PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhuang H et al. | Prostaglandins of J series control heme oxygenase expression: potential significance in modulating neuroinflammation. | 2003 | Ann. N. Y. Acad. Sci. | pmid:12853315 |
| Figueiredo-Pereira ME et al. | Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. | 2016 | Ann. N. Y. Acad. Sci. | pmid:26748744 |
| Padilla J et al. | PPAR-gamma-mediated regulation of normal and malignant B lineage cells. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818446 |
| Padilla J et al. | Effects of 15-deoxy-delta 12,14-PGJ2 on B lineage cells. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818475 |
| Fukushima M et al. | Prostaglandin J2 and related compounds. Mode of action in G1 arrest and preclinical results. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825837 |
| Barrett KE | Effect of histamine and other mast cell mediators on T84 epithelial cells. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456653 |
| Gayarre J et al. | Modification of proteins by cyclopentenone prostaglandins is differentially modulated by GSH in vitro. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17405918 |
| Okuyama S et al. | Redifferentiation of cancer cells: bestatin, estradiol, and prostaglandin D2. | 1985 | Ann. N. Y. Acad. Sci. | pmid:3868328 |
| Kim DH et al. | Effects of 15-deoxy-delta 12, 14-prostaglandin J2 on the expression of p53 in MCF-7 cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723057 |
| Song NY et al. | 15-Deoxy-delta 12, 14-prostaglandin J2 induces upregulation of multidrug resistance-associated protein 1 via Nrf2 activation in human breast cancer cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723058 |
| Cha B et al. | 15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723089 |
| Norman P et al. | BAY u3405 is a potent and competitive antagonist of U46619, PGD2 and 9 alpha, 11 beta PGF2 alpha-induced contractions of airway smooth muscle. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952564 |
| Nowak D et al. | Comparison of airway responsiveness to prostaglandin D2 and histamine, methacholine or exercise in healthy and asthmatic subjects. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952573 |
| Kim EH et al. | Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. | 2006 | Ann. N. Y. Acad. Sci. | pmid:17384282 |
| Hayaishi O | Prostaglandin D2 and sleep. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2774407 |
| Francis HP et al. | The thromboxane receptor antagonist BAY u3405 reverses prostaglandin D2 (PGD2)-induced bronchoconstriction in the anaesthetised guinea pig. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1835329 |
| Zhao X et al. | Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. | 2007 | Ann. Neurol. | pmid:17457822 |
| Liu JJ et al. | Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-gamma ligands induces apoptosis on human myeloid leukemia cells in vitro. | 2005 | Ann. Oncol. | pmid:15642706 |
| Brodsky L et al. | Arachidonic acid metabolites in middle ear effusions of children. | 1991 | Ann. Otol. Rhinol. Laryngol. | pmid:1648326 |
| Shimizu T et al. | A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage. | 2006 | Ann. Surg. | pmid:16794398 |
| Scott HW et al. | Hazards in operative management of patients with systemic mastocytosis. | 1983 | Ann. Surg. | pmid:6189461 |
| Austen KF | Doing what I like. | 2008 | Annu. Rev. Immunol. | pmid:17877459 |
| Chen SY et al. | 15-Deoxy-delta12,14-prostaglandin J2 induces apoptosis of a thyroid papillary cancer cell line (CG3 cells) through increasing intracellular iron and oxidative stress. | 2002 | Anticancer Drugs | pmid:12187333 |
| Eucker J et al. | Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. | 2004 | Anticancer Drugs | pmid:15514564 |
| Fulzele SV et al. | 15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. | 2007 | Anticancer Drugs | pmid:17159504 |
| Eucker J et al. | Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. | 2006 | Anticancer Drugs | pmid:16926626 |
| Dionne S et al. | PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. | 2010 | Anticancer Res. | pmid:20150631 |
