Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bertelé V et al. | Refractoriness of platelets to prostaglandins after infusion in rabbits. | 1985 | J. Lab. Clin. Med. | pmid:2997353 |
Watanabe K et al. | Biosynthesis of prostaglandin F2 alpha from prostaglandins H2 and D2 by an apparently homogeneous enzyme. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936081 |
Liston TE et al. | Prostaglandin D2 is metabolized in humans to 9 alpha,11 beta-prostaglandin F2, a novel biologically active prostaglandin. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936123 |
Toda N et al. | Neuroeffector actions of prostaglandins on isolated arteries. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936153 |
Ueno R et al. | Prostaglandin D2: a cerebral sleep-regulating substance in rats. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936173 |
Schick B and Austen KF | Pharmacological modulation of activation-secretion of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1985 | Immunology | pmid:3935569 |
Fitscha P et al. | Platelet sensitivity to antiaggregatory prostaglandins (PGE1,D2,I2) in patients with peripheral vascular disease. | 1985 | Am. J. Hematol. | pmid:3885723 |
Wong P et al. | Diminished sensitivity of platelet aggregation to prostaglandin D2 in patients with myeloproliferative disorders and in patients with acute leukemia. | 1985 | Nippon Ketsueki Gakkai Zasshi | pmid:3890456 |
Cutler LS et al. | Cytochemical localization of adenylate cyclase in the dense tubule system of human blood platelets stimulated by forskolin, prostacyclin and prostaglandin D2. | 1985 | Biochim. Biophys. Acta | pmid:3890960 |
Siegl PK and Wenger HC | Cardiovascular responses to an isosterically modified prostaglandin analog in the anesthetized dog. | 1985 | Eur. J. Pharmacol. | pmid:3899681 |
Regulatory control and standardization of allergenic extracts. Clinical studies with "standardized" extracts. | 1985 | Arb Paul Ehrlich Inst Georg Speyer Haus Ferdinand Blum Inst Frankf A M | pmid:3901924 | |
McGuire JC et al. | Production of prostaglandin D2 by murine macrophage cell lines. | 1985 | Prostaglandins | pmid:3937182 |
Schleimer RP et al. | Role of human basophils and mast cells in the pathogenesis of allergic diseases. | 1985 | J. Allergy Clin. Immunol. | pmid:2410478 |
Lad PM et al. | Receptor-specific threshold effects of cyclic AMP are involved in the regulation of enzyme release and superoxide production from human neutrophils. | 1985 | Biochim. Biophys. Acta | pmid:2411298 |
Finney MJ et al. | Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. | 1985 | Br. J. Pharmacol. | pmid:2411319 |
Fowler JC et al. | Prostaglandins block a Ca2+-dependent slow spike afterhyperpolarization independent of effects on Ca2+ influx in visceral afferent neurons. | 1985 | Brain Res. | pmid:2412652 |
Levi-Schaffer F et al. | Fibroblasts maintain the phenotype and viability of the rat heparin-containing mast cell in vitro. | 1985 | J. Immunol. | pmid:2413121 |
Forman MB et al. | Increased adventitial mast cells in a patient with coronary spasm. | 1985 | N. Engl. J. Med. | pmid:2413358 |
Arisawa M et al. | Suppressive effect of prostaglandin D2 on prolactin secretion from rat anterior pituitary. | 1985 | Asia Oceania J Obstet Gynaecol | pmid:3860198 |
Spannhake EW et al. | Influence of mediators of anaphylaxis on collateral ventilation and the lung periphery of the dog. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3860642 |
Liston TE and Roberts LJ | Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3862115 |
Tanaka H et al. | The effects of PGD2 and 9-deoxy-delta 9-PGD2 on colony formation of murine osteosarcoma cells. | 1985 | Prostaglandins | pmid:3863195 |
Liston TE and Roberts LJ | Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. | 1985 | J. Biol. Chem. | pmid:3863815 |
