PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sugiyama H et al. | Peroxisome proliferator-activated receptors are expressed in human cultured mast cells: a possible role of these receptors in negative regulation of mast cell activation. | 2000 | Eur. J. Immunol. | pmid:11093153 |
| Fukushima S et al. | Preparation and evaluation of o/w type emulsions containing antitumor prostaglandin. | 2000 | Adv. Drug Deliv. Rev. | pmid:11104898 |
| Faveeuw C et al. | Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-12 production in murine dendritic cells. | 2000 | FEBS Lett. | pmid:11119715 |
| Padilla J et al. | Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells. | 2000 | J. Immunol. | pmid:11120820 |
| Zuckerman SH et al. | The effect of gamma-interferon to inhibit macrophage-high density lipoprotein interactions is reversed by 15-deoxy-delta12,14-prostaglandin J2. | 2000 | Lipids | pmid:11132183 |
| Hsieh FH et al. | T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C(4) synthase expression by interleukin 4. | 2001 | J. Exp. Med. | pmid:11136826 |
| Wright DH et al. | The human prostanoid DP receptor stimulates mucin secretion in LS174T cells. | 2000 | Br. J. Pharmacol. | pmid:11139429 |
| Kitatani K et al. | Role of phospholipase D-derived phosphatidic acid as a substrate for phospholipase A2 in RBL-2H3 cells. | 2000 | Biol. Pharm. Bull. | pmid:11145171 |
| Hamel L et al. | Induction of heat shock protein 70 by herbimycin A and cyclopentenone prostaglandins in smooth muscle cells. | 2000 | Cell Stress Chaperones | pmid:11147963 |
| Person EC et al. | Albumin regulates induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-delta(12-14)-prostaglandin J(2) in vitro and may be an important regulator of PPARgamma function in vivo. | 2001 | Endocrinology | pmid:11159824 |
| Equils O et al. | Bacterial lipopolysaccharide activates HIV long terminal repeat through Toll-like receptor 4. | 2001 | J. Immunol. | pmid:11160291 |
| Kitamura Y et al. | Effects of 15-deoxy-delta(12,14) prostaglandin J(2) and interleukin-4 in Toll-like receptor-4-mutant glial cells. | 2001 | Eur. J. Pharmacol. | pmid:11164379 |
| Kadekaro M et al. | Central interactions between angiotensin II and PGD(2) in the regulation of vasopressin and oxytocin secretion in dehydrated rats. | 2001 | Brain Res. | pmid:11166690 |
| Wilmer WA et al. | A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11178960 |
| Åazarewicz JW et al. | NMDA receptors and nitric oxide regulate prostaglandin D2 synthesis in the rabbit hippocampus in vivo. | 2000 | Acta Neurobiol Exp (Wars) | pmid:11200170 |
| Inoue T et al. | Serum prostaglandin D synthase level after coronary angioplasty may predict occurrence of restenosis. | 2001 | Thromb. Haemost. | pmid:11204569 |
| Hirai H et al. | Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. | 2001 | J. Exp. Med. | pmid:11208866 |
| Tunaz H et al. | Prostaglandin biosynthesis by fat body from true armyworms, Pseudaletia unipuncta. | 2001 | Insect Biochem. Mol. Biol. | pmid:11222953 |
| Reilly CM et al. | Prostaglandin J(2) inhibition of mesangial cell iNOS expression. | 2001 | Clin. Immunol. | pmid:11237557 |
| Szczeklik A et al. | Safety of a specific COX-2 inhibitor in aspirin-induced asthma. | 2001 | Clin. Exp. Allergy | pmid:11251623 |
| Kang SS et al. | Cyclooxygenase-2 inhibitory cerebrosides from phytolaccae radix. | 2001 | Chem. Pharm. Bull. | pmid:11253924 |
| Okayama Y et al. | A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI. | 2001 | J. Immunol. | pmid:11254731 |
| Fahmi H et al. | Peroxisome proliferator--activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes. | 2001 | Arthritis Rheum. | pmid:11263774 |
| Thévenon C et al. | Gas chromatographic-mass spectrometric measurement of 15-deoxy-delta(12,14)-prostaglandin J(2), the peroxisome proliferator-activated receptor gamma ligand, in urine. | 2001 | Clin. Chem. | pmid:11274037 |
