PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Airway Remodeling D056151 3 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Pulmonary Aspergillosis D055732 1 associated lipids
Acute Lung Injury D055371 33 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Angioedemas, Hereditary D054179 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Decapitation D049248 2 associated lipids
Mastocytosis, Systemic D034721 1 associated lipids
Tauopathies D024801 6 associated lipids
Coronary Restenosis D023903 10 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Fetal Weight D020567 12 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Stroke D020521 32 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Sleep Disorders, Circadian Rhythm D020178 3 associated lipids
Thrombophilia D019851 6 associated lipids
Endotoxemia D019446 27 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Optic Neuropathy, Ischemic D018917 2 associated lipids
Cystitis, Interstitial D018856 2 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Vasculitis, Leukocytoclastic, Cutaneous D018366 5 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Coronavirus Infections D018352 4 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Helicobacter Infections D016481 21 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Choroid Diseases D015862 2 associated lipids
Nasal Obstruction D015508 4 associated lipids
HTLV-I Infections D015490 3 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Weight Loss D015431 56 associated lipids
Reperfusion Injury D015427 65 associated lipids
Zollinger-Ellison Syndrome D015043 1 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Wounds, Stab D014951 3 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Urticaria Pigmentosa D014582 4 associated lipids
Urticaria D014581 13 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Uremia D014511 33 associated lipids
Trigeminal Neuralgia D014277 1 associated lipids
Translocation, Genetic D014178 20 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thyroid Diseases D013959 8 associated lipids
Thrombosis D013927 49 associated lipids
Thrombocytopenia D013921 15 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Stomach Ulcer D013276 75 associated lipids
Sneezing D012912 6 associated lipids
Sleep Wake Disorders D012893 7 associated lipids
Seizures D012640 87 associated lipids
Osteosarcoma D012516 50 associated lipids
Sarcoma 180 D012510 21 associated lipids
Sarcoidosis D012507 13 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Rhinitis D012220 10 associated lipids
Retinopathy of Prematurity D012178 9 associated lipids
Respiratory Sounds D012135 3 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Precancerous Conditions D011230 48 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Pleurisy D010998 20 associated lipids
Persistent Fetal Circulation Syndrome D010547 1 associated lipids
Peritonitis D010538 38 associated lipids
Peptic Ulcer D010437 19 associated lipids
Parkinson Disease D010300 53 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pain D010146 64 associated lipids
Neuroblastoma D009447 66 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nasal Polyps D009298 26 associated lipids
Myocardial Infarction D009203 21 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Muscular Dystrophy, Animal D009137 5 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Meningoencephalitis D008590 4 associated lipids
Melanoma D008545 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lung Diseases D008171 37 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Ji JD et al. Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2. 2005 Rheumatology (Oxford) pmid:15840591
Mitchell MD et al. Identification of 9alpha,11beta-prostaglandin F2 in human amniotic fluid and characterization of its production by human gestational tissues. 2005 J. Clin. Endocrinol. Metab. pmid:15840748
Usui S et al. Design, synthesis, and biological activity of novel PPARgamma ligands based on rosiglitazone and 15d-PGJ2. 2005 Bioorg. Med. Chem. Lett. pmid:15745794
Storer PD et al. Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis. 2005 J. Neuroimmunol. pmid:15748950
Spik I et al. Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse. 2005 J. Immunol. pmid:15749909
Mochizuki M et al. Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. 2005 Am. J. Respir. Crit. Care Med. pmid:15750045
Moulin D et al. Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism. 2005 Arthritis Rheum. pmid:15751073
Viñals M et al. Aspirin increases CD36, SR-BI, and ABCA1 expression in human THP-1 macrophages. 2005 Cardiovasc. Res. pmid:15769457
Yuan Z et al. Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade. 2005 Heart pmid:15774612
Inoue K et al. Effects of 15-deoxy-delta(12,14)-prostaglandin J2 on nuclear localization of GATA-3 in the murine lung in the presence of lipopolysaccharide. 2005 Arzneimittelforschung pmid:15819389
Sanchez-Rodriguez J et al. The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells. 2005 Biochem. J. pmid:15819613
Kim YS et al. Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity. 2005 Free Radic. Biol. Med. pmid:15589375
Almishri W et al. Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. 2005 J. Pharmacol. Exp. Ther. pmid:15590767
Hwang J et al. Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. 2005 Am. J. Physiol., Cell Physiol. pmid:15590897
López-Parra M et al. The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin. 2005 J. Hepatol. pmid:15629510
Scher JU and Pillinger MH 15d-PGJ2: the anti-inflammatory prostaglandin? 2005 Clin. Immunol. pmid:15639643
