PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Imashuku S et al. | Tumor differentiation--application of prostaglandins in the treatment of neuroblastoma. | 1985 | Prog. Clin. Biol. Res. | pmid:2986176 |
| Makino S | [Physiological and pharmacological actions of prostaglandins and related substances: inflammation and allergy]. | 1985 | Nippon Rinsho | pmid:2989584 |
| Siegl AM and Daly JW | Receptor (norepinephrine), P-site (2',5'-dideoxyadenosine), and calcium-mediated inhibition of prostaglandin and forskolin-activated cyclic AMP-generating systems in human platelets. | 1985 | J Cyclic Nucleotide Protein Phosphor Res | pmid:2991349 |
| Orchard MA et al. | Thromboxane synthase inhibition causes re-direction of prostaglandin endoperoxides to prostaglandin D2 during collagen stimulated aggregation of human platelet rich plasma. | 1985 | Thromb. Res. | pmid:3936223 |
| McGuire JC et al. | Production of prostaglandin D2 by murine macrophage cell lines. | 1985 | Prostaglandins | pmid:3937182 |
| Lewis RA et al. | Pharmacologic regulation of mediator generation and release from the murine bone marrow derived mast cell. | 1985 | Int. Arch. Allergy Appl. Immunol. | pmid:2409010 |
| Norman PS et al. | Mediator release after allergic and physical nasal challenges. | 1985 | Int. Arch. Allergy Appl. Immunol. | pmid:2409027 |
| Schleimer RP et al. | Role of human basophils and mast cells in the pathogenesis of allergic diseases. | 1985 | J. Allergy Clin. Immunol. | pmid:2410478 |
| Lad PM et al. | Receptor-specific threshold effects of cyclic AMP are involved in the regulation of enzyme release and superoxide production from human neutrophils. | 1985 | Biochim. Biophys. Acta | pmid:2411298 |
| Finney MJ et al. | Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. | 1985 | Br. J. Pharmacol. | pmid:2411319 |
| Fowler JC et al. | Prostaglandins block a Ca2+-dependent slow spike afterhyperpolarization independent of effects on Ca2+ influx in visceral afferent neurons. | 1985 | Brain Res. | pmid:2412652 |
| Lewis RA and Robin JL | Arachidonic acid derivatives as mediators of asthma. | 1985 | J. Allergy Clin. Immunol. | pmid:3926852 |
| Armstrong RA et al. | Competitive antagonism at thromboxane receptors in human platelets. | 1985 | Br. J. Pharmacol. | pmid:2580580 |
| Okuyama S et al. | Redifferentiation of cancer cells: bestatin, estradiol, and prostaglandin D2. | 1985 | Ann. N. Y. Acad. Sci. | pmid:3868328 |
| Okuyama S and Mishina H | Principia of cancer therapy. X. Prostaglandin D2 triggers redifferentiation of the bestatin-treated breast cancer cells in vitro. | 1985 | Sci Rep Res Inst Tohoku Univ Med | pmid:3870142 |
| Okuyama S and Mishina H | Principia of cancer therapy. XI. Prostaglandin D2 induces redifferentiation of M1 leukemia cells in vitro irrespective of bestatin. | 1985 | Sci Rep Res Inst Tohoku Univ Med | pmid:3870143 |
| Murray JJ et al. | Prostaglandin D2 is released during acute allergic bronchospasm in man. | 1985 | Trans. Assoc. Am. Physicians | pmid:3870298 |
| Kasukabe T et al. | Specific inhibition by prostaglandin D2 and its metabolites of lysozyme synthesis in mouse macrophage-like cell line, Mm-1. | 1985 | Biochim. Biophys. Acta | pmid:3855662 |
| Narumiya S and Fukushima M | delta 12-Prostaglandin J2, an ultimate metabolite of prostaglandin D2 exerting cell growth inhibition. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3857041 |
| Abbate R et al. | Decreased number of PGD2 binding sites on platelets from patients with type IIa hyperlipoproteinemia. | 1985 | Atherosclerosis | pmid:3857047 |
| Rocklin RE et al. | Decreased sensitivity of atopic mononuclear cells to prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2). | 1985 | J. Immunol. | pmid:3160784 |
| Banks RO and Jacobson ED | Renal vasodilation with ureteral occlusion and prostaglandins: attenuation by histamine H1 antagonists. | 1985 | Am. J. Physiol. | pmid:2866716 |
| Costall B et al. | Modification of dyskinesias following the intrastriatal injection of prostaglandins in the rodent. | 1985 | Br. J. Pharmacol. | pmid:3862460 |
