Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fox CC et al. | Enhancement of human intestinal mast cell mediator release in active ulcerative colitis. | 1990 | Gastroenterology | pmid:1693122 |
Ikai K and Fukushima M | Effects of cytotoxic prostaglandin, delta 12-PGJ2 on protein synthesis and cytoskeleton in transformed epidermal cells in culture. | 1990 | Arch. Dermatol. Res. | pmid:1693839 |
Ashby B | Novel mechanism of heterologous desensitization of adenylate cyclase: prostaglandins bind with different affinities to both stimulatory and inhibitory receptors on platelets. | 1990 | Mol. Pharmacol. | pmid:1695318 |
Zavoico GB et al. | Enhancement of thrombin- and ionomycin-stimulated prostacyclin and platelet-activating factor production in cultured endothelial cells by a tumor-promoting phorbol ester. | 1990 | J. Cell. Physiol. | pmid:2113537 |
Goh Y and Nakajima M | Stimulatory effects of prostaglandin D2 analogues on adenylate cyclase in rabbit iris-ciliary body membrane fractions. | 1990 | Exp. Eye Res. | pmid:2249731 |
Khan SH and Sorof S | Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2251282 |
Nishimura G | [Antitumor activity and cell cycle effects of delta 12-PGJ2 in vivo]. | 1990 | Nihon Gan Chiryo Gakkai Shi | pmid:2351856 |
Ford WD et al. | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. | 1990 | J. Pediatr. Surg. | pmid:2352080 |
Okumura T and Saito K | Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver. | 1990 | Prostaglandins | pmid:2353117 |
Perreault T et al. | Pulmonary vascular effects of prostaglandin D2 in newborn pig. | 1990 | Am. J. Physiol. | pmid:2337164 |
Ingenito EP et al. | Bronchoalveolar lavage cell and mediator responses to hyperpnea-induced bronchoconstriction in the guinea pig. | 1990 | Am. Rev. Respir. Dis. | pmid:2339838 |
Williams WR et al. | In vitro tests for the diagnosis of aspirin-sensitive asthma. | 1990 | J. Allergy Clin. Immunol. | pmid:2146311 |
Atsmon J et al. | Formation of thiol conjugates of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 and delta 12(E)-prostaglandin D2. | 1990 | Biochemistry | pmid:2340271 |
vom Dahl S et al. | Stimulation of release of prostaglandin D2 and thromboxane B2 from perfused rat liver by extracellular adenosine. | 1990 | Biochem. J. | pmid:2396991 |
Winter JS et al. | A stimulatory effect of interleukin-1 on adrenocortical cortisol secretion mediated by prostaglandins. | 1990 | Endocrinology | pmid:2169407 |
Atsmon J et al. | Conjugation of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 with intracellular glutathione and enhancement of its antiproliferative activity by glutathione depletion. | 1990 | Cancer Res. | pmid:2306739 |
Kikuchi Y et al. | [Therapeutic values of prostaglandin D2 in nude mice bearing human ovarian carcinoma]. | 1990 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:2313142 |
Nambu F et al. | Inhibitory effects of OKY-046 on spasmogen-induced bronchoconstrictions in sensitized and non-sensitized guinea pigs. | 1990 | Jpn. J. Pharmacol. | pmid:2313938 |
Simpkins CO et al. | Prostaglandin D2 modulates human neutrophil intracellular calcium flux and inhibits superoxide release via its ring carbonyl. | 1990 | Life Sci. | pmid:2319907 |
Gadsby JE et al. | Prostaglandin F2 alpha receptors on enzyme-dissociated pig luteal cells throughout the estrous cycle. | 1990 | Endocrinology | pmid:2153525 |
Friedmann PS et al. | Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di-acyl glycerol but not TPA. | 1990 | J. Cell. Physiol. | pmid:2303529 |
Deffebach ME et al. | Prostaglandins alter methacholine-induced secretion in ferret in vitro trachea. | 1990 | Am. J. Physiol. | pmid:2407140 |
Urade Y et al. | Mast cells contain spleen-type prostaglandin D synthetase. | 1990 | J. Biol. Chem. | pmid:2403560 |
Mori H et al. | Augmentation of antiproliferative activity of recombinant human tumor necrosis factor by delta 12-prostaglandin J2. | 1990 | J Biol Response Mod | pmid:2341865 |
Bochner BS et al. | Interleukin-1 is released at sites of human cutaneous allergic reactions. | 1990 | J. Allergy Clin. Immunol. | pmid:2262641 |
Doyle WJ et al. | Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy. | 1990 | J. Allergy Clin. Immunol. | pmid:2262647 |