Hata AN et al. Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2. 2005 Mol. Pharmacol. pmid:15563582
Wu CC et al. 2-(2-Br-phenyl)-8-methoxy-benzoxazinone (HPW-RX2), a direct thrombin inhibitor with a suppressive effect on thromboxane formation in platelets. 2005 Eur. J. Pharmacol. pmid:16313903
Son JK et al. Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. 2005 Biol. Pharm. Bull. pmid:16327145
Nakajima N et al. [Alternation of ion transport of airway epithelium by eicosanoids]. 2005 Arerugi pmid:16407682
Benyó Z et al. GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. 2005 J. Clin. Invest. pmid:16322797
Coyle AT et al. 15-deoxy Delta12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells. 2005 FEBS J. pmid:16156795
Chen WC et al. Induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor gamma activation up-regulating PTEN and inhibiting PI3K activity. 2005 Chin. Med. J. pmid:16157051
Uehara Y [Prostaglandin D2]. 2005 Nippon Rinsho pmid:16149440
Zamuner SR et al. Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2. 2005 Am. J. Pathol. pmid:16251413
Negoro H et al. Endogenous prostaglandin D(2) synthesis decreases vascular cell adhesion molecule-1 expression in human umbilical vein endothelial cells. 2005 Life Sci. pmid:16154157
O'Flaherty JT et al. 5-Oxo-ETE analogs and the proliferation of cancer cells. 2005 Biochim. Biophys. Acta pmid:16154383
Schmidt R et al. LC-MS/MS-analysis of prostaglandin E2 and D2 in microdialysis samples of rats. 2005 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16172029
Wilhelm D et al. Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. 2005 Dev. Biol. pmid:16185683
Jawerbaum A et al. Peroxynitrites and impaired modulation of nitric oxide concentrations in embryos from diabetic rats during early organogenesis. 2005 Reproduction pmid:16264098
Armer RE et al. Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. 2005 J. Med. Chem. pmid:16190744
Koh SH et al. 15-Deoxy-delta12,14-prostaglandin J2, a neuroprotectant or a neurotoxicant? 2005 Toxicology pmid:16191461
Mandal AK et al. Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation. 2005 J. Immunol. pmid:16272277
Soares AF et al. Covalent binding of 15-deoxy-delta12,14-prostaglandin J2 to PPARgamma. 2005 Biochem. Biophys. Res. Commun. pmid:16198309
Xue L et al. Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. 2005 J. Immunol. pmid:16272307
Yuhas Y et al. Involvement of prostaglandins in an animal model of Shigella-related seizures. 2005 J. Neuroimmunol. pmid:16139898
Gayarre J et al. Differential selectivity of protein modification by the cyclopentenone prostaglandins PGA1 and 15-deoxy-Delta12,14-PGJ2: role of glutathione. 2005 FEBS Lett. pmid:16223487
Hatoum OA et al. Novel mechanism of vasodilation in inflammatory bowel disease. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:16141408
Noguchi J et al. Strain difference of murine bone marrow-derived mast cell functions. 2005 J. Leukoc. Biol. pmid:16126842
Marone G et al. Role of human mast cells and basophils in bronchial asthma. 2005 Adv. Immunol. pmid:16227089
Jin YR et al. An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. 2005 Basic Clin. Pharmacol. Toxicol. pmid:16128910
Fujishima H et al. Prostaglandin D2 induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular inflammation in patients with allergic conjunctivitis. 2005 Cornea pmid:16227827
Nie M et al. Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists. 2005 J. Biol. Chem. pmid:15531761
Kobayashi Y et al. Physiological levels of 15-deoxy-Delta12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation. 2005 J. Immunol. pmid:16237065
Na HK et al. ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells. 2005 FEBS Lett. pmid:16253239
Sugimoto H et al. CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. 2005 Eur. J. Pharmacol. pmid:16256979
Iwata C et al. Augmentation of lipogenesis by 15-deoxy-Delta12,14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-Delta12,14-prostaglandin J2 production. 2005 J. Invest. Dermatol. pmid:16297182
Thomas RK et al. Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. 2005 Clin. Cancer Res. pmid:16299251
Chen HH et al. Effects of trichloroethylene and perchloroethylene on muscle contractile responses and epithelial prostaglandin release and acetylcholinesterase activity in swine trachea. 2005 Toxicol. Sci. pmid:15496499
Piva R et al. 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins. 2005 Blood pmid:15498850
Monneret G et al. Effects of prostaglandin D(2) and 5-lipoxygenase products on the expression of CD203c and CD11b by basophils. 2005 J. Pharmacol. Exp. Ther. pmid:15388786
Muñoz U et al. The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients. 2005 Exp. Neurol. pmid:16061222
Chen ZY and Tseng CC 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells. 2005 Mol. Pharmacol. pmid:16077033
Chevalier E et al. Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. 2005 J. Immunol. pmid:16081770
Polikandriotis JA et al. Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:16020752
Kim J et al. Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived products. 2005 Cancer Res. pmid:16024620
Choi YH et al. New anti-inflammatory formulation containing Synurus deltoides extract. 2005 Arch. Pharm. Res. pmid:16114500
Kim KA et al. 15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16098720
Chen C and Bazan NG Lipid signaling: sleep, synaptic plasticity, and neuroprotection. 2005 Prostaglandins Other Lipid Mediat. pmid:16099392
