PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Roberts LJ and Oates JA | Biochemical diagnosis of systemic mast cell disorders. | 1991 | J. Invest. Dermatol. | pmid:16799604 |
| Nelson AM et al. | Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. | 2013 | J. Invest. Dermatol. | pmid:23190891 |
| Iwata C et al. | Augmentation of lipogenesis by 15-deoxy-Delta12,14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-Delta12,14-prostaglandin J2 production. | 2005 | J. Invest. Dermatol. | pmid:16297182 |
| Maciejewski-Lenoir D et al. | Langerhans cells release prostaglandin D2 in response to nicotinic acid. | 2006 | J. Invest. Dermatol. | pmid:17008871 |
| Hawk JL et al. | Increased concentrations of arachidonic acid, prostaglandins E2, D2, and 6-oxo-F1 alpha, and histamine in human skin following UVA irradiation. | 1983 | J. Invest. Dermatol. | pmid:6343514 |
| Robinson C et al. | The IgE- and calcium-dependent release of eicosanoids and histamine from human purified cutaneous mast cells. | 1989 | J. Invest. Dermatol. | pmid:2504819 |
| Ikai K et al. | Effect of ultraviolet irradiation on mast cell-deficient W/Wv mice. | 1985 | J. Invest. Dermatol. | pmid:3859552 |
| el-Lati SG et al. | Complement peptides C3a- and C5a-induced mediator release from dissociated human skin mast cells. | 1994 | J. Invest. Dermatol. | pmid:7513741 |
| Kämpfer H et al. | Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair. | 2003 | J. Invest. Dermatol. | pmid:12713596 |
| Mantel A et al. | Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. | 2012 | J. Invest. Dermatol. | pmid:22170488 |
| Juhlin L et al. | Effect of infrared irradiation on the recoverable levels of free arachidonic acid and prostaglandins in human forearm skin. | 1983 | J. Invest. Dermatol. | pmid:6578272 |
| Krishnaswamy G et al. | Regulation of eosinophil-active cytokine production from human cord blood-derived mast cells. | 2002 | J. Interferon Cytokine Res. | pmid:12034046 |
| Sichletidis L et al. | Comparative efficacy of salbutamol and salmeterol in exercise-induced asthma. | 1993 Mar-Apr | J. Int. Med. Res. | pmid:8243793 |
| Cloutier A et al. | The prostanoid 15-deoxy-Δ12,14-prostaglandin-j2 reduces lung inflammation and protects mice against lethal influenza infection. | 2012 | J. Infect. Dis. | pmid:22219346 |
| Nitta N et al. | Quantitative analysis of eosinophil chemotaxis tracked using a novel optical device -- TAXIScan. | 2007 | J. Immunol. Methods | pmid:17289072 |
| Andersen HB et al. | Comparison of short term in vitro cultured human mast cells from different progenitors - Peripheral blood-derived progenitors generate highly mature and functional mast cells. | 2008 | J. Immunol. Methods | pmid:18538784 |
| Kawata R et al. | Prostaglandin synthase 1 and prostaglandin synthase 2 both participate in activation-induced prostaglandin D2 production in mast cells. | 1995 | J. Immunol. | pmid:7608559 |
| Monneret G et al. | 15-Deoxy-delta 12,14-prostaglandins D2 and J2 are potent activators of human eosinophils. | 2002 | J. Immunol. | pmid:11907120 |
| Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
| Marx N et al. | Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. | 2000 | J. Immunol. | pmid:10843708 |
| Diab A et al. | Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis. | 2002 | J. Immunol. | pmid:11859145 |
| Nencioni A et al. | Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling. | 2003 | J. Immunol. | pmid:14607914 |
| Spik I et al. | Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse. | 2005 | J. Immunol. | pmid:15749909 |
| Peters SP et al. | Arachidonic acid metabolism in purified human lung mast cells. | 1984 | J. Immunol. | pmid:6199420 |
| Clark RB et al. | The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses. | 2000 | J. Immunol. | pmid:10640751 |
| Reilly CM et al. | Inhibition of mesangial cell nitric oxide in MRL/lpr mice by prostaglandin J2 and proliferator activation receptor-gamma agonists. | 2000 | J. Immunol. | pmid:10640767 |
| Hirai H et al. | Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2. | 2002 | J. Immunol. | pmid:11801628 |
| Harris SG et al. | 15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway. | 2002 | J. Immunol. | pmid:11801678 |
| Diaz BL et al. | Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids. | 2002 | J. Immunol. | pmid:11801681 |
| Vaidya S et al. | 15-Deoxy-Delta12,1412,14-prostaglandin J2 inhibits the beta2 integrin-dependent oxidative burst: involvement of a mechanism distinct from peroxisome proliferator-activated receptor gamma ligation. | 1999 | J. Immunol. | pmid:10570310 |
| Patella V et al. | Eosinophil granule proteins activate human heart mast cells. | 1996 | J. Immunol. | pmid:8757629 |
| Maier NK et al. | The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes. | 2015 | J. Immunol. | pmid:25681332 |
| Broide DH et al. | Functional and biochemical characterization of rat bone marrow derived mast cells. | 1988 | J. Immunol. | pmid:2974057 |
