Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Itabashi S et al. | Late asthmatic response causes peripheral airway hyperresponsiveness in dogs treated with metopirone. | 1993 | Int. Arch. Allergy Immunol. | pmid:8508057 |
Spitzer JA and Mayer AM | Hepatic neutrophil influx: eicosanoid and superoxide formation in endotoxemia. | 1993 | J. Surg. Res. | pmid:8412083 |
Rangachari PK and Betti PA | Biological activity of metabolites of PGD2 on canine proximal colon. | 1993 | Am. J. Physiol. | pmid:8498516 |
Johnston SL et al. | The effect of BAY u 3405, a thromboxane receptor antagonist, on prostaglandin D2-induced nasal blockage. | 1993 | J. Allergy Clin. Immunol. | pmid:8473679 |
Wegner CD et al. | The role of 5-lipoxygenase products in preclinical models of asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8473681 |
Kim IK et al. | Prostaglandin A2 and delta 12-prostaglandin J2 induce apoptosis in L1210 cells. | 1993 | FEBS Lett. | pmid:8477853 |
Fredberg JJ et al. | Tissue resistance and the contractile state of lung parenchyma. | 1993 | J. Appl. Physiol. | pmid:8482682 |
Baker DG et al. | Cellular and chemical mediators of type 1 hypersensitivity in calves infected with Ostertagia ostertagi: histamine, prostaglandin D2, prostaglandin E2 and leukotriene C4. | 1993 | Int. J. Parasitol. | pmid:8359983 |
Morrow JD and Minton TA | Improved assay for the quantification of 11-dehydrothromboxane B2 by gas chromatography-mass spectrometry. | 1993 | J. Chromatogr. | pmid:8468374 |
Faili A et al. | Reduction by arachidonic acid of prostaglandin I2-induced cyclic AMP formation. Involvement of prostaglandins E2 and F2 alpha. | 1993 | Biochem. Pharmacol. | pmid:8388209 |
Huttemeier PC et al. | Microdialysis measurements of PGD2, TXB2 and 6-KETO-PGF1 alpha in rat CA1 hippocampus during transient cerebral ischemia. | 1993 | Prostaglandins | pmid:8430228 |
Hata Y et al. | Primary colonic epithelial cell culture of the rabbit producing prostaglandins. | 1993 | Prostaglandins | pmid:8430223 |
Jaffar ZH and Pearce FL | Some characteristics of the ATP-induced histamine release from and permeabilization of rat mast cells. | 1993 | Agents Actions | pmid:7511869 |
Hay DW et al. | Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea. | 1993 | Br. J. Pharmacol. | pmid:7507780 |
Gyenes M and De Groot H | Prostanoid release by Kupffer cells upon hypoxia-reoxygenation: role of pHi and Cai2+. | 1993 | Am. J. Physiol. | pmid:8384798 |
Twentyman OP et al. | The effect of H1-receptor blockade on the development of early- and late-phase bronchoconstriction and increased bronchial responsiveness in allergen-induced asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8099592 |
Rajakulasingam K et al. | Interactive effect of inhaled bradykinin with histamine and PGD2 in bronchial asthma. | 1993 | J. Appl. Physiol. | pmid:8307852 |
Hallbrucker C et al. | Hydroperoxide metabolism in rat liver. K+ channel activation, cell volume changes and eicosanoid formation. | 1993 | Eur. J. Biochem. | pmid:8436107 |
Aichane A et al. | Precision of conjunctival provocation tests in right and left eyes. | 1993 | J. Allergy Clin. Immunol. | pmid:8335854 |
Barski OA and Watanabe K | Kinetic mechanism of ketoreductase activity of prostaglandin F synthase from bovine lung. | 1993 | FEBS Lett. | pmid:8458424 |
Okuda-Ashitaka E et al. | Cyclic-AMP-dependent Ca2+ influx elicited by prostaglandin D2 in freshly isolated nonchromaffin cells from bovine adrenal medulla. | 1993 | Biochim. Biophys. Acta | pmid:8384001 |
Pica F et al. | Inhibition of vesicular stomatitis virus replication by delta 12-prostaglandin J2 is regulated at two separate levels and is associated with induction of stress protein synthesis. | 1993 | Antiviral Res. | pmid:8385894 |
Nowak D et al. | Increased LTB4 metabolites and PGD2 in BAL fluid after methacholine challenge in asthmatic subjects. | 1993 | Eur. Respir. J. | pmid:8386107 |
Satoh M and Yamazaki M | In vitro DNA synthesis of mouse hepatocytes stimulated by tumor necrosis factor is inhibited by glucocorticoids and prostaglandin D2 but enhanced by retinoic acid. | 1993 | J. Cell. Physiol. | pmid:8408229 |
Bull HA et al. | Basophil mediator release in atopic dermatitis. | 1993 | J. Invest. Dermatol. | pmid:7680056 |
