PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miyake A et al. | Prostaglandin D2 stimulates secretion of luteinizing hormone from pituitary gland in vitro. | 1983 | Acta Endocrinol. | pmid:6579807 |
| Soifer SJ et al. | The developmental effects of prostaglandin D2 on the pulmonary and systemic circulations in the newborn lamb. | 1983 | J. Dev. Physiol. | pmid:6579103 |
| Ruzicka T et al. | Changes in arachidonic acid metabolism in UV-irradiated hairless mouse skin. | 1983 | J. Invest. Dermatol. | pmid:6578273 |
| Juhlin L et al. | Effect of infrared irradiation on the recoverable levels of free arachidonic acid and prostaglandins in human forearm skin. | 1983 | J. Invest. Dermatol. | pmid:6578272 |
| Fitzpatrick FA and Wynalda MA | Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. | 1983 | J. Biol. Chem. | pmid:6578214 |
| Schulman ES et al. | Purified human basophils and mast cells: current concepts of mediator release. | 1983 | Eur J Respir Dis Suppl | pmid:6578086 |
| Fukushima M | [Development of antineoplastic prostaglandins]. | 1983 | Gan To Kagaku Ryoho | pmid:6577812 |
| Philips JB and Lyrene RK | Persistent pulmonary hypertension and prostaglandin D2. | 1983 | Prog. Clin. Biol. Res. | pmid:6577475 |
| Ohkubo T et al. | Effect of prostaglandin D2 on pain and inflammation. | 1983 | Jpn. J. Pharmacol. | pmid:6576182 |
| Higashida H et al. | Cytotoxic action of prostaglandin D2 on mouse neuroblastoma cells. | 1983 | Int. J. Cancer | pmid:6574994 |
| Hensby CN et al. | Prostaglandins in human skin disease. | 1983 | Br. J. Dermatol. | pmid:6574787 |
| Kondo K et al. | Effects of intracerebroventricular administration of prostaglandin D2 and angiotensin II on blood pressure in conscious rats. | 1983 | Jpn Heart J | pmid:6574266 |
| Simmet T and Jaffe BM | Inhibition of B-16 melanoma growth in vitro by prostaglandin D2. | 1983 | Prostaglandins | pmid:6573723 |
| Gerritsen ME | PGD2 formation in the vasculature: characteristics of rat tail vein prostaglandin endoperoxide-D isomerase. | 1983 | Prostaglandins | pmid:6573722 |
| Abelson MB et al. | Aspirin therapy in vernal conjunctivitis. | 1983 | Am. J. Ophthalmol. | pmid:6573138 |
| Kootte AM et al. | The flush syndrome: an expression of systemic mastocytosis with increased prostaglandin D2 production. | 1983 | Neth J Med | pmid:6572798 |
| Sakai T et al. | Prostaglandin D2 inhibits the proliferation of human neuroblastoma cells. | 1983 | Cancer Lett. | pmid:6572553 |
| Feinstein MB et al. | Reversal of thrombin-induced myosin phosphorylation and the assembly of cytoskeletal structures in platelets by the adenylate cyclase stimulants prostaglandin D2 and forskolin. | 1983 | J. Biol. Chem. | pmid:6571835 |
| Barrow SE et al. | Measurement of prostaglandin D2 and identification of metabolites in human plasma during intravenous infusion. | 1984 | Prostaglandins | pmid:6441188 |
| Holgate ST and Robinson C | 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells. | 1984 | Br. J. Pharmacol. | pmid:6439267 |
| Ikai K et al. | Prostaglandin D2 and prostaglandin D synthetase in mast cell deficient mice. | 1984 | Prostaglandins | pmid:6435183 |
| Vicenzi E et al. | Human mononuclear phagocytes from different anatomical sites differ in their capacity to metabolize arachidonic acid. | 1984 | Clin. Exp. Immunol. | pmid:6432383 |
| Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
| Gresele P et al. | Serum albumin enhances the impairment of platelet aggregation with thromboxane synthase inhibition by increasing the formation of prostaglandin D2. | 1984 | Biochem. Pharmacol. | pmid:6430299 |
| Erman A and Nasjletti A | Enhancement of renal medulla prostaglandin synthetase activity by dexamethasone treatment in the rat. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428405 |
