Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Atkins PC et al. | In vivo antigen-induced cutaneous mediator release: simultaneous comparisons of histamine, tryptase, and prostaglandin D2 release and the effect of oral corticosteroid administration. | 1990 | J. Allergy Clin. Immunol. | pmid:1698845 |
Pipkorn U | H1-antagonists as a tool in clarifying the pathophysiology of nasal allergy. | 1990 | Clin. Exp. Allergy | pmid:1699643 |
Knapp HR | Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor. | 1990 | N. Engl. J. Med. | pmid:1701029 |
Liu MC et al. | Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:2368958 |
GarcÃa-Sáinz JA et al. | Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2. | 1990 | Biochem. J. | pmid:2375756 |
Zavoico GB et al. | Enhancement of thrombin- and ionomycin-stimulated prostacyclin and platelet-activating factor production in cultured endothelial cells by a tumor-promoting phorbol ester. | 1990 | J. Cell. Physiol. | pmid:2113537 |
Woodward DF et al. | Studies on the ocular pharmacology of prostaglandin D2. | 1990 | Invest. Ophthalmol. Vis. Sci. | pmid:2298534 |
Goh Y and Nakajima M | Stimulatory effects of prostaglandin D2 analogues on adenylate cyclase in rabbit iris-ciliary body membrane fractions. | 1990 | Exp. Eye Res. | pmid:2249731 |
Khan SH and Sorof S | Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2251282 |
Nishimura G | [Antitumor activity and cell cycle effects of delta 12-PGJ2 in vivo]. | 1990 | Nihon Gan Chiryo Gakkai Shi | pmid:2351856 |
Ford WD et al. | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. | 1990 | J. Pediatr. Surg. | pmid:2352080 |
Okumura T and Saito K | Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver. | 1990 | Prostaglandins | pmid:2353117 |
Perreault T et al. | Pulmonary vascular effects of prostaglandin D2 in newborn pig. | 1990 | Am. J. Physiol. | pmid:2337164 |
Ingenito EP et al. | Bronchoalveolar lavage cell and mediator responses to hyperpnea-induced bronchoconstriction in the guinea pig. | 1990 | Am. Rev. Respir. Dis. | pmid:2339838 |
Atsmon J et al. | Formation of thiol conjugates of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 and delta 12(E)-prostaglandin D2. | 1990 | Biochemistry | pmid:2340271 |
vom Dahl S et al. | Stimulation of release of prostaglandin D2 and thromboxane B2 from perfused rat liver by extracellular adenosine. | 1990 | Biochem. J. | pmid:2396991 |
Gadsby JE et al. | Prostaglandin F2 alpha receptors on enzyme-dissociated pig luteal cells throughout the estrous cycle. | 1990 | Endocrinology | pmid:2153525 |
Friedmann PS et al. | Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di-acyl glycerol but not TPA. | 1990 | J. Cell. Physiol. | pmid:2303529 |
Deffebach ME et al. | Prostaglandins alter methacholine-induced secretion in ferret in vitro trachea. | 1990 | Am. J. Physiol. | pmid:2407140 |
Mori H et al. | Augmentation of antiproliferative activity of recombinant human tumor necrosis factor by delta 12-prostaglandin J2. | 1990 | J Biol Response Mod | pmid:2341865 |
Bochner BS et al. | Interleukin-1 is released at sites of human cutaneous allergic reactions. | 1990 | J. Allergy Clin. Immunol. | pmid:2262641 |
Doyle WJ et al. | Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy. | 1990 | J. Allergy Clin. Immunol. | pmid:2262647 |
Kudo M et al. | [Prostaglandin D2-endogenous regulator of physiological sleep-inhibited CRF-induced ACTH secretion from rat anterior pituitary cells]. | 1990 | Nihon Naibunpi Gakkai Zasshi | pmid:1962750 |
Kawano S et al. | Protective effect of PGD2 against ethanol-induced gastric mucosal injury in rats. | 1990 | J. Clin. Gastroenterol. | pmid:2212542 |
Woodward DF et al. | Thromboxane A2-mimetics are potent microvascular permeability factors in the conjunctiva. | 1990 | J. Pharmacol. Exp. Ther. | pmid:2213558 |
Katsuura G et al. | Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1 beta-induced ACTH release. | 1990 | Am. J. Physiol. | pmid:1967907 |