Kudo M et al. | [Prostaglandin D2-endogenous regulator of physiological sleep-inhibited CRF-induced ACTH secretion from rat anterior pituitary cells]. | 1990 | Nihon Naibunpi Gakkai Zasshi | pmid:1962750 |
Nishino S et al. | Prostaglandin E2 levels in cerebrospinal fluid of normal and narcoleptic dogs. | 1990 | Biol. Psychiatry | pmid:2268692 |
Woodward DF et al. | Thromboxane A2-mimetics are potent microvascular permeability factors in the conjunctiva. | 1990 | J. Pharmacol. Exp. Ther. | pmid:2213558 |
Katsuura G et al. | Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1 beta-induced ACTH release. | 1990 | Am. J. Physiol. | pmid:1967907 |
Vigano' T et al. | Binding sites for histamine and sulfidopeptide leukotrienes in normal and hypersensitized human lung fragments. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2144691 |
Eggleston PA et al. | Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells. | 1990 | Am. Rev. Respir. Dis. | pmid:1691604 |
Fukushima M | Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved. | 1990 | Eicosanoids | pmid:2073399 |
Inoue M et al. | Interactions between the brain renin-angiotensin system and brain prostanoids in the control of vasopressin secretion. | 1990 | Exp Brain Res | pmid:2073934 |
Bennegård B et al. | Luteotropic effects of prostaglandins I2 and D2 on isolated human corpora luteum. | 1990 | Fertil. Steril. | pmid:2168845 |
Bettazzoli L et al. | Incorporation of arachidonic acid into glycerophospholipids of a murine bone marrow derived mast cell. | 1990 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2169185 |
Seiler S et al. | SQ-27986 inhibition of platelet aggregation is mediated through activation of platelet prostaglandin D2 receptors. | 1990 | Prostaglandins | pmid:2171039 |
Eriksson LO et al. | Prostaglandin E2 binding sites in human renal tissue: characterization and localization by radioligand binding and autoradiography. | 1990 | Acta Physiol. Scand. | pmid:2173350 |
Lysz TW et al. | Kupffer cell-hepatocyte interactions and the changes in 1-14C-arachidonate incorporation in response to endotoxin in vitro. | 1990 | Prostaglandins | pmid:2112770 |
Jongejan RC et al. | Effects of inflammatory mediators on the responsiveness of isolated human airways to methacholine. | 1990 | Am. Rev. Respir. Dis. | pmid:2240835 |
Marui N et al. | N-myc suppression and cell cycle arrest at G1 phase by prostaglandins. | 1990 | FEBS Lett. | pmid:2226777 |
Koyama Y et al. | Prostaglandin production by isolated Kupffer cells. | 1990 | Gastroenterol. Jpn. | pmid:2227259 |
Okuda-Ashitaka E et al. | Cyclic AMP-mediated inhibition of cell growth by prostaglandin D2 in a fibroblastic cell line (EBTr). | 1990 | Eicosanoids | pmid:1705811 |
Hamid-Bloomfield S et al. | The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C. | 1990 | Br. J. Pharmacol. | pmid:2119842 |
Ito S et al. | Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. | 1990 | Br. J. Pharmacol. | pmid:2158830 |
Tzung SP et al. | Suppression of hepatic lymphokine-activated killer cell induction by murine Kupffer cells and hepatocytes. | 1990 | Hepatology | pmid:2210667 |
White RP et al. | Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus. | 1990 | Am. J. Med. Sci. | pmid:2321665 |
Uda R et al. | Nociceptive effects induced by intrathecal administration of prostaglandin D2, E2, or F2 alpha to conscious mice. | 1990 | Brain Res. | pmid:2322844 |
Broide DH et al. | Airway levels of mast cell-derived mediators in exercise-induced asthma. | 1990 | Am. Rev. Respir. Dis. | pmid:1689974 |
Undem BJ et al. | Inhibition by adenosine 3':5'-monophosphate of eicosanoid and platelet-activating factor biosynthesis in the mouse PT-18 mast cell. | 1990 | J. Biol. Chem. | pmid:1691175 |
Proud D et al. | Inflammatory mediator release on conjunctival provocation of allergic subjects with allergen. | 1990 | J. Allergy Clin. Immunol. | pmid:1692049 |
Miadonna A et al. | Mediator release after endobronchial antigen challenge in patients with respiratory allergy. | 1990 | J. Allergy Clin. Immunol. | pmid:1692050 |
Schulman ES et al. | Histochemical heterogeneity of dispersed human lung mast cells. | 1990 | J. Immunol. | pmid:1692857 |