| Luna-Gomes T et al. | Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation. | 2011 | J. Immunol. | pmid:22102725 |
| Katz HR et al. | Secretory granule mediator release and generation of oxidative metabolites of arachidonic acid via Fc-IgG receptor bridging in mouse mast cells. | 1992 | J. Immunol. | pmid:1309842 |
| Serghides L and Kain KC | Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages. | 2001 | J. Immunol. | pmid:11359831 |
| Tsubosaka Y et al. | A deficiency in the prostaglandin D2 receptor CRTH2 exacerbates adjuvant-induced joint inflammation. | 2014 | J. Immunol. | pmid:25362177 |
| Enomoto A et al. | Redundant and segregated functions of granule-associated heparin-binding group II subfamily of secretory phospholipases A2 in the regulation of degranulation and prostaglandin D2 synthesis in mast cells. | 2000 | J. Immunol. | pmid:11034411 |
| Padilla J et al. | Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells. | 2000 | J. Immunol. | pmid:11120820 |
| Raible DG et al. | Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils. | 1992 | J. Immunol. | pmid:1588043 |
| Hortelano S et al. | Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages. | 2000 | J. Immunol. | pmid:11086094 |
| Hellmann J et al. | Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. | 2013 | J. Immunol. | pmid:23785121 |
| Levi-Schaffer F et al. | Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. | 1987 | J. Immunol. | pmid:2445814 |
| Zhang X et al. | Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2. | 2001 | J. Immunol. | pmid:11390455 |
| Angeli V et al. | Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses. | 2004 | J. Immunol. | pmid:15004188 |
| Heavey DJ et al. | Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells. | 1988 | J. Immunol. | pmid:2450136 |
| Wells E et al. | Characterization of primate bronchoalveolar mast cells. II. Inhibition of histamine, LTC4, and PGD2 release from primate bronchoalveolar mast cells and a comparison with rat peritoneal mast cells. | 1986 | J. Immunol. | pmid:2431049 |
| Parsons WG and Roberts LJ | Transformation of prostaglandin D2 to isomeric prostaglandin F2 compounds by human eosinophils. A potential mast cell-eosinophil interaction. | 1988 | J. Immunol. | pmid:3139758 |
| Rossi AG et al. | Regulation of macrophage phagocytosis of apoptotic cells by cAMP. | 1998 | J. Immunol. | pmid:9531319 |
| Mandal AK et al. | Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation. | 2005 | J. Immunol. | pmid:16272277 |
| Xue L et al. | Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. | 2005 | J. Immunol. | pmid:16272307 |
| Columbo M et al. | The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils. | 1992 | J. Immunol. | pmid:1378071 |
| Kobayashi Y et al. | Physiological levels of 15-deoxy-Delta12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation. | 2005 | J. Immunol. | pmid:16237065 |
| Bureau F et al. | A proinflammatory role for the cyclopentenone prostaglandins at low micromolar concentrations: oxidative stress-induced extracellular signal-regulated kinase activation without NF-kappa B inhibition. | 2002 | J. Immunol. | pmid:11994490 |
| Levi-Schaffer F et al. | Fibroblasts maintain the phenotype and viability of the rat heparin-containing mast cell in vitro. | 1985 | J. Immunol. | pmid:2413121 |
| Janabi N | Selective inhibition of cyclooxygenase-2 expression by 15-deoxy-Delta(12,14)(12,14)-prostaglandin J(2) in activated human astrocytes, but not in human brain macrophages. | 2002 | J. Immunol. | pmid:11971025 |
| Robin JL et al. | Regulation of mediator release from mouse bone marrow-derived mast cells by glucocorticoids. | 1985 | J. Immunol. | pmid:3161947 |
| Ogasawara T et al. | Mouse bone marrow-derived mast cells undergo exocytosis, prostanoid generation, and cytokine expression in response to G protein-activating polybasic compounds after coculture with fibroblasts in the presence of c-kit ligand. | 1997 | J. Immunol. | pmid:8977215 |
| Sturm EM et al. | Opposing roles of prostaglandin D2 receptors in ulcerative colitis. | 2014 | J. Immunol. | pmid:24929001 |
| Steinke JW et al. | Aspirin activation of eosinophils and mast cells: implications in the pathogenesis of aspirin-exacerbated respiratory disease. | 2014 | J. Immunol. | pmid:24890720 |
| Giri S et al. | The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. | 2004 | J. Immunol. | pmid:15470065 |
| Tanaka K et al. | Cutting edge: differential production of prostaglandin D2 by human helper T cell subsets. | 2000 | J. Immunol. | pmid:10679060 |
| Chevalier E et al. | Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. | 2005 | J. Immunol. | pmid:16081770 |
| Lawrence ID et al. | Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity. | 1987 | J. Immunol. | pmid:2444649 |
| Fox CC et al. | Isolation and characterization of human intestinal mucosal mast cells. | 1985 | J. Immunol. | pmid:2582045 |
| Schick B et al. | Activation of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1984 | J. Immunol. | pmid:6425408 |
