Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ahluwalia P et al. | Nedocromil sodium and levocabastine reduce the symptoms of conjunctival allergen challenge by different mechanisms. | 2001 | J. Allergy Clin. Immunol. | pmid:11544467 |
Feng X et al. | Eosinophil production of prostaglandin D2 in patients with aspirin-exacerbated respiratory disease. | 2016 | J. Allergy Clin. Immunol. | pmid:27423494 |
Pienkowski MM et al. | Prostaglandin D2 and histamine during the immediate and the late-phase components of allergic cutaneous responses. | 1988 | J. Allergy Clin. Immunol. | pmid:3292634 |
Gervais FG et al. | Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. | 2001 | J. Allergy Clin. Immunol. | pmid:11742277 |
Williams WR et al. | In vitro tests for the diagnosis of aspirin-sensitive asthma. | 1990 | J. Allergy Clin. Immunol. | pmid:2146311 |
Ruzicka T et al. | Inhibition of rat mast cell arachidonic acid cyclooxygenase by dapsone. | 1983 | J. Allergy Clin. Immunol. | pmid:6413566 |
Johnston SL et al. | The effect of BAY u 3405, a thromboxane receptor antagonist, on prostaglandin D2-induced nasal blockage. | 1993 | J. Allergy Clin. Immunol. | pmid:8473679 |
Wegner CD et al. | The role of 5-lipoxygenase products in preclinical models of asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8473681 |
Knani J et al. | Indirect evidence of nasal inflammation assessed by titration of inflammatory mediators and enumeration of cells in nasal secretions of patients with chronic rhinitis. | 1992 | J. Allergy Clin. Immunol. | pmid:1334102 |
Heavey DJ et al. | Prostaglandin D2 and histamine release in cold urticaria. | 1986 | J. Allergy Clin. Immunol. | pmid:2428856 |
Sedej M et al. | D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on T(H)2 cells. | 2012 | J. Allergy Clin. Immunol. | pmid:21930295 |
Chang JE et al. | Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis. | 2014 | J. Allergy Clin. Immunol. | pmid:24210841 |
Schleimer RP et al. | Role of human basophils and mast cells in the pathogenesis of allergic diseases. | 1985 | J. Allergy Clin. Immunol. | pmid:2410478 |
Emery BE et al. | The effect of IL-4 on human nasal mucosal responses. | 1992 | J. Allergy Clin. Immunol. | pmid:1430703 |
Fajt ML et al. | Prostaglandin Dâ‚‚ pathway upregulation: relation to asthma severity, control, and TH2 inflammation. | 2013 | J. Allergy Clin. Immunol. | pmid:23506843 |
Charlesworth EN et al. | Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction. | 1989 | J. Allergy Clin. Immunol. | pmid:2469708 |
Wachs M et al. | Observations on the pathogenesis of nasal priming. | 1989 | J. Allergy Clin. Immunol. | pmid:2477429 |
Lewis RA and Robin JL | Arachidonic acid derivatives as mediators of asthma. | 1985 | J. Allergy Clin. Immunol. | pmid:3926852 |
Schulman ES et al. | Density heterogeneity of human lung mast cells. | 1988 | J. Allergy Clin. Immunol. | pmid:2455745 |
Shichijo M et al. | Role of cyclic 3',5'-adenosine monophosphate in the regulation of chemical mediator release and cytokine production from cultured human mast cells. | 1999 | J. Allergy Clin. Immunol. | pmid:10329844 |
Xue L et al. | Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells. | 2014 | J. Allergy Clin. Immunol. | pmid:24388011 |
Lebel B et al. | Correlation between symptoms and the threshold for release of mediators in nasal secretions during nasal challenge with grass-pollen grains. | 1988 | J. Allergy Clin. Immunol. | pmid:2461405 |
Bousquet J et al. | Antiallergic activity of H1-receptor antagonists assessed by nasal challenge. | 1988 | J. Allergy Clin. Immunol. | pmid:2461406 |
Norman PS | The John Sheldon memorial lecture. Review of nasal therapy: update. | 1983 | J. Allergy Clin. Immunol. | pmid:6195204 |
Wenzel SE et al. | Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: relationship to the development of late asthmatic responses. | 1991 | J. Allergy Clin. Immunol. | pmid:1993813 |
Bochenek G et al. | A controlled study of 9alpha,11beta-PGF2 (a prostaglandin D2 metabolite) in plasma and urine of patients with bronchial asthma and healthy controls after aspirin challenge. | 2003 | J. Allergy Clin. Immunol. | pmid:12704352 |
Szczeklik W et al. | Functional effects and gender association of COX-2 gene polymorphism G-765C in bronchial asthma. | 2004 | J. Allergy Clin. Immunol. | pmid:15316498 |