D'Onofrio C et al. | The antiproliferative effect of prostaglandin A and J on HTLV-I transformed cells is associated with induction of a heat-shock protein. | 1990 Sep-Oct | Pharmacol. Res. | pmid:2284244 |
Fox CC et al. | Modulation of mediator release from human intestinal mast cells by sulfasalazine and 5-aminosalicylic acid. | 1991 | Dig. Dis. Sci. | pmid:1703070 |
Keenan CM and Rangachari PK | Contrasting effects of PGE2 and PGD2: ion transport in the canine proximal colon. | 1991 | Am. J. Physiol. | pmid:2003610 |
Roberts LJ and Oates JA | Biochemical diagnosis of systemic mast cell disorders. | 1991 | J. Invest. Dermatol. | pmid:16799604 |
Shikada K et al. | NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea. | 1991 | Eur. J. Pharmacol. | pmid:1814761 |
Gaetani P et al. | Effect of high-dose methylprednisolone and U74006F on eicosanoid synthesis after subarachnoid hemorrhage in rats. | 1991 | Stroke | pmid:1900645 |
Brodsky L et al. | Arachidonic acid metabolites in middle ear effusions of children. | 1991 | Ann. Otol. Rhinol. Laryngol. | pmid:1648326 |
Weiler H et al. | Studies on the effects of aminopterin and methotrexate on the release of prostaglandin PGE2, PGD2, and PGI2 from small intestine in the rat in vivo. | 1991 | Clin. Chim. Acta | pmid:1769112 |
Watanabe T et al. | Characterization of prostaglandin and thromboxane receptors expressed on a megakaryoblastic leukemia cell line, MEG-01s. | 1991 | Blood | pmid:1718495 |
Minc-Golomb D et al. | Gene dosage of CuZnSOD and Down's syndrome: diminished prostaglandin synthesis in human trisomy 21, transfected cells and transgenic mice. | 1991 | EMBO J. | pmid:1829676 |
Tasaki Y et al. | Prostaglandin D2 metabolite stimulates collagen synthesis by human osteoblasts during calcification. | 1991 | Prostaglandins | pmid:1871375 |
Vesin MF et al. | Preferential synthesis of prostaglandin D2 by neurons and prostaglandin E2 by fibroblasts and nonneuronal cells in chick dorsal root ganglia. | 1991 | J. Neurochem. | pmid:2051162 |
Ramis I et al. | In vivo release of 15-HETE and other arachidonic acid metabolites in nasal secretions during early allergic reactions. | 1991 | Prostaglandins | pmid:1662405 |
Hori T et al. | Prostaglandins antagonize fibroblast proliferation stimulated by tumor necrosis factor. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1993070 |
White MV et al. | Hydrocortisone inhibits rat basophilic leukemia cell mediator release induced by neutrophil-derived histamine releasing activity as well as by anti-IgE. | 1991 | J. Immunol. | pmid:1712816 |
Morii H and Watanabe Y | Solubilization of prostaglandin D2 binding protein from porcine temporal cortex. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1989614 |
Dore-Duffy P et al. | Cerebrospinal fluid eicosanoid levels: endogenous PGD2 and LTC4 synthesis by antigen-presenting cells that migrate to the central nervous system. | 1991 | Neurology | pmid:1992386 |
Wenzel SE et al. | Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: relationship to the development of late asthmatic responses. | 1991 | J. Allergy Clin. Immunol. | pmid:1993813 |
Norman P et al. | BAY u3405 is a potent and competitive antagonist of U46619, PGD2 and 9 alpha, 11 beta PGF2 alpha-induced contractions of airway smooth muscle. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952564 |
Nowak D et al. | Comparison of airway responsiveness to prostaglandin D2 and histamine, methacholine or exercise in healthy and asthmatic subjects. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952573 |
Alving K et al. | The possible role of prostaglandin D2 in the long-lasting airways vasodilatation induced by allergen in the sensitized pig. | 1991 | Acta Physiol. Scand. | pmid:1957709 |
Gebicke-Haerter PJ et al. | Pertussis and cholera toxins inhibit prostaglandin synthesis in rat astrocyte cultures at distinct metabolic steps. | 1991 | Biochem. Pharmacol. | pmid:1909527 |
Sasaki H et al. | Human ovarian cancer cell lines resistant to cisplatin, doxorubicin, and L-phenylalanine mustard are sensitive to delta 7-prostaglandin A1 and delta 12-prostaglandin J2. | 1991 | Gynecol. Oncol. | pmid:2026357 |