Mouihate A et al. Fever suppression in near-term pregnant rats is dissociated from LPS-activated signaling pathways. 2005 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:16037126
Martínez B et al. The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action. 2005 J. Lipid Res. pmid:15654126
Liang X et al. Prostaglandin D2 mediates neuronal protection via the DP1 receptor. 2005 J. Neurochem. pmid:15659218
Shen ZN et al. Suppression of chondrosarcoma cells by 15-deoxy-Delta 12,14-prostaglandin J2 is associated with altered expression of Bax/Bcl-xL and p21. 2005 Biochem. Biophys. Res. Commun. pmid:15694358
Shiraki T et al. Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma. 2005 J. Biol. Chem. pmid:15695504
Bulló M et al. Stimulation of NGF expression and secretion in 3T3-L1 adipocytes by prostaglandins PGD2, PGJ2, and Delta12-PGJ2. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15713689
García-Bueno B et al. The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. 2005 Psychopharmacology (Berl.) pmid:15719215
Storer PD et al. Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis. 2005 J. Neurosci. Res. pmid:15723383
Migita H and Morser J 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) signals through retinoic acid receptor-related orphan receptor-alpha but not peroxisome proliferator-activated receptor-gamma in human vascular endothelial cells: the effect of 15d-PGJ2 on tumor necrosis factor-alpha-induced gene expression. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15662020
O'Reilly KM et al. Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis. 2005 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:15665045
Jerde TJ et al. Celecoxib inhibits ureteral contractility and prostanoid release. 2005 Urology pmid:15667901
Figarella K et al. Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form. 2005 Cell Death Differ. pmid:15678148
Tanaka T et al. Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. 2005 Eur. J. Pharmacol. pmid:15680279
Genovese T et al. Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury. 2005 Eur. Respir. J. pmid:15684285
Artwohl M et al. Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. 2005 Thromb. Haemost. pmid:15886792
Malki S et al. Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. 2005 EMBO J. pmid:15889150
De Oliveira C et al. Insulin alters nuclear factor-lambdaB and peroxisome proliferator-activated receptor-gamma protein expression induced by glycated bovine serum albumin in vascular smooth-muscle cells. 2005 J. Lab. Clin. Med. pmid:15871306
Planagumà A et al. The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. 2005 FASEB J. pmid:15876570
Kim HY et al. Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14-prostaglandin J2 in mouse peritoneal macrophages. 2005 Immunol. Cell Biol. pmid:15877607
Blanco M et al. Increased plasma levels of 15-deoxyDelta prostaglandin J2 are associated with good outcome in acute atherothrombotic ischemic stroke. 2005 Stroke pmid:15879329
Hashimoto Y et al. Prostaglandin D2 inhibits IgE-mediated scratching by suppressing histamine release from mast cells. 2005 J. Pharmacol. Sci. pmid:15879676
Martín AR et al. The COX-2 inhibitor, rofecoxib, ameliorates dextran sulphate sodium induced colitis in mice. 2005 Inflamm. Res. pmid:15883736
Chen YC et al. Prostaglandin D(2) and J(2) induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen species. 2005 Biochim. Biophys. Acta pmid:15843042
Ackerman WE et al. Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells. 2005 Biol. Reprod. pmid:15843495
Drew PD et al. Hormone regulation of microglial cell activation: relevance to multiple sclerosis. 2005 Brain Res. Brain Res. Rev. pmid:15850670
Kämpfer H et al. Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing. 2005 Diabetes pmid:15855344
Saito H [Mast cells]. 2005 Nippon Rinsho pmid:15861652
Capobianco E et al. 15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism. 2005 Reprod. Fertil. Dev. pmid:15899154
Avis I et al. Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition. 2005 Cancer Res. pmid:15899809
Costello DA et al. Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro. 2005 Neuropharmacology pmid:15993441
Patel KM et al. Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma). 2005 Cell. Signal. pmid:15993751
Zurich MG et al. Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. 2005 Neuroscience pmid:15994020
Chacón P et al. Induction of cyclooxygenase-2 expression by allergens in lymphocytes from allergic patients. 2005 Eur. J. Immunol. pmid:15997464
Honma Y et al. Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice. 2005 Eur. J. Pharmacol. pmid:16000196
Kim HJ et al. 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. 2005 Exp. Mol. Med. pmid:16000871
Ibabe A et al. Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes. 2005 Toxicol In Vitro pmid:15964169
Atkins KB et al. Effects of PPAR-gamma ligands on vascular smooth muscle marker expression in hypertensive and normal arteries. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:15345487
Burgess HA et al. PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. 2005 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:15734787
Inoue K et al. Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharide. 2005 Clin. Exp. Pharmacol. Physiol. pmid:15743408
Berry EB et al. Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B. 2005 Mol. Pharmacol. pmid:15821150
Lindström TM and Bennett PR 15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications. 2005 J. Clin. Endocrinol. Metab. pmid:15755849