Schleimer RP et al. | Inflammatory mediators and mechanisms of release from purified human basophils and mast cells. | 1984 | J. Allergy Clin. Immunol. | pmid:6208229 |
Nakahigashi K et al. | PGD2 induces eotaxin-3 via PPARγ from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis. | 2012 | J. Allergy Clin. Immunol. | pmid:22206772 |
Massey WA and Lichtenstein LM | The effects of antihistamines beyond H1 antagonism in allergic inflammation. | 1990 | J. Allergy Clin. Immunol. | pmid:1979797 |
Awad JA et al. | Detection of the major urinary metabolite of prostaglandin D2 in the circulation: demonstration of elevated levels in patients with disorders of systemic mast cell activation. | 1994 | J. Allergy Clin. Immunol. | pmid:8182221 |
Salari H et al. | Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. | 1994 | J. Allergy Clin. Immunol. | pmid:8182231 |
Aichane A et al. | Precision of conjunctival provocation tests in right and left eyes. | 1993 | J. Allergy Clin. Immunol. | pmid:8335854 |
Proud D et al. | Inflammatory mediator release on conjunctival provocation of allergic subjects with allergen. | 1990 | J. Allergy Clin. Immunol. | pmid:1692049 |
Miadonna A et al. | Mediator release after endobronchial antigen challenge in patients with respiratory allergy. | 1990 | J. Allergy Clin. Immunol. | pmid:1692050 |
Skolnik PR et al. | Stimulation of peroxisome proliferator-activated receptors alpha and gamma blocks HIV-1 replication and TNFalpha production in acutely infected primary blood cells, chronically infected U1 cells, and alveolar macrophages from HIV-infected subjects. | 2002 | J. Acquir. Immune Defic. Syndr. | pmid:12352144 |
Schäfer D et al. | Prostaglandin D2-supplemented "functional eicosanoid testing and typing" assay with peripheral blood leukocytes as a new tool in the diagnosis of systemic mast cell activation disease: an explorative diagnostic study. | 2014 | J Transl Med | pmid:25113638 |
Yamaura K et al. | Repeated application of glucocorticoids exacerbate pruritus via inhibition of prostaglandin D2 production of mast cells in a murine model of allergic contact dermatitis. | 2012 | J Toxicol Sci | pmid:23208428 |
Hayaishi O | Prostaglandin D2 and sleep--a molecular genetic approach. | 1999 | J Sleep Res | pmid:10389108 |
Brugger N et al. | Pharmacological and functional characterization of novel EP and DP receptor agonists: DP1 receptor mediates penile erection in multiple species. | 2008 | J Sex Med | pmid:18047485 |
Inagaki S et al. | Human liver dihydrodiol dehydrogenase 1-catalyzed reaction generating 9alpha,11beta-prostaglandin F2 from prostaglandin D2 followed by micellar electrokinetic chromatography. | 2008 | J Sep Sci | pmid:18307166 |
Kershenovich A et al. | Angiotensin II does not mediate the pressor response to PGD2 (icv). | 2000 | J Renin Angiotensin Aldosterone Syst | pmid:11967813 |
Mooney JJ et al. | Increased Gsα within blood cell membrane lipid microdomains in some depressive disorders: an exploratory study. | 2013 | J Psychiatr Res | pmid:23490066 |
Churi SB et al. | Intrathecal rosiglitazone acts at peroxisome proliferator-activated receptor-gamma to rapidly inhibit neuropathic pain in rats. | 2008 | J Pain | pmid:18387855 |
Farhat A et al. | Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology. | 2011 | J Ovarian Res | pmid:21352547 |
Liu JH | Circadian variations of prostaglandins in the rabbit aqueous humor. | 2000 | J Ocul Pharmacol Ther | pmid:10673131 |
Madhu C et al. | Penetration of natural prostaglandins and their ester prodrugs and analogs across human ocular tissues in vitro. | 1998 | J Ocul Pharmacol Ther | pmid:9811228 |
Hashimoto T et al. | Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs. | 2003 | J Ocul Pharmacol Ther | pmid:14733714 |
Pérez-Nievas BG et al. | Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: mechanisms implicated. | 2010 | J Neuroinflammation | pmid:20929574 |
Wendeburg L et al. | Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells. | 2009 | J Neuroinflammation | pmid:19751497 |
Xiang Z et al. | 15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells. | 2007 | J Neuroinflammation | pmid:17634127 |
Pierre SR et al. | Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice. | 2009 | J Neuroinflammation | pmid:19630993 |