Vigano' T et al. | Binding sites for histamine and sulfidopeptide leukotrienes in normal and hypersensitized human lung fragments. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2144691 |
Eggleston PA et al. | Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells. | 1990 | Am. Rev. Respir. Dis. | pmid:1691604 |
Fukushima M | Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved. | 1990 | Eicosanoids | pmid:2073399 |
Inoue M et al. | Interactions between the brain renin-angiotensin system and brain prostanoids in the control of vasopressin secretion. | 1990 | Exp Brain Res | pmid:2073934 |
Bennegård B et al. | Luteotropic effects of prostaglandins I2 and D2 on isolated human corpora luteum. | 1990 | Fertil. Steril. | pmid:2168845 |
Bettazzoli L et al. | Incorporation of arachidonic acid into glycerophospholipids of a murine bone marrow derived mast cell. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2169185 |
Seiler S et al. | SQ-27986 inhibition of platelet aggregation is mediated through activation of platelet prostaglandin D2 receptors. | 1990 | Prostaglandins | pmid:2171039 |
Eriksson LO et al. | Prostaglandin E2 binding sites in human renal tissue: characterization and localization by radioligand binding and autoradiography. | 1990 | Acta Physiol. Scand. | pmid:2173350 |
Brass EP and Garrity MJ | Structural specificity for prostaglandin effects on hepatocyte glycogenolysis. | 1990 | Biochem. J. | pmid:2158311 |
Lysz TW et al. | Kupffer cell-hepatocyte interactions and the changes in 1-14C-arachidonate incorporation in response to endotoxin in vitro. | 1990 | Prostaglandins | pmid:2112770 |
Jongejan RC et al. | Effects of inflammatory mediators on the responsiveness of isolated human airways to methacholine. | 1990 | Am. Rev. Respir. Dis. | pmid:2240835 |
Marui N et al. | N-myc suppression and cell cycle arrest at G1 phase by prostaglandins. | 1990 | FEBS Lett. | pmid:2226777 |
Koyama Y et al. | Prostaglandin production by isolated Kupffer cells. | 1990 | Gastroenterol. Jpn. | pmid:2227259 |
Okuda-Ashitaka E et al. | Cyclic AMP-mediated inhibition of cell growth by prostaglandin D2 in a fibroblastic cell line (EBTr). | 1990 | Eicosanoids | pmid:1705811 |
Hamid-Bloomfield S et al. | The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C. | 1990 | Br. J. Pharmacol. | pmid:2119842 |
Ito S et al. | Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. | 1990 | Br. J. Pharmacol. | pmid:2158830 |
Imura Y et al. | Antagonistic action of AA-2414 on thromboxane A2/prostaglandin endoperoxide receptor in platelets and blood vessels. | 1990 | Jpn. J. Pharmacol. | pmid:2137886 |
Featherstone RL et al. | Evidence for thromboxane receptor mediated contraction of guinea-pig and human airways in vitro by prostaglandin (PG) D2, 9 alpha,11 beta-PGF2 and PGF2 alpha. | 1990 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2142256 |
Virgolini I et al. | Effects of bopindolol on platelet function in hypertension at rest and during exercise. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2143586 |
Nakahata N et al. | PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells. | 1990 | Prostaglandins | pmid:2177901 |
Massey WA and Lichtenstein LM | The effects of antihistamines beyond H1 antagonism in allergic inflammation. | 1990 | J. Allergy Clin. Immunol. | pmid:1979797 |
White RP et al. | Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus. | 1990 | Am. J. Med. Sci. | pmid:2321665 |
Uda R et al. | Nociceptive effects induced by intrathecal administration of prostaglandin D2, E2, or F2 alpha to conscious mice. | 1990 | Brain Res. | pmid:2322844 |
Broide DH et al. | Airway levels of mast cell-derived mediators in exercise-induced asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:1689974 |
Undem BJ et al. | Inhibition by adenosine 3':5'-monophosphate of eicosanoid and platelet-activating factor biosynthesis in the mouse PT-18 mast cell. | 1990 | J. Biol. Chem. | pmid:1691175 |