| el Attar TM and Virji AS | Effects of indomethacin, cisplatin and delta 12-prostaglandin J2 on growth of oral squamous carcinoma cells. | 1997 Nov-Dec | Anticancer Res. | pmid:9494540 |
| Tejedor M et al. | Potentiation of radiation toxicity in C-6 glioma cells by prostaglandin D2. | 1989 Jul-Aug | Anticancer Res. | pmid:2817802 |
| Conde B et al. | Modulation of cell growth and differentiation induced by prostaglandin D2 in the glioma cell line C6. | 1991 Jan-Feb | Anticancer Res. | pmid:1902073 |
| Pica F et al. | Delta(12)-prostaglandin J(2) is a potent inhibitor of influenza A virus replication. | 2000 | Antimicrob. Agents Chemother. | pmid:10602750 |
| Conti C et al. | Inhibition of poliovirus replication by prostaglandins A and J in human cells. | 1996 | Antimicrob. Agents Chemother. | pmid:8834882 |
| Conti C et al. | Antiviral effect of hyperthermic treatment in rhinovirus infection. | 1999 | Antimicrob. Agents Chemother. | pmid:10103186 |
| Caito S et al. | Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages. | 2008 | Antioxid. Redox Signal. | pmid:17970647 |
| Gong P et al. | Activation of the mouse heme oxygenase-1 gene by 15-deoxy-Delta(12,14)-prostaglandin J(2) is mediated by the stress response elements and transcription factor Nrf2. | 2002 | Antioxid. Redox Signal. | pmid:12006176 |
| Jozkowicz A et al. | Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1. | 2002 | Antioxid. Redox Signal. | pmid:12230869 |
| Jozkowicz A et al. | 15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress. | 2008 | Antioxid. Redox Signal. | pmid:18665800 |
| Amici C et al. | Inhibition of Sendai virus replication by delta 12-prostaglandin J2: induction of heat shock protein synthesis and alteration of protein glycosylation. | 1992 | Antiviral Res. | pmid:1332600 |
| Parker J et al. | Antiviral effect of cyclopentenone prostaglandins on vesicular stomatitis virus replication. | 1995 | Antiviral Res. | pmid:7537950 |
| Pica F et al. | Inhibition of vesicular stomatitis virus replication by delta 12-prostaglandin J2 is regulated at two separate levels and is associated with induction of stress protein synthesis. | 1993 | Antiviral Res. | pmid:8385894 |
| Han H et al. | 15-Deoxy-delta 12,14-prostaglandin J2 (15d-PGJ 2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation. | 2007 | Apoptosis | pmid:17786557 |
| Rahman MS et al. | Cultured preadipocytes undergoing stable transfection with cyclooxygenase-1 in the antisense direction accelerate adipogenesis during the maturation phase of adipocytes. | 2013 | Appl. Biochem. Biotechnol. | pmid:23817787 |
| Syeda PK et al. | Generation of monoclonal antibody for 15-deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚ and development of enzyme-linked immunosorbent assay for its quantification in culture medium of adipocytes. | 2012 | Appl. Biochem. Biotechnol. | pmid:22391692 |
| Regulatory control and standardization of allergenic extracts. Clinical studies with "standardized" extracts. | 1985 | Arb Paul Ehrlich Inst Georg Speyer Haus Ferdinand Blum Inst Frankf A M | pmid:3901924 | |
| Morrow JD et al. | Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans following the application of sorbic acid. | 1994 | Arch Dermatol | pmid:7979442 |
| Leifke E et al. | In vivo comparative study of the seizure- and ischemia-induced synthesis of eicosanoids in the brain of gerbils. | 1994 Sep-Oct | Arch Int Pharmacodyn Ther | pmid:7710301 |
| Hayaishi O et al. | Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep. | 2004 | Arch Ital Biol | pmid:15493554 |
| Ujihara M et al. | Biochemical and immunological demonstration of prostaglandin D2, E2, and F2 alpha formation from prostaglandin H2 by various rat glutathione S-transferase isozymes. | 1988 | Arch. Biochem. Biophys. | pmid:3041912 |
| Kitatani K et al. | Ceramide accelerates dephosphorylation of extracellular signal-regulated kinase 1/2 to decrease prostaglandin D(2) production in RBL-2H3 cells. | 2001 | Arch. Biochem. Biophys. | pmid:11697858 |
| Ujihara M et al. | Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rats. | 1988 | Arch. Biochem. Biophys. | pmid:3124755 |