Marui N et al. | Delta 12-prostaglandin J2 mimics heat shock in inducing cell cycle arrest at G1 phase. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1930204 |
Nakajima M et al. | Effects of prostaglandin D2 and its analogue, BW245C, on intraocular pressure in humans. | 1991 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:1937072 |
Perreault T and De Marte J | Endothelin-1 has a dilator effect on neonatal pig pulmonary vasculature. | 1991 | J. Cardiovasc. Pharmacol. | pmid:1719291 |
van der Donk EM et al. | Leukotriene C4 formation by enriched human basophil preparations from normal and asthmatic subjects. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1719566 |
Vesin MF and Droz B | Biosynthesis of prostaglandins D2 and E2 in chick dorsal root ganglion during development. | 1991 | J. Neurochem. | pmid:1904909 |
Arzubiaga C et al. | Neuropeptide Y, a putative cotransmitter in noradrenergic neurons, induces mast cell degranulation but not prostaglandin D2 release. | 1991 | J. Allergy Clin. Immunol. | pmid:1825102 |
Koshihara Y et al. | Prostaglandin D2 stimulates calcification by human osteoblastic cells. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825424 |
Rubin DB et al. | The influence of exogenous eicosanoids on the radiation response of cultured bovine aortic endothelial cells. | 1991 | Radiat. Res. | pmid:1898781 |
Atsmon J et al. | Modulation of the antiproliferative activity of 9-deoxy-delta 9,delta 12(E)-PGD2 by conjugation with intracellular glutathione. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825432 |
Akerboom T et al. | Cholestasis and changes of portal pressure caused by chlorpromazine in the perfused rat liver. | 1991 | Hepatology | pmid:1899850 |
Hayaishi O | Molecular mechanisms of sleep-wake regulation: roles of prostaglandins D2 and E2. | 1991 | FASEB J. | pmid:1907936 |
Koizumi K et al. | Induction of 31,000 protein by PGD2-treated vascular endothelial cells. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825433 |
Morrow JD et al. | A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825560 |
Howarth P et al. | The comparative nasal effects of prostaglandin D2 in normal and rhinitic subjects. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825579 |
Gundel RH et al. | The effects of a 5-lipoxygenase inhibitor on antigen-induced mediator release, late-phase bronchoconstriction and cellular infiltrates in primates. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825582 |
Watanabe K et al. | The structure and function of prostaglandin F synthase. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825592 |
Woodward DF et al. | Studies on leukotriene D4 as an eosinophil chemoattractant. | 1991 | Drugs Exp Clin Res | pmid:1841046 |
Gebicke-Haerter PJ et al. | Regulation and glucocorticoid-independent induction of lipocortin I in cultured astrocytes. | 1991 | J. Neurochem. | pmid:1828830 |
Walls AF et al. | Inflammatory mediators and cellular infiltration of the lungs in a guinea pig model of the late asthmatic reaction. | 1991 | Lung | pmid:1921474 |
Crivellari MT et al. | Eicosanoid release and mepyramine, LTC4 and LTD4 binding in passively sensitized human lung parenchyma in vitro. | 1991 | Biochem. Pharmacol. | pmid:1859453 |
Francis HP et al. | The thromboxane receptor antagonist BAY u3405 reverses prostaglandin D2 (PGD2)-induced bronchoconstriction in the anaesthetised guinea pig. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1835329 |
Kobayashi Y et al. | Syntheses of 2,6-dideoxy-6-fluoro-2-[(3R and 3S)-3- hydroxytetradecanamido]-3-O-[(3R)-3-(tetradecanoyloxy)tetra decanoyl]-D- glucopyranose 4-(dihydrogen phosphate) and 2-deoxy-2-[(3R and 3S)-3- hydroxytetradecanamido]-3-O-[(3R)-3-(tetradecanoyloxy)tetra decanoyl]- alpha-D-glucopyranosyl fluoride 4-(dihydrogen phosphate): fluorosugar analogues of GLA-60. | 1991 | Carbohydr. Res. | pmid:1813114 |
McMahon TJ et al. | Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed. | 1991 | J. Appl. Physiol. | pmid:1837015 |
Smith GS et al. | Adaptive cytoprotection against alcohol injury in the rat stomach is not due to increased prostanoid synthesis. | 1991 | Prostaglandins | pmid:1906621 |