Campbell AM et al. | Modulation of eicosanoid and histamine release from human dispersed lung cells by terfenadine. | 1993 | Allergy | pmid:7681268 |
Maxwell DL et al. | Inhaled nedocromil sodium reduces histamine release from isolated large airway segments of asthmatic subjects in vivo. | 1993 | Eur. Respir. J. | pmid:7693506 |
Xu L et al. | Effect of culture conditions on mast cell eicosanoid synthesis. | 1993 | Prostaglandins | pmid:8493360 |
van der Linden PW et al. | Insect-sting challenge in 138 patients: relation between clinical severity of anaphylaxis and mast cell activation. | 1992 | J. Allergy Clin. Immunol. | pmid:1629497 |
King KL et al. | Metabolism of arachidonic acid by isolated rabbit ciliary epithelium. | 1992 | Exp. Eye Res. | pmid:1426059 |
Thomas PS et al. | Tobacco smoke releases performed mediators from canine mast cells and modulates prostaglandin production. | 1992 | Am. J. Physiol. | pmid:1636731 |
Sasaguri T et al. | Prostaglandins A and J arrest the cell cycle of cultured vascular smooth muscle cells without suppression of c-myc expression. | 1992 | Exp. Cell Res. | pmid:1572402 |
Sinzinger H et al. | Isradipine improves platelet function in hypertensives. | 1992 | Eur. J. Clin. Pharmacol. | pmid:1531796 |
Ito S et al. | Type-1 and type-2 astrocytes are distinct targets for prostaglandins D2, E2, and F2 alpha. | 1992 | Glia | pmid:1324890 |
Tsukagoshi H and Kurosawa M | [Bronchial hyperresponsiveness to histamine induced by intravenous administration of prostaglandin D2 (PGD2) in guinea pigs]. | 1992 | Nippon Yakurigaku Zasshi | pmid:1559641 |
Magnussen H et al. | Effects of a thromboxane-receptor antagonist, BAY u 3405, on prostaglandin D2- and exercise-induced bronchoconstriction. | 1992 | J. Allergy Clin. Immunol. | pmid:1535083 |
Campbell AM et al. | In vitro activation of bronchoalveolar lavage cells by house dust mite allergens. | 1992 | Ann Allergy | pmid:1371209 |
Gaetani P et al. | Ex vivo release of eicosanoids after aneurysmal subarachnoid hemorrhage: a preliminary experience in humans. | 1992 | Acta Neurol. Scand. | pmid:1414230 |
Mitsuoka S et al. | Inhibitory effect of prostaglandin delta 12-PGJ2 on cell proliferation and alpha-fetoprotein expression in HuH-7 human hepatoma cells. | 1992 | Prostaglandins | pmid:1371888 |
Yen A et al. | Protoporphyrin and long-wave ultraviolet light modulate metabolic events in rat peritoneal mast cells. | 1992 | J. Invest. Dermatol. | pmid:1372341 |
Stellato C et al. | Anti-inflammatory effect of cyclosporin A on human skin mast cells. | 1992 | J. Invest. Dermatol. | pmid:1373749 |
Katz HR et al. | Secretory granule mediator release and generation of oxidative metabolites of arachidonic acid via Fc-IgG receptor bridging in mouse mast cells. | 1992 | J. Immunol. | pmid:1309842 |
Morrow JD et al. | Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. | 1992 | J. Invest. Dermatol. | pmid:1373750 |
Okayama Y et al. | Inhibition profiles of sodium cromoglycate and nedocromil sodium on mediator release from mast cells of human skin, lung, tonsil, adenoid and intestine. | 1992 | Clin. Exp. Allergy | pmid:1375128 |
Okayama Y and Church MK | Comparison of the modulatory effect of ketotifen, sodium cromoglycate, procaterol and salbutamol in human skin, lung and tonsil mast cells. | 1992 | Int. Arch. Allergy Immunol. | pmid:1375203 |
Smith JB et al. | Cyclic AMP does not inhibit collagen-induced platelet signal transduction. | 1992 | Biochem. J. | pmid:1375452 |
Ikai K et al. | Induction of 72-kD heat shock protein and cytoskeleton damage by cytotoxic prostaglandin delta 12-PGJ2 in transformed human epidermal cells in culture. | 1992 | J. Invest. Dermatol. | pmid:1375619 |
Yu SM et al. | Dicentrine, a novel antiplatelet agent inhibiting thromboxane formation and increasing the cyclic AMP level of rabbit platelets. | 1992 | Biochem. Pharmacol. | pmid:1310852 |
Lippton HL et al. | Mechanisms of signal transduction for adenosine and ATP in pulmonary vascular bed. | 1992 | Am. J. Physiol. | pmid:1348400 |
Crea AE et al. | Mediator concentrations in bronchoalveolar lavage fluid of patients with mild asymptomatic bronchial asthma. | 1992 | Eur. Respir. J. | pmid:1348480 |
Shin MH et al. | The effect of azelastine on the early allergic response. | 1992 | Clin. Exp. Allergy | pmid:1349259 |