Zhang Y et al. | Simultaneous and high-throughput quantitation of urinary tetranor PGDM and tetranor PGEM by online SPE-LC-MS/MS as inflammatory biomarkers. | 2011 | J Mass Spectrom | pmid:21706677 |
Urade Y et al. | Molecular mechanism of sleep regulation by prostaglandin D2. | 1996 | J Lipid Mediat Cell Signal | pmid:8906548 |
Negishi M et al. | Biological actions of delta 12-prostaglandin J2. | 1995 | J Lipid Mediat Cell Signal | pmid:8777585 |
Hutchinson SM et al. | Effects of eicosanoids on parameters in isolated rat hepatocytes and isolated rat hepatocyte couplets: protective effects of eicosanoid receptor antagonists. | 1997 | J Lipid Mediat Cell Signal | pmid:9041475 |
Urade Y et al. | Prostaglandin D, E, and F synthases. | 1995 | J Lipid Mediat Cell Signal | pmid:8777570 |
Shahab R et al. | Prostaglandins, leukotrienes and perennial rhinitis. | 2004 | J Laryngol Otol | pmid:15318955 |
Cichocka-Jarosz E et al. | Serum tryptase level is a better predictor of systemic side effects than prostaglandin D2 metabolites during venom immunotherapy in children. | 2011 | J Investig Allergol Clin Immunol | pmid:21721371 |
Hyun J et al. | Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. | 2015 | J Innate Immun | pmid:25171731 |
Chan BC et al. | Traditional Chinese medicine for atopic eczema: PentaHerbs formula suppresses inflammatory mediators release from mast cells. | 2008 | J Ethnopharmacol | pmid:18725279 |
Gay SW and Kosher RA | Prostaglandin synthesis during the course of limb cartilage differentiation in vitro. | 1985 | J Embryol Exp Morphol | pmid:3867724 |
Shashni B et al. | Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPARγ in breast cancer pathophysiology. | 2013 | J Drug Target | pmid:23130662 |
Yamada K et al. | Nose-to-brain delivery of TS-002, prostaglandin D2 analogue. | 2007 | J Drug Target | pmid:17365274 |
Lin MS et al. | Activation of peroxisome proliferator-activated receptor gamma inhibits cell growth via apoptosis and arrest of the cell cycle in human colorectal cancer. | 2007 | J Dig Dis | pmid:17532820 |
Parson HK et al. | Role of prostaglandin D2 and the autonomic nervous system in niacin-induced flushing. | 2013 | J Diabetes | pmid:22727040 |
Siegl AM and Daly JW | Receptor (norepinephrine), P-site (2',5'-dideoxyadenosine), and calcium-mediated inhibition of prostaglandin and forskolin-activated cyclic AMP-generating systems in human platelets. | 1985 | J Cyclic Nucleotide Protein Phosphor Res | pmid:2991349 |
Ashby B | Kinetic evidence indicating separate stimulatory and inhibitory prostaglandin receptors on platelet membranes. | 1986 | J Cyclic Nucleotide Protein Phosphor Res | pmid:2432105 |
Bain G et al. | Pharmacodynamics, pharmacokinetics, and safety of AM211: a novel and potent antagonist of the prostaglandin D2 receptor type 2. | 2012 | J Clin Pharmacol | pmid:22110163 |
Lauring B et al. | Laropiprant in combination with extended-release niacin does not alter urine 11-dehydrothromboxane B2, a marker of in vivo platelet function, in healthy, hypercholesterolemic, and diabetic subjects. | 2009 | J Clin Pharmacol | pmid:19833861 |
Shin JS et al. | Direct analysis of prostaglandin-E2 and -D2 produced in an inflammatory cell reaction and its application for activity screening and potency evaluation using turbulent flow chromatography liquid chromatography-high resolution mass spectrometry. | 2016 | J Chromatogr A | pmid:27524299 |
Willenberg I et al. | Determining cyclooxygenase-2 activity in three different test systems utilizing online-solid phase extraction-liquid chromatography-mass spectrometry for parallel quantification of prostaglandin E(2), D(2) and thromboxane B(2). | 2015 | J Chromatogr A | pmid:25777050 |
Kaur R et al. | A phenotypic screening approach in cord blood-derived mast cells to identify anti-inflammatory compounds. | 2013 | J Biomol Screen | pmid:23983232 |
Mori H et al. | Augmentation of antiproliferative activity of recombinant human tumor necrosis factor by delta 12-prostaglandin J2. | 1990 | J Biol Response Mod | pmid:2341865 |
Omini C et al. | Prostaglandin D2 (PGD2) potentiates cholinergic responsiveness in guinea-pig trachea. | 1986 | J Auton Pharmacol | pmid:3464602 |