| Watanabe Y et al. | Specific bindings of prostaglandin D2, E2 and F2 alpha in postmortem human brain. | 1985 | Brain Res. | pmid:2994820 |
| Fortini A et al. | Heparin does not interfere with prostacyclin and prostaglandin D2 binding to platelets. | 1985 | Thromb. Res. | pmid:3001968 |
| Wasserman SI | The mast cell and theophylline in asthma. | 1985 | Am. J. Med. | pmid:3002176 |
| Bushfield M et al. | Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP. | 1985 | Biochem. J. | pmid:3002327 |
| Shimatsu A et al. | Prostaglandin D2 stimulates vasoactive intestinal polypeptide release into rat hypophysial portal blood. | 1984 Mar-Apr | Peptides | pmid:6591147 |
| Barrow SE et al. | Measurement of prostaglandin D2 and identification of metabolites in human plasma during intravenous infusion. | 1984 | Prostaglandins | pmid:6441188 |
| Bertelé V et al. | Pharmacologic inhibition of thromboxane synthetase and platelet aggregation: modulatory role of cyclooxygenase products. | 1984 | Blood | pmid:6426554 |
| Gresele P et al. | Serum albumin enhances the impairment of platelet aggregation with thromboxane synthase inhibition by increasing the formation of prostaglandin D2. | 1984 | Biochem. Pharmacol. | pmid:6430299 |
| Vicenzi E et al. | Human mononuclear phagocytes from different anatomical sites differ in their capacity to metabolize arachidonic acid. | 1984 | Clin. Exp. Immunol. | pmid:6432383 |
| Nishi S et al. | Different effects of prostaglandin E1, E2 and D2 on pancreatic somatostatin release. | 1984 | Horm. Metab. Res. | pmid:6152434 |
| Neely SM et al. | Mechanism and characteristics of platelet activation by haematin. | 1984 | Br. J. Haematol. | pmid:6383458 |
| Uchizono K | [Studies of sleep inducing substance]. | 1984 | Nippon Rinsho | pmid:6384575 |
| Philips JB and Lyrene RK | Prostaglandins, related compounds, and the perinatal pulmonary circulation. | 1984 | Clin Perinatol | pmid:6386270 |
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| Weichman BM et al. | SK&F 88046: a unique pharmacologic antagonist of bronchoconstriction induced by leukotriene D4, thromboxane and prostaglandins F2 alpha and D2 in vitro. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6582266 |
| Bertelé V et al. | SQ 22536, an adenylate-cyclase inhibitor, prevents the antiplatelet effect of dazoxiben, a thromboxane-synthetase inhibitor. | 1984 | Thromb. Haemost. | pmid:6326343 |
| Chapnick BM | Divergent influences of leukotrienes C4, D4, and E4 on mesenteric and renal blood flow. | 1984 | Am. J. Physiol. | pmid:6326595 |
| Gardiner PJ and Browne JL | Tussive activity of inhaled PGD2 in the cat and characterisation of the receptor(s) involved. | 1984 | Prostaglandins Leukot Med | pmid:6328541 |
| Zavoico GB and Feinstein MB | Cytoplasmic Ca2+ in platelets is controlled by cyclic AMP: antagonism between stimulators and inhibitors of adenylate cyclase. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329175 |
| Pan IQ et al. | Alteration of platelet responses to metabolites of arachidonic acid by oral contraceptives. | 1984 | Br. J. Haematol. | pmid:6089860 |
| Nilsson J and Olsson AG | Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor. | 1984 | Atherosclerosis | pmid:6093830 |
| Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
| Ikai K et al. | Prostaglandin D2 and prostaglandin D synthetase in mast cell deficient mice. | 1984 | Prostaglandins | pmid:6435183 |
| Holgate ST and Robinson C | 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells. | 1984 | Br. J. Pharmacol. | pmid:6439267 |
| Erman A and Nasjletti A | Enhancement of renal medulla prostaglandin synthetase activity by dexamethasone treatment in the rat. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428405 |
| Holgate ST et al. | Anaphylactic- and calcium-dependent generation of prostaglandin D2 (PGD2), thromboxane B2, and other cyclooxygenase products of arachidonic acid by dispersed human lung cells and relationship to histamine release. | 1984 | J. Immunol. | pmid:6206153 |
| Newman JH and Sheller JR | Arachidonic acid metabolites in the healthy and diseased lung. | 1984 | Am. J. Med. Sci. | pmid:6091454 |