Molderings G et al. | Inhibition of noradrenaline release in the rat vena cava via prostanoid receptors of the EP3-subtype. | 1992 | Br. J. Pharmacol. | pmid:1330175 |
Mulkins MA et al. | Mycophenolic acid inhibits the degranulation of rat peritoneal mast cells. | 1992 | Cell. Immunol. | pmid:1349511 |
Conti P et al. | Role of lipoxins A4 and B4 in the generation of arachidonic acid metabolites by rat mast cells and their effect on [3H]serotonin release. | 1992 | Immunol. Lett. | pmid:1612634 |
Liu H et al. | Regulation of the surface expression of the platelet-activating factor receptor in IC-21 peritoneal macrophages. Effects of lipopolysaccharide. | 1992 | J. Biol. Chem. | pmid:1328211 |
González-Utor AL et al. | Cytochemical localization of K(+)-dependent p-nitrophenyl phosphatase and adenylate cyclase by using one-step method in human washed platelets. | 1992 | Histochemistry | pmid:1330994 |
Raible DG et al. | Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils. | 1992 | J. Immunol. | pmid:1588043 |
Amici C et al. | Inhibition of Sendai virus replication by delta 12-prostaglandin J2: induction of heat shock protein synthesis and alteration of protein glycosylation. | 1992 | Antiviral Res. | pmid:1332600 |
Seregi A et al. | Functionally diverse purinergic P2Y-receptors mediate prostanoid synthesis in cultured rat astrocytes: the role of ATP-induced phosphatidyl-inositol breakdown. | 1992 | Eicosanoids | pmid:1333251 |
Björnsson OG et al. | Prostaglandins suppress VLDL secretion in primary rat hepatocyte cultures: relationships to hepatic calcium metabolism. | 1992 | J. Lipid Res. | pmid:1331281 |
Knani J et al. | Indirect evidence of nasal inflammation assessed by titration of inflammatory mediators and enumeration of cells in nasal secretions of patients with chronic rhinitis. | 1992 | J. Allergy Clin. Immunol. | pmid:1334102 |
Stellato C et al. | Human basophil/mast cell releasability. IX. Heterogeneity of the effects of opioids on mediator release. | 1992 | Anesthesiology | pmid:1280014 |
de Paulis A et al. | Anti-inflammatory effect of FK-506 on human skin mast cells. | 1992 | J. Invest. Dermatol. | pmid:1281861 |
Tomita Y et al. | Melanocyte-stimulating properties of arachidonic acid metabolites: possible role in postinflammatory pigmentation. | 1992 | Pigment Cell Res. | pmid:1292020 |
Morii H and Watanabe Y | A possible role of carbohydrate moieties in prostaglandin D2 and prostaglandin E2 receptor proteins from the porcine temporal cortex. | 1992 | Arch. Biochem. Biophys. | pmid:1309289 |
Wang JP et al. | Anti-inflammatory and analgesic effects of magnolol. | 1992 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:1336574 |
Kuchinke W et al. | A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1339268 |
Columbo M et al. | The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils. | 1992 | J. Immunol. | pmid:1378071 |
Johnston SL et al. | The effects of an oral thromboxane TP receptor antagonist BAY u 3405, on prostaglandin D2- and histamine-induced bronchoconstriction in asthma, and relationship to plasma drug concentrations. | 1992 | Br J Clin Pharmacol | pmid:1467134 |
Lin CH et al. | HA-29: an inhibitor of thromboxane A2 formation with antagonism of thromboxane A2/prostaglandin endoperoxide receptor in rabbit platelets. | 1992 | Thromb. Res. | pmid:1412184 |
Koizumi T et al. | Inhibitory effect of an intracellular glutathione on delta 12-prostaglandin J2-induced protein syntheses in porcine aortic endothelial cells. | 1992 | Biochem. Pharmacol. | pmid:1417983 |
Norwitz ER et al. | Prostaglandin D2 production by term human decidua: cellular origins defined using flow cytometry. | 1992 | Obstet Gynecol | pmid:1495703 |
Sasaguri T et al. | Anti-proliferative effect of prostaglandins A and J on cultured vascular smooth muscle cells. | 1992 | Jpn. J. Pharmacol. | pmid:1507558 |
Hoshi A et al. | [Experimental study on the role of prostaglandin D2 in the pathogenesis of bronchial asthma]. | 1992 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:1507684 |
Bacic F et al. | Prostaglandin D2 in cultured capillary and microvascular endothelium of human brain. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1508957 |