Brunelli G et al. | PGD2 induces pulmonary hyperresponsiveness to acetylcholine in vivo in the guinea-pig. | 1987 | J Auton Pharmacol | pmid:3480891 |
Armour CL et al. | Prostaglandin F2 alpha augments the response to parasympathetic fibre stimulation in an isolated innervated preparation of rabbit trachea. | 1988 | J Auton Pharmacol | pmid:3198665 |
Krohn IK et al. | Mast cell FcϵRI density and function dissociate from dependence on soluble IgE concentration at very low and very high IgE concentrations. | 2013 | J Asthma | pmid:23294195 |
Higuchi S et al. | Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury. | 2012 | J Appl Toxicol | pmid:21735453 |
Phillips JE et al. | Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma. | 2016 | J Aerosol Med Pulm Drug Deliv | pmid:27111445 |
Urade Y | Twenty-fifth anniversary of the discovery of somnogenic activity of prostaglandin D2: sleep research directed by Osamu Hayaishi. | 2006 May-Jun | IUBMB Life | pmid:16754308 |
Gaetani P et al. | Prostaglandin D2 monitoring in human CSF after subarachnoid hemorrhage: the possible role of prostaglandin D2 in the genesis of cerebral vasospasm. | 1986 | Ital J Neurol Sci | pmid:3456998 |
Woodward DF et al. | Studies on the ocular pharmacology of prostaglandin D2. | 1990 | Invest. Ophthalmol. Vis. Sci. | pmid:2298534 |
Miller NR et al. | Sustained neuroprotection from a single intravitreal injection of PGJâ‚‚ in a nonhuman primate model of nonarteritic anterior ischemic optic neuropathy. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25298416 |
Sakurai S et al. | Retinal capillary pericyte proliferation and c-Fos mRNA induction by prostaglandin D2 through the cAMP response element. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12147615 |
Shao Z et al. | Choroidal involution is a key component of oxygen-induced retinopathy. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:21546530 |
Kuriyan AE et al. | Orbital fibroblasts from thyroid eye disease patients differ in proliferative and adipogenic responses depending on disease subtype. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:24135759 |
Touitou V et al. | Sustained neuroprotection from a single intravitreal injection of PGJ2 in a rodent model of anterior ischemic optic neuropathy. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:24106118 |
Aoun P et al. | Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12824244 |
Weinreb RN et al. | Prostanoids in rabbit aqueous humor: effect of laser photocoagulation of the iris. | 1985 | Invest. Ophthalmol. Vis. Sci. | pmid:3860488 |
Qin S et al. | Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17065531 |
Choi IK et al. | PPAR-gamma ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo. | 2008 | Invest New Drugs | pmid:18161004 |
Bhuyan BK et al. | Cytotoxicity of combinations of prostaglandin D2 (PGD2) and antitumor drugs for B16 melanoma cells in culture. | 1986 | Invest New Drugs | pmid:3473056 |
Marshall JC | Modeling MODS: what can be learned from animal models of the multiple-organ dysfunction syndrome? | 2005 | Intensive Care Med | pmid:15782317 |
Hauser B et al. | Effects of 15-deoxy-Delta12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia. | 2006 | Intensive Care Med | pmid:16534570 |
Marzocco S et al. | The cyclopentenone prostaglandin 15-deoxydelta(12,14)-prostaglandin J2 attenuates the development of zymosan-induced shock. | 2005 | Intensive Care Med | pmid:15868139 |
Gal D et al. | Effect of radiation on prostaglandin production by human bowel in vitro. | 1984 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:6588048 |
Baker DG et al. | Cellular and chemical mediators of type 1 hypersensitivity in calves infected with Ostertagia ostertagi: histamine, prostaglandin D2, prostaglandin E2 and leukotriene C4. | 1993 | Int. J. Parasitol. | pmid:8359983 |
Hovsepian E et al. | Modulation of inflammatory response and parasitism by 15-Deoxy-Δ(12,14) prostaglandin J(2) in Trypanosoma cruzi-infected cardiomyocytes. | 2011 | Int. J. Parasitol. | pmid:21215746 |
Shim J et al. | The peroxisome proliferator-activated receptor gamma ligands, pioglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), have antineoplastic effects against hepatitis B virus-associated hepatocellular carcinoma cells. | 2010 | Int. J. Oncol. | pmid:19956851 |