Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wendling MG and DuCharme DW | Cardiovascular effects of prostaglandin D3 and D2 in anesthetized dogs. | 1981 | Prostaglandins | pmid:6945633 |
Spannhake EW et al. | Bronchoactive metabolites of arachidonic acid and their role in airway function. | 1981 | Prostaglandins | pmid:6801729 |
Stenson WF et al. | Metabolism of exogenous arachidonic acid by murine macrophage-like tumor cell lines. | 1981 | Prostaglandins | pmid:6803301 |
Claeys M et al. | Lack of prostacyclin biosynthesis by aortic tissue of the chicken. | 1981 | Prostaglandins | pmid:6803304 |
Gerritsen ME and Printz MP | Prostaglandin D synthase in microvessels from the rat cerebral cortex. | 1981 | Prostaglandins | pmid:6119739 |
Lagarde M et al. | Refractoriness of diabetic platelets to inhibitory prostaglandins. | 1981 | Prostaglandins Med | pmid:6273957 |
Smith JB | Prostaglandins and platelet aggregation. | 1981 | Acta Med. Scand. Suppl. | pmid:7034481 |
Nakagawa S et al. | Evaluation of prostaglandin D2 (PGD2) as an anticoagulative agent for haemodialysis in comparison with prostaglandin E1 (PGE1). | 1981 | Proc Eur Dial Transplant Assoc | pmid:7036145 |
McRea JC et al. | Prostaglandin releasing polymers - stability and efficacy. | 1981 | Trans Am Soc Artif Intern Organs | pmid:7036503 |
Harris DN et al. | 9 alpha-homo-9,11-epoxy-5,13-prostadienoic acid analogues: specific stable agonist (SQ 26, 538) and antagonist (SQ 26, 536) of the human platelet thromboxane receptor. | 1981 | Prostaglandins | pmid:6270744 |