Roberts LJ and Sweetman BJ | Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. | 1985 | Prostaglandins | pmid:3864190 |
Banks RO and Jacobson ED | Renal vasodilation with ureteral occlusion and prostaglandins: attenuation by histamine H1 antagonists. | 1985 | Am. J. Physiol. | pmid:2866716 |
Bhattacharya SK and Parmar SS | Prostaglandin D2-induced potentiation of hexobarbitone hypnosis in rats: role of 5-hydroxytryptamine. | 1985 | J. Pharm. Pharmacol. | pmid:2868104 |
Whittle BJ et al. | Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:2871707 |
Shimatsu A et al. | Prostaglandin D2 stimulates vasoactive intestinal polypeptide release into rat hypophysial portal blood. | 1984 Mar-Apr | Peptides | pmid:6591147 |
Neely SM et al. | Mechanism and characteristics of platelet activation by haematin. | 1984 | Br. J. Haematol. | pmid:6383458 |
Uchizono K | [Studies of sleep inducing substance]. | 1984 | Nippon Rinsho | pmid:6384575 |
Philips JB and Lyrene RK | Prostaglandins, related compounds, and the perinatal pulmonary circulation. | 1984 | Clin Perinatol | pmid:6386270 |
Goetzl EJ | Asthma: new mediators and old problems. | 1984 | N. Engl. J. Med. | pmid:6330554 |
Rao PS et al. | Prostaglandin D2 in canine endotoxic shock. Hemodynamic, hematologic, biochemical, and blood gas analyses. | 1984 | Am. J. Obstet. Gynecol. | pmid:6424477 |
Schick B et al. | Activation of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1984 | J. Immunol. | pmid:6425408 |
Imanishi J et al. | [Inhibition of the multiplication of human herpes virus I by prostaglandin D2 and the synergistic effect of human leukocyte interferon]. | 1984 | C. R. Seances Soc. Biol. Fil. | pmid:6100083 |
Mitsuma T and Nogimori T | Effects of substance P, angiotensin II, oxotremorine and prostaglandin D2 on thyrotropin secretion in rats. | 1984 | Horm. Res. | pmid:6201427 |
Ennis M et al. | Prostaglandin and histamine release from stimulated rat peritoneal mast cells. | 1984 | Agents Actions | pmid:6203356 |
Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
Ikai K et al. | Prostaglandin D2 and prostaglandin D synthetase in mast cell deficient mice. | 1984 | Prostaglandins | pmid:6435183 |
Holgate ST and Robinson C | 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells. | 1984 | Br. J. Pharmacol. | pmid:6439267 |
Erman A and Nasjletti A | Enhancement of renal medulla prostaglandin synthetase activity by dexamethasone treatment in the rat. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428405 |
Holgate ST et al. | Anaphylactic- and calcium-dependent generation of prostaglandin D2 (PGD2), thromboxane B2, and other cyclooxygenase products of arachidonic acid by dispersed human lung cells and relationship to histamine release. | 1984 | J. Immunol. | pmid:6206153 |
Schleimer RP et al. | Inflammatory mediators and mechanisms of release from purified human basophils and mast cells. | 1984 | J. Allergy Clin. Immunol. | pmid:6208229 |
Inoué S et al. | Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6592612 |
Inoué S et al. | Little sleep-promoting effect of three sleep substances diurnally infused in unrestrained rats. | 1984 | Neurosci. Lett. | pmid:6593603 |
Marsden KA et al. | The effect of prostaglandin D2 (PGD2) on circulating eosinophils. | 1984 | Prostaglandins Leukot Med | pmid:6593748 |
Abramovich DR et al. | The effect of prostaglandin D2 on the blood vessels of the perfused isolated cotyledon of the human placenta. | 1984 | Br. J. Pharmacol. | pmid:6584189 |
Kikawa Y et al. | 9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6584883 |
Sakai T et al. | Prostaglandin D2 inhibits the proliferation of human malignant tumor cells. | 1984 | Prostaglandins | pmid:6584941 |
Imashuku S et al. | [Differentiation induction and potentiation of chemotherapy by PGE1 infusion in patients with neuroblastoma--effect of PGE1 on metastatic potential of neuroblastoma]. | 1984 | Gan To Kagaku Ryoho | pmid:6585182 |