Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Takeda K et al. | Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells. | 2000 | Circulation | pmid:11023940 |
Dieter P et al. | Functional coupling of cyclooxygenase 1 and 2 to discrete prostanoid synthases in liver macrophages. | 2000 | Biochem. Biophys. Res. Commun. | pmid:11027502 |
Enomoto A et al. | Redundant and segregated functions of granule-associated heparin-binding group II subfamily of secretory phospholipases A2 in the regulation of degranulation and prostaglandin D2 synthesis in mast cells. | 2000 | J. Immunol. | pmid:11034411 |
Lee KH et al. | Stimulatory function of gp49A, a murine Ig-like receptor, in rat basophilic leukemia cells. | 2000 | J. Immunol. | pmid:11046024 |
Honma S et al. | Effects of naturally-occurring acid fog on inflammatory mediators in airway and pulmonary functions in asthmatic patients. | 2000 | Respir Med | pmid:11059945 |
Schaiff WT et al. | Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner. | 2000 | J. Clin. Endocrinol. Metab. | pmid:11061552 |
Kubata BK et al. | Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. | 2000 | J. Exp. Med. | pmid:11067881 |
Kasai K et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11078701 |
Sharif NA et al. | Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand. | 2000 | Br. J. Pharmacol. | pmid:11082108 |
Hortelano S et al. | Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages. | 2000 | J. Immunol. | pmid:11086094 |