Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Goetze S et al. | PPAR gamma-ligands inhibit migration mediated by multiple chemoattractants in vascular smooth muscle cells. | 1999 | J. Cardiovasc. Pharmacol. | pmid:10226869 |
Satoh T et al. | Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10222233 |
Kitamura Y et al. | Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells. | 1999 | Neurosci. Lett. | pmid:10203248 |
Onoe H | [Molecular and neuroanatomical mechanisms of sleep-wakefulness regulation by prostaglandins D2 and E2]. | 1998 | Nippon Yakurigaku Zasshi | pmid:10202759 |
Petrova TV et al. | Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10200320 |
Koro O et al. | Chemical mediators in atopic dermatitis: involvement of leukotriene B4 released by a type I allergic reaction in the pathogenesis of atopic dermatitis. | 1999 | J. Allergy Clin. Immunol. | pmid:10200017 |
Chen Y et al. | Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway. | 1999 | J. Biol. Chem. | pmid:10196163 |
O'Sullivan S et al. | Exposure of healthy volunteers to swine house dust increases formation of leukotrienes, prostaglandin D2, and bronchial responsiveness to methacholine. | 1998 | Thorax | pmid:10195076 |
Norel X et al. | Prostanoid receptors involved in the relaxation of human bronchial preparations. | 1999 | Br. J. Pharmacol. | pmid:10193766 |
Walch L et al. | Prostanoid receptors involved in the relaxation of human pulmonary vessels. | 1999 | Br. J. Pharmacol. | pmid:10193765 |
Brambilla R et al. | Cyclo-oxygenase-2 mediates P2Y receptor-induced reactive astrogliosis. | 1999 | Br. J. Pharmacol. | pmid:10188963 |
Conti C et al. | Antiviral effect of hyperthermic treatment in rhinovirus infection. | 1999 | Antimicrob. Agents Chemother. | pmid:10103186 |
Xin X et al. | Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo. | 1999 | J. Biol. Chem. | pmid:10085162 |
Marx N et al. | PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073956 |
Fujitani Y et al. | [Sleep-promoting substances]. | 1998 | Nihon Ronen Igakkai Zasshi | pmid:10064966 |
Makker HK et al. | Airway endothelin levels in asthma: influence of endobronchial hypertonic saline challenge. | 1999 | Clin. Exp. Allergy | pmid:10051729 |
Rouaud C et al. | The cyclo-oxygenase-dependent regulation of rabbit vein contraction: evidence for a prostaglandin E2-mediated relaxation. | 1999 | Br. J. Pharmacol. | pmid:10051118 |
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