PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fox CC et al. | Enhancement of human intestinal mast cell mediator release in active ulcerative colitis. | 1990 | Gastroenterology | pmid:1693122 |
| Ikai K and Fukushima M | Effects of cytotoxic prostaglandin, delta 12-PGJ2 on protein synthesis and cytoskeleton in transformed epidermal cells in culture. | 1990 | Arch. Dermatol. Res. | pmid:1693839 |
| Ashby B | Novel mechanism of heterologous desensitization of adenylate cyclase: prostaglandins bind with different affinities to both stimulatory and inhibitory receptors on platelets. | 1990 | Mol. Pharmacol. | pmid:1695318 |
| Atkins PC et al. | In vivo antigen-induced cutaneous mediator release: simultaneous comparisons of histamine, tryptase, and prostaglandin D2 release and the effect of oral corticosteroid administration. | 1990 | J. Allergy Clin. Immunol. | pmid:1698845 |
| Pipkorn U | H1-antagonists as a tool in clarifying the pathophysiology of nasal allergy. | 1990 | Clin. Exp. Allergy | pmid:1699643 |
| Knapp HR | Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor. | 1990 | N. Engl. J. Med. | pmid:1701029 |
| Liu MC et al. | Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:2368958 |
| GarcÃa-Sáinz JA et al. | Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2. | 1990 | Biochem. J. | pmid:2375756 |
| Zavoico GB et al. | Enhancement of thrombin- and ionomycin-stimulated prostacyclin and platelet-activating factor production in cultured endothelial cells by a tumor-promoting phorbol ester. | 1990 | J. Cell. Physiol. | pmid:2113537 |
| Woodward DF et al. | Studies on the ocular pharmacology of prostaglandin D2. | 1990 | Invest. Ophthalmol. Vis. Sci. | pmid:2298534 |
| Goh Y and Nakajima M | Stimulatory effects of prostaglandin D2 analogues on adenylate cyclase in rabbit iris-ciliary body membrane fractions. | 1990 | Exp. Eye Res. | pmid:2249731 |
| Khan SH and Sorof S | Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2251282 |
| Nishimura G | [Antitumor activity and cell cycle effects of delta 12-PGJ2 in vivo]. | 1990 | Nihon Gan Chiryo Gakkai Shi | pmid:2351856 |
| Ford WD et al. | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. | 1990 | J. Pediatr. Surg. | pmid:2352080 |
| Okumura T and Saito K | Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver. | 1990 | Prostaglandins | pmid:2353117 |
| Williams WR et al. | In vitro tests for the diagnosis of aspirin-sensitive asthma. | 1990 | J. Allergy Clin. Immunol. | pmid:2146311 |
| Winter JS et al. | A stimulatory effect of interleukin-1 on adrenocortical cortisol secretion mediated by prostaglandins. | 1990 | Endocrinology | pmid:2169407 |
| Nambu F et al. | Inhibitory effects of OKY-046 on spasmogen-induced bronchoconstrictions in sensitized and non-sensitized guinea pigs. | 1990 | Jpn. J. Pharmacol. | pmid:2313938 |
| Simpkins CO et al. | Prostaglandin D2 modulates human neutrophil intracellular calcium flux and inhibits superoxide release via its ring carbonyl. | 1990 | Life Sci. | pmid:2319907 |
| Gadsby JE et al. | Prostaglandin F2 alpha receptors on enzyme-dissociated pig luteal cells throughout the estrous cycle. | 1990 | Endocrinology | pmid:2153525 |
| Friedmann PS et al. | Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di-acyl glycerol but not TPA. | 1990 | J. Cell. Physiol. | pmid:2303529 |
| Urade Y et al. | Mast cells contain spleen-type prostaglandin D synthetase. | 1990 | J. Biol. Chem. | pmid:2403560 |
| Mori H et al. | Augmentation of antiproliferative activity of recombinant human tumor necrosis factor by delta 12-prostaglandin J2. | 1990 | J Biol Response Mod | pmid:2341865 |
| Bochner BS et al. | Interleukin-1 is released at sites of human cutaneous allergic reactions. | 1990 | J. Allergy Clin. Immunol. | pmid:2262641 |
| Doyle WJ et al. | Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy. | 1990 | J. Allergy Clin. Immunol. | pmid:2262647 |
