect of gamma-interferon to inhibit macrophage-high density lipoprotein interactions is reversed by 15-deoxy-delta12,14-prostaglandin J2. | 2000 | Lipids | pmid:11132183 |
| Wright DH et al. | The human prostanoid DP receptor stimulates mucin secretion in LS174T cells. | 2000 | Br. J. Pharmacol. | pmid:11139429 |
| Li LH and Ku BS | [Regulation of SWS by hormones and cytokines]. | 2000 | Sheng Li Ke Xue Jin Zhan | pmid:12532764 |
| Kitatani K et al. | Role of phospholipase D-derived phosphatidic acid as a substrate for phospholipase A2 in RBL-2H3 cells. | 2000 | Biol. Pharm. Bull. | pmid:11145171 |
| Hamel L et al. | Induction of heat shock protein 70 by herbimycin A and cyclopentenone prostaglandins in smooth muscle cells. | 2000 | Cell Stress Chaperones | pmid:11147963 |