Saitoh O et al. | Effect of amogastrin on the release of various prostaglandins into gastric lumen in man. | 1989 Mar-Apr | Jpn. J. Med. | pmid:2733241 |
Tejedor M et al. | Potentiation of radiation toxicity in C-6 glioma cells by prostaglandin D2. | 1989 Jul-Aug | Anticancer Res. | pmid:2817802 |
Ishikawa H et al. | [Changes of protein and RNA content in accumulated G1 cells by delta12-PGJ2]. | 1989 | Gan To Kagaku Ryoho | pmid:2930205 |
Kerr JS et al. | Effects of recombinant interleukin-1 beta on phospholipase A2 activity, phospholipase A2 mRNA levels, and eicosanoid formation in rabbit chondrocytes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2558648 |
Koshihara Y and Kawamura M | Prostaglandin D2 stimulates calcification of human osteoblastic cells. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2930558 |
Kawabe Y et al. | Genesis and recovery of ethanol-induced gastric lesions in rats: possible involvement of prostaglandin D2. | 1989 | Am. J. Gastroenterol. | pmid:2916522 |
Sakai T et al. | Protection by cycloheximide against cytotoxicity induced by vincristine, colchicine, or delta 12-prostaglandin J2 on human osteosarcoma cells. | 1989 | Cancer Res. | pmid:2917351 |
Naclerio RM et al. | The effect of cetirizine on early allergic response. | 1989 | Laryngoscope | pmid:2566879 |
Wolfe LS et al. | Synthesis and functions of cyclooxygenase and lipoxygenase products in brain: new findings and an appraisal. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2568735 |
Wolfe LS and Pellerin L | Arachidonic acid metabolites in the rat and human brain. New findings on the metabolism of prostaglandin D2 and lipoxygenase products. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2570544 |
Bhattacharya SK et al. | Effect of centrally administered prostaglandin D2 and some prostaglandin synthesis inhibitors on carrageenan-induced paw oedema in rats. | 1989 | J. Pharm. Pharmacol. | pmid:2571705 |
Zehr BB et al. | Use of segmental airway lavage to obtain relevant mediators from the lungs of asthmatic and control subjects. | 1989 | Chest | pmid:2539958 |
Benyon RC | The human skin mast cell. | 1989 | Clin. Exp. Allergy | pmid:2667702 |
Leynadier F | [Mast cells and basophils in asthma]. | 1989 | Ann. Biol. Clin. (Paris) | pmid:2675683 |
Hamid-Bloomfield S and Whittle BJ | Antagonism of PGD2 vasodepressor responses in the rat in vivo by the novel, selective antagonist, BW A868C. | 1989 | Br. J. Pharmacol. | pmid:2647205 |
Kuiper J et al. | The role of prostaglandins in endotoxin stimulated glycogenolysis in the liver. | 1989 | Agents Actions | pmid:2653002 |
Amano N et al. | The effect of pentobarbital and ether anesthesia on rat brain PGD2 content. | 1989 | Agressologie | pmid:2610292 |
Shram SI et al. | [Preparation and properties of prostaglandin D2 labelled with tritium with high molar radioactivity]. | 1989 | Bioorg. Khim. | pmid:2590255 |
Yamada K | [The effect of prostaglandin D2 on rat testicular testosterone levels]. | 1989 | Nihon Naibunpi Gakkai Zasshi | pmid:2591605 |
Trist DG et al. | The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. | 1989 | Br. J. Pharmacol. | pmid:2466517 |
Triggiani M et al. | Inhibition of histamine and prostaglandin D2 release from human lung mast cells by ciclosporin A. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468619 |
Robinson C et al. | The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways. | 1989 | Biochem. Pharmacol. | pmid:2818626 |
Emery DL et al. | Prostaglandin D2 causes accumulation of eosinophils in the lumen of the dog trachea. | 1989 | J. Appl. Physiol. | pmid:2793725 |
Yoshimura S et al. | Prostaglandin D2 receptor of mastocytoma P-815 cells--possible regulation by phosphorylation and dephosphorylation. | 1989 | Biochim. Biophys. Acta | pmid:2497784 |
Ikai K et al. | Prostaglandin D2, a mediator in both immediate and delayed-type immune reactions in the skin. | 1989 | Dermatologica | pmid:2506083 |