| Levi-Schaffer F et al. | Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and IgE-mediated release of histamine, prostaglandin D2, and leukotrienes. | 1987 | J. Immunol. | pmid:2439587 |
| Tada K et al. | Induction of cyclooxygenase-2 by secretory phospholipases A2 in nerve growth factor-stimulated rat serosal mast cells is facilitated by interaction with fibroblasts and mediated by a mechanism independent of their enzymatic functions. | 1998 | J. Immunol. | pmid:9794438 |
| Urade Y et al. | The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. | 1989 | J. Immunol. | pmid:2509561 |
| Xue L et al. | Leukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2. | 2012 | J. Immunol. | pmid:22174450 |
| Yoon HJ et al. | Regulation of TLR2 expression by prostaglandins in brain glia. | 2008 | J. Immunol. | pmid:18523308 |
| Bissonnette SL et al. | An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways. | 2008 | J. Immunol. | pmid:18641309 |
| Equils O et al. | Bacterial lipopolysaccharide activates HIV long terminal repeat through Toll-like receptor 4. | 2001 | J. Immunol. | pmid:11160291 |
| Patella V et al. | Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. | 1995 | J. Immunol. | pmid:7533185 |
| Leal-Berumen I et al. | Prostanoid enhancement of interleukin-6 production by rat peritoneal mast cells. | 1995 | J. Immunol. | pmid:7536779 |
| Cheron A et al. | 15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process. | 2004 | J. Immunol. | pmid:15187150 |
| Colville-Nash PR et al. | Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1. | 1998 | J. Immunol. | pmid:9670978 |
| Rocklin RE et al. | Decreased sensitivity of atopic mononuclear cells to prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2). | 1985 | J. Immunol. | pmid:3160784 |
| Shiraishi Y et al. | Cyclooxygenase-2/prostaglandin D2/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation. | 2008 | J. Immunol. | pmid:18097056 |
| Napimoga MH et al. | Peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J2, reduces neutrophil migration via a nitric oxide pathway. | 2008 | J. Immunol. | pmid:18097063 |
| Joo M et al. | Induction and function of lipocalin prostaglandin D synthase in host immunity. | 2007 | J. Immunol. | pmid:17675519 |
| Mizutani N et al. | Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. | 2007 | J. Immunol. | pmid:18025192 |
| Hu ZQ et al. | An essential role of prostaglandin E on mouse mast cell induction. | 1995 | J. Immunol. | pmid:7636261 |
| Murakami M et al. | IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2. | 1995 | J. Immunol. | pmid:7594606 |
| Hammad H et al. | Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1. | 2003 | J. Immunol. | pmid:14530310 |
| Cippitelli M et al. | The cyclopentenone-type prostaglandin 15-deoxy-delta 12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T lymphocytes: interference with promoter activation via peroxisome proliferator-activated receptor-gamma-independent mechanisms. | 2003 | J. Immunol. | pmid:12707336 |
| Heinemann A et al. | Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis. | 2003 | J. Immunol. | pmid:12707356 |
| Gosset P et al. | Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells. | 2003 | J. Immunol. | pmid:12734337 |
| Schulman ES et al. | Heterogeneity of human mast cells. | 1983 | J. Immunol. | pmid:6194221 |
| Holgate ST et al. | Anaphylactic- and calcium-dependent generation of prostaglandin D2 (PGD2), thromboxane B2, and other cyclooxygenase products of arachidonic acid by dispersed human lung cells and relationship to histamine release. | 1984 | J. Immunol. | pmid:6206153 |
| Schlezinger JJ et al. | Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2. | 2004 | J. Immunol. | pmid:15322177 |
| Si Q et al. | 15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications. | 2004 | J. Immunol. | pmid:15322215 |
| Massey WA et al. | Human uterine mast cells. Isolation, purification, characterization, ultrastructure, and pharmacology. | 1991 | J. Immunol. | pmid:1715365 |
| Mesquita-Santos FP et al. | Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin. | 2006 | J. Immunol. | pmid:16424158 |
| Ahmed SR et al. | Prostaglandin D2 regulates CD4+ memory T cell trafficking across blood vascular endothelium and primes these cells for clearance across lymphatic endothelium. | 2011 | J. Immunol. | pmid:21715691 |
| Tagen M et al. | Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. | 2009 | J. Immunol. | pmid:19846869 |
| Ray DM et al. | The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. | 2006 | J. Immunol. | pmid:17015690 |
| Napimoga MH et al. | Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model. | 2012 | J. Immunol. | pmid:22706081 |
| Nomiya R et al. | CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice. | 2008 | J. Immunol. | pmid:18390753 |
| Schulman ES et al. | Histochemical heterogeneity of dispersed human lung mast cells. | 1990 | J. Immunol. | pmid:1692857 |