| Nishino S et al. | Prostaglandin E2 levels in cerebrospinal fluid of normal and narcoleptic dogs. | 1990 | Biol. Psychiatry | pmid:2268692 |
| Kawano S et al. | Protective effect of PGD2 against ethanol-induced gastric mucosal injury in rats. | 1990 | J. Clin. Gastroenterol. | pmid:2212542 |
| Woodward DF et al. | Thromboxane A2-mimetics are potent microvascular permeability factors in the conjunctiva. | 1990 | J. Pharmacol. Exp. Ther. | pmid:2213558 |
| Katsuura G et al. | Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1 beta-induced ACTH release. | 1990 | Am. J. Physiol. | pmid:1967907 |
| Vigano' T et al. | Binding sites for histamine and sulfidopeptide leukotrienes in normal and hypersensitized human lung fragments. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2144691 |
| Eggleston PA et al. | Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells. | 1990 | Am. Rev. Respir. Dis. | pmid:1691604 |
| Fukushima M | Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved. | 1990 | Eicosanoids | pmid:2073399 |
| Inoue M et al. | Interactions between the brain renin-angiotensin system and brain prostanoids in the control of vasopressin secretion. | 1990 | Exp Brain Res | pmid:2073934 |
| Bennegård B et al. | Luteotropic effects of prostaglandins I2 and D2 on isolated human corpora luteum. | 1990 | Fertil. Steril. | pmid:2168845 |
| Eriksson LO et al. | Prostaglandin E2 binding sites in human renal tissue: characterization and localization by radioligand binding and autoradiography. | 1990 | Acta Physiol. Scand. | pmid:2173350 |
| Lysz TW et al. | Kupffer cell-hepatocyte interactions and the changes in 1-14C-arachidonate incorporation in response to endotoxin in vitro. | 1990 | Prostaglandins | pmid:2112770 |
| Marui N et al. | N-myc suppression and cell cycle arrest at G1 phase by prostaglandins. | 1990 | FEBS Lett. | pmid:2226777 |
| Koyama Y et al. | Prostaglandin production by isolated Kupffer cells. | 1990 | Gastroenterol. Jpn. | pmid:2227259 |
| Okuda-Ashitaka E et al. | Cyclic AMP-mediated inhibition of cell growth by prostaglandin D2 in a fibroblastic cell line (EBTr). | 1990 | Eicosanoids | pmid:1705811 |
| Hamid-Bloomfield S et al. | The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C. | 1990 | Br. J. Pharmacol. | pmid:2119842 |
| Ito S et al. | Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. | 1990 | Br. J. Pharmacol. | pmid:2158830 |
| Imura Y et al. | Antagonistic action of AA-2414 on thromboxane A2/prostaglandin endoperoxide receptor in platelets and blood vessels. | 1990 | Jpn. J. Pharmacol. | pmid:2137886 |
| Featherstone RL et al. | Evidence for thromboxane receptor mediated contraction of guinea-pig and human airways in vitro by prostaglandin (PG) D2, 9 alpha,11 beta-PGF2 and PGF2 alpha. | 1990 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2142256 |
| Tzung SP et al. | Suppression of hepatic lymphokine-activated killer cell induction by murine Kupffer cells and hepatocytes. | 1990 | Hepatology | pmid:2210667 |
| Virgolini I et al. | Effects of bopindolol on platelet function in hypertension at rest and during exercise. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2143586 |
| Nakahata N et al. | PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells. | 1990 | Prostaglandins | pmid:2177901 |
| Massey WA and Lichtenstein LM | The effects of antihistamines beyond H1 antagonism in allergic inflammation. | 1990 | J. Allergy Clin. Immunol. | pmid:1979797 |
| White RP et al. | Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus. | 1990 | Am. J. Med. Sci. | pmid:2321665 |
| Uda R et al. | Nociceptive effects induced by intrathecal administration of prostaglandin D2, E2, or F2 alpha to conscious mice. | 1990 | Brain Res. | pmid:2322844 |
| Schulman ES et al. | Histochemical heterogeneity of dispersed human lung mast cells. | 1990 | J. Immunol. | pmid:1692857 |