Hatanaka M et al. | Late-phase accumulation of inositol phosphates stimulated by prostaglandins D2 and F2 alpha in neuroblastoma x glioma hybrid NG108-15 cells. | 1989 | J. Neurochem. | pmid:2507741 |
Urade Y et al. | The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. | 1989 | J. Immunol. | pmid:2509561 |
Ito S et al. | Prostaglandin D2: a biochemical perspective. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2510183 |
Lapointe DS and Olson MS | Platelet-activating factor-stimulated hepatic glycogenolysis is not mediated through cyclooxygenase-derived metabolites of arachidonic acid. | 1989 | J. Biol. Chem. | pmid:2501299 |
Virgolini I et al. | Effects of taprostene, a chemically stable prostacyclin analogue, in patients with ischaemic peripheral vascular disease: a placebo controlled double-blind trial. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2514430 |
Robinson C et al. | The IgE- and calcium-dependent release of eicosanoids and histamine from human purified cutaneous mast cells. | 1989 | J. Invest. Dermatol. | pmid:2504819 |
Stürzebecher S et al. | Effects of PGD2, PGE1, and PGI2-analogues on PGDF-release and aggregation of human gelfiltered platelets. | 1989 | Prog. Clin. Biol. Res. | pmid:2477855 |
Cohan VL et al. | Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin. | 1989 | Am. Rev. Respir. Dis. | pmid:2478059 |
Reshef A et al. | The pattern and kinetics in human skin of erythema and mediators during the acute and late-phase response (LPR). | 1989 | J. Allergy Clin. Immunol. | pmid:2478604 |
Marone G et al. | Human basophil/mast cell releasability. VII. Heterogeneity of the effect of adenosine on mediator secretion. | 1989 | Life Sci. | pmid:2480501 |
Giles H et al. | The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. | 1989 | Br. J. Pharmacol. | pmid:2924081 |
Reiss TF et al. | Local mediator release after antigen challenge of a bronchial segment in allergic dogs. | 1989 | Am. J. Physiol. | pmid:2481982 |
Levi-Schaffer F and Shalit M | Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells activated with peptides. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2482257 |
Watanabe K | [Structure and function of prostaglandin F synthetase]. | 1989 | Seikagaku | pmid:2693551 |
Preclik G et al. | Alimentary tract and pancreas. Stimulation of mucosal prostaglandin synthesis in human stomach and duodenum by antacid treatment. | 1989 | Gut | pmid:2703138 |
Napier FE and Temple DM | The influence of xanthines on the contractile responses of PGF2 alpha and PGD2 in human parenchymal strips. | 1989 | Prostaglandins | pmid:2772222 |
Dieter P et al. | 4-Bromophenacyl bromide inhibits prostaglandin D2 synthesis from arachidonic acid rather than phospholipase A2 activity in liver macrophages. | 1989 | Biol. Chem. Hoppe-Seyler | pmid:2775481 |
Coe JY et al. | A fetal-instrumented model to study age-specific responses to leukotriene D4 and prostaglandin D2 in unsedated newborn lambs. | 1989 | Can. J. Physiol. Pharmacol. | pmid:2776077 |
Ehara H | [An experimental study on antitumor effect of prostaglandin D2]. | 1989 | Nihon Geka Gakkai Zasshi | pmid:2796985 |
Thierauch KH et al. | ZK 110 841--a selective and potent prostaglandin D2 analogue. | 1989 | Prog. Clin. Biol. Res. | pmid:2798462 |
Ashida Y et al. | A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. | 1989 | Prostaglandins | pmid:2748922 |
Raisz LG and Woodiel FN | Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin. | 1989 | Prostaglandins | pmid:2727307 |
Wolfe LS et al. | Metabolism of prostaglandin D2 by human cerebral cortex into 9 alpha, 11 beta-prostaglandin F2 by an active NADPH-dependent 11-ketoreductase. | 1989 | J. Neurochem. | pmid:2723663 |
Rodriguez y Baena R et al. | Effects of nicardipine on the ex vivo release of eicosanoids after experimental subarachnoid hemorrhage. | 1989 | J. Neurosurg. | pmid:2585083 |