Thomas PS et al. | Prostaglandin D2 production and identification of prostaglandin H synthase within canine mast cell granule. | 1992 | Am. J. Physiol. | pmid:1514641 |
Kaiser L et al. | Dirofilaria immitis: do filarial cyclooxygenase products depress endothelium-dependent relaxation in the in vitro rat aorta? | 1992 | Exp. Parasitol. | pmid:1516664 |
Braun M and Schrör K | Prostaglandin D2 relaxes bovine coronary arteries by endothelium-dependent nitric oxide-mediated cGMP formation. | 1992 | Circ. Res. | pmid:1385004 |
Goto H et al. | Age-associated decreases in prostaglandin contents in human gastric mucosa. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1510674 |
Emery BE et al. | The effect of IL-4 on human nasal mucosal responses. | 1992 | J. Allergy Clin. Immunol. | pmid:1430703 |
Barrett KE | Effect of histamine and other mast cell mediators on T84 epithelial cells. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456653 |
Diener M et al. | Characterization of the antisecretory action of prostaglandin D2 in the rat colon. | 1992 | Acta Physiol. Scand. | pmid:1502910 |
Virgolini I et al. | Characterization of prostaglandin (PG)-binding sites expressed on human basophils. Evidence for a prostaglandin E1, I2, and a D2 receptor. | 1992 | J. Biol. Chem. | pmid:1377673 |
Watanabe-Kohno S et al. | MCI-826 is a potent and selective antagonist of peptide leukotrienes (p-LTs) and has characteristics distinctive from those of FPL 55712. | 1992 | Jpn. J. Pharmacol. | pmid:1460800 |
Baumgarten CR et al. | Bradykinin and other inflammatory mediators in BAL-fluid from patients with active pulmonary inflammation. | 1992 | Agents Actions Suppl. | pmid:1462881 |
Ellis JL and Undem BJ | Antigen-induced enhancement of noncholinergic contractile responses to vagus nerve and electrical field stimulation in guinea pig isolated trachea. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1323657 |
Tamaoki J et al. | Prostaglandin D2 increases Cl secretion across canine tracheal epithelium through cyclo-oxygenase stimulation and cAMP production. | 1992 | Acta Physiol. Scand. | pmid:1323920 |
Froldi M et al. | Mediator release in cerebrospinal fluid of human immunodeficiency virus-positive patients with central nervous system involvement. | 1992 | J. Neuroimmunol. | pmid:1315794 |
Fukushima M | Biological activities and mechanisms of action of PGJ2 and related compounds: an update. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1438462 |
Shimakura S and Boland CR | Eicosanoid production by the human gastric cancer cell line AGS and its relation to cell growth. | 1992 | Cancer Res. | pmid:1551103 |
Ninomiya H et al. | Endothelin-1 induces stimulation of prostaglandin synthesis in cells obtained from canine airways by bronchoalveolar lavage. | 1992 | Prostaglandins | pmid:1584994 |
Lee DY et al. | Prostaglandin profile and synthetic capacity of the colon: comparison of tissue sources and subcellular fractions. | 1992 | Prostaglandins | pmid:1542741 |
Picado C et al. | Release of peptide leukotriene into nasal secretions after local instillation of aspirin in aspirin-sensitive asthmatic patients. | 1992 | Am. Rev. Respir. Dis. | pmid:1309968 |
Kawada N et al. | Possible induction of fatty acid cyclo-oxygenase in lipopolysaccharide-stimulated rat Kupffer cells. | 1992 | Gastroenterology | pmid:1499903 |
Eguchi N et al. | Permeability of brain structures and other peripheral tissues to prostaglandins D2, E2 and F2 alpha in rats. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1527717 |
Rangachari PK | Concerning prostaglandin D2: forgotten, promiscuous, capricious. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456655 |
Krueger JM et al. | Prostaglandins E2 and D2 have little effect on rabbit sleep. | 1992 | Physiol. Behav. | pmid:1523224 |
D'Onofrio C et al. | Comparative anti-viral and anti-proliferative activity of PGA1 and PGJ2 against HTLV-I-infected MT-2 cells. | 1992 | Int. J. Cancer | pmid:1592539 |
Wang D et al. | Terbutaline acts at multiple sites to inhibit bronchoconstriction induced by dry air in canine peripheral airways. | 1992 | Am. Rev. Respir. Dis. | pmid:1595994 |
Hogaboam CM et al. | Platelet-activating factor synthesis by peritoneal mast cells and its inhibition by two quinoline-based compounds. | 1992 | Br. J. Pharmacol. | pmid:1596692 |