| Rohn TT et al. | 15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis. | 2001 | Neuroreport | pmid:11277593 |
| Satoh T et al. | Neurotrophic actions of novel compounds designed from cyclopentenone prostaglandins. | 2001 | J. Neurochem. | pmid:11279261 |
| Drew PD and Chavis JA | The cyclopentone prostaglandin 15-deoxy-Delta(12,14) prostaglandin J2 represses nitric oxide, TNF-alpha, and IL-12 production by microglial cells. | 2001 | J. Neuroimmunol. | pmid:11282151 |
| Wang C et al. | Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1. | 2001 | Mol. Cell. Biol. | pmid:11287611 |
| Jiang JG et al. | Peroxisome proliferator-activated receptor gamma-mediated transcriptional up-regulation of the hepatocyte growth factor gene promoter via a novel composite cis-acting element. | 2001 | J. Biol. Chem. | pmid:11292834 |
| Niyonsaba F et al. | Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. | 2001 | Eur. J. Immunol. | pmid:11298331 |
| Harris SG and Phipps RP | The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis. | 2001 | Eur. J. Immunol. | pmid:11298334 |
| Guyton K et al. | Differential effects of 15-deoxy-delta(12,14)-prostaglandin J2 and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation. | 2001 | J. Leukoc. Biol. | pmid:11310850 |
| Govoni S et al. | The Cycloxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat. | 2001 | Neurosci. Lett. | pmid:11311500 |
| Tomlinson JW et al. | Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. | 2001 | Endocrinology | pmid:11316764 |
| Azuma Y et al. | 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-10 and IL-12 production by macrophages. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11327705 |
| Tanaka H and Nagai H | [Inflammation-allergy and prostanoids. (2). The role of prostanoids in allergic inflammation]. | 2001 | Nippon Yakurigaku Zasshi | pmid:11338375 |
| Tsubouchi Y et al. | Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11350047 |
| Serghides L and Kain KC | Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages. | 2001 | J. Immunol. | pmid:11359831 |
| Angeli V et al. | Role of the parasite-derived prostaglandin D2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection. | 2001 | J. Exp. Med. | pmid:11369785 |
| Krawiec ME et al. | Persistent wheezing in very young children is associated with lower respiratory inflammation. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11371398 |
| Saarinen JV et al. | Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects of leukotriene C4 and prostaglandin D2. | 2001 | Eur. J. Clin. Pharmacol. | pmid:11372583 |
| Park JM | Role of prostaglandins in bladder smooth muscle cell gene expression. | 2001 | Urology | pmid:11378068 |
| Chang TS et al. | NQ-Y15 inhibits the calcium mobilization by elevation of cyclic AMP in rat platelets. | 2001 | Biol. Pharm. Bull. | pmid:11379764 |
| Fajas L et al. | PPAR gamma: an essential role in metabolic control. | 2001 | Nutr Metab Cardiovasc Dis | pmid:11383325 |
| Boutaud O et al. | Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid. | 2001 | Biochemistry | pmid:11389610 |
| Zhang X et al. | Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2. | 2001 | J. Immunol. | pmid:11390455 |
| Chen NG and Han X | Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11401521 |
| Lau HY and Chan CL | Modulation of intracellular cyclic AMP in immunologically activated rat peritoneal mast cells by prostaglandin D2. | 2001 | Inflamm. Res. | pmid:11411605 |
| Serhan CN and Devchand PR | Novel antiinflammatory targets for asthma. A role for PPARgamma? | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11415929 |
| Wang AC et al. | Peroxisome proliferator-activated receptor-gamma regulates airway epithelial cell activation. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11415933 |