PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Airway Remodeling D056151 3 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Pulmonary Aspergillosis D055732 1 associated lipids
Acute Lung Injury D055371 33 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Angioedemas, Hereditary D054179 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Decapitation D049248 2 associated lipids
Mastocytosis, Systemic D034721 1 associated lipids
Tauopathies D024801 6 associated lipids
Coronary Restenosis D023903 10 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Fetal Weight D020567 12 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Stroke D020521 32 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Sleep Disorders, Circadian Rhythm D020178 3 associated lipids
Thrombophilia D019851 6 associated lipids
Endotoxemia D019446 27 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Optic Neuropathy, Ischemic D018917 2 associated lipids
Cystitis, Interstitial D018856 2 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Vasculitis, Leukocytoclastic, Cutaneous D018366 5 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Coronavirus Infections D018352 4 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Helicobacter Infections D016481 21 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Choroid Diseases D015862 2 associated lipids
Nasal Obstruction D015508 4 associated lipids
HTLV-I Infections D015490 3 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Weight Loss D015431 56 associated lipids
Reperfusion Injury D015427 65 associated lipids
Zollinger-Ellison Syndrome D015043 1 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Wounds, Stab D014951 3 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Urticaria Pigmentosa D014582 4 associated lipids
Urticaria D014581 13 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Uremia D014511 33 associated lipids
Trigeminal Neuralgia D014277 1 associated lipids
Translocation, Genetic D014178 20 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thyroid Diseases D013959 8 associated lipids
Thrombosis D013927 49 associated lipids
Thrombocytopenia D013921 15 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Stomach Ulcer D013276 75 associated lipids
Sneezing D012912 6 associated lipids
Sleep Wake Disorders D012893 7 associated lipids
Seizures D012640 87 associated lipids
Osteosarcoma D012516 50 associated lipids
Sarcoma 180 D012510 21 associated lipids
Sarcoidosis D012507 13 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Rhinitis D012220 10 associated lipids
Retinopathy of Prematurity D012178 9 associated lipids
Respiratory Sounds D012135 3 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Precancerous Conditions D011230 48 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Pleurisy D010998 20 associated lipids
Persistent Fetal Circulation Syndrome D010547 1 associated lipids
Peritonitis D010538 38 associated lipids
Peptic Ulcer D010437 19 associated lipids
Parkinson Disease D010300 53 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pain D010146 64 associated lipids
Neuroblastoma D009447 66 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nasal Polyps D009298 26 associated lipids
Myocardial Infarction D009203 21 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Muscular Dystrophy, Animal D009137 5 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Meningoencephalitis D008590 4 associated lipids
Melanoma D008545 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lung Diseases D008171 37 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Reginato MJ et al. Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma. 1998 J. Biol. Chem. pmid:9442016
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Jiang C et al. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. 1998 Nature pmid:9422509
Tan W et al. Modulation of nicotinic AChR channels by prostaglandin E2 in chick sympathetic ganglion neurons. 1998 J. Neurophysiol. pmid:9463448
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Daculsi R et al. Effect of PGE2 on the cell surface molecule expression in PMA treated thymocytes. 1998 Immunol. Lett. pmid:9557948
Chan CL and Lau HY Effects of prostanoid receptor agonists on immunologically-activated rat peritoneal mast cells. 1998 Inflamm. Res. pmid:9561397
Lau HY and Stenton GR Effects of non-steroidal anti-inflammatory drugs and cyclooxygenase-2 specific inhibitors on mediator release from rat peritoneal mast cells. 1998 Inflamm. Res. pmid:9561398
Hwang GS et al. Effects of Brazilin on the phospholipase A2 activity and changes of intracellular free calcium concentration in rat platelets. 1998 Arch. Pharm. Res. pmid:9868555
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Terao A et al. Enhancement of slow-wave sleep by tumor necrosis factor-alpha is mediated by cyclooxygenase-2 in rats. 1998 Neuroreport pmid:9875706
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Thomson AM et al. Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase. 1998 Biochem. J. pmid:9657971
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Fiebich BL et al. Potential link between interleukin-6 and arachidonic acid metabolism in Alzheimer's disease. 1998 J. Neural Transm. Suppl. pmid:9850935
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Molderings GJ et al. Modulation of noradrenaline release from the sympathetic nerves of human right atrial appendages by presynaptic EP3- and DP-receptors. 1998 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9826066
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Csala M et al. Prostaglandin-independent stimulation of interleukin-6 production by fibrinogen degradation product D in perfused murine liver. 1998 Scand. J. Immunol. pmid:9743211
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Moon TC et al. Regulation of cyclooxygenase-2 and endogenous cytokine expression by bacterial lipopolysaccharide that acts in synergy with c-kit ligand and Fc epsilon receptor I crosslinking in cultured mast cells. 1998 Cell. Immunol. pmid:9636692
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Chou TC and Li CY Inhibitory mechanisms of dantrolene on platelet aggregation. 1999 Thromb. Res. pmid:10593433
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