| Kawamura M and Koshihara Y | Prostaglandin D2 lowers nuclear DNA polymerase activity in cultured mastocytoma cells. | 1984 | Prostaglandins | pmid:6427850 |
| Ogorochi T et al. | Regional distribution of prostaglandins D2, E2, and F2 alpha and related enzymes in postmortem human brain. | 1984 | J. Neurochem. | pmid:6427411 |
| Dembinska-Kieć A et al. | Formation of leukotriene C4-like material by rat brain tissue. | 1984 | Eur. J. Pharmacol. | pmid:6426980 |
| Bertelé V et al. | Pharmacologic inhibition of thromboxane synthetase and platelet aggregation: modulatory role of cyclooxygenase products. | 1984 | Blood | pmid:6426554 |
| Schick B et al. | Activation of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1984 | J. Immunol. | pmid:6425408 |
| Rao PS et al. | Prostaglandin D2 in canine endotoxic shock. Hemodynamic, hematologic, biochemical, and blood gas analyses. | 1984 | Am. J. Obstet. Gynecol. | pmid:6424477 |
| Drummond WH | Persistent pulmonary hypertension of the neonate (persistent fetal circulation syndrome). | 1983 | Adv Pediatr | pmid:6424420 |
| Ruzicka T et al. | Inhibition of rat mast cell arachidonic acid cyclooxygenase by dapsone. | 1983 | J. Allergy Clin. Immunol. | pmid:6413566 |
| Lifschitz MD | Renal effects of nonsteroidal anti-inflammatory agents. | 1983 | J. Lab. Clin. Med. | pmid:6411840 |
| Osama H et al. | Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids. | 1983 | Biochim. Biophys. Acta | pmid:6407532 |
| Ahlquist DA et al. | Factors influencing metabolism of arachidonic acid in guinea pig gastric mucosa. | 1983 | Am. J. Physiol. | pmid:6401937 |
| Vincent JE et al. | The effect of 5-(2-chlorobenzyl)-5,6,7,7a-tetrahydro 4H-thieno (3.2-C)-pyridine-2-one hydrochloride (PCR 3787), a metabolite of ticlopidine, on the aggregation of human platelets in vitro and on the aggregation inhibiting action of PGI2 and PGD2. | 1984 | Prostaglandins Leukot Med | pmid:6396655 |
| Philips JB and Lyrene RK | Prostaglandins, related compounds, and the perinatal pulmonary circulation. | 1984 | Clin Perinatol | pmid:6386270 |
| Uchizono K | [Studies of sleep inducing substance]. | 1984 | Nippon Rinsho | pmid:6384575 |
| Neely SM et al. | Mechanism and characteristics of platelet activation by haematin. | 1984 | Br. J. Haematol. | pmid:6383458 |
| Bito LZ | Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. | 1984 | Exp. Eye Res. | pmid:6370708 |
| Gimeno AL et al. | Prostacyclin induces a surprising long-lasting motility in quiescent uterine strips (indomethacin-treated) isolated from ovariectomized rats. | 1983 | Prostaglandins | pmid:6361911 |
| Horie H et al. | Modulation by prostaglandin D2 of glucagon and insulin secretion in the perfused rat pancreas. | 1983 | Prostaglandins Leukot Med | pmid:6361782 |
| Tasaka K et al. | Prostaglandin D2 induces release of luteinizing hormone from the rat pituitary gland without the modulation of hypothalamic luteinizing hormone releasing hormone. | 1983 | J. Endocrinol. | pmid:6361197 |
| Bedwani JR et al. | Effects of prostaglandins E2, I2 and D2 on pig nasal vasculature. | 1983 | Clin Otolaryngol Allied Sci | pmid:6357570 |
| Inoué S | [Sleep substances: their roles and evolution]. | 1983 | Seikagaku | pmid:6355327 |
| Naclerio RM et al. | Mediator release after nasal airway challenge with allergen. | 1983 | Am. Rev. Respir. Dis. | pmid:6354022 |
| Homma T and Malik KU | Effect of secretin and caerulein in canine pancreas: relation to prostaglandins. | 1983 | Am. J. Physiol. | pmid:6344655 |
| Whittle BJ et al. | Platelet and cardiovascular activity of the hydantoin BW245C, a potent prostaglandin analogue. | 1983 | Prostaglandins | pmid:6344147 |
| Hawk JL et al. | Increased concentrations of arachidonic acid, prostaglandins E2, D2, and 6-oxo-F1 alpha, and histamine in human skin following UVA irradiation. | 1983 | J. Invest. Dermatol. | pmid:6343514 |