Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fukushima M et al. | Prostaglandin D2, a potential antineoplastic agent. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6953969 |
Watanabe T et al. | NADP-linked 15-hydroxyprostaglandin dehydrogenase for prostaglandin D in human blood platelets. | 1982 | Arch. Biochem. Biophys. | pmid:6954879 |
Sirén AL | Central cardiovascular and thermal effects of prostaglandin D2 in rats. | 1982 | Prostaglandins Leukot Med | pmid:6955803 |
Mitchell MD et al. | The human placenta: a major source of prostaglandin D2. | 1982 | Prostaglandins Leukot Med | pmid:6955806 |
Gualde N et al. | Stimulation of prostaglandin synthesis by the serum factor (FTS). | 1982 | Cell. Immunol. | pmid:6957270 |
Tokumoto H et al. | An NADP-linked 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin D2 from swine brain. | 1982 | J. Biol. Chem. | pmid:6958674 |
Narumiya S et al. | Prostaglandin D2 in rat brain, spinal cord and pituitary: basal level and regional distribution. | 1982 | Life Sci. | pmid:6960222 |
Lewis RA et al. | Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. | 1982 | J. Immunol. | pmid:6809826 |
Karniguian A et al. | Prostaglandins: specific inhibition of platelet adhesion to collagen and relationship with cAMP level. | 1982 | Prostaglandins | pmid:6287536 |
Shimizu T et al. | Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties, and distribution. | 1982 | J. Biol. Chem. | pmid:6292197 |