Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
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Sinha D et al. | 15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene. | 1999 | Metab. Clin. Exp. | pmid:10381155 |
Miadonna A et al. | Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. | 1999 | Clin. Exp. Allergy | pmid:10383595 |
Hayaishi O | Prostaglandin D2 and sleep--a molecular genetic approach. | 1999 | J Sleep Res | pmid:10389108 |
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Sarraf P et al. | Loss-of-function mutations in PPAR gamma associated with human colon cancer. | 1999 | Mol. Cell | pmid:10394368 |
O'Sullivan S et al. | Analyses of prostaglandin D2 metabolites in urine: comparison between enzyme immunoassay and negative ion chemical ionisation gas chromatography-mass spectrometry. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410385 |
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Obata T et al. | Eicosapentaenoic acid inhibits prostaglandin D2 generation by inhibiting cyclo-oxygenase-2 in cultured human mast cells. | 1999 | Clin. Exp. Allergy | pmid:10457118 |
Stillman BA et al. | Importance of the extracellular domain for prostaglandin EP(2) receptor function. | 1999 | Mol. Pharmacol. | pmid:10462542 |
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Keelan JA et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10471366 |
Jackson SM et al. | Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10479650 |
Furutani K et al. | Substance P- and antigen-induced release of leukotriene B4, prostaglandin D2 and histamine from guinea pig skin by different mechanisms in vitro. | 1999 Jul-Aug | Arch. Dermatol. Res. | pmid:10482019 |
Pucci ML et al. | Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. | 1999 | Am. J. Physiol. | pmid:10484490 |
Santos J et al. | Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy. | 1999 | Gut | pmid:10486364 |
Alvarez-Dolado M et al. | Retinoic acid and 1,25-dihydroxyvitamin D3 inhibit tenascin-C expression in rat glioma C6 cells. | 1999 | J. Neurosci. Res. | pmid:10502285 |
Anderson LE et al. | Prostaglandin moieties that determine receptor binding specificity in the bovine corpus luteum. | 1999 | J. Reprod. Fertil. | pmid:10505064 |
Clay CE et al. | Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells. | 1999 | Carcinogenesis | pmid:10506103 |
Valmaseda A et al. | Opposite regulation of PPAR-alpha and -gamma gene expression by both their ligands and retinoic acid in brown adipocytes. | 1999 | Mol. Cell. Endocrinol. | pmid:10509805 |
Asano M et al. | Troglitazone and pioglitazone attenuate agonist-dependent Ca2+ mobilization and cell proliferation in vascular smooth muscle cells. | 1999 | Br. J. Pharmacol. | pmid:10516648 |
Reddy ST et al. | Genetic evidence for distinct roles of COX-1 and COX-2 in the immediate and delayed phases of prostaglandin synthesis in mast cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10548515 |
Graf BA et al. | Biphenotypic B/macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin E(2) production in response to pro-inflammatory signals. | 1999 | Eur. J. Immunol. | pmid:10556836 |
Jang MK et al. | Regulation of ferritin light chain gene expression by oxidized low-density lipoproteins in human monocytic THP-1 cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10558912 |
Petersen LJ and Skov PS | The effect of salmeterol and salbutamol on mediator release and skin responses in immediate and late phase allergic cutaneous reactions. | 1999 | Inflamm. Res. | pmid:10563469 |
Vaidya S et al. | 15-Deoxy-Delta12,1412,14-prostaglandin J2 inhibits the beta2 integrin-dependent oxidative burst: involvement of a mechanism distinct from peroxisome proliferator-activated receptor gamma ligation. | 1999 | J. Immunol. | pmid:10570310 |
Thornhill J and Asselin J | Temperature and hemodynamic changes associated with increased neural damage to global hemispheric hypoxic ischemia by prior prostaglandin E2, D2 and F2alpha administration. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574644 |
Tokuda H et al. | Prostaglandin D2 induces interleukin-6 synthesis via Ca2+ mobilization in osteoblasts: regulation by protein kinase C. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10582659 |
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Pica F et al. | Delta(12)-prostaglandin J(2) is a potent inhibitor of influenza A virus replication. | 2000 | Antimicrob. Agents Chemother. | pmid:10602750 |
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Clark RB et al. | The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses. | 2000 | J. Immunol. | pmid:10640751 |
Reilly CM et al. | Inhibition of mesangial cell nitric oxide in MRL/lpr mice by prostaglandin J2 and proliferator activation receptor-gamma agonists. | 2000 | J. Immunol. | pmid:10640767 |
Dumont I et al. | Regulation of endothelial nitric oxide synthase by PGD(2) in the developing choroid. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10644584 |
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Butler R et al. | Nonapoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferator-activated receptor gamma ligand, 15-deoxy-delta12,14-prostaglandin J2. | 2000 | Cell Growth Differ. | pmid:10672903 |
Liu JH | Circadian variations of prostaglandins in the rabbit aqueous humor. | 2000 | J Ocul Pharmacol Ther | pmid:10673131 |
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Charpigny G et al. | Correlation of increased concentration of ovine endometrial cyclooxygenase 2 with the increase in PGE2 and PGD2 in the late luteal phase. | 1999 | J. Reprod. Fertil. | pmid:10690199 |
Yamashita M et al. | Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells. | 2000 | Br. J. Pharmacol. | pmid:10694244 |
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Chan CL et al. | Characterization of prostanoid receptors mediating inhibition of histamine release from anti-IgE-activated rat peritoneal mast cells. | 2000 | Br. J. Pharmacol. | pmid:10711359 |
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Sanchez Mejia RO et al. | Matrix-associated transforming growth factor-beta1 primes mouse bone marrow-derived mast cells for increased high-affinity Fc receptor for immunoglobulin E-dependent eicosanoid biosynthesis. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10783127 |
Feng J et al. | Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma. | 2000 | J. Lipid Res. | pmid:10787429 |
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Macfarlane AJ et al. | Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10806153 |
Taba Y et al. | Fluid shear stress induces lipocalin-type prostaglandin D(2) synthase expression in vascular endothelial cells. | 2000 | Circ. Res. | pmid:10807869 |
Padilla J et al. | PPAR-gamma-mediated regulation of normal and malignant B lineage cells. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818446 |
Padilla J et al. | Effects of 15-deoxy-delta 12,14-PGJ2 on B lineage cells. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818475 |
Hwang SW et al. | Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10823958 |
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